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MDCO

The Medicines Co.

$35.81

0.71 (2.02%)

07:17
10/18/16
10/18
07:17
10/18/16
07:17

Medicines Co. says data from ORION-1 affirm PCSK9si's highly-competitive profile

The Medicines Company announced top-line results from the interim analysis with Day 90 follow-up for all 501 patients enrolled in the ongoing ORION-1 study of PCSK9si, its investigational first-in-class PCSK9 synthesis inhibitor. Data from the interim analysis confirm the significant and durable LDL-C reduction demonstrated up to Day 90 in the preceding Phase 1 study. PCSK9si was well tolerated and no material safety issue was observed in the Day 90 interim analysis of unblinded safety data, including no investigational drug-related elevation of liver enzymes, neuropathy or change in renal function. Injection site reactions were infrequent, mild or moderate, and short-lived. "We are highly encouraged by the strength and consistency of the Day 90 efficacy and safety data from ORION-1, which build significantly on the promise generated by the preceding Phase 1 study of PCSK9si. These compelling interim data affirm PCSK9si's highly-competitive profile and validate PCSK9si's game-changing potential. We look forward to presenting results from the ORION-1 study, including Day 180 follow-up for up to 200 patients, at the AHA meeting on November 15, 2016,," said Clive Meanwell, M.D., Ph.D., CEO of The Medicines Company. David Kallend, MBBS, Vice President and Global Medical Director at The Medicines Company, added: "Based on the results from our ORION-1 Day 90 interim analysis, PCSK9si has again demonstrated robust and durable knockdown of LDL-C, as well as impressive safety and tolerability. These results validate a triannual, and potentially biannual, low volume subcutaneous dose regimen, which we believe represents a compelling, highly-differentiated approach for treating patients with hypercholesterolemia."

  • 26

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    Oct

MDCO The Medicines Co.
$35.81

0.71 (2.02%)

10/06/16
JEFF
10/06/16
NO CHANGE
Target $43
JEFF
Buy
Alnylam setback has no read-through to Medicines Co., says Jefferies
Jefferies analyst Biren Amin believes Alnylam Pharmaceuticals' (ALNY) decision to stop revusiran due to lack of a treatment benefit has no read-through to The Medicines Co.'s (MDCO) PCSK9 program. Amin keeps a Buy rating on Medicines Co. with a $43 price target.
10/06/16
RBCM
10/06/16
NO CHANGE
RBCM
Alnylam news not a negative read through on other RNAi drugs, says RBC Capital
After Alnylam (ALNY) announced that it was discontinuing one of its Phase III RNAi drugs due to poor clinical outcomes, RBC Capital analyst Michael Yee does not thinks that the news indicates problems with all RNAi drugs. Rather, he thinks that RNAi was not the proper treatment for the disease that Alnylam was targeting. Other companies with RNAi treatments include The Medicines Company (MDCO0, Ionis Pharmaceuticals (IONS), Arrowhead (ARWR), and Arbutus Biopharma (ABUS).
10/06/16
GUGG
10/06/16
NO CHANGE
GUGG
The Medicines Co. weakness a buying opportunity, says Guggenheim
10/18/16
JEFF
10/18/16
NO CHANGE
JEFF
Jefferies sees 'attractive buying opportunities' in Biotech
The Jefferies Biotechnology team sees "attractive buying opportunities" amidst the pre-election weakness. While volatility will likely continue into the election, valuation multiples are near-historic lows and policy concerns, while valid, are likely overstated, the analysts tell investors in a research note. They recommend using the weakness to buy select names ahead of a potential improvement in sentiment. Jefferies likes Gilead (GILD) and Celgene (CELG) among large-caps, The Medicines Co. (MDCO), Alkermes (ALKS) and Vertex (VRTX) among mid-caps, and Alder Biopharmaceuticals (ALDR), Cempra (CEMP), Ultragenyx (RARE) and Immunomedics (IMMU) among small-caps.

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KMX

CarMax

$68.84

0.17 (0.25%)

, FINL

Finish Line

$9.22

-0.21 (-2.23%)

20:25
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FINL

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HPE

HP Enterprise

$13.79

0.16 (1.17%)

18:47
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Periodicals
HP Enterprise planning approximately 5,000 job cuts, Bloomberg reports »

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RP

RealPage

$39.35

-0.1 (-0.25%)

18:41
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HPE

HP Enterprise

$13.79

0.16 (1.17%)

18:39
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Periodicals
Breaking Periodicals news story on HP Enterprise »

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YUM

Yum! Brands

$76.48

0.11 (0.14%)

18:37
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09/21
18:37
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18:37
Conference/Events
Yum! Brands management to meet with JPMorgan »

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MAR

Marriott

$107.57

-0.12 (-0.11%)

18:32
09/21/17
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18:32
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18:32
Conference/Events
Marriott management to meet with JPMorgan »

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ESPGY

Esprit Holdings

$1.21

0.018 (1.51%)

18:29
09/21/17
09/21
18:29
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18:29
Conference/Events
Esprit Holdings management to meet with JPMorgan »

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BA

Boeing

$256.04

0.58 (0.23%)

18:18
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18:18
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18:18
Hot Stocks
Boeing: Turkish Airlines announces intent to order 40 787-9 Dreamliners »

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  • 23

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M

Macy's

$21.16

-0.32 (-1.49%)

18:18
09/21/17
09/21
18:18
09/21/17
18:18
Conference/Events
Macy's management to meet with JPMorgan »

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  • 26

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TAHO

Tahoe Resources

$5.60

0.02 (0.36%)

18:12
09/21/17
09/21
18:12
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18:12
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Tahoe Resources raises 2017 gold operations view to 400K-500K »

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ATKR

Atkore

$18.42

0.02 (0.11%)

18:11
09/21/17
09/21
18:11
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18:11
Conference/Events
Atkore management to meet with JPMorgan »

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  • 26

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YOGA

YogaWorks

$4.00

-0.04 (-0.99%)

, TXN

Texas Instruments

$86.05

0.22 (0.26%)

18:11
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09/21
18:11
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18:11
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS:…

YOGA

YogaWorks

$4.00

-0.04 (-0.99%)

TXN

Texas Instruments

$86.05

0.22 (0.26%)

PSDO

Presidio

$13.95

-0.06 (-0.43%)

VSAR

Versartis

$21.60

-0.25 (-1.14%)

ASND

Ascendis Pharma

$27.74

-1.55 (-5.29%)

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  • 21

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FTR

Frontier Communications

$11.69

-0.31 (-2.58%)

18:10
09/21/17
09/21
18:10
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18:10
Hot Stocks
Frontier Communications operations in Florida return to near-normal levels »

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PLYA

Playa Hotels & Resorts

$10.66

-0.06 (-0.56%)

18:07
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09/21
18:07
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18:07
Hot Stocks
Playa Hotels & Resorts reports no significant damage from Maria »

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  • 08

    Nov

ASND

Ascendis Pharma

$27.74

-1.55 (-5.29%)

, VSAR

Versartis

$21.60

-0.25 (-1.14%)

18:07
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Hot Stocks
Ascendis spikes higher after Versartis Velocity trial fails to meet endpoint »

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ASND

Ascendis Pharma

$27.74

-1.55 (-5.29%)

VSAR

Versartis

$21.60

-0.25 (-1.14%)

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CE

Celanese

$103.90

-0.04 (-0.04%)

18:04
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Hot Stocks
Celanese increases price of acetyl intermediates »

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DNOW

NOW Inc.

$12.98

0.1 (0.78%)

18:03
09/21/17
09/21
18:03
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18:03
Conference/Events
NOW Inc. management to meet with JPMorgan »

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  • 25

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  • 01

    Nov

JOBS

51job

$58.50

0.01 (0.02%)

18:02
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09/21
18:02
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18:02
Hot Stocks
51job announces strategic investment in Lagou »

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HES

Hess Corp.

$43.63

0.17 (0.39%)

17:53
09/21/17
09/21
17:53
09/21/17
17:53
Conference/Events
Hess Corp. management to meet with JPMorgan »

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  • 25

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APC

Anadarko

$48.49

3.68 (8.21%)

17:43
09/21/17
09/21
17:43
09/21/17
17:43
Recommendations
Anadarko analyst commentary at MUFG »

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  • 27

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HCC

Warrior Met Coal

$23.28

-1.05 (-4.32%)

17:42
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17:42
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17:42
Hot Stocks
Warrior Met Coal receives favorable IRS private letter ruling »

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MAA

MAA

$107.27

-0.03 (-0.03%)

17:35
09/21/17
09/21
17:35
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17:35
Hot Stocks
MAA announces estimated impact of Hurricanes Irma and Harvey »

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NOC

Northrop Grumman

$280.42

0.38 (0.14%)

17:31
09/21/17
09/21
17:31
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17:31
Hot Stocks
Northrop Grumman awarded $124.7M government contract »

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