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APTO

Aptose Biosciences

$2.77

0.3941 (16.57%)

07:16
10/13/16
10/13
07:16
10/13/16
07:16

Aptose says FDA needs more information to remove APTO-253 clinical hold

Aptose Biosciences announced that it received a response from the FDA regarding the clinical hold of Aptose's Phase 1b clinical trial of APTO-253 in patients with hematologic cancers requesting additional information and informing Aptose that the hold would not be removed until this information is submitted and reviewed. The FDA response to Aptose focused exclusively on the request to provide the FDA with complete Chemistry, Manufacturing and Control information on the final GMP drug substance and drug product intended for the clinic.

APTO Aptose Biosciences
$2.77

0.3941 (16.57%)

06/13/16
ROTH
06/13/16
UPGRADE
ROTH
Buy
Aptose Biosciences upgraded to Buy from Neutral at Roth Capital
06/13/16
ROTH
06/13/16
UPGRADE
Target $8
ROTH
Buy
Aptose Biosciences upgraded to Buy at Roth Capital
As previously reported, Roth Capital analyst Joseph Pantginis upgraded Aptose Biosciences to Buy from Neutral based on an expected inflection point in the near term, namely the allowance for APTO-253 to return to the clinical. Furthermore, the analyst notes that the company has made a "significant" addition to its pipeline, signing an agreement with CrystalGenomics for CG-806, an inhibitor of Bruton's tyrosine kinase, FMS-like tyrosine kinase 3 and Aurora kinases. Pantginis expects increasing visibility for this candidate to help to drive the shares as well. The analyst raised his price target on Aptose Biosciences' shares to $8 from $4.
06/13/16
06/13/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Agios Pharmaceuticals (AGIO) upgraded to Buy from Hold at Canaccord and upgraded to Overweight from Neutral at JPMorgan with Canaccord analyst John Newman raising his price target for the shares to $90 from $50 and JPMorgan analyst Anupam Rama raising his price target for the shares to $62 from $50. 2. Estee Lauder (EL) upgraded to Buy from Outperform at CLSA after analyst Caroline Levy had a meeting with CEO Fabrizio Freda and CFO Tracey Travis and came away impressed by their confidence in Estee's business outlook, despite secular pressure on U.S. department stores and a shift in travel patterns by emerging market consumers. 3. NVIDIA (NVDA) upgraded to Buy from Neutral at Nomura with the firm saying it expects the company to benefit from strong secular trends, including higher gaming ASPs, and a strong datacenter outlook. 4. Aptose Biosciences (APTO) upgraded to Buy from Neutral at Roth Capital with analyst Joseph Pantginis saying the company has made a "significant" addition to its pipeline, signing an agreement with CrystalGenomics for CG-806, an inhibitor of Bruton's tyrosine kinase, FMS-like tyrosine kinase 3 and Aurora kinases. 5. Concho Resources (CXO) upgraded to Overweight from Equal Weight at Morgan Stanley with analysts led by Evan Calio citing a more constructive view on the long-term commodity outlook, raising long-term oil price assumption for Brent to $80 and upgraded the E&P industry view to Attractive. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/13/16
ROTH
09/13/16
NO CHANGE
Target $8
ROTH
Buy
Clinical hold on Aptose Biosciences drug soon to be removed, says Roth Capital
Roth Capital analyst Joseph Pantginis notes that Aptose Biosciences has submitted its formal response to the FDA regarding the clinical hold on its APTO-253, which was in an ongoing Phase 1b study in hematological malignancies. The analyst sees this as an important milestone for the company and says he believes the clinical hold will be removed over the next month. He reiterates a Buy rating and $8 price target on the shares.

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