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KPTI

Karyopharm

$9.92

0.06 (0.61%)

06:24
10/05/16
10/05
06:24
10/05/16
06:24

Karyopharm to present SIGN Phase 2 data on gynecologic cancers

Karyopharm Therapeutics announced an oral presentation highlighting updated clinical data from the company's ongoing Phase 2 study of selinexor, its Selective Inhibitor of Nuclear Export / SINE compound that inhibits exportin 1, for the treatment of gynecological cancers. Two posters featuring predictive biomarker data supporting selinexor's activity in gynecological and colorectal cancers will also be presented. The oral presentation will describe clinical data from the study, which includes durable anti-cancer activity in gynecological malignancies with disease control rates up to 49% and good tolerability. Selinexor-associated adverse events were found to be manageable. Ovarian cancer patients receiving 50 mg/m2 of selinexor once weekly achieved similar benefit with considerably fewer adverse events compared to those receiving twice weekly dosing. Of the 59 evaluable patients with ovarian cancer, 29 met the primary endpoint for a disease control rate of 49%. Median progression free survival for the ovarian cancer arm was 3 months and median overall survival was 7 months. Of the 20 evaluable patients with endometrial cancer, 9 met the primary endpoint for a DCR of 45%. Median PFS for the endometrial cancer arm was 3 months and median OS was 8 months.

  • 07

    Oct

KPTI Karyopharm
$9.92

0.06 (0.61%)

05/27/16
RAJA
05/27/16
INITIATION
Target $13
RAJA
Outperform
Karyopharm initiated with an Outperform at Raymond James
Raymond James analyst Christopher Raymond initiated Karyopharm with an Outperform and $13 price target. Raymond said Karyopharm is close to a value creation period with key trial read outs that can help advance lead compound selinexor and transition Karyopharm to a commercial entity. Further, its wholly-owned, novel technology platform with an experienced management team and an attractive valuation make shares a compelling investment, the analyst added.
06/27/16
BARD
06/27/16
INITIATION
Target $16
BARD
Outperform
Karyopharm initiated with an Outperform at Baird
Target $16.
08/18/16
HCWC
08/18/16
INITIATION
Target $15
HCWC
Buy
Karyopharm initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Shaunak Deepak started Karyopharm Therapeutics with a Buy rating and $15 price target.
08/30/16
JEFF
08/30/16
UPGRADE
Target $12
JEFF
Buy
Karyopharm upgraded to Buy from Hold at Jefferies
Jefferies analyst Brian Abrahams upgraded Karyopharm Therapeutics to Buy citing increasing confidence that near-term data will support a path forward and potential role for selinexor in the future multiple myeloma landscape. The analyst believes selinexor presents a significant revenue opportunity and he upped his price target for the shares to $12 from $9.

TODAY'S FREE FLY STORIES

AZRX

AzurRx BioPharma

$3.51

-0.04 (-1.13%)

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OMF

OneMain Holdings

$23.36

-1.26 (-5.12%)

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CHFC

Chemical Financial

$47.97

-0.79 (-1.62%)

15:50
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Upgrade
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  • 03

    May

BOFI

BofI Holding

$24.76

0.52 (2.15%)

15:46
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Options
BofI Holding call volume above normal and directionally bullish »

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  • 09

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B

Barnes Group

$55.35

2.1 (3.94%)

15:43
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Downgrade
Barnes Group rating change  »

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  • 28

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ADI

Analog Devices

$77.85

-0.13 (-0.17%)

15:36
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Options
Analog Devices put volume heavy and directionally bearish »

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  • 31

    May

MDXG

MiMedx

$11.40

0.3 (2.70%)

15:32
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Recommendations
MiMedx analyst commentary  »

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  • 28

    Apr

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  • 06

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GST

Gastar Exploration

$1.31

0.01 (0.77%)

15:30
04/28/17
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15:30
Conference/Events
Gastar Exploration to host special shareholder meeting »

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  • 02

    May

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    May

CLVS

Clovis

$58.21

-0.43 (-0.73%)

15:26
04/28/17
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15:26
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15:26
Options
Clovis call volume above normal and directionally bullish »

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  • 03

    May

$NSD

NASDAQ Market Internals

15:17
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Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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FIG

Fortress

$8.04

0.005 (0.06%)

, SFTBF

SoftBank

$75.60

0.71 (0.95%)

15:17
04/28/17
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Periodicals
Fortress exploring sale of Logan Circle bond fund unit, Reuters says »

Fortress Investment Group…

FIG

Fortress

$8.04

0.005 (0.06%)

SFTBF

SoftBank

$75.60

0.71 (0.95%)

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$NYE

NYSE Market Internals

15:16
04/28/17
04/28
15:16
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15:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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15:15
04/28/17
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General news
Treasury Closing Summary: »

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CAG

Conagra Brands

$38.82

0.005 (0.01%)

15:11
04/28/17
04/28
15:11
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Options
Downside put buyer in Conagra Foods »

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CAH

Cardinal Health

$72.36

-0.78 (-1.07%)

15:10
04/28/17
04/28
15:10
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Initiation
Cardinal Health initiated  »

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  • 01

    May

FIG

Fortress

$8.04

0.01 (0.12%)

15:04
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04/28
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Periodicals
Breaking Periodicals news story on Fortress »

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S

Sprint

$9.06

0.03 (0.33%)

15:01
04/28/17
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Options
Sprint calls active ahead of earnings next week »

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  • 03

    May

GME

GameStop

$22.80

-0.3 (-1.30%)

14:56
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Options
GameStop put volume heavy and directionally bearish »

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  • 25

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BSX

Boston Scientific

$26.43

0.25 (0.95%)

14:55
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Boston Scientific analyst commentary  »

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  • 09

    May

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TKPYY

Takeda Pharmaceutical Co. Ltd.

$23.98

0.05 (0.21%)

14:51
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PGR

Progressive

$39.76

-0.34 (-0.85%)

14:48
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Conference/Events
The Progressive Corporation to hold a conference call »

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CVO

Cenveo

$4.39

0.095 (2.21%)

14:48
04/28/17
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Hot Stocks
Breaking Hot Stocks news story on Cenveo »

Nathu Ram Puri reports…

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  • 04

    May

BMY

Bristol-Myers

$56.01

0.34 (0.61%)

14:42
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14:42
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14:42
Hot Stocks
Bristol-Myers announces European Commission approval of Opdivo »

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  • 02

    May

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  • 06

    Jun

TAP

Molson Coors

$95.84

0.06 (0.06%)

14:41
04/28/17
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14:41
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14:41
Conference/Events
Molson Coors to hold an earnings follow-up conference call »

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  • 03

    May

IWM

iShares Trust Russell 2000 Index Fund

$139.37

-1.58 (-1.12%)

, RUT

Russell 2000 Index

14:40
04/28/17
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14:40
Technical Analysis
On The Fly: Weekly technical notes for Russell 2000 »

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IWM

iShares Trust Russell 2000 Index Fund

$139.37

-1.58 (-1.12%)

RUT

Russell 2000 Index

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