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MESO

Mesoblast

$4.29

0.03 (0.70%)

06:08
10/06/16
10/06
06:08
10/06/16
06:08

Mesoblast publishes Phase 2 trial results of cell therapy for kidney disease

Mesoblast announced results from the randomized, placebo-controlled Phase 2 trial of its proprietary allogeneic Mesenchymal Precursor Cell product candidate, MPC-300-IV, in patients with diabetic kidney disease, published in the current issue of the peer-reviewed journal EBioMedicine. The paper concluded that a single intravenous infusion of MPC-300-IV was well tolerated and had positive effects on renal function at the 12-week primary endpoint in a Phase 2 trial in adult patients with type 2 diabetic nephropathy. The Phase 2, double-blind, randomized, placebo-controlled, dose-escalating trial evaluated MPC-300-IV in patients with type 2 diabetes and moderate to severe renal impairment, stage 3b-4 chronic kidney disease, who were already on a stable regimen of the standard of care therapy for diabetic nephropathy. Safety profile for MPC-300-IV treatment was similar to placebo, with no treatment-related adverse events. Efficacy testing showed that patients receiving a single MPC infusion at either dose had improved renal function relative to placebo.

MESO Mesoblast
$4.29

0.03 (0.70%)

02/19/16
CHDN
02/19/16
INITIATION
Target $5.5
CHDN
Neutral
Mesoblast initiated with a Neutral at Chardan
Target $5.50.
03/07/16
JPMS
03/07/16
DOWNGRADE
Target $10
JPMS
Neutral
Mesoblast downgraded to Neutral from Overweight at JPMorgan
JPMorgan analyst Anupam Rama downgraded Mesoblast to Neutral citing the 44% year-to-date rise in the shares. The analyst has a $10 price target for the name.
06/14/16
FBCO
06/14/16
DOWNGRADE
Target $5
FBCO
Neutral
Mesoblast downgraded to Neutral from Outperform at Credit Suisse
Credit Suisse analyst Alethia Young downgraded Mesoblast (MESO) to Neutral citing caution following the company's break-up with Teva (TEVA). Mesoblast should be able to find a new partner for its chronic heart failure program, but it could take some time, Young tells investors in a research note. She lowered her probability of success for the program to 25% from 40%. The analyst halved her price target for Mesoblast shares to $5 from $10. The shares have been halted since May 31, when they closed at $7.07.
06/15/16
JPMS
06/15/16
NO CHANGE
JPMS
Neutral
JPMorgan still cautious on Mesoblast, removes price target
JPMorgan analyst Anupam Rama says he remains cautious on Mesoblast (MESO) shares post the company's update related to MPC-150-IM in chronic heart failure. There are still some open questions following the two week trading halt, including why Teva (TEVA) has backed out following an interim data monitoring committee assessment and after committing resources to the program. The analyst sees growing concerns related to management credibility and removed his $10 price target for the stock. He keeps a Neutral rating on Mesoblast.

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CHRS

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NRCIA

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CC

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