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ALXN

Alexion

$122.89

-2.62 (-2.09%)

16:37
10/06/16
10/06
16:37
10/06/16
16:37

Alexion reports long-term data from extension of Phase 3 Kanuma study

Alexion Pharma announced that researchers presented new long-term data from an ongoing, open-label extension of the pivotal Phase 3 ARISE trial of Kanuma in children and adults with lysosomal acid lipase deficiency. At 52 weeks of Kanuma treatment, nearly all patients -- 97 percent -- who had received Kanuma from the start of the double-blind period had a rapid and sustained reduction in alanine aminotransferase, with a mean percent reduction of 53 percent, and an increase from 31 percent to 45 percent of patients achieving ALT normalization. Similarly, after 52 weeks of Kanuma treatment, nearly all patients -- 97 percent -- who had initially received placebo during the double-blind period had a reduction in ALT, with a mean percent reduction of 52 percent, and 48 percent of patients achieving ALT normalization. Sustained improvements were also observed in both groups in markers of lipid abnormalities, including LDL cholesterol, non-HDL cholesterol, triglycerides, and HDL cholesterol, through 52 weeks of Kanuma treatment. The safety profile of Kanuma during the extended open-label period was consistent with that observed in the double-blind period. No patient discontinued the open-label study because of adverse events. The data were reported at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition.

  • 06

    Nov

ALXN Alexion
$122.89

-2.62 (-2.09%)

09/23/16
WEDB
09/23/16
INITIATION
Target $132
WEDB
Neutral
Alexion initiated with a Neutral at Wedbush
Wedbush analyst Heather Behanna initiated Alexion with a Neutral and a $132 price target.
09/23/16
JEFF
09/23/16
NO CHANGE
Target $120
JEFF
Hold
Alexion price target lowered to $120 from $140 at Jefferies
Jefferies analyst Eun Yang lowered her price target for Alexion Pharmaceuticals to $120 after conducting a survey of 35 U.S. hematologists/nephrologists. The survey results support a cautious outlook on Soliris sales in 2021 and beyond due to potential competition, Yang tells investors in a research note. Specifically, 60% of those surveyed will shift away from Soliris to biosimilars if they are available due to cost, Yang tells investors in a research note. The analyst keeps a Hold rating on Alexion.
09/26/16
LEER
09/26/16
NO CHANGE
Target $211
LEER
Outperform
Alexion to dominate terminal complement inhibitor market, says Leerink
Leerink analyst Geoffrey Porges expects Alexion's flagship complement inhibition franchise to remain the dominant, if not only, terminal complement inhibitor on the market. The analyst notes that his research finds that the number of manufacturers with competing programs in early stage development face "significant" technical and market-related challenges to match or surpass Soliris. Porges continues to view Alexion's complement franchise as durable and capable of sustaining revenue growth throughout the mid-term as the company expands into other rare diseases. He reiterates an Outperform rating on the stock and raised his price target on the shares to $211 from $210.
10/04/16
BMUR
10/04/16
INITIATION
Target $221
BMUR
Buy
Alexion assumed with a Buy at Brean Capital
Brean Capital analyst Jason Wittes assumed coverage of Alexion Pharmaceuticals with a Buy rating and $221 price target.

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