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ESPR

Esperion

$12.32

-0.58 (-4.50%)

13:46
10/13/16
10/13
13:46
10/13/16
13:46

Needham positive on Esperion after positive data, upbeat regulatory commentary

Needham analyst Chad Messer notes that Esperion reported positive high dose statin combo data, with Phase 2 trial showing a placebo adjusted additional low-density lipoprotein, or LDL, reduction of 22% when bempedoic acid was added to 80mg of Lipitor. Additionally, the company was more upbeat about the U.S. regulatory process and released details of its Phase 3 program that will now include patients on any statin at any dose, which could be a driver of commercial adoption, he adds. Messer believes an earlier LDL based approval would represent "significant upside," which may become the likely outcome if PCSK9 cardiovascular outcome trials read out positive in the first half of 2017. The analyst reiterates a Buy rating and $25 price target on the shares.

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ESPR Esperion
$12.32

-0.58 (-4.50%)

06/29/16
06/29/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on the today's top five analyst downgrades with this list compiled by The Fly: 1. HeartWare (HTWR) downgraded to Equal Weight from Overweight at Barclays by analyst Matthew Taylor, saying he does not expect a competing takeover bid to Medtronic's (MDT) offer. The analyst raised his price target for the shares to $58 from $35. Similarly, shares were downgraded to Market Perform from Outperform at Wells Fargo, with analyst Larry Biegelsen saying he sees a low likelihood that a higher bidder will emerge. The analyst believes Medtronic paid a fair valuation for HeartWare. HeartWare was also downgraded to Neutral from Buy at BTIG. 2. Esperion (ESPR) downgraded to Neutral from Overweight at JPMorgan by analyst Jessica Fye, who slashed her price target for shares to $15 from $50. The analyst says last night's regulatory update is a net negative. Disappointingly, the FDA did not sign off on the use of LDL-C lowering as an acceptable regulatory endpoint for approval of bempedoic acid for the treatment of statin-intolerant patients, Fye tells investors in a research note. The analyst still believes bempedoic acid is an effective LDL-C lowering agent, but now sees a drawn out path to approval in the U.S. Esperion was also downgraded to Underperform at Neutral at Credit Suisse by analyst Vamil Divan, who says the update on the development plans for bempedoic acid leaves him increasingly concerned about the products outlook in the U.S. market. The analyst was surprised that the FDA may not be willing to allow LDL-C as a surrogate endpoint for initial approval but believes there will be significant pressure, and limited upside, on shares until that certainty is obtained, and that process may take years to play out. Esperion was also downgraded to Sector Perform from Outperform at RBC Capital. 3. Comerica (CMA) downgraded to Underperform from Neutral at BofA/Merrill, which reduced its price target to $36 from $45. The firm's analyst lowered estimates 8% below consensus for 2016 and 17% below consensus in 2017 due to low rates that will pressure spread revenue growth, slower U.S. economic growth, and continued reserve build. The firm also downgraded Regions Financial (RF), Synovus (SNV), Texas Capital (TCBI) and Franklin Financial Network (FSB) to Neutral from Buy, as well as Zions Bancorp (ZION) to Underperform from Neutral. 4. comScore (SCOR) downgraded to Neutral from Positive at Susquehanna, citing uncertainty surrounding its accounting issues. The firm continues to like the long-term fundamental story, but with an unclear timeline for its resolution, they are moving to the sidelines. Susquehanna lowered its price target to $18 from $30 on comScore shares. 5. Harman (HAR) downgraded to Sector Perform from Outperform at RBC Capital partly based on the low number of new car launches next year, the firm's forecast for reduced production by the company's European customers, and the firm's reduction in its U.S. auto production versus its previous forecast. Additionally, the firm expects GM (GM) to delay a number of its connected car launches that had been slated for fiscal 2017 until fiscal 2018. The firm lowered its price target to $73 from $85. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
06/29/16
LEHM
06/29/16
DOWNGRADE
LEHM
Equal Weight
Esperion downgraded to Equal Weight from Overweight at Barclays
07/05/16
UBSW
07/05/16
DOWNGRADE
Target $11
UBSW
Neutral
Esperion downgraded to Neutral from Buy at UBS
UBS analyst Jeffrey Hung downgraded Esperion Therapeutics to Neutral citing an uncertain U.S. regulatory pathway after the FDA did not specifically state that LDL-lowering data could be used for accelerated approval. The analyst cut his price target for the shares to $11 from $69.
07/05/16
WBTH
07/05/16
DOWNGRADE
WBTH
Hold
Esperion downgraded to Hold from Buy at WallachBeth (pre-open)

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UTX

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GPRO

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HMC

Honda

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0.18 (0.61%)

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ORCL

Oracle

$48.16

0.19 (0.40%)

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SIX

Six Flags

$58.96

1.14 (1.97%)

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ONCE

Spark Therapeutics

$85.15

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, AVXS

AveXis

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VYGR

Voyager Therapeutics

$17.50

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AET

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0.18 (0.12%)

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AVA

Avista

$51.40

0.1 (0.19%)

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BMWYY

BMW

$34.00

0.083 (0.24%)

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CSCO

Cisco

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BMY

Bristol-Myers

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INSE

Inspired Entertainment

$13.60

0.3 (2.26%)

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MNOV

MediciNova

$6.18

0.3 (5.10%)

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Breaking Syndicate news story on MediciNova »

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ISRG

Intuitive Surgical

$1,031.52

1.31 (0.13%)

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Intuitive Surgical to host special shareholder meeting »

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GD

General Dynamics

$205.41

-0.31 (-0.15%)

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CHRS

Coherus Biosciences

$12.85

0.3 (2.39%)

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FIBK

First Interstate

$36.90

0.3 (0.82%)

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NRCIA

National Research, also tag NRCIB

$37.45

0.55 (1.49%)

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National Research, also tag NRCIA

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CC

Chemours

$51.79

-0.16 (-0.31%)

, HON

Honeywell

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