OncoCyte, Wistar Institute present lung cancer diagnostic data at CHEST 2016
OncoCyte announced a summary of the data that will be presented at the American College of Chest Physician's CHEST 2016 Annual Meeting, which will be held October 22-26 in Los Angeles. The data will be presented by lead investigator Louise Showe, Ph.D., professor in the Molecular and Cellular Oncogenesis Program and associate director for the Center for Systems and Computational Biology at The Wistar Institute. The study demonstrates the ability of a lung cancer diagnostic to distinguish malignant from benign lung growths based on previously identified gene expression signatures, co-developed by Wistar and OncoCyte, under a license from Wistar. The study, A Blood Based Non-Small Cell Lung Cancer Diagnostic, was conducted at Wistar and analyzed 610 human blood samples based on nodule sizes from 3 mm to 42 mm that were derived from six collection sites. The data suggest that it is possible to distinguish malignant from benign lung growths based on the gene expression signature, and that the classifier can also provide a preliminary stratification of patients by nodule size and thus cancer risk. Using all 610 samples, without accounting for nodule size, the biomarker study derived a sensitivity of 90% and specificity of 46%. However, specificity changed as a function of nodule size, with smaller nodules having higher specificity; consequently, using only nodules less than 10 mm in size (median 6mm), sensitivity was 90% and specificity 54%.