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NVS

Novartis

$78.29

-0.16 (-0.20%)

15:02
10/09/16
10/09
15:02
10/09/16
15:02

Novartis reports Phase 3 data on Tafinlar-Mekinist in melanoma

Novartis announced data from the Phase III COMBI-v study demonstrating an overall survival and a progression-free survival benefit for patients with BRAF V600 mutation-positive advanced melanoma when treated first-line with the combination of Tafinlar and Mekinist compared to vemurafenib monotherapy. The results of the study, which was conducted in 704 patients, are being presented at the European Society for Medical Oncology 2016 Congress. Results from the COMBI-v study found the estimated three-year survival rate to be 45% of patients receiving the combination of Tafinlar + Mekinist compared with 31% of patients who received vemurafenib monotherapy. There were 34 patients who crossed over from the vemurafenib monotherapy arm to the combination arm after the combination demonstrated a significant OS benefit in a prior analysis. Additionally, the estimated three-year progression-free survival rate was 24% for the combination arm and 10%m for the vemurafenib monotherapy arm. At three years of follow up, the combination of Tafinlar + Mekinist continued to demonstrate a benefit on the measures of duration of response and overall response rate, in line with results seen at the two-year follow up analysis. The safety results were consistent with the profile observed to date for the combination and consistent with the profile observed for vemurafenib monotherapy; no new safety concerns were observed.

NVS Novartis
$78.29

-0.16 (-0.20%)

08/31/16
LEER
08/31/16
NO CHANGE
Target $61
LEER
Outperform
Teva price target lowered to $61 from $66 at Leerink
Leerink analyst Jason Gerberry lowered his price target for Teva (TEVA) to $61 from $66 on loss of Copaxone patent challenge as an upside catalyst. The analyst believes Teva's share price implies a generic entrant sometime in the second half of 2017 after losing an Inter Partes Review decision on two Copaxone 40mg anchor patents. In order to mitigate EPS downside in 2017-2018 and eliminate business uncertainty, Gerberry thinks the company should settle its Copaxone patent dispute with Novartis (NVS) and Momenta (MNTA), which he sees as "the most credible" generic threat. The analyst reiterates an Outperform rating on Teva's shares.
08/31/16
PIPR
08/31/16
NO CHANGE
PIPR
Piper's Schimmer unsure of impact from Novartis CAR-T shakeup
Piper Jaffray analyst Joshua Schimmer said he's struggling with the implications of the news that Novartis (NVS) is reportedly eliminating its Cell and Gene Therapy unit as a stand-alone entity, which is primarily focused on development of CAR-T and adoptive immunotherapies. On the one hand, removing a leading competitor is a positive for the rest of the field, Schimmer tells investors in a research note. On the other hand, the move by Novartis could signal "significant challenges" in the field, the analyst adds. Schimmer continues to prefer companies "with unique and differentiated approaches," namely Bellicum Pharmaceuticals (BLCM), Cellectis (CLLS), Lion Biotechnologies (LBIO), Amgen (AMGN), Celgene (CELG) and bluebird bio (BLUE). Juno Therapeutics (JUNO) and Kite Pharma (KITE) are down 6% and 5%, respectively, in midday trading.
09/02/16
LEER
09/02/16
NO CHANGE
LEER
Outperform
Teva third Copaxone patent invalidated as expected, says Leerink
Leerink analyst Jason Gerberry says Teva (TEVA) suffered a largely expected loss in its Copaxone 40mg patent battle, with the Patent Trial and Appeal Board, or PTAB, ruling a third patent invalid. The analyst believes the company will likely appeal the loss, along with PTAB rulings rendered last week that other Copaxone patents were invalid. Gerberry sees the bull case scenario of Teva securing patent exclusivity of the Copaxone 40mg as unlikely and says a settlement with Momenta (MNTA) and Novartis (NVS) is the most logical course of action to mitigate 2017-2018E EPS risk. He reiterates an Outperform rating on Teva's shares.
09/20/16
CHDN
09/20/16
INITIATION
Target $95
CHDN
Buy
Novartis initiated with a Buy at Chardan
Chardan initiated Novartis with a Buy and a $95 price target.

TODAY'S FREE FLY STORIES

AGU

Agrium

$99.37

-1.19 (-1.18%)

, AAL

American Airlines

$46.28

0.18 (0.39%)

04:55
02/26/17
02/26
04:55
02/26/17
04:55
Conference/Events
BMO Capital to hold a conference »

26th Global Metals &…

AGU

Agrium

$99.37

-1.19 (-1.18%)

AAL

American Airlines

$46.28

0.18 (0.39%)

ABX

Barrick Gold

$19.54

-0.12 (-0.61%)

AEM

Agnico Eagle

$45.32

-0.06 (-0.13%)

ANTO

Use ANFGY

BLT

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CCO

Clear Channel Outdoor

$4.65

0.1797 (4.02%)

FCX

Freeport McMoRan

$13.25

-0.23 (-1.71%)

FNV

Franco-Nevada

$65.89

-0.85 (-1.27%)

GEM

Pepsi-Gemex ADR

$29.39

-0.3 (-1.01%)

GG

Goldcorp

$16.57

-0.25 (-1.49%)

HBM

Hudbay Minerals

$8.00

0.25 (3.23%)

IVN

trades under IVPAF

NUE

Nucor

$60.86

-0.03 (-0.05%)

PDL

Project Design Labs

POT

Potash

$17.87

-0.2 (-1.11%)

RIO

Rio Tinto

$41.69

-0.82 (-1.93%)

SLW

Silver Wheaton

$21.15

-0.36 (-1.67%)

STLD

Steel Dynamics

$35.59

0.07 (0.20%)

TECK

Teck Resources

$20.72

-0.09 (-0.43%)

NEM

Newmont Mining

$36.08

0.22 (0.61%)

MOS

Mosaic

$31.42

-0.41 (-1.29%)

AA

Alcoa

$34.48

0.16 (0.47%)

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AGU

Agrium

$99.37

-1.19 (-1.18%)

, AAL

American Airlines

$46.28

0.18 (0.39%)

16:10
02/25/17
02/25
16:10
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16:10
Conference/Events
BMO Capital to hold a conference »

26th Global Metals &…

AGU

Agrium

$99.37

-1.19 (-1.18%)

AAL

American Airlines

$46.28

0.18 (0.39%)

ABX

Barrick Gold

$19.54

-0.12 (-0.61%)

AEM

Agnico Eagle

$45.32

-0.06 (-0.13%)

ANTO

Use ANFGY

BLT

Blount

CCO

Clear Channel Outdoor

$4.65

0.1797 (4.02%)

FCX

Freeport McMoRan

$13.25

-0.23 (-1.71%)

FNV

Franco-Nevada

$65.89

-0.85 (-1.27%)

GEM

Pepsi-Gemex ADR

$29.39

-0.3 (-1.01%)

GG

Goldcorp

$16.57

-0.25 (-1.49%)

HBM

Hudbay Minerals

$8.00

0.25 (3.23%)

IVN

trades under IVPAF

NUE

Nucor

$60.86

-0.03 (-0.05%)

PDL

Project Design Labs

POT

Potash

$17.87

-0.2 (-1.11%)

RIO

Rio Tinto

$41.69

-0.82 (-1.93%)

SLW

Silver Wheaton

$21.15

-0.36 (-1.67%)

STLD

Steel Dynamics

$35.59

0.07 (0.20%)

TECK

Teck Resources

$20.72

-0.09 (-0.43%)

NEM

Newmont Mining

$36.08

0.22 (0.61%)

MOS

Mosaic

$31.42

-0.41 (-1.29%)

AA

Alcoa

$34.48

0.16 (0.47%)

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SO

Southern Company

$50.50

0.83 (1.67%)

15:07
02/25/17
02/25
15:07
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15:07
Conference/Events
Southern Company participates in a conference call with Wolfe Research »

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DK

Delek US

$23.19

-0.21 (-0.90%)

15:04
02/25/17
02/25
15:04
02/25/17
15:04
Conference/Events
Delek US management participates in a dinner meeting with Wolfe Research »

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ANTM

Anthem

$163.83

-0.09 (-0.05%)

15:00
02/25/17
02/25
15:00
02/25/17
15:00
Conference/Events
Anthem management to meet with Wolfe Research »

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MCO

Moody's

$113.29

0.06 (0.05%)

14:56
02/25/17
02/25
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14:56
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Moody's analysts participate in a meeting with Wolfe Research »

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ONCS

OncoSec

$1.39

-0.03 (-2.11%)

, NKTR

Nektar

$13.45

0.25 (1.89%)

04:55
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02/25
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Conference/Events
American Society of Clinical Oncology to hold a symposium »

2017 ASCO-SITC Clinical…

ONCS

OncoSec

$1.39

-0.03 (-2.11%)

NKTR

Nektar

$13.45

0.25 (1.89%)

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MMM

3M

$187.41

0.22 (0.12%)

, BIOL

BIOLASE

$1.49

-0.01 (-0.67%)

04:55
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02/25
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Chicago Dental Society to hold a meeting »

Chicago Dental Midwinter…

MMM

3M

$187.41

0.22 (0.12%)

BIOL

BIOLASE

$1.49

-0.01 (-0.67%)

COF

Capital One

$92.61

-0.8 (-0.86%)

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RNECY

Renesas

$4.14

-0.17 (-3.94%)

, ISIL

Intersil

19:04
02/24/17
02/24
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Renesas sees Intersil acquisition accretive to non-GAAP EPS, free cash flows »

Renesas Electronics…

RNECY

Renesas

$4.14

-0.17 (-3.94%)

ISIL

Intersil

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HSIC

Henry Schein

$173.53

1.61 (0.94%)

18:45
02/24/17
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Conference/Events
Henry Schein management to meet with Jefferies »

Group dinner to be held…

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TWX

Time Warner

$97.28

0.6225 (0.64%)

18:38
02/24/17
02/24
18:38
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18:38
Periodicals
Turner, Univision to win U.S. Champions League rights, Bloomberg reports »

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  • 06

    Mar

TRUE

TrueCar

$14.28

0.18 (1.28%)

18:33
02/24/17
02/24
18:33
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18:33
Hot Stocks
TrueCar's ALG sees February total new vehicle sales 1.325M units, down 1.4% »

ALG projects total new…

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GE

General Electric

$30.19

0.17 (0.57%)

18:24
02/24/17
02/24
18:24
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18:24
Hot Stocks
GE does not see after-tax charges from GE Capital exit plan to exceed $23B »

GE said in a regulatory…

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CE

Celanese

$88.79

-0.88 (-0.98%)

18:02
02/24/17
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18:02
Hot Stocks
Celanese announces vinyl acetate-based emulsions price increases in Asia »

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ELNK

EarthLink

$5.63

-0.22 (-3.76%)

, WIN

Windstream

$7.27

-0.02 (-0.27%)

17:56
02/24/17
02/24
17:56
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17:56
Hot Stocks
EarthLink, Windstream holders approve merger »

EarthLink (ELNK)…

ELNK

EarthLink

$5.63

-0.22 (-3.76%)

WIN

Windstream

$7.27

-0.02 (-0.27%)

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PFE

Pfizer

$34.26

0.2 (0.59%)

17:43
02/24/17
02/24
17:43
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17:43
Periodicals
Pfizer subpoenaed in investigation of charity connections, Bloomberg says »

Pfizer has received two…

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C

Citi

$59.56

-1.06 (-1.75%)

17:32
02/24/17
02/24
17:32
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17:32
Hot Stocks
U.S. regulators investigating Citi over foreign hiring practices »

In a regulatory filing,…

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FDX

FedEx

$193.11

1.93 (1.01%)

17:25
02/24/17
02/24
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02/24/17
17:25
Hot Stocks
FedEx, USPS amend transportation agreement »

According to a regulatory…

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URRE

Uranium Resources

$1.94

-0.09 (-4.43%)

17:21
02/24/17
02/24
17:21
02/24/17
17:21
Syndicate
Breaking Syndicate news story on Uranium Resources »

Uranium Resources files…

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RTN

Raytheon

$153.48

0.19 (0.12%)

17:13
02/24/17
02/24
17:13
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17:13
Hot Stocks
Raytheon awarded $1B government contract »

Raytheon Co., Woburn,…

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COTV

Cotiviti Holdings

$38.74

-0.06 (-0.15%)

17:06
02/24/17
02/24
17:06
02/24/17
17:06
Syndicate
Breaking Syndicate news story on Cotiviti Holdings »

Cotiviti Holdings files…

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    Mar

ENH

Endurance Specialty

$92.90

0.02 (0.02%)

17:05
02/24/17
02/24
17:05
02/24/17
17:05
Earnings
Endurance reports Q4 EPS 30c, may not compare to consensus $1.26 »

Reports Q4 gross premiums…

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ORPN

Bio Blast Pharma

$1.13

-0.0098 (-0.86%)

17:04
02/24/17
02/24
17:04
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17:04
Syndicate
Breaking Syndicate news story on Bio Blast Pharma »

Bio Blast Pharma files to…

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MNTA

Momenta

$15.40

0.3 (1.99%)

, PFE

Pfizer

$34.26

0.2 (0.59%)

16:44
02/24/17
02/24
16:44
02/24/17
16:44
General news
On The Fly: Stocks end week higher as rally continues »

Stocks ended the week…

MNTA

Momenta

$15.40

0.3 (1.99%)

PFE

Pfizer

$34.26

0.2 (0.59%)

STLD

Steel Dynamics

$35.59

0.07 (0.20%)

AKS

AK Steel

$8.02

-0.1 (-1.23%)

X

U.S. Steel

$37.01

-0.3 (-0.80%)

FLR

Fluor

$55.09

-0.26 (-0.47%)

GVA

Granite Construction

$53.91

0.78 (1.47%)

VMC

Vulcan Materials

$117.82

1.47 (1.26%)

PWR

Quanta Services

$37.76

0.62 (1.67%)

ACM

AECOM

$35.77

-0.58 (-1.60%)

JEC

Jacobs Engineering

$56.03

-0.07 (-0.12%)

KBR

KBR

$15.60

-0.55 (-3.41%)

CBI

CB&I

$33.87

-0.02 (-0.06%)

MTZ

MasTec

$40.10

3.05 (8.23%)

KHC

Kraft Heinz

$93.08

0.14 (0.15%)

UN

Unilever; also tag UL

$46.91

0.33 (0.71%)

UL

Unilever; also tag UN

$47.12

0.22 (0.47%)

QSR

Restaurant Brands

$55.47

-0.08 (-0.14%)

PLKI

Popeyes

TROX

Tronox

$17.40

-0.67 (-3.71%)

WMT

Wal-Mart

$72.39

1.08 (1.51%)

HD

Home Depot

$145.95

1.24 (0.86%)

CYH

Community Health

$9.22

0.32 (3.60%)

TOL

Toll Brothers

$33.74

-0.22 (-0.65%)

GRMN

Garmin

$53.03

0.72 (1.38%)

CHS

Chico's

$14.75

0.3 (2.08%)

HPQ

HP Inc.

$17.65

0.05 (0.28%)

CRI

Carter's

$90.04

2.98 (3.42%)

SQ

Square

$17.43

0.28 (1.63%)

JWN

Nordstrom

$46.46

2.52 (5.74%)

FL

Foot Locker

$75.01

6.43 (9.38%)

AAOI

Applied Optoelectronics

$45.98

8.51 (22.71%)

RH

Restoration Hardware

$31.34

6.15 (24.41%)

M

Macy's

$33.17

0.73 (2.25%)

PZZA

Papa John's

$78.70

-0.07 (-0.09%)

FSLR

First Solar

$37.90

0.71 (1.91%)

TXRH

Texas Roadhouse

$42.22

0.13 (0.31%)

TSLA

Tesla

$257.00

1.01 (0.39%)

LB

Labarge

$50.99

2.05 (4.19%)

W

Wayfair

$39.30

0.72 (1.87%)

HPE

HP Enterprise

$22.96

-1.7 (-6.89%)

JCP

J.C. Penney

$6.46

-0.4 (-5.83%)

ACIA

Acacia Communications

$54.04

-9.39 (-14.80%)

BGS

B&G Foods

$43.65

-3.25 (-6.93%)

SPLK

Splunk

$62.80

-2.1 (-3.24%)

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NBEV

New Age Beverages

$3.90

-0.04 (-1.02%)

16:41
02/24/17
02/24
16:41
02/24/17
16:41
Hot Stocks
Breaking Hot Stocks news story on New Age Beverages »

Park West AM reports 6.3%…

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