Breaking News Instant updates and real-time market news.

MDCO

The Medicines Co.

$38.51

0.32 (0.84%)

, ALNY

Alnylam

$70.30

1.73 (2.52%)

16:40
10/05/16
10/05
16:40
10/05/16
16:40

Medicines Co. gives update after Alnylam drug halt, says finds no safety issues

The Medicines Company (MDCO) provided a progress update on the ongoing ORION-1 study of PCSK9si, its investigational first-in-class PCSK9 synthesis inhibitor. ORION-1 is a Phase II trial in patients with atherosclerotic cardiovascular disease or ASCVD-risk equivalents and elevated LDL-C despite maximum tolerated doses of LDL-C lowering therapies. The study exceeded its enrollment target of 480 patients ahead of schedule, enrolling a total of 501 patients between January 21 and June 2. An interim analysis of Day 90 follow-up for all 501 patients will be conducted and presented at the AHA Scientific Sessions on November 15. In addition, the company anticipates that top-line data from Day 180 follow-up for up to 200 patients will be presented at the late-breaking clinical trial session and Day 180 follow-up in all 501 patients will be completed, analyzed and top-line results disclosed before the end of 2016. The independent data monitoring committee has raised no safety concerns and made no safety-related study recommendations through its most recent review on August 26. Moreover, based upon the company's review of blinded safety data through September 29, the most recent date for which safety data has been made available, no material safety issue and, in particular, no drug-related neuropathy, elevation of liver enzymes or changes in renal function, has been observed. At that date, the 501 study patients had treatment exposure of between 4 and 8 months. The statements follow Alnylam's (ALNY) development halt on its revusiran drug. Alnylam is partnered with Medicines Co. on the ALN-PCSsc program.

MDCO

The Medicines Co.

$38.51

0.32 (0.84%)

ALNY

Alnylam

$70.30

1.73 (2.52%)

  • 14

    Oct

  • 06

    Nov

MDCO The Medicines Co.
$38.51

0.32 (0.84%)

05/13/16
JEFF
05/13/16
NO CHANGE
Target $43
JEFF
Buy
The Medicines Co. could rally $4/share on positive data, says Jefferies
Jefferies analyst Biren Amin says The Medicines Co. has a "catalyst-rich" second half of 2016, including the Phase III trials of Carbavance in complicated urinary tract infections and carbapenem resistant enterobacteriaceae infections. The analyst expects both of the trials will be successful and show non-inferiority leading to potential FDA approval. Amin thinks shares could move $3 to $4 per share on positive data readout. He keeps a Buy rating on The Medicines Co. with a $43 price target.
07/11/16
JEFF
07/11/16
NO CHANGE
Target $43
JEFF
Buy
Jefferies views The Medicines Co. ruling as positive surprise
Jefferies analyst Biren Amin views today's Court of Appeals ruling as a "positive surprise" for The Medicines Company. The ruling "breathes potential life" into the company's Angiomax patents, Amin tells investors in a research note. He expects Hospira to file an appeal within 90 days. The analyst has a Buy rating on The Medicines Co. with a $43 price target.
08/02/16
EVER
08/02/16
NO CHANGE
EVER
Buy
Pfizer shelves oral PCSK9, a Medicines Co. competitor, says Evercore ISI
Evercore ISI analyst Umer Raffat said Pfizer (PFE) management does not thin the profile for oral PCSK9 will be competitive with the strong efficacy of antibodies and have moved other interesting products forward. Raffat said some Medicines Co. (MDCO) investors had worried that a potential oral PCSk9 from Pfizer could greatly reduce enthusiasm for an every-6-month PCSk9 from MDCO. The analyst said the next catalyst for The Medicines Co. is A1 Milano readout this month. Raffat rates The Medicines Co. a Buy with a $52 price target.
09/09/16
LEER
09/09/16
NO CHANGE
LEER
Leerink updates therapeutics best ideas for 2016
In a note to investors this morning, Leerink has updated its best ideas for 2016 from the firm's five therapeutics analysts. The list includes Alexion (ALXN), Dermira (DERM), Intra-Cellular (ITCI), Sanofi (SNY), Allergan (AGN), Alnylam (ALNY), Innate Pharma (IPHYF), The Medicines Co. (MDCO), and Ophthotech (OPHT).
ALNY Alnylam
$70.30

1.73 (2.52%)

08/22/16
WEDB
08/22/16
NO CHANGE
WEDB
Intellia Therapeutics data positive, says Wedbush
Wedbush analyst David Nierengarten says that additional data on Intella's (NTLA) TTR program in mice was "meaningful" and indicates that the program compares favorably with competing products. The analyst says that competing programs, including those of Alnylam (ALNY) and Ionis (IONS) have shown "only a transient benefit." He reiterates a $38 price target and Outperform rating on Intella.
09/15/16
FBRC
09/15/16
INITIATION
Target $82
FBRC
Underperform
FBR calls Alexion overvalued, starts shares at Underperform
FBR Capital analyst Christopher James initiated coverage of Alexion Pharmaceuticals (ALXN) with an Underperform rating and $82 price target. The biotech focused on patients with ultra-rare disorders closed yesterday up $2.63 to $129.42. Alexion shares are overpriced as the company is facing a competitive near-term landscape, particularly from Alnylam's (ALNY) ALN-CC5, James tells investors in a research note. Further, near-term expansion into additional indications will be challenging given the recent failed study with eculizumab in refractory generalized myasthenia gravis, the analyst contends. He also sees possible pricing pressures from biosimilars, including an Amgen (AMGN) biosimilar product in development. James this morning also initiated Achillion Pharmaceuticals (ACHN) and Arena Pharmaceuticals (ARNA) with Outperform ratings.
09/28/16
JANY
09/28/16
INITIATION
Target $74
JANY
Neutral
Alnylam initiated with a Neutral at Janney Capital
Janney Capital analyst Roy Buchanan initiated Alnylam with a Neutral and a $74 fair value estimate. The analyst is not confident about the outcome for the pivotal study for patisiran in transthyretin familial amyloid neuropathy, expected in about 12 months, and give patisiran a 50% chance of success.

TODAY'S FREE FLY STORIES

KHC

Kraft Heinz

$96.65

9.37 (10.74%)

, UN

Unilever; also tag UL

$48.79

6.47 (15.29%)

19:22
02/19/17
02/19
19:22
02/19/17
19:22
Hot Stocks
Kraft Heinz withdraws proposal to acquire Unilever »

Unilever (UN, UL) and…

KHC

Kraft Heinz

$96.65

9.37 (10.74%)

UN

Unilever; also tag UL

$48.79

6.47 (15.29%)

UL

Unilever; also tag UN

$48.53

5.96 (14.00%)

BRK.A

Berkshire Hathaway

$252,838.00

1338 (0.53%)

BRK.B

Berkshire Hathaway

$168.57

0.83 (0.49%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Feb

  • 19

    Mar

MNTA

Momenta

13:43
02/19/17
02/19
13:43
02/19/17
13:43
Conference/Events
Momenta to hold a conference call »

Management provides an…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Feb

RSPP

RSP Permian

$42.28

-0.54 (-1.26%)

12:48
02/19/17
02/19
12:48
02/19/17
12:48
Conference/Events
RSP Permian to hold a special shareholder meeting »

Special Shareholder…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Feb

  • 28

    Feb

  • 20

    Mar

AXP

American Express

$79.71

0.2 (0.25%)

, MAT

Mattel

$26.10

0.43 (1.68%)

04:55
02/19/17
02/19
04:55
02/19/17
04:55
Conference/Events
Toy Industry Association to hold fair »

International Toy Fair…

AXP

American Express

$79.71

0.2 (0.25%)

MAT

Mattel

$26.10

0.43 (1.68%)

HAS

Hasbro

$98.50

0.86 (0.88%)

COST

Costco

$175.86

0.11 (0.06%)

AMZN

Amazon.com

$845.07

0.93 (0.11%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Feb

  • 21

    Feb

  • 21

    Feb

  • 22

    Feb

  • 22

    Feb

  • 28

    Feb

  • 14

    Mar

  • 19

    Mar

  • 28

    Mar

QUNR

Qunar

$30.88

-0.14 (-0.45%)

15:28
02/18/17
02/18
15:28
02/18/17
15:28
Conference/Events
Qunar to host special shareholder meeting »

Special Shareholder…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Feb

REG

Regency Centers

$69.75

0.23 (0.33%)

, EQY

Equity One

$31.29

0.16 (0.51%)

15:21
02/18/17
02/18
15:21
02/18/17
15:21
Conference/Events
Equity One to host special shareholder meeting »

Special Shareholder…

REG

Regency Centers

$69.75

0.23 (0.33%)

EQY

Equity One

$31.29

0.16 (0.51%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Feb

EQY

Equity One

$31.29

0.16 (0.51%)

, REG

Regency Centers

$69.75

0.23 (0.33%)

15:18
02/18/17
02/18
15:18
02/18/17
15:18
Conference/Events
Regency Centers to host special shareholder meeting »

Special Shareholder…

EQY

Equity One

$31.29

0.16 (0.51%)

REG

Regency Centers

$69.75

0.23 (0.33%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

WIN

Windstream

$7.05

0.03 (0.43%)

, ELNK

EarthLink

$5.63

-0.01 (-0.18%)

15:12
02/18/17
02/18
15:12
02/18/17
15:12
Conference/Events
EarthLink to host special shareholder meeting »

Special Shareholder…

WIN

Windstream

$7.05

0.03 (0.43%)

ELNK

EarthLink

$5.63

-0.01 (-0.18%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Feb

  • 01

    Mar

  • 06

    Mar

ELNK

EarthLink

$5.63

-0.01 (-0.18%)

, WIN

Windstream

$7.05

0.03 (0.43%)

15:09
02/18/17
02/18
15:09
02/18/17
15:09
Conference/Events
Windstream to host special shareholder meeting »

Virtual Special…

ELNK

EarthLink

$5.63

-0.01 (-0.18%)

WIN

Windstream

$7.05

0.03 (0.43%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 01

    Mar

  • 06

    Mar

HNR

Harvest Natural

14:50
02/18/17
02/18
14:50
02/18/17
14:50
Conference/Events
Harvest Natural to host special shareholder meeting »

Special Shareholder…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

PH

Parker-Hannifin

$153.89

-0.52 (-0.34%)

, CLC

Clarcor

14:30
02/18/17
02/18
14:30
02/18/17
14:30
Conference/Events
Clarcor to host special shareholder meeting »

Special Shareholder…

PH

Parker-Hannifin

$153.89

-0.52 (-0.34%)

CLC

Clarcor

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Feb

AZN

AstraZeneca

$29.16

0.4 (1.39%)

, BAYRY

Bayer

$113.29

0.05 (0.04%)

04:55
02/18/17
02/18
04:55
02/18/17
04:55
Conference/Events
American Society of Clinical Oncology to hold a symposium »

2017 Genitourinary…

AZN

AstraZeneca

$29.16

0.4 (1.39%)

BAYRY

Bayer

$113.29

0.05 (0.04%)

BMY

Bristol-Myers

$54.59

0.31 (0.57%)

ESALY

Eisai

$54.40

0.205 (0.38%)

EXEL

Exelixis

$23.12

0.47 (2.08%)

GHDX

Genomic Health

$29.11

0.61 (2.14%)

MRK

Merck

$65.39

0.13 (0.20%)

MYGN

Myriad Genetics

$18.62

1.35 (7.82%)

NVS

Novartis

$77.20

0.47 (0.61%)

OPK

OPKO Health

$8.81

0.06 (0.69%)

PFE

Pfizer

PGNX

Progenics

$10.62

0.08 (0.76%)

SNY

Sanofi

$43.16

-0.38 (-0.87%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 19

    Feb

  • 21

    Feb

  • 21

    Feb

  • 21

    Feb

  • 22

    Feb

  • 23

    Feb

  • 27

    Feb

  • 01

    Mar

  • 02

    Mar

  • 08

    Mar

  • 09

    Mar

  • 15

    Mar

  • 17

    Mar

  • 23

    Mar

  • 29

    Mar

  • 01

    Apr

  • 10

    May

  • 27

    May

  • 14

    Jun

  • 26

    Jun

MDT

Medtronic

$78.88

0.89 (1.14%)

, NVO

Novo Nordisk

$35.46

0.02 (0.06%)

04:55
02/18/17
02/18
04:55
02/18/17
04:55
Conference/Events
Kenes International Organizers to hold a conference »

10th International…

MDT

Medtronic

$78.88

0.89 (1.14%)

NVO

Novo Nordisk

$35.46

0.02 (0.06%)

RHHBY

Roche

$30.53

0.02 (0.07%)

ABT

Abbott

$44.69

0.49 (1.11%)

SNY

Sanofi

$43.16

-0.38 (-0.87%)

LLY

Eli Lilly

$80.39

0.35 (0.44%)

DXCM

Dexcom

$81.89

0.5 (0.61%)

JNJ

Johnson & Johnson

$118.86

0.78 (0.66%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Feb

  • 21

    Feb

  • 21

    Feb

  • 21

    Feb

  • 22

    Feb

  • 23

    Feb

  • 24

    Feb

  • 24

    Feb

  • 27

    Feb

  • 27

    Feb

  • 28

    Feb

  • 06

    Mar

  • 07

    Mar

  • 09

    Mar

  • 17

    Mar

  • 21

    Mar

  • 27

    Mar

  • 29

    Mar

  • 19

    Apr

  • 26

    Jun

AXP

American Express

$79.71

0.2 (0.25%)

, MAT

Mattel

$26.10

0.43 (1.68%)

04:55
02/18/17
02/18
04:55
02/18/17
04:55
Conference/Events
Toy Industry Association to hold fair »

International Toy Fair…

AXP

American Express

$79.71

0.2 (0.25%)

MAT

Mattel

$26.10

0.43 (1.68%)

HAS

Hasbro

$98.50

0.86 (0.88%)

COST

Costco

$175.86

0.11 (0.06%)

AMZN

Amazon.com

$845.07

0.93 (0.11%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Feb

  • 21

    Feb

  • 21

    Feb

  • 22

    Feb

  • 22

    Feb

  • 28

    Feb

  • 14

    Mar

  • 19

    Mar

  • 28

    Mar

PKY

Parkway

$21.58

0.08 (0.37%)

18:20
02/17/17
02/17
18:20
02/17/17
18:20
Hot Stocks
Parkway to sell 49% interest in Houston Greenway portfolio for $512.1M »

Parkway announced that it…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Feb

  • 01

    Mar

VIA

Viacom

$47.00

-0.2 (-0.42%)

, VIAB

Viacom

$43.99

-0.17 (-0.38%)

18:15
02/17/17
02/17
18:15
02/17/17
18:15
Periodicals
Paramount CEO Brad Grey to leave studio as early as next week, Reuters says »

Brad Grey, chairman and…

VIA

Viacom

$47.00

-0.2 (-0.42%)

VIAB

Viacom

$43.99

-0.17 (-0.38%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 06

    Mar

MNTA

Momenta

, PFE

Pfizer

18:03
02/17/17
02/17
18:03
02/17/17
18:03
Hot Stocks
Momenta: Sandoz partner Pfizer receives FDA warning letter »

Momenta Pharmaceuticals…

MNTA

Momenta

PFE

Pfizer

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 17

    Feb

  • 21

    Feb

  • 21

    Feb

  • 21

    Feb

  • 02

    Mar

  • 09

    Mar

  • 17

    Mar

  • 23

    Mar

  • 01

    Apr

CI

Cigna

$143.56

-1.77 (-1.22%)

, ANTM

Anthem

$160.25

-3.52 (-2.15%)

17:53
02/17/17
02/17
17:53
02/17/17
17:53
Periodicals
Cigna claims Anthem attempted to harm its business, Bloomberg says »

Cigna (CI) has accused…

CI

Cigna

$143.56

-1.77 (-1.22%)

ANTM

Anthem

$160.25

-3.52 (-2.15%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SCMP

Sucampo

$11.80

0.05 (0.43%)

, NILE

Blue Nile

17:50
02/17/17
02/17
17:50
02/17/17
17:50
Hot Stocks
Sucampo to replace Blue Nile in the S&P 600 as of February 23 open »

Sucampo Pharmaceuticals…

SCMP

Sucampo

$11.80

0.05 (0.43%)

NILE

Blue Nile

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Mar

VRML

Vermillion

$1.75

0.08 (4.79%)

17:39
02/17/17
02/17
17:39
02/17/17
17:39
Hot Stocks
Jack Schuler raises stake in Vermillion to 19.6% »

As of the date hereof,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

SITO

SITO Mobile

$2.29

0.08 (3.62%)

17:34
02/17/17
02/17
17:34
02/17/17
17:34
Hot Stocks
SITO Mobile announces Jerry Hug resigned as CEO, names O'Connell interim »

Effective February 1,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 01

    Mar

  • 29

    Mar

CEMI

Chembio Diagnostics

$6.05

0.05 (0.83%)

17:32
02/17/17
02/17
17:32
02/17/17
17:32
Hot Stocks
Breaking Hot Stocks news story on Chembio Diagnostics »

ARS Investment Partners…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BTX

BioTime

17:31
02/17/17
02/17
17:31
02/17/17
17:31
Hot Stocks
Broadwood raises stake in BioTime to 24.5% »

Broadwood Partners,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 21

    Mar

AHP

Ashford Hospitality Prime

$13.39

0.19 (1.44%)

17:30
02/17/17
02/17
17:30
02/17/17
17:30
Hot Stocks
Breaking Hot Stocks news story on Ashford Hospitality Prime »

Sessa Capital cuts…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Feb

HIIQ

Health Insurance Innovations

17:28
02/17/17
02/17
17:28
02/17/17
17:28
Hot Stocks
Breaking Hot Stocks news story on Health Insurance Innovations »

Patrick McNamee reports…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 20

    Mar

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.