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MDCO

The Medicines Co.

$38.51

0.32 (0.84%)

, ALNY

Alnylam

$70.30

1.73 (2.52%)

16:40
10/05/16
10/05
16:40
10/05/16
16:40

Medicines Co. gives update after Alnylam drug halt, says finds no safety issues

The Medicines Company (MDCO) provided a progress update on the ongoing ORION-1 study of PCSK9si, its investigational first-in-class PCSK9 synthesis inhibitor. ORION-1 is a Phase II trial in patients with atherosclerotic cardiovascular disease or ASCVD-risk equivalents and elevated LDL-C despite maximum tolerated doses of LDL-C lowering therapies. The study exceeded its enrollment target of 480 patients ahead of schedule, enrolling a total of 501 patients between January 21 and June 2. An interim analysis of Day 90 follow-up for all 501 patients will be conducted and presented at the AHA Scientific Sessions on November 15. In addition, the company anticipates that top-line data from Day 180 follow-up for up to 200 patients will be presented at the late-breaking clinical trial session and Day 180 follow-up in all 501 patients will be completed, analyzed and top-line results disclosed before the end of 2016. The independent data monitoring committee has raised no safety concerns and made no safety-related study recommendations through its most recent review on August 26. Moreover, based upon the company's review of blinded safety data through September 29, the most recent date for which safety data has been made available, no material safety issue and, in particular, no drug-related neuropathy, elevation of liver enzymes or changes in renal function, has been observed. At that date, the 501 study patients had treatment exposure of between 4 and 8 months. The statements follow Alnylam's (ALNY) development halt on its revusiran drug. Alnylam is partnered with Medicines Co. on the ALN-PCSsc program.

MDCO

The Medicines Co.

$38.51

0.32 (0.84%)

ALNY

Alnylam

$70.30

1.73 (2.52%)

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  • 06

    Nov

MDCO The Medicines Co.
$38.51

0.32 (0.84%)

05/13/16
JEFF
05/13/16
NO CHANGE
Target $43
JEFF
Buy
The Medicines Co. could rally $4/share on positive data, says Jefferies
Jefferies analyst Biren Amin says The Medicines Co. has a "catalyst-rich" second half of 2016, including the Phase III trials of Carbavance in complicated urinary tract infections and carbapenem resistant enterobacteriaceae infections. The analyst expects both of the trials will be successful and show non-inferiority leading to potential FDA approval. Amin thinks shares could move $3 to $4 per share on positive data readout. He keeps a Buy rating on The Medicines Co. with a $43 price target.
07/11/16
JEFF
07/11/16
NO CHANGE
Target $43
JEFF
Buy
Jefferies views The Medicines Co. ruling as positive surprise
Jefferies analyst Biren Amin views today's Court of Appeals ruling as a "positive surprise" for The Medicines Company. The ruling "breathes potential life" into the company's Angiomax patents, Amin tells investors in a research note. He expects Hospira to file an appeal within 90 days. The analyst has a Buy rating on The Medicines Co. with a $43 price target.
08/02/16
EVER
08/02/16
NO CHANGE
EVER
Buy
Pfizer shelves oral PCSK9, a Medicines Co. competitor, says Evercore ISI
Evercore ISI analyst Umer Raffat said Pfizer (PFE) management does not thin the profile for oral PCSK9 will be competitive with the strong efficacy of antibodies and have moved other interesting products forward. Raffat said some Medicines Co. (MDCO) investors had worried that a potential oral PCSk9 from Pfizer could greatly reduce enthusiasm for an every-6-month PCSk9 from MDCO. The analyst said the next catalyst for The Medicines Co. is A1 Milano readout this month. Raffat rates The Medicines Co. a Buy with a $52 price target.
09/09/16
LEER
09/09/16
NO CHANGE
LEER
Leerink updates therapeutics best ideas for 2016
In a note to investors this morning, Leerink has updated its best ideas for 2016 from the firm's five therapeutics analysts. The list includes Alexion (ALXN), Dermira (DERM), Intra-Cellular (ITCI), Sanofi (SNY), Allergan (AGN), Alnylam (ALNY), Innate Pharma (IPHYF), The Medicines Co. (MDCO), and Ophthotech (OPHT).
ALNY Alnylam
$70.30

1.73 (2.52%)

08/22/16
WEDB
08/22/16
NO CHANGE
WEDB
Intellia Therapeutics data positive, says Wedbush
Wedbush analyst David Nierengarten says that additional data on Intella's (NTLA) TTR program in mice was "meaningful" and indicates that the program compares favorably with competing products. The analyst says that competing programs, including those of Alnylam (ALNY) and Ionis (IONS) have shown "only a transient benefit." He reiterates a $38 price target and Outperform rating on Intella.
09/15/16
FBRC
09/15/16
INITIATION
Target $82
FBRC
Underperform
FBR calls Alexion overvalued, starts shares at Underperform
FBR Capital analyst Christopher James initiated coverage of Alexion Pharmaceuticals (ALXN) with an Underperform rating and $82 price target. The biotech focused on patients with ultra-rare disorders closed yesterday up $2.63 to $129.42. Alexion shares are overpriced as the company is facing a competitive near-term landscape, particularly from Alnylam's (ALNY) ALN-CC5, James tells investors in a research note. Further, near-term expansion into additional indications will be challenging given the recent failed study with eculizumab in refractory generalized myasthenia gravis, the analyst contends. He also sees possible pricing pressures from biosimilars, including an Amgen (AMGN) biosimilar product in development. James this morning also initiated Achillion Pharmaceuticals (ACHN) and Arena Pharmaceuticals (ARNA) with Outperform ratings.
09/28/16
JANY
09/28/16
INITIATION
Target $74
JANY
Neutral
Alnylam initiated with a Neutral at Janney Capital
Janney Capital analyst Roy Buchanan initiated Alnylam with a Neutral and a $74 fair value estimate. The analyst is not confident about the outcome for the pivotal study for patisiran in transthyretin familial amyloid neuropathy, expected in about 12 months, and give patisiran a 50% chance of success.

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MFSF

MutualFirst Financial

$36.15

0.9 (2.55%)

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CSCO

Cisco

$32.10

0.25 (0.78%)

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SITO

SITO Mobile

$3.66

0.02 (0.55%)

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REGN

Regeneron

$517.33

-9.2 (-1.75%)

, CELG

Celgene

$134.31

0.63 (0.47%)

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REGN

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$517.33

-9.2 (-1.75%)

CELG

Celgene

$134.31

0.63 (0.47%)

GILD

Gilead

$70.54

0.06 (0.09%)

BIIB

Biogen

$280.32

-0.25 (-0.09%)

VRTX

Vertex

$133.50

-2.03 (-1.50%)

AMGN

Amgen

$172.50

-1.32 (-0.76%)

ABBV

AbbVie

$72.64

-0.54 (-0.74%)

ALXN

Alexion

$126.07

-0.16 (-0.13%)

BA

Boeing

$202.23

2.79 (1.40%)

ORCL

Oracle

$50.95

0.65 (1.29%)

EQT

EQT Corporation

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4.16 (8.00%)

RICE

Rice Energy

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SYK

Stryker

$141.12

-0.1 (-0.07%)

NVDQ

Novadaq

$11.78

-0.02 (-0.17%)

PRXL

Parexel

$86.80

-0.31 (-0.36%)

LH

LabCorp

$151.62

1.28 (0.85%)

ICLR

ICON plc

$96.37

-0.26 (-0.27%)

NKE

Nike

$52.85

0.45 (0.86%)

AMZN

Amazon.com

$1,003.74

2.44 (0.24%)

INTC

Intel

$34.19

-0.17 (-0.49%)

AMD

AMD

$14.15

-0.23 (-1.60%)

LZB

La-Z-Boy

$32.30

0.7 (2.22%)

RHT

Red Hat

$99.42

0.54 (0.55%)

AAL

American Airlines

$48.63

-0.34 (-0.69%)

HCA

HCA Holdings

$86.24

0.1 (0.12%)

LPNT

LifePoint

$65.50

-1.6 (-2.38%)

THC

Tenet

$18.52

-0.38 (-2.01%)

SCS

Steelcase

$13.65

-0.45 (-3.19%)

ACN

Accenture

$122.74

0.66 (0.54%)

BBBY

Bed Bath & Beyond

$29.65

-4.09 (-12.12%)

BBRY

BlackBerry

$9.71

-1.35 (-12.21%)

BAC

Bank of America

$22.82

-0.11 (-0.48%)

C

Citi

$63.41

-0.21 (-0.33%)

GS

Goldman Sachs

$217.19

-2.58 (-1.17%)

JPM

JPMorgan

$86.86

-0.16 (-0.18%)

MS

Morgan Stanley

$43.69

-0.92 (-2.06%)

WFC

Wells Fargo

$52.45

-0.04 (-0.08%)

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16:39
06/23/17
06/23
16:39
06/23/17
16:39
General news
Moody's raises Greece rating to Caa2 from Caa3, outlook to positive from stable »

Moody's has upgraded…

CFCO

CF Corporation

$11.42

-0.04 (-0.35%)

16:38
06/23/17
06/23
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16:38
Hot Stocks
Breaking Hot Stocks news story on CF Corporation »

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AKS

AK Steel

$6.65

0.35 (5.56%)

, X

U.S. Steel

$22.25

1.18 (5.60%)

16:34
06/23/17
06/23
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16:34
General news
On The Fly: Top stock stories for Friday »

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AKS

AK Steel

$6.65

0.35 (5.56%)

X

U.S. Steel

$22.25

1.18 (5.60%)

PTLA

Portola Pharmaceuticals

$56.13

17.88 (46.75%)

BAC

Bank of America

$22.82

-0.11 (-0.48%)

C

Citi

$63.41

-0.21 (-0.33%)

GS

Goldman Sachs

$217.19

-2.58 (-1.17%)

JPM

JPMorgan

$86.86

-0.16 (-0.18%)

MS

Morgan Stanley

$43.69

-0.92 (-2.06%)

WFC

Wells Fargo

$52.45

-0.04 (-0.08%)

SNCR

Synchronoss

$16.24

4.06 (33.33%)

BBBY

Bed Bath & Beyond

$29.65

-4.09 (-12.12%)

BBRY

BlackBerry

$9.71

-1.35 (-12.21%)

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FMC

FMC Corporation

$74.78

0.52 (0.70%)

16:31
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16:30
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Options
Preliminary option volume of 15.0M today »

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ESNC

EnSync

$0.33

0.0151 (4.79%)

16:25
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Syndicate
Breaking Syndicate news story on EnSync »

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PTLA

Portola Pharmaceuticals

$56.13

17.88 (46.75%)

16:25
06/23/17
06/23
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16:25
Conference/Events
Portola Pharmaceuticals hold a conference call »

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DTE

DTE Energy

$108.89

-0.69 (-0.63%)

16:24
06/23/17
06/23
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Earnings
DTE Energy backs FY17 operating EPS view $5.15-$5.46, consensus $5.33 »

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$NSD

NASDAQ Market Internals

16:17
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Technical Analysis
NASDAQ market internals summary »

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VHI

Valhi Inc

$3.29

0.14 (4.44%)

16:16
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Valhi Inc termiantes purchase deal for sale of Waste Control Specialists »

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$NYE

NYSE Market Internals

16:16
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Technical Analysis
NYSE market internals summary »

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GBL

GAMCO Investors

$29.63

-0.24 (-0.80%)

, LSXMA

Liberty SiriusXM

$40.83

0.79 (1.97%)

16:14
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Hot Stocks
Breaking Hot Stocks news story on GAMCO Investors, Liberty SiriusXM »

Gabelli reports 5.22%…

GBL

GAMCO Investors

$29.63

-0.24 (-0.80%)

LSXMA

Liberty SiriusXM

$40.83

0.79 (1.97%)

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WETF

WisdomTree

$9.98

-0.11 (-1.09%)

16:13
06/23/17
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16:13
Hot Stocks
WisdomTree to close, liquidate three ETFs »

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CONN

Conn's

$17.10

0.15 (0.88%)

16:11
06/23/17
06/23
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16:11
Hot Stocks
Breaking Hot Stocks news story on Conn's »

Point72 Asset reports…

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WMT

Wal-Mart

$74.87

-0.655 (-0.87%)

, WFM

Whole Foods

$42.95

-0.255 (-0.59%)

16:11
06/23/17
06/23
16:11
06/23/17
16:11
Periodicals
Wal-Mart not weighing offer for Whole Foods, Reuters reports »

Wal-Mart (WMT) is not…

WMT

Wal-Mart

$74.87

-0.655 (-0.87%)

WFM

Whole Foods

$42.95

-0.255 (-0.59%)

AMZN

Amazon.com

$1,003.74

2.44 (0.24%)

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APDN

Applied DNA Sciences

$1.09

0.06 (5.83%)

16:10
06/23/17
06/23
16:10
06/23/17
16:10
Hot Stocks
Applied DNA Sciences receives order to tag 27.5M pounds of cotton »

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MOCO

Mocon

16:08
06/23/17
06/23
16:08
06/23/17
16:08
Hot Stocks
Gabelli liquidates stake in Mocon »

As a result of the…

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TKTDY

Takata

$3.15

1.2199 (63.21%)

16:03
06/23/17
06/23
16:03
06/23/17
16:03
Periodicals
Takata to seek bankruptcy protection as soon as Sunday, WSJ reports »

Takata intends to seek…

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TIPT

Tiptree Financial

16:02
06/23/17
06/23
16:02
06/23/17
16:02
Hot Stocks
Tiptree Financial repurchases 1M shares from Nomura Securities »

Tiptree has repurchased…

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PFBC

Preferred Bank

16:01
06/23/17
06/23
16:01
06/23/17
16:01
Hot Stocks
Preferred Bank raises quarterly dividend 11% to 20c per share »

Preferred Bank reported…

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AMGN

Amgen

16:01
06/23/17
06/23
16:01
06/23/17
16:01
Hot Stocks
Amgen receives positive CHMP opinion to expand use of Mimpara »

Amgen announced that the…

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