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CEMP

Cempra

$22.59

-0.52 (-2.25%)

16:24
10/04/16
10/04
16:24
10/04/16
16:24

Cempra presents analysis showing rates of failure for existing CABP antibiotics

Cempra announced the presentation of three abstracts based upon analyzing treatment failures with existing antibiotics from more than 400,000 records of patients diagnosed with community-acquired bacterial pneumonia, CABP, in a large U.S. insurance claims database. The data analysis will be presented at the annual Academy of Managed Care Pharmacy Nexus meeting in National Harbor, MD from October 3-6, 2016. These patient records were analyzed to assess rates of failure to the most commonly prescribed antibiotics to treat CABP. Treatment failure was defined as antibiotic prescription refill, new antibiotic claim, emergency room visit, or hospitalization occurring within 30 days of initial therapy. This analysis showed that more than one out of five adult CABP patients failed initial antibiotic monotherapy, with the failure rate exceeding one out of four for an elderly population with certain comorbidities. In a separate analysis of the same database, an association was observed between macrolide-resistant S. pneumoniae, the most common cause of CABP, and macrolide treatment failure by region in the U.S., with the frequency of macrolide-resistant S. pneumoniae as high as 64 percent in the West South Central region of the U.S. Nationwide, the average frequency of macrolide-resistant S. pneumoniae was approximately 49 percent. "These data, showing a high level of macrolide resistance and a high level of treatment failure with the most commonly used antibiotics in CABP, highlight the urgent need for new treatment options for CABP," said Prabhavathi Fernandes, Ph.D., president and chief executive officer of Cempra.

  • 04

    Nov

  • 27

    Dec

CEMP Cempra
$22.59

-0.52 (-2.25%)

06/24/16
NEED
06/24/16
NO CHANGE
Target $48
NEED
Buy
Needham expects 'moderate success' for Cempra Solithera
After attending the company's investor day, Needham analyst Alan Carr says that he expects Cempra to have moderate success in commercializing its Solithera independently, due to challenges for a biotech company in penetrating urgent and primary care. However, and despite believing that the commercial opportunity is probably larger in hands of Big Pharma, the analyst thinks the company's share price does not reflect what Cempra can accomplish independently. He reiterates a Buy rating and $48 price target on the shares.
06/24/16
06/24/16
NO CHANGE

Needham sees Brexit making EU drug reviews 'less efficient, more expensive'
Needham analyst including Alan Carr, Chad Messer, Danielle Brill and Esther Pang noted that if Article 50 is invoked following the Brexit vote, the European Medicines Agency will need to move out of its current base in London and the U.K. will need to create its own separate regulatory organization for drugs, concluding that Brexit will lead to a "less efficient, more expensive, and potentially lengthier regulatory process" for drug approval in the EU and the U.K. Among the companies that are currently in discussions with the EMA or have drugs under MAA review, Needham lists ACADIA (ACAD) Celator (CPXX), Cempra (CEMP), Gilead (GILD) Intercept (ICPT), Seattle Genetics (SGEN), Valeant (VRX) and Progenics (PGNX).
07/12/16
JPMS
07/12/16
INITIATION
Target $31
JPMS
Overweight
Cempra initiated with an Overweight at JPMorgan
JPMorgan analyst Jessica Fye started Cempra with an Overweight rating and $31 price target. The analyst sees a "high probability of Fast Track US approval" by year-end for Solithera, a new antibiotic for community acquired pneumonia in adults. The analyst believes current share levels offer an attractive entry point.
09/13/16
RAJA
09/13/16
INITIATION
Target $32
RAJA
Outperform
Cempra initiated with an Outperform at Raymond James
Raymond James analyst Christopher Raymond initiated Cempra with an Outperform and a $32 price target. He believes Cempra's lead antibiotic Solithera holds a unique value proposition, the efficacy of a macrolide with improved barrier to resistance and a more favorable safety profile over fluoroquinolones. Raymond's 2025 end-market revenue estimate of $904 million assumes solely CAP usage, leaving other opportunities as call options.

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