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ABBV

AbbVie

$61.55

1.41 (2.34%)

, NBIX

Neurocrine

$44.59

2.29 (5.41%)

09:02
10/19/16
10/19
09:02
10/19/16
09:02

AbbVie reports 'positive' Phase 3 data from Elagolix trials

AbbVie (ABBV) in cooperation with Neurocrine Biosciences (NBIX) announced detailed results from two replicate pivotal Phase 3 clinical trials evaluating the efficacy and safety of Elagolix in premenopausal women who suffer from endometriosis. The data demonstrate that, compared to placebo at month three and month six, patients treated with Elagolix reported statistically significant reductions in scores for menstrual pain and non-menstrual pelvic pain associated with endometriosis as measured by the Daily Assessment of Endometriosis Pain scale. The results were presented at the 72nd American Society for Reproductive Medicine Scientific Congress & Expo in Salt Lake City, as well as additional abstracts. In the two studies, both doses of Elagolix administered orally demonstrated a statistically significant (p less than or equal to 0.001) improvement versus placebo in the percentage of DYS and NMPP responders. In the first study, at month three, 46 percent of patients treated with 150 mg once daily and 76 percent of patients treated with 200 mg twice daily of Elagolix were classified as DYS responders, versus 20 percent of patients in the placebo group. Fifty percent of patients treated with 150 mg once daily and 55 percent of patients treated with 200 mg twice daily of Elagolix were classified as NMPP responders, versus 36 percent of patients in the placebo group. The second pivotal Phase 3 study demonstrated similar results.

ABBV

AbbVie

$61.55

1.41 (2.34%)

NBIX

Neurocrine

$44.59

2.29 (5.41%)

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ABBV AbbVie
$61.55

1.41 (2.34%)

10/18/16
LEER
10/18/16
INITIATION
Target $70
LEER
Market Perform
AbbVie initiated with a Market Perform at Leerink
Leerink analyst Geoffrey Porges started AbbVie with a Market Perform rating and $70 price target. The analyst sees "significant uncertainty" about the durability of the company's dominant franchise, Humira.
10/13/16
JEFF
10/13/16
DOWNGRADE
Target $36
JEFF
Hold
Pfizer downgraded to Hold from Buy at Jefferies
Jefferies analyst Jeffrey Holford downgraded Pfizer (PFE) to Hold citing a lack of positive catalysts. The analyst says the drivers for his upgrade to Buy have either played out or have not materialized, namely an inversion or GEP unit separation. To reflect the infusion business disposal and weaker Ibrance trends, Holford cut his mid-term earnings estimates for Pfizer by up to 7% and cut his price target for the shares to $36 from $39. The stock closed yesterday down 6c to $33.07. The analyst also sees increased risk of a major acquisition occurring over the next 12 months. In the global pharma space, Holford lists AbbVie (ABBV), Eli Lilly (LLY), Novartis (NVS) and AstraZeneca (AZN) as his top picks.
10/12/16
RBCM
10/12/16
NO CHANGE
RBCM
Outperform
Vertex competitor to report data soon, but has long way to go, says RBC Capital
RBC Capital analyst Michael Yee noted that Galapagos NV (GLPG) and partner AbbVie (ABBV) are likely to present new Phase IIa data for GLP-1837 for cystic fibrosis and host an analyst event on October 27, adding that he believes the data will likely be positive and suggest they are "on track" with progress on their triple pill. Yee adds it won't be surprising if Galapagos has positive '1837 "potentiator" data, as this is the easier of the components and only the first piece of a 3-pill drug. Vertex (VRTX) is also hosting an analyst event on Oct. 27 and will probably also give an update on its own "triple," said Yee, who thinks it should stay in the lead with most advanced triple. Yee keeps an Outperform rating on Vertex shares.
10/03/16
LEER
10/03/16
NO CHANGE
LEER
Market Perform
AASLD abstracts hint at potential competitive threat to Gilead HCV, says Leerink
Leerink analyst Geoffrey Porges says abstracts for the American Association for the Study of Liver Diseases, or AASLD, meeting revealed very limited efficacy information about the new Hepatitis C regimens for Gilead (GILD), Merck (MRK) and AbbVie (ABBV). Nonetheless, the analyst believes the abstracts hint at the potential competitive threat to Gilead's HCV dominance. While the new 12-week HCV regimens may compete on price, the forthcoming 8-week regimens put the most pressure on Gilead's market share, Porges argues. He reiterates a Market Perform rating on Gilead's shares.
NBIX Neurocrine
$44.59

2.29 (5.41%)

10/18/16
NEED
10/18/16
INITIATION
Target $62
NEED
Buy
Neurocrine initiated with a Buy at Needham
Needham analyst Alan Carr initiated Neurocrine with a Buy and a $62 price target.
10/13/16
BMOC
10/13/16
NO CHANGE
BMOC
Neurocrine recent weakness unwarranted, says BMO Capital
BMO Capital analyst M. Ian Somaiya says that Neurocrine (NBIX) has been weak recently in the wake of Myovant's S-1 filing. According to the analyst, investors view Myovant's relugolix as a more convenient alternative to Neurocrine's elagolix. However, the analyst thinks that relugolix's longer half-life "could complicate add-back therapy," while the wording of the questionnaire for relugolix's Phase 3 trial increases endometriosis clinical development risk. Additionally, the analyst says that Neurocrine's elagolix has a two to three year lead time over relugolix, setting the stage for both drugs to do well. He keeps a $66 price target and Outperform rating on Neurocrine.
10/12/16
LEER
10/12/16
NO CHANGE
Target $70
LEER
Outperform
Neurocrine recent selloff a buying opportunity, says Leerink
Leerink analyst Paul Matteis views the 18% pullback in shares of Neurocrine Biosciences (NBIX) over the past few weeks as a buying opportunity. The analyst finds the catalyst for the selloff "difficult to pinpoint," but notes he's been receiving questions from investors on the size of the market opportunity for vesicular monoamine transporters in Tardive Dyskinesia. A doctor survey suggests a target market of 300,000 TD patients for Neurocrine's and Teva's VMAT2 inhibitors, which is enough to offer a "significant revenue opportunity" for both drugs, Matteis tells investors in a research note. Further, the analyst believes the upcoming Phase II data in Tourette's Syndrome, which he sees as having a high probability of success, offers a "nice catalyst for investors" into Q1 of next year. Matteis reiterates an Outperform rating on Neurocrine with a $70 price target.
10/06/16
LEHM
10/06/16
DOWNGRADE
Target $50
LEHM
Equal Weight
Alnylam downgraded to Equal Weight from Overweight at Barclays
Barclays analyst Geoff Meacham downgraded Alnylam Pharmaceuticals (ALNY) to Equal Weight saying he views other SMid cap biotech names as more attractive following the company's recent pipeline setbacks. The analyst removed Revusiran sales from his Alnylam model after the program was discontinued yesterday and he cut his price target for the shares to $50 from $85. Meacham lists Neurocrine (NBIX), Prothena (PTRA) and Incyte (INCY) as names he finds more attractive over the next 12 months. Alnylam is trading down 44% in pre-market trading to $39.25.

TODAY'S FREE FLY STORIES

WMT

Wal-Mart

$70.88

0.21 (0.30%)

18:17
12/02/16
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Wal-Mart to pay $7.5M to settle same-sex spouse benefit case, Reuters reports »

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GMED

Globus Medical

$21.89

0.12 (0.55%)

, TLN

Talen Energy

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S&P announces changes to S&P MidCap 400, S&P SmallCap 600 indices »

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GMED

Globus Medical

$21.89

0.12 (0.55%)

TLN

Talen Energy

UMBF

UMB Financial

$77.00

-0.43 (-0.56%)

IM

Ingram Micro

$38.88

1.31 (3.49%)

HMST

HomeStreet

$29.35

-0.2 (-0.68%)

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JNJ

Johnson & Johnson

$111.96

0.58 (0.52%)

, ALIOF

Actelion

$206.01

15.21 (7.97%)

18:11
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Periodicals
Johnson & Johnson said to raise offer for Actelion above $250, Bloomberg says »

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JNJ

Johnson & Johnson

$111.96

0.58 (0.52%)

ALIOF

Actelion

$206.01

15.21 (7.97%)

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CE

Celanese

$79.10

0.3 (0.38%)

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Celanese to raise list, off-list selling prices for paraformaldehyde »

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HMST

HomeStreet

$29.35

-0.2 (-0.68%)

, GMED

Globus Medical

$21.89

0.12 (0.55%)

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On The Fly: After Hours Movers »

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HMST

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$29.35

-0.2 (-0.68%)

GMED

Globus Medical

$21.89

0.12 (0.55%)

BGS

B&G Foods

$42.50

0.2 (0.47%)

ZEN

Zendesk

$21.17

0.34 (1.63%)

03/08/13
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ZEN

Zendesk

$21.17

0.34 (1.63%)

17:53
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Zendesk says SVPs Amanda Kleha and Marcus Bragg to resign »

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AIXG

Aixtron

$3.97

-0.05 (-1.24%)

17:42
12/02/16
12/02
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17:42
Periodicals
President Obama blocks China's Fujian from acquiring Aixtron, CNBC reports »

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CX

CEMEX

$7.83

0.09 (1.16%)

17:31
12/02/16
12/02
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17:31
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CEMEX to divest ready-mix concrete pumping assets in Mexico »

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SRNE

Sorrento Therapeutics

$5.15

-0.1 (-1.90%)

17:30
12/02/16
12/02
17:30
12/02/16
17:30
Syndicate
Breaking Syndicate news story on Sorrento Therapeutics »

Sorrento files to sell…

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  • 06

    Dec

MBRX

Moleculin Biotech

$2.63

-0.14 (-5.05%)

17:29
12/02/16
12/02
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12/02/16
17:29
Syndicate
Breaking Syndicate news story on Moleculin Biotech »

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  • 06

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NEOG

Neogen

$61.59

-1.46 (-2.32%)

17:28
12/02/16
12/02
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17:28
Hot Stocks
Neogen acquires U.K.-based Quat-Chem, terms undisclosed »

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RRC

Range Resources

$36.36

-0.23 (-0.63%)

17:25
12/02/16
12/02
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17:25
Hot Stocks
Breaking Hot Stocks news story on Range Resources »

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EOG

EOG Resources

$103.74

-1.01 (-0.96%)

17:25
12/02/16
12/02
17:25
12/02/16
17:25
Syndicate
Breaking Syndicate news story on EOG Resources »

EOG Resources files to…

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HMST

HomeStreet

$29.35

-0.2 (-0.68%)

, UMBF

UMB Financial

$77.00

-0.43 (-0.56%)

17:22
12/02/16
12/02
17:22
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17:22
Hot Stocks
Breaking Hot Stocks news story on HomeStreet, UMB Financial »

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HMST

HomeStreet

$29.35

-0.2 (-0.68%)

UMBF

UMB Financial

$77.00

-0.43 (-0.56%)

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UMBF

UMB Financial

$77.00

-0.43 (-0.56%)

, IM

Ingram Micro

$38.88

1.31 (3.49%)

17:21
12/02/16
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UMB Financial to replace Ingram Micro in S&P 400 as of 12/6 close »

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UMBF

UMB Financial

$77.00

-0.43 (-0.56%)

IM

Ingram Micro

$38.88

1.31 (3.49%)

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GMED

Globus Medical

$21.89

0.12 (0.55%)

, TLN

Talen Energy

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Globus Medical to replace Talen Energy in S&P 400 as of 12/6 close »

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GMED

Globus Medical

$21.89

0.12 (0.55%)

TLN

Talen Energy

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AIXG

Aixtron

$3.97

-0.05 (-1.24%)

17:16
12/02/16
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Periodicals
President Obama blocks China's takeover of Aixtron, CNBC reports »

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DB

Deutsche Bank

$15.74

-0.32 (-1.99%)

17:07
12/02/16
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Periodicals
Deutsche Bank to pay $60M settlement over gold price-fixing case, Reuters says »

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  • 10

    Jan

ALB

Albemarle

$84.86

-0.79 (-0.92%)

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Albemarle to increase prices for select brominated products »

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  • 16

    Mar

FOR

Forestar Group

$13.40

0.2 (1.52%)

17:06
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Breaking Hot Stocks news story on Forestar Group »

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FANG

Diamondback Energy

$108.14

-1.86 (-1.69%)

17:04
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Breaking Syndicate news story on Diamondback Energy »

Diamondback Energy files…

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OSIR

Osiris

$5.68

0.06 (1.07%)

17:02
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Hot Stocks
Osiris: Nasdaq grants company's request for additional time »

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STOR

STORE Capital

$24.45

0.52 (2.17%)

17:00
12/02/16
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Hot Stocks
STORE Capital director Donovan acquires 4,350 shares »

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CARB

Carbonite

$17.95

0.25 (1.41%)

16:48
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Breaking Hot Stocks news story on Carbonite »

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GIB

CGI Group

$47.11

0.16 (0.34%)

16:48
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CGI Group announces specific share repurchase program »

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