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AZN

AstraZeneca

$33.00

0.14 (0.43%)

06:25
10/04/16
10/04
06:25
10/04/16
06:25

AstraZeneca says Brilinta did not meet primary endpoint in EUCLID trial

AstraZeneca announced top-line results from the EUCLID trial. Brilinta did not demonstrate a benefit over clopidogrel in a symptomatic peripheral artery disease patient population and therefore did not meet the primary endpoint of the trial.The EUCLID trial included 13,885 patients in 28 countries and is the largest cardiovascular outcomes trial to date conducted exclusively in symptomatic patients with PAD. It evaluated the treatment of Brilinta 90mg tablets twice daily versus clopidogrel 75mg once daily for the prevention of atherothrombotic events. The primary endpoint of the trial was the time to first occurrence of any such event. Based on preliminary analyses, safety data is consistent with the known safety profile of Brilinta. Sean Bohen, Executive Vice President, Global Medicines Development and Chief Medical Officer at AstraZeneca, said: "The proven benefits of Brilinta in acute coronary syndrome and post-myocardial infarction patients are established and remain unchanged. We are disappointed that the EUCLID trial results showed Brilinta did not demonstrate a benefit over clopidogrel in this specific symptomatic PAD population." Full results from the EUCLID trial are expected to be presented at the American Heart Association Scientific Sessions in New Orleans, Louisiana in November 2016.

  • 07

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  • 16

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AZN AstraZeneca
$33.00

0.14 (0.43%)

09/23/16
09/23/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Morgan Stanley analyst Brian Nowak initiated Activision Blizzard (ATVI) and Electronic Arts (EA), both with Overweight ratings. The analyst is bullish on the digital gaming shift away from "units sold" to a business model based on users, engagement, and digital monetization. He sees digital in-game offerings resulting in recurring and growth user bases, increased per-game engagement, and further monetization opportunities. 2. AstraZeneca (AZN) and GlaxoSmithKline (GSK) both initiated with Overweight ratings by Piper Jaffray analyst Richard Purkiss. 3. Achillion (ACHN) initiated with an Outperform by Wedbush analyst Heather Behanna, who set a $13 price target on the shares. 4. Sysco (SYY) initiated with an Underweight at Barclays and $48 price target by analyst Karen Short. 5. Five Below (FIVE), Dollar Tree (DLTR) and Dollar General (DG) all initiated with Equal Weight ratings by Barclays analyst Karen Short. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/23/16
PIPR
09/23/16
INITIATION
PIPR
Overweight
AstraZeneca initiated with an Overweight at Piper Jaffray
Piper Jaffray analyst Richard Purkiss started AstraZeneca with an Overweight rating and GBP 60 price target.
09/13/16
EXAN
09/13/16
DOWNGRADE
EXAN
Neutral
AstraZeneca downgraded to Neutral from Outperform at Exane BNP Paribas
09/12/16
09/12/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pandora (P) upgraded to Buy from Neutral at SunTrust with analyst Robert Peck saying he thinks that a new interactive offering by the company could raise its contribution profit by 4%-9% and that the Street's 2017 estimates for the company "seem conservative." The analyst added that he thinks it's "very possible" that Pandora will be acquired. 2. AstraZeneca (AZN) upgraded to Buy from Hold at Jefferies with analyst Jeffrey Holford saying the company's MYSTIC oncology study could drive 39% share upside if successful. 3. Apache (APA) and upgraded to Overweight from Neutral at Atlantic Equities and to Peer Perform from Underperform at Wolfe Research. 4. Philip Morris (PM) upgraded to Conviction Buy from Neutral at Goldman with analyst Judy Hong saying she is increasingly bullish on the prospects of Next Generation Products and expects them to contribute 5%-6% of earnings by 2020. 5. Wal-Mart (WMT) upgraded to Outperform from Market Perform at Cowen with analysts led by Oliver Chen saying price investments, integration of physical and digital, and the Jet acquisitions position the company to regain its dominance. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

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VNCE

Vince Holding

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NWBO

Northwest Biotherapeutics

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AAPL

Apple

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Microsoft

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ATKR

Atkore

$19.71

-0.11 (-0.55%)

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  • 08

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BPMC

Blueprint Medicines

$26.20

-2.23 (-7.84%)

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Syndicate
Blueprint Medicines 5M share Secondary priced at $25.00 »

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  • 08

    Dec

LULU

lululemon

$59.84

2.6 (4.54%)

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lululemon CFO says early Q4 trends strengthened into December »

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LULU

lululemon

$59.84

2.6 (4.54%)

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lululemon CEO highlights Q3 gross margin, reports 11% comp growth in pants »

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CVX

Chevron

$114.44

1.68 (1.49%)

19:20
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Chevron announces $19.8B capital, exploratory budget for 2017 »

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  • 13

    Dec

X

U.S. Steel

$37.49

1.54 (4.28%)

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Periodicals
U.S. Steel CEO: Company may bring back 10,000 U.S. jobs, CNBC says »

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VNDA

Vanda

$15.40

-0.6 (-3.75%)

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Vanda settles Fanapt patent litigation with Apotex »

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AE

Adams Resources

$42.31

-0.68 (-1.58%)

, SWN

Southwestern Energy

$12.37

-0.08 (-0.64%)

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AE

Adams Resources

$42.31

-0.68 (-1.58%)

SWN

Southwestern Energy

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EZPW

EZCORP

$11.80

0.05 (0.43%)

18:42
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Earnings
EZCORP reports Q4 EPS with items (31c), may not compare to consensus 6c »

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  • 08

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RICE

Rice Energy

$24.59

-0.16 (-0.65%)

18:33
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AMZN

Amazon.com

$770.42

5.7 (0.75%)

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Amazon spokesperson denies 2,000 grocery stores report, CNET says »

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ICON

Iconix Brand

$9.26

0.14 (1.54%)

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Iconix Brand reports employment termination of Chief Strategy Officer Blumberg »

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PBYI

Puma Biotechnology

$39.80

-2 (-4.78%)

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FTK

Flotek

$11.10

-2.01 (-15.33%)

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PBYI

Puma Biotechnology

$39.80

-2 (-4.78%)

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PNM

PNM Resources

$32.05

0.45 (1.42%)

18:09
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  • 14

    Dec

BK

BNY Mellon

$48.55

0.56 (1.17%)

18:03
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TLRD

Tailored Brands

$18.93

0.62 (3.39%)

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  • 08

    Dec

FLXS

Flexsteel Industries

$59.12

2.92 (5.20%)

, UNH

UnitedHealth

$159.40

2.08 (1.32%)

17:50
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Flexsteel names Eric Rangen chair of the board »

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FLXS

Flexsteel Industries

$59.12

2.92 (5.20%)

UNH

UnitedHealth

$159.40

2.08 (1.32%)

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NKE

Nike

$52.10

1.53 (3.03%)

, UA

Under Armour

$27.03

1.62 (6.38%)

17:49
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Periodicals
Nike losing market share to faster-growing rivals, Barron's reports »

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NKE

Nike

$52.10

1.53 (3.03%)

UA

Under Armour

$27.03

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ADDYY

adidas

$76.96

1.225 (1.62%)

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  • 20

    Dec

T

AT&T

$40.45

1.1 (2.80%)

17:45
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Conference/Events
AT&T management to meet with Jefferies »

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