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OGXI

OncoGenex

$0.45

0.015 (3.46%)

07:31
10/13/16
10/13
07:31
10/13/16
07:31

OncoGenex says Phase 3 ENSPIRIT trial did not meet primary endpoint

OncoGenex Pharmaceuticals announced results from the final analysis of the Phase 3 ENSPIRIT trial of custirsen in patients whose non-small cell lung cancer has progressed following initial treatments. The trial did not meet the primary endpoint of demonstrating a statistically significant improvement in overall survival for patients treated with custirsen in combination with docetaxel compared to docetaxel alone. The median overall survival for the custirsen arm was 9.0 months versus 7.9 months for the control arm with a hazard ratio of 0.915 (one-sided p=0.178). Safety results were consistent with those observed in previous trials of custirsen in combination with chemotherapy. "Following the negative results of previous custirsen trials, an early final analysis of the ENSPIRIT trial was conducted in an effort to conserve capital and extend our cash runway," said Scott Cormack, President and CEO of OncoGenex. "We will continue to take appropriate steps to realize the most value for our shareholders once we receive the results of our apatorsen Phase 2 Borealis-2 bladder cancer trial which are expected by the end of October."

OGXI OncoGenex
$0.45

0.015 (3.46%)

12/02/15
12/02/15
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: ARM Holdings (ARMH) downgraded on royalty outlook at JMP Securities... ArcBest (ARCB) downgraded to Underperform from Neutral at BofA/Merrill... ArcelorMittal (MT) downgraded to Neutral from Buy at Citi... Banco Bilbao (BBVA) downgraded to Underperform from Neutral at BofA/Merrill... Bayer (BAYRY) downgraded to Neutral from Buy at Citi... Belgacom (BGAOY) downgraded to Sell from Neutral at Citi... C.H. Robinson (CHRW) downgraded to Underperform from Neutral at BofA/Merrill... Cepheid (CPHD) downgraded to Market Perform from Outperform at Wells Fargo... Eagle Bancorp (EGBN) downgraded to Market Perform from Outperform at Keefe Bruyette... Franklin Street (FSP) downgraded to Underweight from Equalweight at Capital One... Golar LNG (GLNG) downgraded to Neutral from Buy at BofA/Merrill... Grifols (GRFS) downgraded to Hold from Buy at HSBC... ITC Holdings (ITC) downgraded to Hold from Buy at Argus... Johnson Controls (JCI) downgraded to Market Perform from Outperform at William Blair... Knight Transportation (KNX) downgraded to Neutral from Buy at BofA/Merrill... Liberty Property (LPT) downgraded to Equalweight from Overweight at Capital One... Mattson (MTSN) downgraded to Hold from Buy at Needham... Nike (NKE) downgraded to Buy from Conviction Buy at Goldman... Old Dominion (ODFL) downgraded to Neutral from Buy at BofA/Merrill... OncoGenex (OGXI) downgraded on data miss at Stifel... STAG Industrial (STAG) downgraded to Equalweight from Overweight at Capital One... SunCoke Energy (SXC) downgraded to Neutral from Buy at Clarksons Platou... Swift Energy (SFY) downgraded to Underperform from Market Perform at Wells Fargo... Swift Transport (SWFT) downgraded to Neutral from Buy at BofA/Merrill... TerraForm Global (GLBL) downgraded to Sell from Neutral at Goldman... Thor Industries (THO) downgraded to Hold from Buy at Gabelli... Werner (WERN) downgraded to Underperform from Neutral at BofA/Merrill.
12/02/15
STFL
12/02/15
DOWNGRADE
STFL
Hold
OncoGenex downgraded on data miss at Stifel
As noted earlier, Stifel downgraded OncoGenex to Hold from Buy. The firm downgraded the stock after the company's AFFINITY drug combination failed to achieve a statistical threshold for overall survival in a subpopulation of metastatic castrate-resistant prostate cancer patients with poor-prognostic risk factors. The firm thinks that the drug combination's visibility is currently minimal.
12/02/15
STFL
12/02/15
DOWNGRADE
STFL
Hold
OncoGenex downgraded to Hold from Buy at Stifel

TODAY'S FREE FLY STORIES

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ATKR

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BPMC

Blueprint Medicines

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LULU

lululemon

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2.6 (4.54%)

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LULU

lululemon

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CVX

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X

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VNDA

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AE

Adams Resources

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, SWN

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SWN

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EZPW

EZCORP

$11.80

0.05 (0.43%)

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RICE

Rice Energy

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-0.16 (-0.65%)

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AMZN

Amazon.com

$770.42

5.7 (0.75%)

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ICON

Iconix Brand

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PBYI

Puma Biotechnology

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FTK

Flotek

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PBYI

Puma Biotechnology

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PNM

PNM Resources

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BK

BNY Mellon

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TLRD

Tailored Brands

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FLXS

Flexsteel Industries

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2.92 (5.20%)

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FLXS

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UNH

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NKE

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1.53 (3.03%)

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NKE

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UA

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ADDYY

adidas

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  • 20

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T

AT&T

$40.45

1.1 (2.80%)

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AT&T management to meet with Jefferies »

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  • 07

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EFC

Ellington Financial

$16.30

0.2 (1.24%)

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Ellington Financial reports estimated book value per share $19.80 as of Nov 30 »

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