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SGEN

Seattle Genetics

$54.33

-1.18 (-2.13%)

, ALPMF

Astellas Pharma

09:01
10/07/16
10/07
09:01
10/07/16
09:01

Seattle Genetics, Astellas afiiliate highlight 'promising' Phase 1 data at ESMO

Seattle Genetics and Agensys, an affiliate of Astellas (ALPMF), presented updated clinical data for enfortumab vedotin and ASG-15ME at the European Society for Medical Oncology Congress being held October 7-11, 2016 in Copenhagen, Denmark. Enfortumab vedotin and ASG-15ME are investigational antibody-drug conjugates that target the cell surface proteins Nectin-4 and SLITRK6, respectively. The clinical data for both agents continue to demonstrate overall response rates in patients with previously treated metastatic urothelial cancer, including those with prior checkpoint inhibitors. Safety and recommended phase 2 doses were also presented for both programs. While both phase 1 studies will continue to enroll patients, the companies plan to advance enfortumab vedotin and discuss next steps with regulatory agencies. Evaluation of next developmental steps for ASG-15ME is ongoing. Interim data from two phase 1 dose-escalation studies of enfortumab vedotin and ASG-15ME monotherapy in patients with metastatic urothelial cancer will be presented at the ESMO Congress during poster sessions on Sunday, October 9, 2016. The respective clinical trial data showed that each agent had antitumor activity in patients previously treated with platinum-based chemotherapy, checkpoint inhibitors, taxanes and those with liver metastases. Enfortumab vedotin and ASG-15ME were generally well-tolerated, and phase 1 enrollment is ongoing with both agents, with an increased focus on checkpoint-inhibitor treated patients to further understand safety and activity in this population.

SGEN

Seattle Genetics

$54.33

-1.18 (-2.13%)

ALPMF

Astellas Pharma

  • 07

    Oct

  • 06

    Nov

SGEN Seattle Genetics
$54.33

-1.18 (-2.13%)

09/07/16
MSCO
09/07/16
INITIATION
Target $60
MSCO
Overweight
Seattle Genetics initiated with an Overweight at Morgan Stanley
Morgan Stanley analyst Andrew Berens initiated Seattle Genetics with an Overweight and $60 price target. The analyst expects Adcetris will peak at $2.5B by 2030 and thinks the company is likely to move Adcetris to the frontline in Hodgkin's lymphoma treatment.
09/15/16
GSCO
09/15/16
UPGRADE
GSCO
Neutral
Seattle Genetics upgraded to Neutral from Sell at Goldman
Goldman Sachs analyst Salveen Richter upgraded Seattle Genetics to Neutral after raising her estimates for Adcetris in Hodgkin lymphoma. The analyst also introduced a takeover component to her valuation given the company's "scarcity of commercial oncology assets and emerging optionality from the pipeline." She raised her price target for Seattle Genetics to $47 from $30. The biotechnology company closed yesterday up $2.36 to $54.06.
09/16/16
LEER
09/16/16
NO CHANGE
Target $62
LEER
Outperform
Seattle Genetics price target raised to $62 from $52 at Leerink
After assuming coverage of Seattle Genetics, Leerink analyst Michael Schmidt raised the price target on the stock to $62 from $52, saying he sees additional upside for the shares over the next 12-18 months. The analyst has an Outperform rating on Seattle Genetics' stock.
10/07/16
GSCO
10/07/16
NO CHANGE
GSCO
Smid-cap Biotech sector upgraded to Attractive from Neutral at Goldman
Goldman analyst Salveen Richter upgraded the Smid-cap biotechnology to Attractive and said he favors and companies with near-term pipeline data or regulatory events where he has conviction.Names he recommends are Buy rated BioMarin (BMRN), bluebird bio (BLUE), GW Pharma (GWPH), Incyte (INCY), Kite (KITE), and Sage (SAGE).
ALPMF Astellas Pharma

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HIMX

Himax

$8.17

-0.02 (-0.24%)

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ARQL

ArQule

$1.17

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, NLNK

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ARQL

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$1.17

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$7.36

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STML

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$9.97

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RARX

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CDTX

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GBT

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PTLA

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TGTX

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$11.95

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ANTM

Anthem

$190.17

-3.19 (-1.65%)

18:58
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SVU

Supervalu

$2.94

-0.04 (-1.34%)

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GILD

Gilead

$70.52

0.04 (0.06%)

18:14
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Gilead no longer a 'value trap,' Barron's reports »

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