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CATB

Catabasis Pharmaceuticals

$5.43

0.03 (0.56%)

08:05
10/06/16
10/06
08:05
10/06/16
08:05

Catabasis Pharmaceuticals presents data from Part A of MoveDMD trial

Catabasis Pharmaceuticals announced that Catabasis is presenting data from Part A of the MoveDMD trial of edasalonexent for the treatment of Duchenne muscular dystrophy at the World Muscle Society Congress. The World Muscle Society Congress is being held October 4 - October 8, 2016, in Granada, Spain, at the Palacio de Congresos de Granada. Joanne Donovan, M.D., Ph.D., Chief Medical Officer of Catabasis, will present the poster "CAT-1004, an oral agent targeting NF-kB: MoveDMD trial results in Duchenne muscular dystrophy" and Pradeep Bista, Ph.D., Principal Scientist at Catabasis, will present the poster "Serum pro-inflammatory proteins have potential utility as biomarkers for NF-kB targeting approaches in DMD." Both poster presentations will take place in Poster Presentations 3: Parallel Sessions today from 3:00pm - 4:30pm local time in the Poster area of the Palacio de Congresos de Granada. Catabasis has previously announced positive biomarker results from Part A of the MoveDMD clinical trial demonstrating successful NF-kB target engagement and detailed data are being presented at the World Muscle Society Congress. After one week of dosing with edasalonexent in 4-7-year-old boys affected by DMD, a pre-selected NF-kB gene set was significantly inhibited in whole blood mRNA at each of the two higher doses. The evaluated gene set is 200 expressed genes known to be regulated by NF-kB that was curated by the Broad Institute. This gene set was significantly decreased when compared to all other expressed genes. In addition to gene expression, serum proteins were also evaluated. In the combined group of patients on 67 mg/kg and 100 mg/kg, levels of NF-kB-regulated proteins, IL-12 and osteopontin, were significantly reduced following 7 days of dosing with edasalonexent. These data further support the ongoing evaluation of the 67 and 100 mg/kg edasalonexent doses in the Phase 2 MoveDMD clinical trial. Baseline data for boys from Part A of the trial who are also participating in Part B are being presented at the World Muscle Society Congress as well. Timed function tests were assessed before the boys had started dosing with edasalonexent in Part A of the trial as well as at baseline before they started dosing with edasalonexent in Part B of the trial. For all three of the timed function tests that we are evaluating, 10-meter walk/run, 4-step climb and time-to-stand, there was an increase in the average time to complete the tests from Part A baseline to Part B baseline. The time elapsed between Part A baseline and Part B baseline ranged from 4 to 11 months for these 15 boys. Although the MoveDMD trial is not powered to show statistically significant changes in these three timed function tests in Part B, the observations provide data on disease progression within the MoveDMD trial that shows a decline in function when these boys are predominantly not on treatment and may provide additional context for assessing these secondary end points during the on-treatment part of the trial. The primary end point of Part B of the MoveDMD trial is change in MRI T2 signal of the lower leg muscles for edasalonexent as compared with placebo.

CATB Catabasis Pharmaceuticals
$5.43

0.03 (0.56%)

12/10/15
WEDB
12/10/15
NO CHANGE
Target $27
WEDB
Outperform
Catabasis results could lead to partnership discussions, says Wedbush
Wedbush analyst Liana Moussatos said Catabsis announced the initiation of its Phase 2a trial of CAT-2054, its orally available SREBP inhibitor, in patients with hypercholesterolemia. Moussatos believes results from this trial could provide a basis for partnering discussions with a Big Pharma company with a presence in the metabolic space. The analyst sees potential peak worldwide sales of over $5.7B, and a partnering deal could have a lucrative upfront payment as well as significant milestones and royalties. Moussatos rates Catabasis an Outperform with a $27 price target on shares.
04/08/16
SBSH
04/08/16
NO CHANGE
SBSH
Citi lays out potential targets after break of Pfizer, Allergan deal
Citi analysts Yigal Nochomovitz, Liav Abraham and Joel Beatty argue that the break of the Pfizer (PFE), Allergan (AGN) merger could accelerate smaller scale acquisitions in the Biotechnology sector. The implication that larger companies could accelerate M&A activity to bolster pipelines in lieu of the mega-merger pathway aided shares in the sector this week, the analysts contend in a research note. They now believe that Ardelyx (ARDX), Medivation (MDVN), Ophthotech (OPHT), Puma Biotechnology (PBYI), Portola Pharmaceuticals (PTLA), Ultragenyx (RARE), Relypsa (RLYP) and Versartis (VSAR) have a greater probability of being acquired in the next 12-18 months. Beside these favored names for a takeover, analyst Joel Beatty sees a greater chance of Catabasis Pharmaceuticals (CATB), Intercept Pharmaceuticals (ICPT), Novavax (NVAX) and Raptor Pharmaceuticals (RPTP) getting acquired over the next 18 months.
06/08/16
COWN
06/08/16
NO CHANGE
Target $30
COWN
Outperform
Catabasis Pharmaceuticals DMD drug potential undervalued, says Cowen
Cowen noted Catabasis Pharmaceuticals halted its Phase-2 trial for CAT-2054 as it did not meet its primary endpoint in reducing LDL in hypercholesterolemia. Cowen, however, feels the shares are undervalued based on the potential of its edasalonexent drug candidate for Duchenne muscular dystropy, or DMD. The firm said the drug has the potential to be effective in all DMD patients regardless of the patient's underlying dystrophin mutation. Cowen maintained its Outperform rating and $30 price target on Catabasis shares.
06/09/16
SBSH
06/09/16
NO CHANGE
Target $8
SBSH
Buy
Catabasis Pharmaceuticals price target lowered to $8 from $16 at Citi
Citi analyst Joel Beatty halved his price target for Catabasis Pharmaceuticals to $8 and removed CAT-2054 from his model after the agent failed to lower cholesterol on top of statins in a Phase 2 trial. The analyst, however, continues to see favorable risk/reward into Phase 2 data in late 2016 for lead agent CAT-1004 in Duchenne Muscular Dystrophy. Beatty keeps a Buy rating on Catabasis.

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