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DVAX

Dynavax

$10.82

0.05 (0.46%)

, MRK

Merck

$62.77

0.11 (0.18%)

17:24
10/09/16
10/09
17:24
10/09/16
17:24

Dynavax reports Phase 1/2 data on SD-101

Dynavax Technologies (DVAX) announced the first presentation of findings from an ongoing Phase 1/2 study evaluating SD-101 in combination with Keytruda, Merck's (MRK) anti-PD-1 treatment. Early results evaluating five patients with metastatic melanoma for efficacy and 16 patients for safety were reported. In patients naive to anti-PD-1 treatment objective responses were observed in three out of four, including one complete response and two partial responses. One patient with progressive disease while receiving anti-PD-1 therapy was observed to have stable disease. SD-101 in combination with pembrolizumab was well-tolerated. No dose-limiting toxicities of the combination were observed in any dose cohort, and a maximum tolerated dose was not identified. No immune-related adverse events were reported, and the most common treatment-emergent adverse events were grade 1-2 flu-like symptoms, including fever, chills and myalgia consistent with the engagement of TLR9 and production of interferon alpha. The study also included biomarker assessments suggesting that treatment with SD-101 and pembrolizumab resulted in elevation of gene signatures consistent with an increase in immune cell types and multiple immune functions.

DVAX

Dynavax

$10.82

0.05 (0.46%)

MRK

Merck

$62.77

0.11 (0.18%)

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DVAX Dynavax
$10.82

0.05 (0.46%)

04/27/16
COWN
04/27/16
NO CHANGE
Target $60
COWN
Outperform
Dynavax PDUFA extension will not impact approval chances, says Cowen
Cowen analyst Phil Nadeau does not beleive Dynavax's Heplisav PDUFA extension by 3 months will impact chances of approval. The analyst suspects that the PDUFA change has more to do with FDA managing its workload than any reflection on the substance of the BLA, since both the FDA and Dynavax had agreed upon the original format of the BLA resubmission. Nadeau continues to rate Dynavax an Outperform and top small cap pick with a $60 price target on shares.
04/27/16
RBCM
04/27/16
DOWNGRADE
RBCM
Sector Perform
Dynavax downgraded to Sector Perform from Outperform at RBC Capital
04/28/16
RBCM
04/28/16
DOWNGRADE
RBCM
Sector Perform
Dynavax downgraded on drug safety concerns at RBC Capital
As noted earlier, RBC Capital downgraded Dynavax to Sector Perform from Outperform, The firm cited concerns about the safety of the company's Heplisav-B drug as the reason for its downgrade. RBC says that the FDA's decision to request individual trial data instead of the integrated dataset shows that the agency's scrutiny of the drug's safety has increased. Target to $17 from $48.
09/06/16
WBLR
09/06/16
NO CHANGE
WBLR
Outperform
FDA panel cancelation positive for Dynavax, says William Blair
William Blair analyst Y. Katherine Xu views the FDA's decision to canceled the November 16 Vaccines and Related Biological Products Advisory Committee meeting for Heplisav as a net positive for Dynavax. The agency's decision to move straight to the PDUFA date suggests that the Heplisav package is "sufficiently strong and adequate to warrant approval in the absence of a panel," Xu tells investors in a research note. She keeps an Outperform rating on Dynavax. The stock is up 19% to $13.00 in pre-market trading.
MRK Merck
$62.77

0.11 (0.18%)

09/21/16
FBCO
09/21/16
UPGRADE
Target $41
FBCO
Outperform
Clovis upgraded to Outperform from Neutral at Credit Suisse
Credit Suisse analyst Kennen MacKay upgraded Clovis Oncology (CLVS) to Outperform and raised his price target for the shares to $41 from $19. Clovis closed yesterday up 13%, or $3.92, to $34.83. The potential for a takeover "outweighs concerns surrounding patent life, limited experience in platinum resistant/refractory patients, and PARPi competition," MacKay tells investors in a research note. Clovis could be worth $35-$41 per share in a buyout on operational synergies, and $52-$55 per share with leveraged tax benefits, MacKay estimates. He points out that Eli Lilly (Lill)y, Merck (MRK), Japan's Takeda and others have expressed interest in acquiring U.S. oncology companies.
09/27/16
PIPR
09/27/16
NO CHANGE
Target $62
PIPR
Neutral
Bristol-Myers price target lowered to $62 from $65 at Piper Jaffray
Piper Jaffray analyst Richard Purkiss lowered his price target for Bristol-Myers Squibb (BMY) to $62 saying he sees the company ceding Opdivo's early-mover advantage in lung cancer to competitors. The analyst expects to see details from Roche's (RHHBY) positive OAK trial of Tecentriq vs. docetaxel in non-small cell lung cancer at the upcoming ESMO meeting. Purkiss also expects to see details from Merck's (MRK) positive KEYNOTE-024 trial of Keytruda. The analyst lowered his post-2016 Opdivo forecasts and reiterates a Neutral rating on Bristol shares.
10/03/16
LEER
10/03/16
NO CHANGE
LEER
Market Perform
AASLD abstracts hint at potential competitive threat to Gilead HCV, says Leerink
Leerink analyst Geoffrey Porges says abstracts for the American Association for the Study of Liver Diseases, or AASLD, meeting revealed very limited efficacy information about the new Hepatitis C regimens for Gilead (GILD), Merck (MRK) and AbbVie (ABBV). Nonetheless, the analyst believes the abstracts hint at the potential competitive threat to Gilead's HCV dominance. While the new 12-week HCV regimens may compete on price, the forthcoming 8-week regimens put the most pressure on Gilead's market share, Porges argues. He reiterates a Market Perform rating on Gilead's shares.
10/07/16
LEER
10/07/16
NO CHANGE
LEER
Outperform
Incyte Epacadostat Phase 1 Melanoma data maturing well, says Leerink
Leerink analyst Michael Schmidt says the data from ECHO-202 Phase 1 study evaluating the combination of Incyte's (INCY) IDO1 inhibitor epacadostat with Merck's (MRK) Keytruda confirms the previously published results and appears to be maturing well. The analyst reiterates an Outperform rating on Incyte's shares, saying Jakafi remains a compelling long-term growth driver for the company, expectations for baricitinib are still moderate, and its maturing oncology pipeline of 14 molecules including epacadostat represents a long-term value driver.

TODAY'S FREE FLY STORIES

FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

, FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

20:36
04/30/17
04/30
20:36
04/30/17
20:36
Hot Stocks
On The Fly: Top five weekend stock stories »

Catch up on the…

FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

BX

Blackstone

$30.84

-0.13 (-0.42%)

TRCO

Tribune Media

$36.56

-0.28 (-0.76%)

SBGI

Sinclair Broadcast

$39.45

-0.9 (-2.23%)

TSLA

Tesla

$314.07

5.44 (1.76%)

TWTR

Twitter

$16.48

-0.13 (-0.78%)

CMCSA

Comcast

$39.19

-0.4 (-1.01%)

CMCSK

Comcast

DIS

Disney

$115.60

-0.24 (-0.21%)

CAT

Caterpillar

$102.26

-0.42 (-0.41%)

NEE

NextEra Energy

$133.56

0.04 (0.03%)

EPC

Edgewell Personal Care

$71.49

-0.14 (-0.20%)

COH

Coach

$39.39

-0.43 (-1.08%)

LITE

Lumentum

$42.75

-1.05 (-2.40%)

OCLR

Oclaro

$8.01

0.08 (1.01%)

ESRX

Express Scripts

$61.34

-0.06 (-0.10%)

CMG

Chipotle

$474.47

-7.53 (-1.56%)

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AWI

Armstrong World

$46.75

-0.75 (-1.58%)

, L

Loews

$46.62

-0.71 (-1.50%)

20:25
04/30/17
04/30
20:25
04/30/17
20:25
Earnings
Notable companies reporting before Monday's open »

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AWI

Armstrong World

$46.75

-0.75 (-1.58%)

L

Loews

$46.62

-0.71 (-1.50%)

ENSG

Ensign Group

$17.95

-1.17 (-6.12%)

DO

Diamond Offshore

$14.42

-0.07 (-0.48%)

DISH

Dish

$64.44

-0.56 (-0.86%)

BSFT

BroadSoft

$38.40

-0.05 (-0.13%)

CNA

CNA Financial

$45.26

-0.57 (-1.24%)

CMS

CMS Energy

$45.40

-0.09 (-0.20%)

BWP

Boardwalk Pipeline

$18.14

-0.02 (-0.11%)

CAH

Cardinal Health

$72.59

-0.55 (-0.75%)

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19:56
04/30/17
04/30
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19:56
Periodicals
Trump signs two orders on trade, CNN reports »

President Donald Trump on…

TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

, TOSYY

Toshiba, also use TOSBF

$12.14

0.25 (2.10%)

19:45
04/30/17
04/30
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Innovation Network Corp to lead joint bid for Toshiba chip unit, Nikkei says »

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TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

TOSYY

Toshiba, also use TOSBF

$12.14

0.25 (2.10%)

WDC

Western Digital

$89.07

3.36 (3.92%)

KKR

KKR

$18.98

0.25 (1.33%)

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TRCO

Tribune Media

$36.56

-0.28 (-0.76%)

, FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

19:42
04/30/17
04/30
19:42
04/30/17
19:42
Periodicals
Fox, Blackstone in talks to launch offer for Tribune, FT reports »

Twenty-First Century Fox…

TRCO

Tribune Media

$36.56

-0.28 (-0.76%)

FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

BX

Blackstone

$30.84

-0.13 (-0.42%)

SBGI

Sinclair Broadcast

$39.45

-0.9 (-2.23%)

03/08/13
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HESM

Hess Midstream Partners

$25.58

0.08 (0.31%)

19:39
04/30/17
04/30
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04/30/17
19:39
Initiation
Hess Midstream Partners initiated at Goldman Sachs »

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SFTBF

SoftBank

$75.98

0.38 (0.50%)

19:28
04/30/17
04/30
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Periodicals
SoftBank poised to invest more than $1.5B in Paytm, WSJ says »

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NVO

Novo Nordisk

$38.68

-0.1 (-0.26%)

19:12
04/30/17
04/30
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19:12
Periodicals
Novo Nordisk settles probe of drug marketing practices, Bloomberg says »

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BDRBF

Bombardier

$1.56

-0.0722 (-4.42%)

, BA

Boeing

$184.83

1.61 (0.88%)

19:08
04/30/17
04/30
19:08
04/30/17
19:08
Periodicals
Bombardier says Boeing allegations 'absurd,' Bloomberg reports »

Bombardier (BDRBF) has…

BDRBF

Bombardier

$1.56

-0.0722 (-4.42%)

BA

Boeing

$184.83

1.61 (0.88%)

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AMZN

Amazon.com

$924.99

6.61 (0.72%)

19:04
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Hot Stocks
Amazon to phase out free app program »

Amazon announced in a…

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TSLA

Tesla

$314.07

5.44 (1.76%)

18:28
04/30/17
04/30
18:28
04/30/17
18:28
Periodicals
SolarCity to curtail door-to-door sales tactic, Reuters says »

Tesla's SolarCity is…

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DIS

Disney

$115.60

-0.24 (-0.21%)

, CMCSA

Comcast

$39.19

-0.4 (-1.01%)

18:16
04/30/17
04/30
18:16
04/30/17
18:16
Periodicals
Hulu likely to unveil cable bundle at end of May, NY Post says »

Hulu will likely unveil…

DIS

Disney

$115.60

-0.24 (-0.21%)

CMCSA

Comcast

$39.19

-0.4 (-1.01%)

CMCSK

Comcast

FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

TWX

Time Warner

$99.27

-0.63 (-0.63%)

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TCEHY

Tencent

$31.35

-0.11 (-0.35%)

, FB

Facebook

$150.25

2.55 (1.73%)

17:52
04/30/17
04/30
17:52
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17:52
Periodicals
Tencent plans to launch VR headset later this year, FT says »

Tencent (TCEHY) is…

TCEHY

Tencent

$31.35

-0.11 (-0.35%)

FB

Facebook

$150.25

2.55 (1.73%)

SSNLF

Samsung

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CYH

Community Health

$8.61

0.18 (2.14%)

, HCA

HCA Holdings

$84.21

0.77 (0.92%)

17:49
04/30/17
04/30
17:49
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17:49
Hot Stocks
Pence: 'Hope' to replace Obamacare before year end »

Speaking in an NBC…

CYH

Community Health

$8.61

0.18 (2.14%)

HCA

HCA Holdings

$84.21

0.77 (0.92%)

LPNT

LifePoint

$62.15

1.4 (2.30%)

THC

Tenet

$15.67

0.2 (1.29%)

UHS

Universal Health

$120.76

2.55 (2.16%)

UNH

UnitedHealth

$174.88

0.25 (0.14%)

KND

Kindred Healthcare

$9.60

0.25 (2.67%)

VTR

Ventas

$64.01

-0.11 (-0.17%)

AET

Aetna

$135.07

1.09 (0.81%)

ANTM

Anthem

$177.89

-0.41 (-0.23%)

CI

Cigna

$156.37

0.16 (0.10%)

HUM

Humana

$221.98

3.31 (1.51%)

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DAL

Delta Air Lines

$45.44

-0.3 (-0.66%)

17:25
04/30/17
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17:25
Periodicals
Delta pilot returns to duty after possibly striking brawling woman, NYT says »

A Delta pilot who stepped…

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TSLA

Tesla

$314.07

5.44 (1.76%)

17:13
04/30/17
04/30
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17:13
Hot Stocks
Tesla CEO hints at plans for additional Gigafactories »

The TED organization has…

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TSLA

Tesla

$314.07

5.44 (1.76%)

17:03
04/30/17
04/30
17:03
04/30/17
17:03
Periodicals
Tesla CEO releases teaser image of semi truck, Fortune says »

During a "TED"…

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CMCSA

Comcast

$39.19

-0.4 (-1.01%)

, CMCSK

Comcast

16:47
04/30/17
04/30
16:47
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16:47
Hot Stocks
Box Office Battle: 'Furious' crosses $1B as 'Guardians Of Galaxy' preps launch »

Comcast's (CMCSA)…

CMCSA

Comcast

$39.19

-0.4 (-1.01%)

CMCSK

Comcast

LGF.A

Lionsgate

$26.17

-0.11 (-0.42%)

LGF.B

Lionsgate

$23.85

-0.15 (-0.63%)

FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

DIS

Disney

$115.60

-0.24 (-0.21%)

SNE

Sony

$34.52

0.8 (2.37%)

TWX

Time Warner

$99.27

-0.63 (-0.63%)

VIA

Viacom

$44.60

-0.8 (-1.76%)

VIAB

Viacom

$42.56

-0.75 (-1.73%)

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ELLO

Ellomay Capital

$8.05

0.0019 (0.02%)

14:33
04/30/17
04/30
14:33
04/30/17
14:33
Hot Stocks
Ellomay Capital enters agreement to acquire Talasol Solar »

Ellomay Capital announced…

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GLPG

Galapagos NV

$86.86

0.87 (1.01%)

14:23
04/30/17
04/30
14:23
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14:23
Hot Stocks
Galapagos presents preclinical data on osteoarthritis candidate GLPG1972 »

Galapagos announced…

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SO

Southern Company

$49.80

-0.27 (-0.54%)

, TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

14:16
04/30/17
04/30
14:16
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14:16
Hot Stocks
Southern Co subsidiary extends interim agreement for Vogtle nuclear expansion »

Georgia Power and…

SO

Southern Company

$49.80

-0.27 (-0.54%)

TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

TOSYY

Toshiba, also use TOSBF

$12.14

0.25 (2.10%)

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CG

Carlyle Group

$17.70

0.2 (1.14%)

14:10
04/30/17
04/30
14:10
04/30/17
14:10
Hot Stocks
Sequa completes recapitalization with participation from Carlyle Group »

Sequa Corp announced…

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IBM

IBM

$160.29

-0.03 (-0.02%)

14:07
04/30/17
04/30
14:07
04/30/17
14:07
Hot Stocks
IBM says granted patent for drone package transfer »

IBM announced Friday that…

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GRAM

Grana y Montero

$3.37

0.07 (2.12%)

14:05
04/30/17
04/30
14:05
04/30/17
14:05
Hot Stocks
Grana y Montero completes sale of PRINSUR stake for $25M »

Grana y Montero announced…

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KO

Coca-Cola

$43.15

0.14 (0.33%)

13:49
04/30/17
04/30
13:49
04/30/17
13:49
Hot Stocks
Coca-Cola Bottling UNITED says closes Georgia transaction with Coca-Cola »

Coca-Cola Bottling…

03/08/13
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03/08/13
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