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CYTR

CytRx

$0.56

-0.0079 (-1.40%)

07:02
11/29/16
11/29
07:02
11/29/16
07:02

CytRx reports 'positive' results from Phase 3 Aldoxorubicin trial

CytRx announced positive updated results from its pivotal Phase 3 clinical trial evaluating aldoxorubicin compared to investigator's choice in patients with relapsed or refractory soft tissue sarcomas. The study, which enrolled 433 patients, demonstrated a statistically significant improvement in progression-free survival between aldoxorubicin and investigator's choice therapy in 246 patients with leiomyosarcoma and liposarcoma, (p=0.007). The hazard ratio was 0.62 (95% CI 0.44-0.88), representing a 38% reduction in the risk of tumor progression for patients receiving aldoxorubicin versus investigator's choice. Leiomyosarcoma and liposarcoma are the two most common types of STS and accounted for 57% of the patients enrolled in the trial. Aldoxorubicin demonstrated a statistically significant improvement in PFS over investigator's choice in 312 patients treated in North America (p=0.028; HR=0.71, 95% CI 0.53-0.97). Notably, aldoxorubicin performed better than investigator's choice for the entire study population and narrowly missed statistical significance (p=0.12; HR=0.81, 95% CI 0.64-1.06). All responses were determined by an independent, blinded central lab assessment of scans. CytRx plans to submit the results of this clinical trial for presentation at an upcoming major scientific meeting.

CYTR CytRx
$0.56

-0.0079 (-1.40%)

01/07/16
JEFF
01/07/16
INITIATION
Target $3
JEFF
Hold
CytRx initiated with a Hold at Jefferies
Jefferies analyst Chris Howerton started CytRx with a Hold rating and $3 price target. The stock is fairly valued given the opportunity for Aldoxorubicin in 2nd-line soft tissue sarcoma, the analyst tells investors in a research note.
01/07/16
01/07/16
INITIATION

On The Fly: Analyst Initiation Summary
Today's noteworthy initiations include: Agilent (A) initiated with a Hold at Deutsche Bank... Alexion (ALXN) initiated with a Buy at SunTrust... Alibaba (BABA) initiated with an Outperform at Baird... Bruker (BRKR) initiated with a Market Perform at Avondale... Care Capital Properties (CCP) initiated with a Neutral at Mizuho... Celgene (CELG) initiated with a Buy at SunTrust... Cepheid (CPHD) initiated with an Outperform at Avondale... Community Bank System (CBU) initiated with a Neutral at Piper Jaffray... CytRx (CYTR) initiated with a Hold at Jefferies... Del Taco (TACO) initiated with a Buy (yesterday) at BTIG... Depomed (DEPO) initiated with a Neutral at Mizuho... Ensco (ESV) initiated with an Equal Weight at Stephens... FCB Financial (FCB) initiated with a Buy at Gabelli... FactSet (FDS) initiated with a Hold at Evercore ISI... Fluidigm (FLDM) initiated with a Buy at Deutsche Bank... GTT Communications (GTT) initiated with an Overweight at Stephens... IBERIABANK (IBKC) initiated with a Neutral at Piper Jaffray... Illumina (ILMN) initiated with a Hold at Deutsche Bank... InspireMD (NSPR) initiated with a Buy at Rodman & Renshaw... Johnson Controls (JCI) initiated with an Outperform at Oppenheimer... McGraw Hill Financial (MHFI) initiated with a Buy at Evercore ISI... Moody's (MCO) initiated with a Hold at Evercore ISI... Myriad Genetics (MYGN) initiated with a Buy at Deutsche Bank... NBT Bancorp (NBTB) initiated with a Neutral at Piper Jaffray... Omnicell (OMCL) initiated with a Buy at Benchmark... Ophthotech (OPHT) initiated with a Buy at SunTrust... Paycom (PAYC) initiated with an Outperform at Baird... Paylocity (PCTY) initiated with an Outperform at Baird... PerkinElmer (PKI) initiated with a Hold at Deutsche Bank... Rowan Companies (RDC) initiated with an Equal Weight at Stephens... Shopify (SHOP) initiated with an Outperform at Baird... Syngenta (SYT) initiated with a Neutral at Macquarie... Thermo Fisher (TMO) initiated with a Buy at Deutsche Bank... Trovagene (TROV) initiated with a Market Perform at Avondale... UTi Worldwide (UTIW) to host special shareholder meeting... Waters (WAT) initiated with a Hold at Deutsche Bank... Wayfair (W) initiated with a Neutral at Baird... Willis Towers Watson (WLTW) initiated with an Underweight at JPMorgan.
07/12/16
FBRC
07/12/16
NO CHANGE
Target $3
FBRC
Outperform
CytRx price target lowered to $3 from $8 at FBR Capital
FBR Capital analyst Christopher James cut his price target for CytRx to $3 after the company's Phase III study with aldoxorubicin in patients with relapsed or refractory soft-tissue sarcoma was unable to meet its primary endpoint. Despite missing on the endpoint, aldoxorubicin demonstrated clear clinical activity, with an objective response rate nearly double the rate observed within the comparator arm, James tells investors in a research note. He keeps an Outperform rating on CytRx. In pre-market trading, the stock is down 69% to 77c.
07/12/16
JEFF
07/12/16
NO CHANGE
Target $0.75
JEFF
Hold
CytRx price target lowered to 75c from $2.50 at Jefferies
Jefferies analyst Chris Howerton cut his price target for CytRx to 75c from $2.50 after removing aldoxorubicin from his model following today's study failure. The analyst does not see a path forward for the drug in soft tissue sarcomas or any other indications. He keeps a Hold rating on the name. FBR Capital analyst Christopher James said this morning that despite missing on the endpoint, aldoxorubicin demonstrated clear clinical activity, with an objective response rate nearly double the rate observed within the comparator arm. CytRx is down 62% to 95c in late morning trading.

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