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GEMP

Gemphire Therapeutics

$9.70

0.1 (1.04%)

11:12
11/28/16
11/28
11:12
11/28/16
11:12

Gemphire Therapeutics enrolls first patient in ROYAL-1 trial

Gemphire Therapeutics announced enrollment of its first patients in ROYAL-1, a Phase 2b trial designed to investigate gemcabene in the treatment of patients with hypercholesterolemia not adequately controlled on high-intensity or moderate-intensity stable statin therapy. It is designed to enroll a broad patient population, including patients with heterozygous familial hypercholesterolemia and atherosclerotic cardiovascular disease, who have baseline LDL-C, or "bad cholesterol," values greater than or equal to 100 mg/dL. The randomized, placebo-controlled, double-blind Phase 2b trial, "A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins," will enroll up to 104 adult patients at clinical sites in the United States. Patients meeting eligibility requirements are being randomized in a 1:1 ratio to 600mg of gemcabene or placebo. The primary endpoint is the percent change from baseline of LDL-C at 12 weeks. Secondary endpoints include the change from baseline in non-HDL-C, total cholesterol, triglycerides, ApoB, and hsCRP at the 12-week time point. Gemphire currently anticipates the 12-week study to complete enrollment and all patient follow-up visits in the second half of 2017. The company re-issued its initial press release to correct that in the original the phrase "The open-label" should have read "The randomized, placebo-controlled, double-blind".

  • 06

    Dec

GEMP Gemphire Therapeutics
$9.70

0.1 (1.04%)

08/30/16
JEFF
08/30/16
INITIATION
Target $15
JEFF
Buy
Gemphire Therapeutics initiated with a Buy at Jefferies
Jefferies analyst Matthew Andrews started Gemphire Therapeutics with a Buy rating and $15 price target. The company's gemcabene has a favorable profile in the broad dyslipidemia market, Andrews tells investors in a research note.
08/30/16
ADAM
08/30/16
INITIATION
Target $17
ADAM
Buy
Gemphire Therapeutics initiated with a Buy at Canaccord
Canaccord Genuity analyst John Newman started Gemphire Therapeutics with a Buy rating and $17 price target. The company's oral cholesterol drug gemcabene has a $2.8B U.S. peak market potential, Newman tells investors in a research note.
08/30/16
RBCM
08/30/16
INITIATION
Target $25
RBCM
Outperform
Gemphire Therapeutics initiated with an Outperform at RBC Capital
RBC Capital analyst Adnan Butt started Gemphire Therapeutics with an Outperform rating and $25 price target.
08/30/16
08/30/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. BofA Merrill Lynch resumed coverage on Hershey (HSY) with an Underperform rating and $100 price target, as the firm expects shares to trade on fundamentals, which are under pressure. Last night, Mondelez (MDLZ) announced it has ended discussions with Hershey regarding a possible combination of the two companies. 2. eBay (EBAY) initiated with a Long-Term Buy at Hilliard Lyons by analyst Stephen Turner , who set a $35 price target on the stock. 3. Galapagos NV (GLPG) initiated with a Buy at Janney Capital by Debjit Chattopadhyay, who said that filgotinib, the company's oral JAK inhibitor, is "shaping up to be a blockbuster." 4. Gemphire Therapeutics (GEMP) initiated with with a Buy rating and $17 price target by Canaccord Genuity analyst John Newman and with a Buy rating and $15 price target by Jefferies analyst Matthew Andrews. 5. Sophiris Bio (SPHS) initiated with an an Overweight rating and $7 price target by Piper Jaffray analyst Charles Duncan. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

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