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AZN

AstraZeneca

$27.34

0.22 (0.81%)

07:31
11/22/16
11/22
07:31
11/22/16
07:31

AstraZeneca resumes enrollment for head/neck cancer trials after hold lifted

AstraZeneca announced that the U.S. FDA has lifted the partial clinical hold on the enrollment of new patients with head and neck squamous cell carcinoma for clinical trials of durvalumab as monotherapy and in combination with tremelimumab or other potential medicines. The Phase 3 KESTREL trial has already re-opened for new patient enrollment at some clinical study sites and the EAGLE trial is expected to resume recruitment shortly, without amendments to either protocol. AstraZeneca will progressively resume enrollment for all HNSCC trials across the participating sites in the U.S. and globally, subject to national health authority and ethics committee approval where required. The status of active recruitment will be reflected on clinicaltrials.gov in the coming days. The partial clinical hold on new patient enrollment was communicated on October 27, after preliminary findings from ongoing clinical trials related specifically to head and neck cancer. The FDA lifted the partial clinical hold following a review of the comprehensive analysis provided by AstraZeneca of bleeding events that were observed as part of the routine safety monitoring of the Phase 3 KESTREL and EAGLE trials.

  • 16

    Feb

AZN AstraZeneca
$27.34

0.22 (0.81%)

10/13/16
JEFF
10/13/16
DOWNGRADE
Target $36
JEFF
Hold
Pfizer downgraded to Hold from Buy at Jefferies
Jefferies analyst Jeffrey Holford downgraded Pfizer (PFE) to Hold citing a lack of positive catalysts. The analyst says the drivers for his upgrade to Buy have either played out or have not materialized, namely an inversion or GEP unit separation. To reflect the infusion business disposal and weaker Ibrance trends, Holford cut his mid-term earnings estimates for Pfizer by up to 7% and cut his price target for the shares to $36 from $39. The stock closed yesterday down 6c to $33.07. The analyst also sees increased risk of a major acquisition occurring over the next 12 months. In the global pharma space, Holford lists AbbVie (ABBV), Eli Lilly (LLY), Novartis (NVS) and AstraZeneca (AZN) as his top picks.
10/20/16
JANY
10/20/16
NO CHANGE
Target $1.5
JANY
Neutral
Cerulean cash infusion gives chance to execute on programs, says Janney Capital
Janney Capital analyst Debjit Chattopadhyay said Cerulean's (CERU) collaboration with Novartis (NVS), which comes with a "modest" $5M upfront payment, and its $20M ATM facility with Aspire Capital, while "not ideal," gives management a chance to execute on three of its ongoing programs, the most important of which is the dose escalation study with Olaparib with partner AstraZeneca (AZN) that should have preliminary data in 2Q17. The analyst raised his fair value estimate on Cerulean to $1.50 from $1.00 and keeps a Neutral rating on the stock.
10/26/16
PIPR
10/26/16
NO CHANGE
PIPR
Neutral
Piper still uncertain on Clovis position after AstraZeneca data
AstraZeneca's (AZN) Phase III study of Lynparza in ovarian cancer "substantially improved" progression-free survival over what was seen in study 19, suggesting a profile at least similar to TESARO's (TSRO) niraparib, Piper Jaffray analyst Steven Breazzano tells investors in a research note. The new data confirm that the various PARP inhibitors are more similar than different, which bodes well for Clovis Oncology's (CLVS) own maintenance study, the analyst contends. Breazzano, however, remains the sidelines with respect to Clovis shares given the "increasingly competitive dynamic" in ovarian cancer and uncertainty in the company's position in the important maintenance setting. The analyst keeps a Neutral rating on Clovis.
11/09/16
SBSH
11/09/16
NO CHANGE
SBSH
Citi sees Healthcare 'relief rally' after Trump win
Citi analyst Andrew Baum expects a "'relief rally" to drive near-term sector outperformance for names in the Healthcare space given the "inability of the Democrats to attain the Presidency, the House or Congress." Longer term, however, the analyst still sees "significant continued legislative risk" for pharma reimbursement. Baum prefers GlaxoSmithKline (GSK), AstraZeneca (AZN), Shire (SHPG) and Roche (RHHBY) among European majors and Bristol-Myers (BMY) and Eli Lilly (LLY) in the U.S.

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AZO

AutoZone

$535.19

-28.21 (-5.01%)

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09/20/17
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RGNX

Regenxbio

$29.05

-0.75 (-2.52%)

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  • 25

    Sep

AMZN

Amazon.com

$969.86

-4.33 (-0.44%)

, BABA

Alibaba

$180.07

0.09 (0.05%)

07:17
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07:17
Periodicals
Amazon takes on rivals in India digital payments market, The Information says »

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AMZN

Amazon.com

$969.86

-4.33 (-0.44%)

BABA

Alibaba

$180.07

0.09 (0.05%)

SFTBF

SoftBank

$82.75

4.45 (5.68%)

GOOG

Alphabet

$921.81

6.81 (0.74%)

GOOGL

Alphabet Class A

$936.86

7.11 (0.76%)

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SBNY

Signature Bank

$120.15

0.21 (0.18%)

07:16
09/20/17
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07:16
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07:16
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Signature Bank rating change  »

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HK

Halcon Resources

$6.23

-0.19 (-2.96%)

07:14
09/20/17
09/20
07:14
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07:14
Hot Stocks
Halcon Resources announces sale of non-operated Williston Basin assets »

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  • 16

    May

BBBY

Bed Bath & Beyond

$27.03

-0.27 (-0.99%)

07:14
09/20/17
09/20
07:14
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07:14
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Bed Bath & Beyond analyst commentary  »

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CSCO

Cisco

$32.49

-0.03 (-0.09%)

07:12
09/20/17
09/20
07:12
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07:12
Conference/Events
Cisco management to meet with Oppenheimer »

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    Nov

AVEO

AVEO Oncology

$3.84

0.07 (1.86%)

, BMY

Bristol-Myers

$62.93

0.23 (0.37%)

07:12
09/20/17
09/20
07:12
09/20/17
07:12
Hot Stocks
AVEO Oncology, EUSA Pharma announce TiNivo combination study opt-in »

AVEO Oncology (AVEO) and…

AVEO

AVEO Oncology

$3.84

0.07 (1.86%)

BMY

Bristol-Myers

$62.93

0.23 (0.37%)

03/08/13
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  • 09

    Nov

  • 05

    Mar

ADBE

Adobe

$156.60

0.83 (0.53%)

07:12
09/20/17
09/20
07:12
09/20/17
07:12
Recommendations
Adobe analyst commentary  »

Adobe price target raised…

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  • 22

    Oct

SUPN

Supernus

$38.05

-11.6 (-23.36%)

07:11
09/20/17
09/20
07:11
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07:11
Recommendations
Supernus analyst commentary  »

Jefferies still sees…

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  • 25

    Sep

WFC

Wells Fargo

$53.36

0.65 (1.23%)

07:10
09/20/17
09/20
07:10
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07:10
Periodicals
Wells Fargo general counsel aims to clean up reputation, Reuters reports »

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  • 23

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  • 15

    Jan

ELY

Callaway Golf

$14.14

0.12 (0.86%)

07:09
09/20/17
09/20
07:09
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07:09
Recommendations
Callaway Golf analyst commentary  »

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BA

Boeing

$252.46

-0.62 (-0.24%)

07:09
09/20/17
09/20
07:09
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07:09
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Boeing analyst commentary  »

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  • 23

    Sep

MTCH

Match Group

$23.45

-0.02 (-0.09%)

07:08
09/20/17
09/20
07:08
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07:08
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Match Group analyst commentary  »

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GIS

General Mills

$55.38

-1.05 (-1.86%)

07:08
09/20/17
09/20
07:08
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07:08
Hot Stocks
Breaking Hot Stocks news story on General Mills »

General Mills down 4.3%…

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  • 20

    Sep

KPTI

Karyopharm

$10.52

-0.34 (-3.13%)

07:07
09/20/17
09/20
07:07
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07:07
Hot Stocks
Karyopharm: 'successful' outcome from Phase 2 portion of Phase 2/3 SEAL study »

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  • 25

    Sep

GIS

General Mills

$55.38

-1.05 (-1.86%)

07:05
09/20/17
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07:05
Hot Stocks
General Mills CEO says FY18 priority is 'strengthening our topline performance' »

"Our number one…

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  • 20

    Sep

SNY

Sanofi

$49.10

0.46 (0.95%)

, ALNY

Alnylam

$75.04

-0.96 (-1.26%)

07:05
09/20/17
09/20
07:05
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07:05
Hot Stocks
Sanofi and Alnylam report topline results of patisiran in ATTR amyloidosis »

Sanofi's (SNY)…

SNY

Sanofi

$49.10

0.46 (0.95%)

ALNY

Alnylam

$75.04

-0.96 (-1.26%)

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  • 18

    Oct

ADBE

Adobe

$156.60

0.83 (0.53%)

07:04
09/20/17
09/20
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07:04
Recommendations
Adobe analyst commentary  »

Adobe near-term weakness…

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  • 22

    Oct

WDC

Western Digital

$89.92

0.74 (0.83%)

07:04
09/20/17
09/20
07:04
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07:04
Technical Analysis
Technical View: Western Digital falls as Toshiba selects Bain-led group as buyer »

Toshiba (TOSBF, TOSYY)…

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GIS

General Mills

$55.38

-1.05 (-1.86%)

07:04
09/20/17
09/20
07:04
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07:04
Hot Stocks
General Mills CEO says 'confident in improved momentum' for rest of year »

CEO Harmening said,…

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  • 20

    Sep

SIX

Six Flags

$56.75

-0.32 (-0.56%)

07:03
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Six Flags says no expected material impact from Mexico earthquake »

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  • 28

    Sep

PG

Procter & Gamble

$94.17

1.02 (1.10%)

07:03
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07:03
Hot Stocks
Procter & Gamble: Peltz 'lacks specific qualities' P&G seeking in board members »

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GIS

General Mills

$55.38

-1.05 (-1.86%)

07:03
09/20/17
09/20
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07:03
Hot Stocks
General Mills reports Q1 gross margin down 150 bps to 34.8% »

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  • 20

    Sep

07:02
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General news
MBA Mortgage Applications Composite Index data reported »

Week of 9/15 MBA Mortgage…

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