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BIIB

Biogen

$313.03

7.25 (2.37%)

10:16
10/03/16
10/03
10:16
10/03/16
10:16

Biogen potential trading opportunity into year-end, says BMO Capital

BMO Capital hosted a call with an expert on Alzheimers that may present a trading opportunity in Biogen (BIIB) shares as we approach sola Phase 3 and aducanumab titration data expected at year end. The expert said evidence supports the amyloid hypothesis of AD outweighs the evidence that undercuts it, but suggested that patient selection and trial design/execution key to demonstrating benefit to support regulatory approval. He estimated that Lilly's (LLY) EXPEDITION-3 trial has a ~60% probability of success, with Biogen's aducanumab greater than70% as long as rates of ARIA-E can be reduced with titration. Analyst Ian Somaiya believes positive Phase III Sola data could provide a positive read through to aducanumab and results in Biogen shares trading up 20-25%. If Sola misses, aducanumab's ability to clear beta amyloid oligomers & plaques and in our opinion a better trial design could limit downside in shares to approximately 10%. Somaiya rates Biogen a Market Perform with a $304 price target.

  • 26

    Oct

  • 06

    Nov

BIIB Biogen
$313.03

7.25 (2.37%)

09/26/16
PIPR
09/26/16
NO CHANGE
Target $46
PIPR
Overweight
Ionis nusinersen program advancing faster than expected, says Piper Jaffray
After Biogen (BIIB) and Ionis (IONS) announced that Biogen has completed the rolling submission of a New Drug Application to the U.S. FDA for the approval of nusinersen, an investigational treatment for spinal muscular atrophy, Piper Jaffray analyst Joshua Schimmer said that the nusinersen program is advancing faster than many have expected. Nusinersen may launch before AveXis (AVXS) starts its next Phase 3 trial, added Schimmer, who believes nusinersen will emerge as a multi-billion dollar product. The analyst keeps an Overweight rating and $46 price target on Ionis shares.
09/28/16
JEFF
09/28/16
NO CHANGE
Target $50
JEFF
Buy
Jefferies parent survey shows interest in AveXis pivotal trial
Jefferies analyst Biren Amin conducted a survey of parents of spinal muscular atrophy patients amid investor questions surrounding AveXis' (AVXS) ability to enroll a pivotal trial with AVXS-101 given the open access program with nusinersen, the investigational drug being developed by Ionis Pharmaceuticals (IONS) and Biogen (BIIB). Parents value the option of nusinersen treatment but are also willing to enroll in clinical trials of AVXS-101, Amin tells investors in a research note, citing his survey of seven parents. A single arm trial of AVXS-101 was the most preferred clinical trial design for the upcoming Phase 3 of AVXS-101, he added. The analyst believes his parent responses suggest excitement over nusinersen but also a willingness to enroll into the AVXS-101 trials, especially if it is a single-arm trial. Parents were also attracted to AVXS-101 intravenous delivery, which could be a "meaningful advantage," Amin contends. The analyst keeps a Buy rating on AveXis with a $50 price target. The stock closed yesterday up 88c to $41.00. Amin caused a rally in AveXis shares on September 19 when writing about finding a video online of a spinal muscular atrophy baby walking that he believed to be a patient in the company's trial of AVXS-101.
09/28/16
BERN
09/28/16
NO CHANGE
BERN
Biogen likely to benefit from Lilly Alzheimer's drug results, says Bernstein
Bernstein analyst Aaron Gal says that the results of a trial of Eli Lilly's (LLY) Alzheimer's drug, solanezumab, due out in late 2016 or early 2017, are likely to impact perceptions of Biogen's (BIIB) Alzheimer's drug, aducanumab. The analyst expects Lilly's solanezumab "to show at least directional evidence" of cognitive improvement, although he is "less convinced" that the impact will be clearly statistically significant. The best results from Biogen's perspective will be if Lilly's drug shows "marginal success," according to Gal. However, statistically significant results are also good for Biogen, as they will show that reducing amyloid beta does mitigate Alzheimer's symptoms, the analyst stated. And if Lilly's drug completely fails, Biogen's drug "could well succeed," given the significant differences between them, wrote Gal,who gives Biogen's aducanumab a 65% chance of success. He keeps a $345 price target and Outperform rating on Biogen.

TODAY'S FREE FLY STORIES

KBR

KBR

$14.05

-1.43 (-9.24%)

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SMMT

Summit Therapeutics

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TKPYY

Takeda Pharmaceutical Co. Ltd.

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0.85 (3.54%)

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FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

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SGBK

Stonegate Bank

$45.90

-0.52 (-1.12%)

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PROV

Provident Financial

$19.23

-0.03 (-0.16%)

17:45
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YGE

Yingli Green Energy

$2.66

-0.03 (-1.12%)

17:40
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EPC

Edgewell Personal Care

$71.49

-0.14 (-0.20%)

17:40
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Breaking Hot Stocks news story on Edgewell Personal Care »

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  • 02

    May

ORC

Orchid Island Capital

$10.60

-0.33 (-3.02%)

17:35
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Syndicate
Breaking Syndicate news story on Orchid Island Capital »

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AEP

American Electric

$67.83

-0.27 (-0.40%)

17:35
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ORC

Orchid Island Capital

$10.60

-0.33 (-3.02%)

17:34
04/28/17
04/28
17:34
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17:34
Syndicate
Breaking Syndicate news story on Orchid Island Capital »

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  • 28

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HBHC

Hancock Holding

$46.70

-0.5 (-1.06%)

, FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

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Whitney to acquire branches, assets, liabilities of First NBC from FDIC »

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HBHC

Hancock Holding

$46.70

-0.5 (-1.06%)

FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

03/08/13
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  • 06

    Jun

TSLA

Tesla

$314.07

5.44 (1.76%)

17:31
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04/28
17:31
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17:31
Periodicals
Tesla aims to hire engineers from Mexico to work at CA plant, Reuters says »

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  • 03

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LMT

Lockheed Martin

$269.45

-1.69 (-0.62%)

17:22
04/28/17
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Lockheed Martin awarded $332.1M government contract »

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  • 31

    May

BA

Boeing

$184.83

1.61 (0.88%)

17:21
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Boeing awarded $541M government contract modification »

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  • 31

    May

WBA

Walgreens Boots Alliance

$86.54

0.65 (0.76%)

, RAD

Rite Aid

$4.00

0.05 (1.27%)

17:20
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Periodicals
Walgreens to push regulators over decision on Rite Aid deal, NY Post says »

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WBA

Walgreens Boots Alliance

$86.54

0.65 (0.76%)

RAD

Rite Aid

$4.00

0.05 (1.27%)

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GE

General Electric

$28.99

-0.09 (-0.31%)

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  • 09

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SIX

Six Flags

$62.61

-0.26 (-0.41%)

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  • 03

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LMT

Lockheed Martin

$269.45

-1.69 (-0.62%)

17:18
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Lockheed Martin awarded $1.38B government contract »

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  • 31

    May

SBBP

Strongbridge Biopharma

$4.50

0.05 (1.12%)

17:16
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Syndicate
Breaking Syndicate news story on Strongbridge Biopharma »

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  • 11

    May

CYH

Community Health

$8.61

0.18 (2.14%)

17:12
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Community Health completes divestiture of Anniston, Alabama hospital »

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  • 02

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MRUS

Merus

$22.20

-0.14 (-0.63%)

17:07
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Earnings
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  • 02

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AEZS

Aeterna Zentaris

$3.35

0.3 (9.84%)

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  • 09

    May

ANY

Sphere 3D

$0.19

-0.006 (-3.13%)

17:00
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Breaking Syndicate news story on Sphere 3D »

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  • 11

    May

MRUS

Merus

$22.20

-0.14 (-0.63%)

16:56
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Merus provides anticipated 2017 pipeline milestones »

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  • 02

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