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NVS

Novartis

$78.29

-0.16 (-0.20%)

15:02
10/09/16
10/09
15:02
10/09/16
15:02

Novartis reports Phase 3 data on Tafinlar-Mekinist in melanoma

Novartis announced data from the Phase III COMBI-v study demonstrating an overall survival and a progression-free survival benefit for patients with BRAF V600 mutation-positive advanced melanoma when treated first-line with the combination of Tafinlar and Mekinist compared to vemurafenib monotherapy. The results of the study, which was conducted in 704 patients, are being presented at the European Society for Medical Oncology 2016 Congress. Results from the COMBI-v study found the estimated three-year survival rate to be 45% of patients receiving the combination of Tafinlar + Mekinist compared with 31% of patients who received vemurafenib monotherapy. There were 34 patients who crossed over from the vemurafenib monotherapy arm to the combination arm after the combination demonstrated a significant OS benefit in a prior analysis. Additionally, the estimated three-year progression-free survival rate was 24% for the combination arm and 10%m for the vemurafenib monotherapy arm. At three years of follow up, the combination of Tafinlar + Mekinist continued to demonstrate a benefit on the measures of duration of response and overall response rate, in line with results seen at the two-year follow up analysis. The safety results were consistent with the profile observed to date for the combination and consistent with the profile observed for vemurafenib monotherapy; no new safety concerns were observed.

NVS Novartis
$78.29

-0.16 (-0.20%)

08/31/16
LEER
08/31/16
NO CHANGE
Target $61
LEER
Outperform
Teva price target lowered to $61 from $66 at Leerink
Leerink analyst Jason Gerberry lowered his price target for Teva (TEVA) to $61 from $66 on loss of Copaxone patent challenge as an upside catalyst. The analyst believes Teva's share price implies a generic entrant sometime in the second half of 2017 after losing an Inter Partes Review decision on two Copaxone 40mg anchor patents. In order to mitigate EPS downside in 2017-2018 and eliminate business uncertainty, Gerberry thinks the company should settle its Copaxone patent dispute with Novartis (NVS) and Momenta (MNTA), which he sees as "the most credible" generic threat. The analyst reiterates an Outperform rating on Teva's shares.
08/31/16
PIPR
08/31/16
NO CHANGE
PIPR
Piper's Schimmer unsure of impact from Novartis CAR-T shakeup
Piper Jaffray analyst Joshua Schimmer said he's struggling with the implications of the news that Novartis (NVS) is reportedly eliminating its Cell and Gene Therapy unit as a stand-alone entity, which is primarily focused on development of CAR-T and adoptive immunotherapies. On the one hand, removing a leading competitor is a positive for the rest of the field, Schimmer tells investors in a research note. On the other hand, the move by Novartis could signal "significant challenges" in the field, the analyst adds. Schimmer continues to prefer companies "with unique and differentiated approaches," namely Bellicum Pharmaceuticals (BLCM), Cellectis (CLLS), Lion Biotechnologies (LBIO), Amgen (AMGN), Celgene (CELG) and bluebird bio (BLUE). Juno Therapeutics (JUNO) and Kite Pharma (KITE) are down 6% and 5%, respectively, in midday trading.
09/02/16
LEER
09/02/16
NO CHANGE
LEER
Outperform
Teva third Copaxone patent invalidated as expected, says Leerink
Leerink analyst Jason Gerberry says Teva (TEVA) suffered a largely expected loss in its Copaxone 40mg patent battle, with the Patent Trial and Appeal Board, or PTAB, ruling a third patent invalid. The analyst believes the company will likely appeal the loss, along with PTAB rulings rendered last week that other Copaxone patents were invalid. Gerberry sees the bull case scenario of Teva securing patent exclusivity of the Copaxone 40mg as unlikely and says a settlement with Momenta (MNTA) and Novartis (NVS) is the most logical course of action to mitigate 2017-2018E EPS risk. He reiterates an Outperform rating on Teva's shares.
09/20/16
CHDN
09/20/16
INITIATION
Target $95
CHDN
Buy
Novartis initiated with a Buy at Chardan
Chardan initiated Novartis with a Buy and a $95 price target.

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DUK

Duke Energy

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-0.32 (-0.37%)

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PPL

PPL Corp.

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AEP

American Electric

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Ameren

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WEC Energy

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NSRGY

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0.4 (0.47%)

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TKTDY

Takata

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TKTDY

Takata

$3.15

1.2199 (63.21%)

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TKTDY

Takata

$3.15

1.2199 (63.21%)

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TKTDY

Takata

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1.2199 (63.21%)

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IRDM

Iridium

$10.75

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TKTDY

Takata

$3.15

1.2199 (63.21%)

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Takata files for bankruptcy in U.S., Bloomberg says »

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SEAS

SeaWorld

$15.65

-0.16 (-1.01%)

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FB

Facebook

$155.07

1.67 (1.09%)

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Facebook plans to offer TV-quality content by late summer, WSJ says »

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FRO

Frontline

$5.59

0.08 (1.45%)

, GNRT

Gener8 Maritime

$6.12

0.21 (3.55%)

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Frontline abandons plans to buy Gener8, WSJ says »

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FRO

Frontline

$5.59

0.08 (1.45%)

GNRT

Gener8 Maritime

$6.12

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NSRGY

Nestle

$84.83

0.4 (0.47%)

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WMT

Wal-Mart

$74.84

-0.68 (-0.90%)

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GOOG

Alphabet

$965.59

8.5 (0.89%)

, GOOGL

Alphabet Class A

$986.09

9.47 (0.97%)

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GOOG

Alphabet

$965.59

8.5 (0.89%)

GOOGL

Alphabet Class A

$986.09

9.47 (0.97%)

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NSRGY

Nestle

$84.83

0.4 (0.47%)

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LNG

Cheniere Energy

$47.62

0.34 (0.72%)

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VIA

Viacom

$39.15

0.1 (0.26%)

, VIAB

Viacom

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DIS

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LGF.B

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FOX

21st Century Fox

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FOXA

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$27.19

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SNE

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CMCSA

Comcast

$39.50

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CMCSK

Comcast

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GSK

GlaxoSmithKline

$44.29

0.13 (0.29%)

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BHVN

Biohaven Pharmaceutical

$25.33

-0.13 (-0.51%)

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ESALY

Eisai

$56.42

-0.075 (-0.13%)

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PTNR

Partner Communications

$5.25

0.1123 (2.19%)

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