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ALNY

Alnylam

$70.30

1.73 (2.52%)

, NBIX

Neurocrine

$51.26

0.99 (1.97%)

05:38
10/06/16
10/06
05:38
10/06/16
05:38

Alnylam downgraded to Equal Weight from Overweight at Barclays

Barclays analyst Geoff Meacham downgraded Alnylam Pharmaceuticals (ALNY) to Equal Weight saying he views other SMid cap biotech names as more attractive following the company's recent pipeline setbacks. The analyst removed Revusiran sales from his Alnylam model after the program was discontinued yesterday and he cut his price target for the shares to $50 from $85. Meacham lists Neurocrine (NBIX), Prothena (PTRA) and Incyte (INCY) as names he finds more attractive over the next 12 months. Alnylam is trading down 44% in pre-market trading to $39.25.

ALNY

Alnylam

$70.30

1.73 (2.52%)

NBIX

Neurocrine

$51.26

0.99 (1.97%)

PRTA

Prothena

$62.92

1.11 (1.80%)

INCY

Incyte

$95.69

1.52 (1.61%)

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    Oct

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    Oct

  • 06

    Nov

ALNY Alnylam
$70.30

1.73 (2.52%)

09/15/16
FBRC
09/15/16
INITIATION
Target $82
FBRC
Underperform
FBR calls Alexion overvalued, starts shares at Underperform
FBR Capital analyst Christopher James initiated coverage of Alexion Pharmaceuticals (ALXN) with an Underperform rating and $82 price target. The biotech focused on patients with ultra-rare disorders closed yesterday up $2.63 to $129.42. Alexion shares are overpriced as the company is facing a competitive near-term landscape, particularly from Alnylam's (ALNY) ALN-CC5, James tells investors in a research note. Further, near-term expansion into additional indications will be challenging given the recent failed study with eculizumab in refractory generalized myasthenia gravis, the analyst contends. He also sees possible pricing pressures from biosimilars, including an Amgen (AMGN) biosimilar product in development. James this morning also initiated Achillion Pharmaceuticals (ACHN) and Arena Pharmaceuticals (ARNA) with Outperform ratings.
09/09/16
LEER
09/09/16
NO CHANGE
LEER
Leerink updates therapeutics best ideas for 2016
In a note to investors this morning, Leerink has updated its best ideas for 2016 from the firm's five therapeutics analysts. The list includes Alexion (ALXN), Dermira (DERM), Intra-Cellular (ITCI), Sanofi (SNY), Allergan (AGN), Alnylam (ALNY), Innate Pharma (IPHYF), The Medicines Co. (MDCO), and Ophthotech (OPHT).
08/22/16
WEDB
08/22/16
NO CHANGE
WEDB
Intellia Therapeutics data positive, says Wedbush
Wedbush analyst David Nierengarten says that additional data on Intella's (NTLA) TTR program in mice was "meaningful" and indicates that the program compares favorably with competing products. The analyst says that competing programs, including those of Alnylam (ALNY) and Ionis (IONS) have shown "only a transient benefit." He reiterates a $38 price target and Outperform rating on Intella.
09/28/16
JANY
09/28/16
INITIATION
Target $74
JANY
Neutral
Alnylam initiated with a Neutral at Janney Capital
Janney Capital analyst Roy Buchanan initiated Alnylam with a Neutral and a $74 fair value estimate. The analyst is not confident about the outcome for the pivotal study for patisiran in transthyretin familial amyloid neuropathy, expected in about 12 months, and give patisiran a 50% chance of success.
NBIX Neurocrine
$51.26

0.99 (1.97%)

06/06/16
BMOC
06/06/16
NO CHANGE
BMOC
Neurocrine price target raised to $66 from $57 at BMO Capital
BMO Capital raised its price target on Neutrocirne (NBIX) as it believes that the company's elagolix drug has a positive read through from data recently presented by AbbVie (ABBV). .
09/23/16
LEER
09/23/16
NO CHANGE
LEER
Outperform
Positive data paves way for Teva SD-809 indication, says Leerink
Leerink analyst Jason Gerberry says the AIM-TD study readout clinically de-risks Teva's (TEVA) SD-809 opportunity for tardive dyskinesia, with the investor focus shifting to market size and competitive differentiation versus Neurocrine's (NBIX) valbenazine. The analyst believes Teva's SD-809 is well positioned to compete against valbenazine with an equally efficacious and well tolerated drug. Further, he expects Teva to exit 2017 with a broader label. Gerberry reiterates an Outperform rating on Teva's shares.
10/04/16
LEER
10/04/16
INITIATION
Target $70
LEER
Outperform
Neurocrine reinstated with an Outperform at Leerink
Leerink analyst Paul Matteis resumed coverage of Neurocrine with an Outperform rating and $70 price target.
06/29/16
HCWC
06/29/16
INITIATION
Target $80
HCWC
Buy
Neurocrine initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Andrew Fein started Neurocrine Biosciences with a Buy rating and $80 price target.
PRTA Prothena
$62.92

1.11 (1.80%)

06/10/16
RBCM
06/10/16
NO CHANGE
RBCM
Prothena data positive, says RBC Capital
RBc Capital believes that the Phase I data for Prothena's antibody program, '003, was positive. The firm thinks the treatment "could be a new psoriasis drug or go after other big inflammatory markets." The firm expects '003 to begin to get attention from investors, and it views the product as "somewhat de-risked." RBC keeps an Outperform rating on the shares.
09/27/16
RBCM
09/27/16
NO CHANGE
RBCM
Prothena CEO change 'neutral, natural, and positive' says RBC Capital
Afte Prothena announced its CEO was taking a medical leave and that it was elevating its COO, Gene Kinney, to interim CEO, RBC Capital analyst Michael Yee says "this a a neutral and natural positive development." Yee reports that Kinney " has been generally in charge of and overseen the R&D and clinical development of their 3 lead programs and involved in leading discussions with the FDA." The analyst believes that the company had previously been planning for succession and that investors should not be surprised by this development, as they knew that the CEO had health problems. Yee keeps an Outperform rating on the shares.
08/03/16
LTCO
08/03/16
NO CHANGE
Target $80
LTCO
Buy
Prothena price target raised to $80 from $77 at Ladenburg
Ladenburg Thalmann analyst Robert Hazlett said the recently released clinical data from the Phase 1/2 study of NEOD001 continue to point to promising organ responses that do not appear to be related to prior plasma cell directed therapy. Noting there are catalysts upcoming for NEOD001, PRX002 and PRX003, the analyst raised his price target on the stock to $80, adding that he assigns a 70% probability of Prothena operating independently and a 30% probability to a takeover.
09/27/16
UBSW
09/27/16
NO CHANGE
Target $73
UBSW
Buy
Prothena management has continuity during CEO leave of absence, says UBS
UBS analyst Jeffrey Hung noted that Prothena's COO Gene Kinney will lead the company while its CEO, Dale Schenk, is on a medical leave of absence. Hung notes that the NEOD001 strategy is already largely in place and he believes the Board's confidence in Kinney, combined with his recent promotion, points to the potential for a natural succession. The analyst keeps a Buy rating and $73 price target on Prothena shares.
INCY Incyte
$95.69

1.52 (1.61%)

08/22/16
GSCO
08/22/16
NO CHANGE
GSCO
Goldman lists companies to be in focus after Medivation deal
After Pfizer (PFE) announced it has agreed to acquire Medivation (MDVN) for $81.50 per share in cash, Goldman Sachs analyst Salveen Richter said he expects a focus on other commercial small-to-mid-cap cancer companies, including Incyte (INCY), Seattle Genetics (SGEN), ARIAD (ARIA) and Exelixis (EXEL). Also noting that Sanofi (SNY), which was pursuing Medivation, has recently suggested an interest in a rare disease transaction up to potentially as large as $20B, he would expect rare disease companies of that size - such as BioMarin (BMRN), Amicus (FOLD) and Ultragenyx (RARE) - to be in focus as well.
09/29/16
RAJA
09/29/16
UPGRADE
Target $115
RAJA
Outperform
Incyte upgraded to Outperform from Market Perform at Raymond James
Raymond James analyst Reni Benjamin upgraded Incyte to Outperform with a $115 price target following the release of an abstract showcasing "positive" long-term follow-up results for epacadostat in melanoma. Epacadostat plus pembrolizumab, should ;the results be confirmed in the ongoing Phase III study, could effectively compete with ipilimumab and nivolumab, Benjamin tells investors in a research note.
09/29/16
09/29/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. eBay (EBAY) upgraded to Buy from Hold at Deutsche Bank with analyst Ross Sandler saying eBay is likely to outperform Internet peers over the next two years now that its re-platforming is in the latter stages. 2. BlackBerry (BBRY) upgraded to Neutral from Underperform at Macquarie with analyst Gus Papageorgiou saying he expects operations to stabilize and profitability to return next year. 3. Endo (ENDP) upgraded to Outperform from Market Perform at Northland. 4. Rex Energy (REXX) upgraded to Hold from Sell at Stifel with analyst Michael Scialla saying the production cut may not actually occur, but he believes that other factors, along with positive commentary from OPEC, "appears to be building an oil price floor of $40." 5. Incyte (INCY) upgraded to Outperform from Market Perform at Raymond James with analyst Reni Benjamin saying Epacadostat plus pembrolizumab, should ;the results be confirmed in the ongoing Phase III study, could effectively compete with ipilimumab and nivolumab. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/21/16
09/21/16
NO CHANGE

RBC identifies top biotech takeover candidates
RBC Capital identified the following names as its top potential takeover candidates in the biotech space: ARIAD (ARIA), Spark Therapeutics (ONCE), BioMarin (BMRN), Aerie Pharmaceuticals (AERI), Intra-Cellular (ITCI), TESARO (TSRO), Incyte (INCY), Sarepta (SRPT), and Puma Biotechnology (PBYI). The firm thinks that investors are underestimating the positive impact that M&A will have on biotech stock prices.

TODAY'S FREE FLY STORIES

V

Visa

$102.90

-2.665 (-2.52%)

14:50
09/25/17
09/25
14:50
09/25/17
14:50
Options
Bullish option play opened in Visa as shares slump »

Bullish option play…

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  • 22

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RHT

Red Hat

$105.41

-0.89 (-0.84%)

14:49
09/25/17
09/25
14:49
09/25/17
14:49
Options
Red Hat options imply 10.7% move in share price post-earnings, above median historical move »

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APRN

Blue Apron

$5.47

0.28 (5.40%)

14:45
09/25/17
09/25
14:45
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14:45
Options
Blue Apron call volume above normal and directionally bullish »

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TRIP

TripAdvisor

$44.37

0.125 (0.28%)

, PCLN

Priceline

$1,862.13

-4.22 (-0.23%)

14:42
09/25/17
09/25
14:42
09/25/17
14:42
Hot Stocks
Analysts trim TripAdvisor estimates on increasing online travel concerns »

Shares of TripAdvisor…

TRIP

TripAdvisor

$44.37

0.125 (0.28%)

PCLN

Priceline

$1,862.13

-4.22 (-0.23%)

TRVG

trivago

$10.70

-0.04 (-0.37%)

EXPE

Expedia

$145.77

2.65 (1.85%)

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DY

Dycom

$81.51

-1.185 (-1.43%)

14:36
09/25/17
09/25
14:36
09/25/17
14:36
Conference/Events
Dycom management to meet with Stephens »

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DY

Dycom

$81.56

-1.13 (-1.37%)

14:35
09/25/17
09/25
14:35
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14:35
Options
Dycom put volume heavy and directionally bearish »

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  • 26

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AMZN

Amazon.com

$955.10

-9.55 (-0.99%)

14:31
09/25/17
09/25
14:31
09/25/17
14:31
Technical Analysis
Technical View: Amazon.com falls, topping process confirmed »

The shares are down 2.1%…

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  • 03

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DIS

Disney

$99.37

0.77 (0.78%)

14:27
09/25/17
09/25
14:27
09/25/17
14:27
Recommendations
Disney analyst commentary  »

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  • 09

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ESV

Ensco

$5.77

0.53 (10.11%)

14:25
09/25/17
09/25
14:25
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14:25
Options
Ensco call volume above normal and directionally bullish »

Bullish option flow…

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  • 02

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    Oct

NFLX

Netflix

$187.35

-1.43 (-0.76%)

14:21
09/25/17
09/25
14:21
09/25/17
14:21
Technical Analysis
Technical View: Netflix trades near lows of the day »

The shares are down over…

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$NSD

NASDAQ Market Internals

14:17
09/25/17
09/25
14:17
09/25/17
14:17
Technical Analysis
NASDAQ market internals summary »

Volume is average for…

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$NYE

NYSE Market Internals

14:16
09/25/17
09/25
14:16
09/25/17
14:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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GREK

Global X MSCI Greece ETF

$9.18

-0.635 (-6.47%)

14:10
09/25/17
09/25
14:10
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14:10
Options
MSCI Greek Fund puts are active as shares falter »

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AMD

AMD

$13.30

-0.11 (-0.82%)

, NVDA

Nvidia

$179.00

-1.76 (-0.97%)

14:08
09/25/17
09/25
14:08
09/25/17
14:08
Hot Stocks
AMD, NVIDIA fall after Intel unveils next generation of core processors »

Shares of AMD (AMD) and…

AMD

AMD

$13.30

-0.11 (-0.82%)

NVDA

Nvidia

$179.00

-1.76 (-0.97%)

INTC

Intel

$37.18

-0.02 (-0.05%)

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  • 05

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HLF

Herbalife

$67.51

-0.06 (-0.09%)

14:06
09/25/17
09/25
14:06
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14:06
Hot Stocks
FTC grants Carl Icahn clearance for additional Herbalife purchases »

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YY

YY

$80.52

4.45 (5.85%)

14:05
09/25/17
09/25
14:05
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14:05
Options
YY call volume above normal and directionally bullish »

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14:05
09/25/17
09/25
14:05
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14:05
General news
Treasury Option Action: heavy put spread demand at the short-end »

Treasury Option Action:…

RCII

Rent-A-Center

$10.80

-0.07 (-0.64%)

13:55
09/25/17
09/25
13:55
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13:55
Options
Rent A Center put volume heavy and directionally bearish »

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13:55
09/25/17
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13:55
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Conference/Events
Senate Finance Committee holds a hearing »

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GS

Goldman Sachs

$230.10

-0.93 (-0.40%)

13:54
09/25/17
09/25
13:54
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13:54
Periodicals
Symphony to raise $100M to expand, The Information says »

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AMDA

Amedica

$0.33

0.005 (1.56%)

13:50
09/25/17
09/25
13:50
09/25/17
13:50
Downgrade
Amedica rating change  »

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  • 26

    Sep

SCWX

SecureWorks

$12.57

0.15 (1.21%)

13:47
09/25/17
09/25
13:47
09/25/17
13:47
Hot Stocks
Breaking Hot Stocks news story on SecureWorks »

ETF Managers Group…

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DVN

Devon Energy

$36.59

0.81 (2.26%)

13:45
09/25/17
09/25
13:45
09/25/17
13:45
Options
Devon Energy call volume above normal and directionally bullish »

Bullish option flow…

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  • 01

    Nov

13:45
09/25/17
09/25
13:45
09/25/17
13:45
General news
Treasury Action: coupon supply commences Tuesday »

Treasury Action: coupon…

ADP

ADP

$108.16

1.37 (1.28%)

13:43
09/25/17
09/25
13:43
09/25/17
13:43
Hot Stocks
Pershing: ADP overstates shareholder return during CEO's tenure »

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