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CELG

Celgene

$98.50

-2.13 (-2.12%)

08:02
10/17/16
10/17
08:02
10/17/16
08:02

Celgene: Open-label Touchstone extension study showed symptom improvement

Celgene International Sarl announced that data from the open-label extension of the TOUCHSTONE phase 2 clinical trial of ozanimod in patients with moderate to severe ulcerative colitis are to be presented at the United European Gastroenterology Week in Vienna, Austria and at the American College of Gastroenterology Annual Scientific Meeting in Las Vegas. Ozanimod is an investigational selective S1P 1 and 5 receptor modulator. TOUCHSTONE evaluated the efficacy and safety of 0.5 mg and 1 mg doses of ozanimod compared with placebo after eight weeks of treatment in 197 patients with moderate to severe active ulcerative colitis. Patients who achieved a clinical response at week 8 continued with their original treatment through week 32 in a maintenance phase. The primary endpoint was the proportion of patients in remission at week 8. Secondary endpoints were: the proportion of patients achieving a clinical response, the proportion of patients with mucosal improvement and the change from baseline in Mayo score. Previously reported results showed TOUCHSTONE met its primary endpoint and secondary endpoints with statistical significance for patients on the 1 mg dose of ozanimod versus placebo. TOUCHSTONE participants in all three treatment arms entered the open-label extension if they did not respond to treatment after the induction phase, relapsed during the maintenance phase or completed the maintenance phase The objective of the open-label extension phase is to evaluate the long-term efficacy and safety of daily ozanimod 1 mg. Treatment with ozanimod 1 mg in the extension phase also showed a decrease in the proportion of patients with rectal bleeding and moderate or severe diarrhea. "Findings from this extension study at week 44 showed improvements in efficacy measures for patients who took ozanimod throughout both the blinded study and the extension," said Scott Smith, President, Celgene Inflammation & Immunology. "We recognize the strong need for innovative treatments that help patients with inflammatory bowel disease achieve durable results. We are committed to advancing additional transformational oral treatment options for these patients."

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    Nov

CELG Celgene
$98.50

-2.13 (-2.12%)

09/30/16
PIPR
09/30/16
NO CHANGE
Target $25
PIPR
Overweight
Piper's Schimmer found Nektar validation at Celgene event
Piper Jaffray analyst Joshua Schimmer says Celgene's (CELG) analyst event provided "another indirect validation" of Nektar Therapeutics' (NKTR) oncology approach. Celgene surprisingly implicated IL-2 as one of the primary mechanisms of Revlimid, Schimmer tells investors in a research note. He views the development as supporting his "enthusiastic outlook" for NKTR-214, the company's long-acting IL-2 targeting Teffector cells. The analyst reiterates an Overweight rating on Nektar with a $25 price target.
10/14/16
ADAM
10/14/16
NO CHANGE
Target $156
ADAM
Buy
Celgene pipeline broader and stronger than ever, says Canaccord
Canaccord analyst John Newman said Celgene's pipeline is broader and stronger than at any point in its history.He reiterated his Buy rating based on his confidence in the commercial potential for GED-0301 for Crohn's disease, ozanimod in both ulcerative colitis and multiple sclerosis, and continued growth for Otezla. Newman reiterated his $156 price target on Celgene shares.
10/17/16
WELS
10/17/16
NO CHANGE
WELS
Celgene data better than expected, says Wells Fargo
After Celgene announced detailed results from a phase 1b study of oral mogersen in moderate-to severe Crohn's Disease, Wells Fargo says that the results "are better than expected" and leave the company's drug "favorably" positioned relative to approved biologics. The firm says that Celgene's drug "could be positioned as the first highly effective oral for Crohn's Disease," and it keeps an Outperform rating on the stock.
10/17/16
LEER
10/17/16
NO CHANGE
LEER
Market Perform
Celgene data suggests viable drug, says Leerink
Leerink analyst Geoffrey Porges notes that Celgene has announced top-line results from Phase 1b study of GED-301 in Crohn's Disease, and says that absent statistical analyses or a greater insight into participant performance across the study's treatment arms, or longer duration of follow-up, it is difficult to evaluate the full significance of these results. Nonetheless, the analyst believes the drug seems to have some modest efficacy which bodes positively for potential approval as a front-line agent in Crohn's Disease. He reiterates a Market Perform rating on the shares.

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TRCO

Tribune Media

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HESM

Hess Midstream Partners

$25.58

0.08 (0.31%)

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SFTBF

SoftBank

$75.98

0.38 (0.50%)

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NVO

Novo Nordisk

$38.68

-0.1 (-0.26%)

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BDRBF

Bombardier

$1.56

-0.0722 (-4.42%)

, BA

Boeing

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BA

Boeing

$184.83

1.61 (0.88%)

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AMZN

Amazon.com

$924.99

6.61 (0.72%)

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TSLA

Tesla

$314.07

5.44 (1.76%)

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DIS

Disney

$115.60

-0.24 (-0.21%)

, CMCSA

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$39.19

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DIS

Disney

$115.60

-0.24 (-0.21%)

CMCSA

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$39.19

-0.4 (-1.01%)

CMCSK

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FOX

21st Century Fox

$29.86

-0.07 (-0.23%)

FOXA

21st Century Fox

$30.54

-0.02 (-0.07%)

TWX

Time Warner

$99.27

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TCEHY

Tencent

$31.35

-0.11 (-0.35%)

, FB

Facebook

$150.25

2.55 (1.73%)

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TCEHY

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$31.35

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FB

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$150.25

2.55 (1.73%)

SSNLF

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CYH

Community Health

$8.61

0.18 (2.14%)

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THC

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KND

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AET

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ANTM

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HUM

Humana

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DAL

Delta Air Lines

$45.44

-0.3 (-0.66%)

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TSLA

Tesla

$314.07

5.44 (1.76%)

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TSLA

Tesla

$314.07

5.44 (1.76%)

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CMCSA

Comcast

$39.19

-0.4 (-1.01%)

, CMCSK

Comcast

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CMCSA

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$39.19

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CMCSK

Comcast

LGF.A

Lionsgate

$26.17

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LGF.B

Lionsgate

$23.85

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FOX

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$29.86

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FOXA

21st Century Fox

$30.54

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DIS

Disney

$115.60

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SNE

Sony

$34.52

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TWX

Time Warner

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VIA

Viacom

$44.60

-0.8 (-1.76%)

VIAB

Viacom

$42.56

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ELLO

Ellomay Capital

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0.0019 (0.02%)

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GLPG

Galapagos NV

$86.86

0.87 (1.01%)

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SO

Southern Company

$49.80

-0.27 (-0.54%)

, TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

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SO

Southern Company

$49.80

-0.27 (-0.54%)

TOSBF

Toshiba, also use TOSYY

$2.03

0.06 (3.05%)

TOSYY

Toshiba, also use TOSBF

$12.14

0.25 (2.10%)

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CG

Carlyle Group

$17.70

0.2 (1.14%)

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IBM

IBM

$160.29

-0.03 (-0.02%)

14:07
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GRAM

Grana y Montero

$3.37

0.07 (2.12%)

14:05
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KO

Coca-Cola

$43.15

0.14 (0.33%)

13:49
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13:49
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Coca-Cola Bottling UNITED says closes Georgia transaction with Coca-Cola »

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