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EXEL

Exelixis

$13.18

0.06 (0.46%)

, RHHBY

Roche

$30.54

-0.29 (-0.94%)

04:51
10/07/16
10/07
04:51
10/07/16
04:51

Exelixis announces Genentech presentation of preliminary phase 1b trial results

Exelixis (EXEL) announced that its collaborator Genentech, a member of the Roche Group (RHHBY), will present preliminary results from a phase 1b clinical trial evaluating the safety and clinical activity of the triple combination of cobimetinib, vemurafenib, and atezolizumab in patients with previously untreated BRAF V600 mutation-positive advanced melanoma. The results will be the subject of a poster discussion presentation at the European Society of Medical Oncology 2016 Congress, which is being held October 7-11 in Copenhagen, Denmark. "Cobimetinib and vemurafenib is FDA-approved to treat specific forms of BRAF V600 mutation-positive unresectable or metastatic melanoma and has been associated with significant improvements in progression-free survival, overall survival and objective response rate as compared to vemurafenib alone," said Michael M. Morrissey, Ph.D., president and chief executive officer of Exelixis. "The preliminary results to be presented at the ESMO Congress suggest that adding atezolizumab to the combination regimen is associated both with a manageable safety profile and promising antitumor activity."

EXEL

Exelixis

$13.18

0.06 (0.46%)

RHHBY

Roche

$30.54

-0.29 (-0.94%)

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EXEL Exelixis
$13.18

0.06 (0.46%)

09/28/16
LEER
09/28/16
NO CHANGE
LEER
Outperform
Exelixis selloff based on ESMO abstracts overdone, says Leerink
Leerink analyst Michael Schmidt believes Exelixis' selloff following the publication of ESMO poster abstracts is overdone. The analyst notes that abstract includes updated data from a Phase Ib trial evaluating the combination of axitinib with pembrolizumab and appears to have sparked competitive concerns for Exelixis. However, he believes it is highly premature to draw conclusions at this point on the company's Cabometyx' market opportunity or potential in Renal Cell Carcinoma. Schmidt reiterates an Outperform rating on the shares. In afternoon trading, Exelixis' stock has dropped over 15% to $13.12 per share.
09/28/16
LEER
09/28/16
NO CHANGE
LEER
Exelixis selloff overdone, says Leerink
08/22/16
GSCO
08/22/16
NO CHANGE
GSCO
Goldman lists companies to be in focus after Medivation deal
After Pfizer (PFE) announced it has agreed to acquire Medivation (MDVN) for $81.50 per share in cash, Goldman Sachs analyst Salveen Richter said he expects a focus on other commercial small-to-mid-cap cancer companies, including Incyte (INCY), Seattle Genetics (SGEN), ARIAD (ARIA) and Exelixis (EXEL). Also noting that Sanofi (SNY), which was pursuing Medivation, has recently suggested an interest in a rare disease transaction up to potentially as large as $20B, he would expect rare disease companies of that size - such as BioMarin (BMRN), Amicus (FOLD) and Ultragenyx (RARE) - to be in focus as well.
08/04/16
STFL
08/04/16
NO CHANGE
STFL
Exelixis price target raised to $12 from $10 at Stifel
Stifel analyst Stephen Willey raised his price target on Exelixis after the company reported significantly better than expected Cabometyx and residual/off-label Cometriq sales into the newly launched indication of refractory renal cell carcinom. Willey expects the results to improve investors' confidence towards the company's growth outlook, and he says that anticipation of front-line CABOSUN results places a near-term floor on the stock. The analyst keeps a Buy rating on the shares.
RHHBY Roche
$30.54

-0.29 (-0.94%)

09/27/16
PIPR
09/27/16
NO CHANGE
Target $62
PIPR
Neutral
Bristol-Myers price target lowered to $62 from $65 at Piper Jaffray
Piper Jaffray analyst Richard Purkiss lowered his price target for Bristol-Myers Squibb (BMY) to $62 saying he sees the company ceding Opdivo's early-mover advantage in lung cancer to competitors. The analyst expects to see details from Roche's (RHHBY) positive OAK trial of Tecentriq vs. docetaxel in non-small cell lung cancer at the upcoming ESMO meeting. Purkiss also expects to see details from Merck's (MRK) positive KEYNOTE-024 trial of Keytruda. The analyst lowered his post-2016 Opdivo forecasts and reiterates a Neutral rating on Bristol shares.
09/12/16
JEFF
09/12/16
NO CHANGE
Target $57
JEFF
Hold
Jefferies cuts Bristol-Myers price target, upgrades AstraZeneca
Jefferies analyst Jeffrey Holford lowered his price target for Bristol-Myers Squibb (BMY) to $57 from $69 saying the stock is positioned for a "rough mid term ride." The analyst sees a "difficult catalyst" set for Bristol shares with "numerous" upcoming competitor read-outs in non-small cell lung cancer. The market could see worse than expected data from Bristol's CM-026 and CM-568 studies as well as better than expected data from AstraZeneca's (AZN) MYSTIC study and Roche's (RHHBY) Chemo-IO studies in the first half of 2017, Holford tells investors in a research note. He keeps a Hold rating on Bristol and upgraded this morning AstraZeneca to Buy from Hold. Holford prefers Astra for its immunology exposure.
09/07/16
09/07/16
NO CHANGE

BioLineRx partnering with Roche company in cancer therapy research
BioLineRx (BLRX) has entered into a collaboration with Genentech, a member of the Roche (RHHBY) Group, to support several Phase 1b studies investigating BioLineRx's BL-8040 in combination with Atezolizumab, Genentech's anti-PDL1 cancer immunotherapy, in multiple cancer indications. The Phase 1b studies will evaluate the clinical response, safety and tolerability of the combination of these therapies, as well as multiple pharmacodynamic parameters, in hematologic malignancies and solid tumors. Under the agreement, Genentech will sponsor and conduct several Phase 1b trials in multiple solid cancer indications. In addition, BioLineRx will sponsor and conduct a Phase 1b study in acute myeloid leukemia patients. The studies are designed to evaluate the safety and efficacy of the combination of BL-8040 and Atezolizumab. Upon completion of the studies, both parties will have the option to expand the collaboration to include a pivotal registration study. Additional details of the collaboration were not disclosed.
09/01/16
BMOC
09/01/16
NO CHANGE
BMOC
Bristol-Myers has negative read through from Roche data, says BMO Capital
BMO Capital analyst Alex Arfaei says that the positive data on Roche's (RHHBY) TECENTRIQ for second line NSCLC is negative for Bristol-Myers' (BMY) cancer drug, Opdivo. The analyst does not think that TECENTRIQ's results will be superior to that of Opdivo, but he believes that Roche's drug appears to have "a significant" benefit in PD-L1 positive patients." He predicts that Roche's drug could take "meaningful market share, particularly outside of the U.S." The analyst keeps a Market Perform rating on Bristol-Myers.

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CNX

CONSOL

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CONE Midstream

$21.33

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15:02
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CONE Midstream participates in an analyst and investor day »

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CONSOL

$21.30

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14:59
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CONSOL to host analyst and investor day »

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BG

Bunge

$73.36

-0.04 (-0.05%)

14:54
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Bunge to host investor day »

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AMD

AMD

14:50
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AMD to host Summit Ridge a "Zen"-based CPU at New Horizon »

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AJG

Arthur J. Gallagher

$50.76

0.61 (1.22%)

14:41
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NYT

New York Times

$14.10

0.15 (1.08%)

14:34
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Detroit Economic Club to hold a luncheon meeting »

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AZN

AstraZeneca

$27.16

0.89 (3.39%)

14:28
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AstraZeneca has a luncheon meeting with Philadelphia Securities Association »

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CASC

Cascadian Therapeutics

$5.65

-0.03 (-0.53%)

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Genomic Health

$30.81

-0.17 (-0.55%)

04:55
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UT Health Science Center to hold a symposium »

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Cascadian Therapeutics

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GHDX

Genomic Health

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MYGN

Myriad Genetics

$17.40

0.41 (2.41%)

RDUS

Radius Health

$43.94

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OCX

OncoCyte

$6.15

0.05 (0.82%)

ABBV

AbbVie

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0.64 (1.05%)

BAYRY

Bayer

$100.04

1.14 (1.15%)

CELG

Celgene

$113.47

0.41 (0.36%)

CLDX

Celldex

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DNA

Bought by RHHBY

HRTX

Heron Therapeutics

$14.90

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PFE

Pfizer

$31.70

0.76 (2.46%)

PBYI

Puma Biotechnology

$36.50

0.05 (0.14%)

TSRO

TESARO

$129.97

-1.57 (-1.19%)

NSTG

NanoString

$21.79

-0.35 (-1.58%)

NVS

Novartis

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2.15 (3.18%)

NVTA

Invitae

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0.28 (4.02%)

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BBSI

Barrett Business

$62.30

1.85 (3.06%)

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Craft Brew

$16.65

0.45 (2.78%)

04:55
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Roth Capital to hold a conference »

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Barrett Business

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BREW

Craft Brew

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CHKE

Cherokee

$11.10

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DFBG

Differential Brands

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0.25 (8.47%)

DLA

Delta Apparel

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ESCA

Escalade

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FLKS

Flex Pharma

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KONA

Kona Grill

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LNDC

Landec

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MEET

MeetMe

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MITK

Mitek Systems

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MB

MINDBODY

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OSI Systems

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PLNT

Planet Fitness

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ROX

Castle Brands

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U.S. Auto Parts

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RadiSys

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Smith & Wesson

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Vista Outdoor

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WMAR

West Marine

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Cisco

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Arista Networks favored in ITC initial determination on four of six patents »

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U.S. DOT looks to accelerate pace of Takata air bag replacements, Reuters says »

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DeVry

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Breaking Hot Stocks news story on DeVry »

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CSOD

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18:10
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Cornerstone OnDemand considers sale amid activist pressure, Bloomberg reports »

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CVM

CEL-SCI

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NYSE MKT says CEL-SCI noncompliant with certain listing requirements »

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Exxon CEO Tillerson emerges as top candidate for secretary of state, WSJ says »

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H.B. Fuller

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H.B. Fuller announces restructuring, to eliminate, relocate 220 positions »

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Biogen

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Biogen looks like a bargain, Barron's reports »

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Sanofi

$40.40

0.63 (1.58%)

17:42
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Sanofi to lay off 20% of U.S. diabetes, cardiovascular staff, Bloomberg says »

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CSOD

Cornerstone OnDemand

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Cornerstone OnDemand considers sale amid activist pressure, Bloomberg reports »

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TACO

Del Taco

$14.75

-0.39 (-2.58%)

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UNVR

Univar

$26.36

0.54 (2.09%)

, BXLT

Baxalta

17:30
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Univar names Eric Foster chief information officer »

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Univar

$26.36

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Baxalta

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PARN

Parnell

$1.42

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17:30
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Breaking Hot Stocks news story on Parnell 

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BSX

Boston Scientific

$20.81

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Nevro

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Boston Scientific files patent infringement suit against Nevro »

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BSX

Boston Scientific

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NVRO

Nevro

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-1.88 (-2.40%)

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RTN

Raytheon

$146.30

0.14 (0.10%)

17:21
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Raytheon awarded $101.9M government contract »

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CX

CEMEX

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-0.16 (-1.79%)

17:18
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CEMEX receives subpoena from SEC regarding Foreign Corrupt Practices Act »

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