Cempra presents analysis showing rates of failure for existing CABP antibiotics
Cempra announced the presentation of three abstracts based upon analyzing treatment failures with existing antibiotics from more than 400,000 records of patients diagnosed with community-acquired bacterial pneumonia, CABP, in a large U.S. insurance claims database. The data analysis will be presented at the annual Academy of Managed Care Pharmacy Nexus meeting in National Harbor, MD from October 3-6, 2016. These patient records were analyzed to assess rates of failure to the most commonly prescribed antibiotics to treat CABP. Treatment failure was defined as antibiotic prescription refill, new antibiotic claim, emergency room visit, or hospitalization occurring within 30 days of initial therapy. This analysis showed that more than one out of five adult CABP patients failed initial antibiotic monotherapy, with the failure rate exceeding one out of four for an elderly population with certain comorbidities. In a separate analysis of the same database, an association was observed between macrolide-resistant S. pneumoniae, the most common cause of CABP, and macrolide treatment failure by region in the U.S., with the frequency of macrolide-resistant S. pneumoniae as high as 64 percent in the West South Central region of the U.S. Nationwide, the average frequency of macrolide-resistant S. pneumoniae was approximately 49 percent. "These data, showing a high level of macrolide resistance and a high level of treatment failure with the most commonly used antibiotics in CABP, highlight the urgent need for new treatment options for CABP," said Prabhavathi Fernandes, Ph.D., president and chief executive officer of Cempra.