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REPH

Recro Pharma

$7.76

-0.23 (-2.88%)

07:13
11/28/16
11/28
07:13
11/28/16
07:13

Recro Pharma meloxicam Phase III clinical trial achieves primary endpoint

Recro Pharma announced positive results from its second of two Phase III clinical trials evaluating intravenous meloxicam for the treatment of acute postoperative pain. In this trial, IV meloxicam achieved the primary endpoint of a statistically significant difference in Summed Pain Intensity Difference, or SPID, over the first 24 hours, or SPID24, compared to placebo, in patients following abdominoplasty surgery. With the positive data from this study, the company believes this completes the efficacy program for the IV meloxicam New Drug Application, or NDA. In this multicenter, randomized, double-blind, placebo-controlled clinical trial, 219 patients were enrolled and randomly assigned to receive a postoperative regimen of IV meloxicam or placebo in a 1:1 ratio, once every 24 hours. The IV meloxicam treatment arm demonstrated a statistically significant reduction in SPID24 compared to the placebo arm. The study also achieved statistical significance for 10 of the secondary endpoints, including statistically significant differences in SPID12, time to perceptible pain relief, subjects with greater than or equal to 30% improvement at 24 hours, number of times patients required rescue in the first 24 hours after randomization, as well as number of times rescued from 24 to 48 hours, and several other pain relief metrics, compared to placebo. The safety results demonstrated that IV meloxicam was well tolerated with no difference in serious adverse events, or SAEs, related to bleeding for IV meloxicam treated patients versus placebo. There were two additional SAEs observed in the placebo group. The most common adverse events, or AEs, were nausea, headache, vomiting, and dizziness. The incidence of these events was lower than those observed in the placebo group. The majority of AEs were mild in nature and one patient in the placebo group discontinued treatment due to an adverse event of post-procedural bleeding. There were no meaningful differences between treatment groups in vital signs, ECGs or clinical lab assessments.

  • 29

    Nov

REPH Recro Pharma
$7.76

-0.23 (-2.88%)

08/29/16
JANY
08/29/16
INITIATION
JANY
Buy
Recro Pharma initiated with a Buy at Janney Capital
Target $21.
08/29/16
08/29/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Netflix (NFLX) initiated with a Sell at Axiom by analyst Victor Anthony, who set an $80 price target on shares of the streaming service operator. The company's is seeing rising competition and diminishing pricing power, Anthony tells investors in a research note. He adds that rising content costs will pressure Netflix's ability to meet Street estimates. 2. Invuity (IVTY) initiated with a Buy rating and $25 price target by Craig-Hallum analyst Charles Haff, who believes the company's surgical lighting products offer higher quality resolution and are safer and more effective than the current standard of care in minimally-invasive procedures. 3. Recro Pharma (REPH) initiated by Janney Capital analyst Ken Trbovich with a Buy rating and $21 fair value estimate. 4. Neuralstem (CUR) initiated by Roth Capital analyst Joseph Pantginis with a Buy rating and $1.20 price target. 5. At Home Group (HOME) initiated with an Outperform rating at William Blair and with a Buy rating and $20 price target at Jefferies. To see The Fly's full Street Research coverage, Reference Link
09/16/16
ROTH
09/16/16
INITIATION
Target $24
ROTH
Buy
Recro Pharma initiated with a Buy at Roth Capital
Roth Capital analyst Scott Henry started Recro Pharma with a Buy rating and $24 price target.
10/03/16
BMUR
10/03/16
INITIATION
Target $21
BMUR
Buy
Recro Pharma coverage assumed with a Buy at Brean Capital
Brean Capital analyst Difei Yang assumed coverage on Recro Pharma with a Buy rating citing upcoming catalysts and its lead product candidate which could serve as a non-opioid alternative for pain management. Yang placed a $21 price target on Recro Pharma shares, which is reduced from the firm's prior price target of $28.

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