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CTRV

ContraVir Pharmaceuticals

$1.12

-0.05 (-4.27%)

11:02
10/13/16
10/13
11:02
10/13/16
11:02

ContraVir jumps after reporting positive interim data for CMX157

ContraVir Pharmaceuticals reported positive interim data for CMX157, the Company's highly potent prodrug of tenofovir, from its ongoing Phase 2a multiple ascending dose clinical study. The head-to-head study is the first evaluation of CMX157 in HBV patients, and directly compares CMX157 to tenofovir disoproxil fumarate, TDF, Gilead's (GILD) Viread, in chronically infected hepatitis B, HBV, patients. Patients successfully completed both 5 mg and 10 mg cohorts, and interim data reported below are from 10 HBV-infected patients who completed 14 days of once-a-day oral dosing of 25 mg of CMX157, and two HBV patients treated for 14 days of oral dosing with 300 mg TDF. The CMX157 treated patients showed an average 99% reduction in HBV viral load compared to baseline. Significantly, the observed antiviral activity for CMX157 is comparable to that observed in TDF-treated patients, but at 1/12th the dose. A key goal of this study was to monitor levels of active tenofovir in the blood, exposure to which is a key predictor of off-target side effects. Following oral dosing, levels of CMX157 and active tenofovir in the bloodstream are approximately dose proportional and similar both in chronic HBV patients as well as in an earlier healthy volunteer study. Notably, CMX157 does not appear to break down readily into active tenofovir in the blood in contrast to patients taking Viread. The high levels of circulating tenofovir in subjects taking Viread are consistent with results from earlier published clinical studies of Viread in HIV and HBV patients. These results are significant considering that CMX157 achieved similar antiviral activity compared to Viread while significantly reducing systemic tenofovir exposure. Active tenofovir levels observed in blood following oral dosing of CMX157 are significantly below levels seen for Viread-treated patients, regardless of dose used, which is consistent with CMX157 targeting the liver followed by activation of CMX157 specifically within the liver. This is further supported by the observation that viral load reductions with CMX157 are comparable to Viread despite a significantly lower dose. "We are pleased and excited with these clinical results, as they demonstrate CMX157's great potential in our ongoing effort to develop a cure for HBV," said James Sapirstein, CEO of ContraVir. "The significant viral load reduction and favorable safety at this low dose of CMX157 speaks to the unique liver-targeting mechanism of our drug, which concentrates the antiviral activity of tenofovir in the liver, enabling anti-HBV efficacy at lower doses and minimal drug exposure to other tissues. We believe, based on the data that are being generated, that CMX157 has great potential as a safe and highly potent backbone of combination therapy against HBV." Pharmacokinetic data observed for CMX157 to date in healthy and HBV-infected subjects are similar across the completed Phase 1b and ongoing Phase 2a studies, consistent with the prodrug's site of action and anticipated improved safety profile. CMX157 was earlier found to be safe and well tolerated at daily oral doses of up to 100 mg in healthy volunteers and is presently demonstrating an excellent safety profile at 25 mg dose in the ongoing Phase 2a study in HBV patients. Upon completion of the 4-week dosing regimen and independent safety review, dose escalation is planned to continue at the 50 mg and 100 mg levels, respectively. Similarity of pharmacokinetic profiles observed for CMX157 in healthy and HBV-infected subjects strongly suggests that the remaining 50 mg and 100 mg doses of CMX157 in the ongoing Phase 2a study will also be safe and potentially even more active against HBV. Shares of ContraVir are up 21.44% or 24c to $1.36 per share in morning trading.

  • 01

    Nov

CTRV ContraVir Pharmaceuticals
$1.12

-0.05 (-4.27%)

05/06/16
MAXM
05/06/16
INITIATION
Target $4
MAXM
Buy
ContraVir Pharmaceuticals initiated with a Buy at Maxim
Target $4.

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BlackBerry

$9.71

-1.35 (-12.21%)

BAC

Bank of America

$22.82

-0.11 (-0.48%)

C

Citi

$63.41

-0.21 (-0.33%)

GS

Goldman Sachs

$217.19

-2.58 (-1.17%)

JPM

JPMorgan

$86.86

-0.16 (-0.18%)

MS

Morgan Stanley

$43.69

-0.92 (-2.06%)

WFC

Wells Fargo

$52.45

-0.04 (-0.08%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

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