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EPZM

Epizyme

06:31
11/28/16
11/28
06:31
11/28/16
06:31

Epizyme announces Fast Track designation for Tazemetostat in DLBCL

Epizyme announced advancements in the company's clinical programs evaluating tazemetostat, its first-in-class EZH2 inhibitor. The U.S. FDA has granted tazemetostat Fast Track designation in patients with diffuse large B-cell lymphoma with EZH2 activating mutations. Additionally, Epizyme is focusing its Phase 2 registration-enabling study in adult patients with genetically-defined solid tumors on those cancers marked by loss of INI1, and has expanded enrollment in the epithelioid sarcoma cohort of the study based on encouraging early activity in this patient population

  • 03

    Dec

EPZM Epizyme

04/05/16
04/05/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Epizyme (EPZM) initiated with a Buy at Citi by analyst Robyn Karnauskas, who said long-term platform valuation could come in 2017. 2. AT&T (T) initiated with an Outperform at Macquarie. 3. General Dynamics (GD) initiated with a Buy at Guggenheim. 4. Grainger (GWW) initiated with an Outperform at BMO Capital. 5. McDonald's (MCD) initiated with a Hold at Evercore ISI. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
06/20/16
RBCM
06/20/16
NO CHANGE
RBCM
Epizyme data could improve over time, says RBC Capital
After the overall response rate of refractory non-Hodgkin lymphoma patients taking Epizyme's Tazemetostat came in at 28%, down from 56% and 60% in prior trials, RBC Capital says that the data could improve over time. Specifically, the firm thinks that some of the patients whose tumors shrunk may become responsive over the longer term. Additionally, RBC Capital reports that there was a 100% overall response rate in the FL EZH2 mutant arm of the trial. The firm keeps an Outperform rating on the shares.
08/09/16
LEER
08/09/16
NO CHANGE
Target $39
LEER
Outperform
Epizyme weakness unwarranted, says Leerink
Leerink analyst Seamus Fernandez says Epizyme announced during its Q2 earnings call that it now plans to report results from its two ongoing Phase 2 trials of tazemetostat in the first half of 2017, rather than at medical conferences in late 2016 as previously anticipated. The analyst believes the delay may allow for data to mature and says the weakness in the stock is unwarranted. Fernandez reiterates an Outperform rating and $39 price target on the shares.
09/21/16
09/21/16
NO CHANGE

Epizyme collaborates with Foundation Medicine for tazemetostat Phase 2 trial
Epizyme (EPZM) has entered into a collaboration agreement with Foundation Medicine FMI) to support patient identification and enrollment for Epizyme's ongoing Phase 2 clinical trial of tazemetostat in patients with non-Hodgkin lymphoma. Foundation Medicine's SmartTrials Precision Enrollment Program and FoundationOne Heme panel will assist in identifying a population of individuals with NHL who harbor EZH2 mutations and constitute specific cohorts in the Epizyme trial. Tazemetostat is Epizyme's oral, first-in-class EZH2 inhibitor being investigated in multiple ongoing clinical trials. Early clinical data suggest tazemetostat has encouraging clinical activity and a favorable safety profile in patients with relapsed and refractory NHL.

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