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CALA

Calithera Biosciences

$3.35

-0.05 (-1.47%)

18:05
11/29/16
11/29
18:05
11/29/16
18:05

Calithera Biosciences reports Phase 1 data on kidney cancer treatment

Calithera Biosciences announced that clinical data from its lead product candidate CB-839, a first-in-class glutaminase inhibitor, will be presented at the EORTC-NCI-AACR Symposium. "The data demonstrate the clinical activity, tolerability and unique mechanism of action of CB-839 in patients with renal cell carcinoma," the company noted, adding that "we are pleased to present combination data of CB-839 with everolimus that demonstrates high rates of disease control with a well-tolerated combination therapy." On the specific Phase 1 data to be presented, Calithera noted: "As of October 25, 15 renal cell carcinoma patients were treated and evaluable for response, including 12 clear cell patients, and three papillary patients. Ninety-three percent have disease control; one patient has a partial response, one patient has progressive disease, and 13 patients have stable disease. The median progression free survival is 8.5 months and for the majority of patients, their time on therapy is longer than their time on treatment in their prior therapy. In the clear cell patient population the disease control rate is 100% and eight patients remain on study. For comparison, in a separate trial of everolimus vs. cabozantinib, the progression free survival of patients in the everolimus group from the Meteor Phase 3 study in second and third line patients was 3.9 months... The addition of CB-839 to full dose everolimus has been well tolerated, with a similar safety profile to the known profile of everolimus alone. Grade 3 events include two events of hyperglycemia and one event each of diarrhea, anemia and fatigue." The company said that, on the basis of this efficacy and safety data, it plans to continue development in combination therapy for clear cell renal cell carcinoma.

CALA Calithera Biosciences
$3.35

-0.05 (-1.47%)

10/25/16
SBSH
10/25/16
INITIATION
Target $1
SBSH
Sell
Calithera Biosciences initiated with a Sell at Citi
Citi analyst Robyn Karnauskas started Calithera Biosciences with a Sell rating and $1 price target. The company is targeting cancer metabolism but it could take a long time before meaningful data is seen, Karnauskas tells investors in a research note. The analyst sees a lack of potentially stock moving catalysts.

TODAY'S FREE FLY STORIES

HLX

Helix Energy

$7.41

-0.32 (-4.14%)

19:24
02/20/17
02/20
19:24
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19:24
Earnings
Helix Energy reports Q4 EPS with items (46c), may not compare to consensus (6c) »

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    Feb

CSII

Cardiovascular Systems

$29.19

0.76 (2.67%)

19:21
02/20/17
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Cardiovascular Systems reports one-year data from COAST study »

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CRMT

America's Car-Mart

$38.85

-1.15 (-2.88%)

19:17
02/20/17
02/20
19:17
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19:17
Earnings
America's Car-Mart reports Q3 EPS 35c, may not compare to consensus 64c »

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ROG

Rogers Corporation

$78.80

-1.34 (-1.67%)

19:12
02/20/17
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19:12
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19:12
Earnings
Rogers Corporation sees Q1 adjusted EPS $1.09-$1.19, consensus 99c »

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ROG

Rogers Corporation

$78.80

-1.34 (-1.67%)

19:11
02/20/17
02/20
19:11
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19:11
Earnings
Rogers Corporation reports Q4 EPS 94c, consensus 82c »

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HBHC

Hancock Holding

$46.80

-0.2 (-0.43%)

, FNBC

First NBC Bank

$4.75

-0.25 (-5.00%)

19:04
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Hancock Holding says gets approval to close First NBC Bank transaction »

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HBHC

Hancock Holding

$46.80

-0.2 (-0.43%)

FNBC

First NBC Bank

$4.75

-0.25 (-5.00%)

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NDSN

Nordson

$119.95

0.77 (0.65%)

19:03
02/20/17
02/20
19:03
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19:03
Earnings
Nordson sees Q2 EPS $1.21-$1.33, consensus $1.22 »

Sees Q2 revenue up 3%-7%.…

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NDSN

Nordson

$119.95

0.77 (0.65%)

19:01
02/20/17
02/20
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Hot Stocks
Breaking Hot Stocks news story on Nordson »

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  • 21

    Feb

NDSN

Nordson

$119.95

0.77 (0.65%)

19:00
02/20/17
02/20
19:00
02/20/17
19:00
Earnings
Nordson reports Q1 EPS 86c, consensus 82c »

Reports Q1 revenue $407M,…

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  • 21

    Feb

NDSN

Nordson

$119.95

0.77 (0.65%)

18:57
02/20/17
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18:57
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Nordson to acquire Vention AT for $705M »

Nordson announced it has…

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  • 21

    Feb

CYH

Community Health

$6.90

-0.22 (-3.09%)

18:55
02/20/17
02/20
18:55
02/20/17
18:55
Earnings
Community Health sees FY17 cont ops EPS 30c-$1.10 »

EPS consensus 61c. Sees…

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CYH

Community Health

$6.90

-0.22 (-3.09%)

18:51
02/20/17
02/20
18:51
02/20/17
18:51
Earnings
Community Health reports Q4 adjusted EPS 46c, may not compare to consensus 13c »

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  • 21

    Feb

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  • 21

    Mar

HSIC

Henry Schein

$168.11

0.86 (0.51%)

18:47
02/20/17
02/20
18:47
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18:47
Hot Stocks
Henry Schein to acquire Southern Anesthesia + Surgical »

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UIHC

United Insurance

$15.95

0.01 (0.06%)

18:45
02/20/17
02/20
18:45
02/20/17
18:45
Earnings
United Insurance reports Q4 EPS (49c), consensus (39c) »

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  • 21

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VIPS

Vipshop

$12.16

-0.13 (-1.06%)

18:40
02/20/17
02/20
18:40
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18:40
Earnings
Breaking Earnings news story on Vipshop »

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  • 21

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VIPS

Vipshop

$12.16

-0.13 (-1.06%)

18:39
02/20/17
02/20
18:39
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18:39
Earnings
Vipshop reports Q4 adjusted income per ADS 23c, consensus 21c »

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  • 21

    Feb

WFC

Wells Fargo

$58.09

-0.03 (-0.05%)

, BK

BNY Mellon

$47.14

0.07 (0.15%)

18:36
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Wells Fargo names two new independent directors »

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WFC

Wells Fargo

$58.09

-0.03 (-0.05%)

BK

BNY Mellon

$47.14

0.07 (0.15%)

SPLS

Staples

$9.31

0.04 (0.43%)

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BIOA

BioAmber

$3.66

-0.07 (-1.88%)

18:33
02/20/17
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BioAmber says CEO Huc resigns, COO Orecchioni appointed president »

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CBB

Cincinnati Bell

$19.85

-0.65 (-3.17%)

18:31
02/20/17
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Cincinnati Bell subsidiary acquires SunTel Services »

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  • 27

    Feb

VZ

Verizon

$49.19

0.73 (1.51%)

, AAPL

Apple

$135.72

0.375 (0.28%)

18:23
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Hot Stocks
Verizon appoints Apple's Andrew McKechnie as creative chief of in-house agency »

Verizon (VZ) announced…

VZ

Verizon

$49.19

0.73 (1.51%)

AAPL

Apple

$135.72

0.375 (0.28%)

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  • 06

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NEE

NextEra Energy

$126.86

0.67 (0.53%)

18:19
02/20/17
02/20
18:19
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18:19
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NextEra Energy subsidiary says expands solar energy projects »

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  • 28

    Feb

SNX

SYNNEX

$118.37

-0.23 (-0.19%)

18:14
02/20/17
02/20
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18:14
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Raritan announces distribution agreement with SYNNEX »

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FCX

Freeport McMoRan

$14.91

-0.16 (-1.06%)

18:06
02/20/17
02/20
18:06
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18:06
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Freeport McMoRan says fails to reach deal with Indonesia, sees Q1 sales impact »

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  • 26

    Feb

WEN

Wendy's

$14.13

0.44 (3.21%)

18:01
02/20/17
02/20
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18:01
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Delight Restaurant Group acquires 30 Wendy's restaurants »

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  • 21

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CMG

Chipotle

$427.61

2.85 (0.67%)

17:59
02/20/17
02/20
17:59
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17:59
Hot Stocks
Chipotle says 'Smarter Pickup Times' technology rolled out across U.S. »

Chipotle announced it has…

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