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NVS

Novartis

$78.29

-0.16 (-0.20%)

14:44
10/09/16
10/09
14:44
10/09/16
14:44

Novartis reports Phase 3 data on LEE011 in breast cancer

Novartis announced that results from the pivotal Phase III MONALEESA-2 study show LEE011, or ribociclib, plus letrozole significantly extended progression-free survival compared to a standard of care, letrozole, as a first-line treatment in postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative advanced or metastatic breast cancer. The results demonstrate that LEE011 plus letrozole reduced the risk of death or progression by 44% over letrozole alone. The combination significantly improved PFS across all patient subgroups, regardless of disease characteristics or demographics. More than half of women with measurable disease taking LEE011 plus letrozole saw their tumor size shrink by at least 30% -- overall response rate in patients with measurable disease was 53% vs 37%. Most adverse events in the MONALEESA-2 trial were mild to moderate in severity, identified early through routine monitoring, and generally managed through dose interruption and reduction. The discontinuation rate due to adverse events in the MONALEESA-2 trial was 7.5% for LEE011 plus letrozole and 2.1% for letrozole alone. The most common grade 3/4 adverse events were as follows for LEE011 plus letrozole compared to letrozole alone: neutropenia 60% vs 1%, leukopenia 21% vs 1%, elevated alanine aminotransferase 9% vs 1%, lymphopenia 7% vs 1%, and elevated aspartate aminotransferase 6% vs 1%. Due to the significant extension of PFS and clinical benefit seen with LEE011, analysis of the primary endpoint in MONALEESA-2 was stopped early in May as recommended by the Independent Data Monitoring Committee. Follow up to measure overall survival is ongoing.

NVS Novartis
$78.29

-0.16 (-0.20%)

09/20/16
CHDN
09/20/16
INITIATION
Target $95
CHDN
Buy
Novartis initiated with a Buy at Chardan
Chardan initiated Novartis with a Buy and a $95 price target.
09/02/16
LEER
09/02/16
NO CHANGE
LEER
Outperform
Teva third Copaxone patent invalidated as expected, says Leerink
Leerink analyst Jason Gerberry says Teva (TEVA) suffered a largely expected loss in its Copaxone 40mg patent battle, with the Patent Trial and Appeal Board, or PTAB, ruling a third patent invalid. The analyst believes the company will likely appeal the loss, along with PTAB rulings rendered last week that other Copaxone patents were invalid. Gerberry sees the bull case scenario of Teva securing patent exclusivity of the Copaxone 40mg as unlikely and says a settlement with Momenta (MNTA) and Novartis (NVS) is the most logical course of action to mitigate 2017-2018E EPS risk. He reiterates an Outperform rating on Teva's shares.
08/31/16
PIPR
08/31/16
NO CHANGE
PIPR
Piper's Schimmer unsure of impact from Novartis CAR-T shakeup
Piper Jaffray analyst Joshua Schimmer said he's struggling with the implications of the news that Novartis (NVS) is reportedly eliminating its Cell and Gene Therapy unit as a stand-alone entity, which is primarily focused on development of CAR-T and adoptive immunotherapies. On the one hand, removing a leading competitor is a positive for the rest of the field, Schimmer tells investors in a research note. On the other hand, the move by Novartis could signal "significant challenges" in the field, the analyst adds. Schimmer continues to prefer companies "with unique and differentiated approaches," namely Bellicum Pharmaceuticals (BLCM), Cellectis (CLLS), Lion Biotechnologies (LBIO), Amgen (AMGN), Celgene (CELG) and bluebird bio (BLUE). Juno Therapeutics (JUNO) and Kite Pharma (KITE) are down 6% and 5%, respectively, in midday trading.
08/31/16
LEER
08/31/16
NO CHANGE
Target $61
LEER
Outperform
Teva price target lowered to $61 from $66 at Leerink
Leerink analyst Jason Gerberry lowered his price target for Teva (TEVA) to $61 from $66 on loss of Copaxone patent challenge as an upside catalyst. The analyst believes Teva's share price implies a generic entrant sometime in the second half of 2017 after losing an Inter Partes Review decision on two Copaxone 40mg anchor patents. In order to mitigate EPS downside in 2017-2018 and eliminate business uncertainty, Gerberry thinks the company should settle its Copaxone patent dispute with Novartis (NVS) and Momenta (MNTA), which he sees as "the most credible" generic threat. The analyst reiterates an Outperform rating on Teva's shares.

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VNCE

Vince Holding

$4.55

0.35 (8.33%)

20:25
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Notable companies reporting before tomorrow's open »

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NWBO

Northwest Biotherapeutics

$0.55

0.0227 (4.33%)

20:17
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Northwest Biotherapeutics to delist from Nasdaq, confirms clinical trial plans »

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AAPL

Apple

$111.03

1.08 (0.98%)

, MSFT

Microsoft

$61.37

1.42 (2.37%)

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Periodicals
NHL in negotiations to bring Apple devices to team benches, TSN says »

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Apple

$111.03

1.08 (0.98%)

MSFT

Microsoft

$61.37

1.42 (2.37%)

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ATKR

Atkore

$19.71

-0.11 (-0.55%)

19:59
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19:59
Syndicate
Atkore 8M share Secondary priced at $19.00 »

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BPMC

Blueprint Medicines

$26.20

-2.23 (-7.84%)

19:58
12/07/16
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19:58
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19:58
Syndicate
Blueprint Medicines 5M share Secondary priced at $25.00 »

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LULU

lululemon

$59.84

2.6 (4.54%)

19:50
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19:50
Hot Stocks
lululemon CFO says early Q4 trends strengthened into December »

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LULU

lululemon

$59.84

2.6 (4.54%)

19:50
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19:50
Hot Stocks
lululemon CEO highlights Q3 gross margin, reports 11% comp growth in pants »

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CVX

Chevron

$114.44

1.68 (1.49%)

19:20
12/07/16
12/07
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19:20
Hot Stocks
Chevron announces $19.8B capital, exploratory budget for 2017 »

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X

U.S. Steel

$37.49

1.54 (4.28%)

18:49
12/07/16
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18:49
Periodicals
U.S. Steel CEO: Company may bring back 10,000 U.S. jobs, CNBC says »

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VNDA

Vanda

$15.40

-0.6 (-3.75%)

18:47
12/07/16
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18:47
Hot Stocks
Vanda settles Fanapt patent litigation with Apotex »

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AE

Adams Resources

$42.31

-0.68 (-1.58%)

, SWN

Southwestern Energy

$12.37

-0.08 (-0.64%)

18:46
12/07/16
12/07
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18:46
Hot Stocks
Adams Resources appoints Josh Anders as CFO »

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AE

Adams Resources

$42.31

-0.68 (-1.58%)

SWN

Southwestern Energy

$12.37

-0.08 (-0.64%)

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EZPW

EZCORP

$11.80

0.05 (0.43%)

18:42
12/07/16
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18:42
Earnings
EZCORP reports Q4 EPS with items (31c), may not compare to consensus 6c »

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RICE

Rice Energy

$24.59

-0.16 (-0.65%)

18:33
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18:33
Initiation
Rice Energy initiated  »

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AMZN

Amazon.com

$770.42

5.7 (0.75%)

18:30
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Periodicals
Amazon spokesperson denies 2,000 grocery stores report, CNET says »

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ICON

Iconix Brand

$9.26

0.14 (1.54%)

18:23
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Hot Stocks
Iconix Brand reports employment termination of Chief Strategy Officer Blumberg »

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PBYI

Puma Biotechnology

$39.80

-2 (-4.78%)

18:23
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Hot Stocks
Puma Biotechnology 'pleased' to complete biomarker analysis of neratinib »

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FTK

Flotek

$11.10

-2.01 (-15.33%)

18:17
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Hot Stocks
Flotek: Reviewing FourWorld Capital short report, remain confident in product »

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PBYI

Puma Biotechnology

$39.80

-2 (-4.78%)

18:09
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18:09
Hot Stocks
Puma Biotechnology 'pleased' with preliminary neratinib activity »

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PNM

PNM Resources

$32.05

0.45 (1.42%)

18:09
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Hot Stocks
PNM Resources requests an electric rate increase of $99M in New Mexico »

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BK

BNY Mellon

$48.55

0.56 (1.17%)

18:03
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Periodicals
BNY Mellon outage led to certain Swift payment failures, WSJ reports »

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TLRD

Tailored Brands

$18.93

0.62 (3.39%)

17:52
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Hot Stocks
Tailored Brands up 22% to $23.20 after Q3 results beat estimates »

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FLXS

Flexsteel Industries

$59.12

2.92 (5.20%)

, UNH

UnitedHealth

$159.40

2.08 (1.32%)

17:50
12/07/16
12/07
17:50
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17:50
Hot Stocks
Flexsteel names Eric Rangen chair of the board »

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FLXS

Flexsteel Industries

$59.12

2.92 (5.20%)

UNH

UnitedHealth

$159.40

2.08 (1.32%)

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NKE

Nike

$52.10

1.53 (3.03%)

, UA

Under Armour

$27.03

1.62 (6.38%)

17:49
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17:49
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17:49
Periodicals
Nike losing market share to faster-growing rivals, Barron's reports »

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NKE

Nike

$52.10

1.53 (3.03%)

UA

Under Armour

$27.03

1.62 (6.38%)

ADDYY

adidas

$76.96

1.225 (1.62%)

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  • 20

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T

AT&T

$40.45

1.1 (2.80%)

17:45
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17:45
Conference/Events
AT&T management to meet with Jefferies »

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