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VBLT

VBL Therapeutics

07:02
11/29/16
11/29
07:02
11/29/16
07:02

VBL Therapeutics announces OS data for VB-111 Phase 2 study

VBL Therapeutics announced top-line results from its exploratory Phase 2 study of VB-111 in patients with advanced, differentiated thyroid cancer. As previously announced, this trial met its primary endpoint, which was defined as 25% progression-free survival at 6 months, in heavily-pretreated patients with late-stage disease. A dose-dependent response was seen, with 35% of patients reaching PFS-6 in the therapeutic dose cohort, versus 25% in a low-dose cohort. Given this positive clinical response, the Company continued to follow patients for overall survival, or OS, data, which was not a primary endpoint. Although the trial included a small number of patients and was not powered to show OS differences, the new data show a dose-response and evidence of an overall survival benefit in the cohort of patients treated with multiple therapeutic doses of VB-111, compared to patients who received a single low dose of VB-111. Only one patient remained alive in the low-dose cohort, compared to a tail of about 50% in the high dose group.

  • 29

    Nov

VBLT VBL Therapeutics

06/06/16
CHDN
06/06/16
NO CHANGE
CHDN
VBL Therapeutics data provides enhanced visibility, says Chardan
Chardan noted that VBL announced that in a Phase II trial involving glioblastoma multiforme patients, VBL's VB-111 drug followed by VB-111 with Avastin led to a statistically significant increase in median overall survival, or OS, of 59 weeks compared to 32 weeks of OS in patients who received VB-111 followed by Avastin only. The firm says that the data reduces the uncertainty of the Phase III trial of VB-111 and "further reinforces the unprecedented nature" of VB-111's Phase II data. The firm keeps a $20 price target and Buy rating on the shares.
06/06/16
ROTH
06/06/16
NO CHANGE
Target $22
ROTH
Buy
VBL Therapeutics' ASCO presentations underscore potential, says Roth Capital
Roth Capital analyst Joseph Pantginis said VBL Therapeutics' two poster presentations on VB-111 at ASCO underscore the platform's potential in various cancers. Most notably, maturing data from an ongoing trial in ovarian cancer showed an "impressive" dose-response relationship, said Pantginis, who keeps a Buy rating and $22 price target on VBL shares.
06/07/16
CHDN
06/07/16
NO CHANGE
Target $20
CHDN
Buy
Chardan continues to see significant upside for VBL Therapeutics
Chardan continues to see significant upside for VBL Therapeutics shares given VB-111 has convincing efficacy signals for rGBM, ovarian, and thyroid cancer types, an immune-therapeutic effect for VB-111 has been supported in the rGBM and ovarian trials, and the product has orphan drug designations in the US and Euripe for rGBM, Fast Track designation by the FDA for rGBM, and a special protocol assessment by the FDA for the Phase III program in rGBM. Chardan rates VBL Therapeutics a Buy with a $20 price target on shares.
06/28/16
HCWC
06/28/16
INITIATION
Target $11
HCWC
Buy
VBL Therapeutics initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Swayampakula Ramakanth started VBL Therapeutics with a Buy rating and $11 price target.

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