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MDCO

The Medicines Co.

$35.81

0.71 (2.02%)

07:17
10/18/16
10/18
07:17
10/18/16
07:17

Medicines Co. says data from ORION-1 affirm PCSK9si's highly-competitive profile

The Medicines Company announced top-line results from the interim analysis with Day 90 follow-up for all 501 patients enrolled in the ongoing ORION-1 study of PCSK9si, its investigational first-in-class PCSK9 synthesis inhibitor. Data from the interim analysis confirm the significant and durable LDL-C reduction demonstrated up to Day 90 in the preceding Phase 1 study. PCSK9si was well tolerated and no material safety issue was observed in the Day 90 interim analysis of unblinded safety data, including no investigational drug-related elevation of liver enzymes, neuropathy or change in renal function. Injection site reactions were infrequent, mild or moderate, and short-lived. "We are highly encouraged by the strength and consistency of the Day 90 efficacy and safety data from ORION-1, which build significantly on the promise generated by the preceding Phase 1 study of PCSK9si. These compelling interim data affirm PCSK9si's highly-competitive profile and validate PCSK9si's game-changing potential. We look forward to presenting results from the ORION-1 study, including Day 180 follow-up for up to 200 patients, at the AHA meeting on November 15, 2016,," said Clive Meanwell, M.D., Ph.D., CEO of The Medicines Company. David Kallend, MBBS, Vice President and Global Medical Director at The Medicines Company, added: "Based on the results from our ORION-1 Day 90 interim analysis, PCSK9si has again demonstrated robust and durable knockdown of LDL-C, as well as impressive safety and tolerability. These results validate a triannual, and potentially biannual, low volume subcutaneous dose regimen, which we believe represents a compelling, highly-differentiated approach for treating patients with hypercholesterolemia."

  • 26

    Oct

  • 26

    Oct

MDCO The Medicines Co.
$35.81

0.71 (2.02%)

10/06/16
JEFF
10/06/16
NO CHANGE
Target $43
JEFF
Buy
Alnylam setback has no read-through to Medicines Co., says Jefferies
Jefferies analyst Biren Amin believes Alnylam Pharmaceuticals' (ALNY) decision to stop revusiran due to lack of a treatment benefit has no read-through to The Medicines Co.'s (MDCO) PCSK9 program. Amin keeps a Buy rating on Medicines Co. with a $43 price target.
10/06/16
RBCM
10/06/16
NO CHANGE
RBCM
Alnylam news not a negative read through on other RNAi drugs, says RBC Capital
After Alnylam (ALNY) announced that it was discontinuing one of its Phase III RNAi drugs due to poor clinical outcomes, RBC Capital analyst Michael Yee does not thinks that the news indicates problems with all RNAi drugs. Rather, he thinks that RNAi was not the proper treatment for the disease that Alnylam was targeting. Other companies with RNAi treatments include The Medicines Company (MDCO0, Ionis Pharmaceuticals (IONS), Arrowhead (ARWR), and Arbutus Biopharma (ABUS).
10/06/16
GUGG
10/06/16
NO CHANGE
GUGG
The Medicines Co. weakness a buying opportunity, says Guggenheim
10/18/16
JEFF
10/18/16
NO CHANGE
JEFF
Jefferies sees 'attractive buying opportunities' in Biotech
The Jefferies Biotechnology team sees "attractive buying opportunities" amidst the pre-election weakness. While volatility will likely continue into the election, valuation multiples are near-historic lows and policy concerns, while valid, are likely overstated, the analysts tell investors in a research note. They recommend using the weakness to buy select names ahead of a potential improvement in sentiment. Jefferies likes Gilead (GILD) and Celgene (CELG) among large-caps, The Medicines Co. (MDCO), Alkermes (ALKS) and Vertex (VRTX) among mid-caps, and Alder Biopharmaceuticals (ALDR), Cempra (CEMP), Ultragenyx (RARE) and Immunomedics (IMMU) among small-caps.

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BMS

Bemis

$44.90

-0.28 (-0.62%)

20:30
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ATUS

Altice USA

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  • 22

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BBRY

BlackBerry

$11.06

0.41 (3.85%)

, FINL

Finish Line

$12.73

0.23 (1.84%)

20:25
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BBRY

BlackBerry

$11.06

0.41 (3.85%)

FINL

Finish Line

$12.73

0.23 (1.84%)

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NBRV

Nabriva Therapeutics

$10.50

1.19 (12.78%)

20:22
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Nabriva Therapeutics initiated at Cantor »

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  • 06

    Jul

WIX

Wix.com

$72.80

0.5 (0.69%)

20:20
06/22/17
06/22
20:20
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20:20
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Wix.com initiated at Wedbush »

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  • 28

    Jun

OCLR

Oclaro

$9.44

-0.1 (-1.05%)

20:19
06/22/17
06/22
20:19
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20:19
Initiation
Oclaro initiated at DA Davidson »

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  • 22

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ACIA

Acacia Communications

$41.64

0.65 (1.59%)

20:19
06/22/17
06/22
20:19
06/22/17
20:19
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Acacia Communications initiated at DA Davidson »

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  • 22

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LITE

Lumentum

$62.45

-0.05 (-0.08%)

20:19
06/22/17
06/22
20:19
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Initiation
Lumentum initiated at DA Davidson »

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  • 22

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LEJU

Leju

$2.46

0.07 (2.93%)

20:05
06/22/17
06/22
20:05
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20:05
Downgrade
Leju rating change at JPMorgan »

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GCP

GCP Applied Technologies

$30.40

0.3 (1.00%)

20:04
06/22/17
06/22
20:04
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20:04
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GCP Applied Technologies rating change at KeyBanc »

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PHM

PulteGroup

$24.04

-0.24 (-0.99%)

19:58
06/22/17
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19:58
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Initiation
PulteGroup initiated at Credit Suisse »

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DHI

D.R. Horton

$33.47

-0.5 (-1.47%)

19:58
06/22/17
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19:58
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19:58
Initiation
D.R. Horton initiated at Credit Suisse »

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CAA

CalAtlantic

$34.80

-0.34 (-0.97%)

19:57
06/22/17
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Initiation
CalAtlantic initiated at Credit Suisse »

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BZH

Beazer Homes

$13.01

0.03 (0.23%)

19:57
06/22/17
06/22
19:57
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19:57
Initiation
Beazer Homes initiated at Credit Suisse »

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MTH

Meritage Homes

$40.40

-0.4 (-0.98%)

19:57
06/22/17
06/22
19:57
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19:57
Initiation
Meritage Homes initiated at Credit Suisse »

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TOL

Toll Brothers

19:57
06/22/17
06/22
19:57
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19:57
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Toll Brothers initiated at Credit Suisse »

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LEN

Lennar

$52.41

-0.84 (-1.58%)

19:57
06/22/17
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19:57
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Initiation
Lennar initiated at Credit Suisse »

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KBH

KB Home

$22.23

-0.1 (-0.45%)

19:57
06/22/17
06/22
19:57
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Initiation
KB Home initiated at Credit Suisse »

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  • 27

    Jun

MHK

Mohawk

$242.70

-0.22 (-0.09%)

19:27
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Mohawk initiated at Credit Suisse »

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FBHS

Fortune Brands

$65.09

0.06 (0.09%)

19:27
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19:27
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19:27
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Fortune Brands initiated at Credit Suisse »

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JELD

JELD-WEN Holding

$34.60

-0.29 (-0.83%)

19:26
06/22/17
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19:26
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19:26
Initiation
JELD-WEN Holding initiated at Credit Suisse »

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IBP

Installed Building Products

$52.75

-1 (-1.86%)

19:26
06/22/17
06/22
19:26
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19:26
Initiation
Installed Building Products initiated at Credit Suisse »

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OC

Owens Corning

$66.42

-0.85 (-1.26%)

19:26
06/22/17
06/22
19:26
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19:26
Initiation
Owens Corning initiated at Credit Suisse »

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WHR

Whirlpool

$195.16

1.35 (0.70%)

19:26
06/22/17
06/22
19:26
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19:26
Initiation
Whirlpool initiated at Credit Suisse »

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