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PFE

Pfizer

$31.92

0.38 (1.20%)

08:32
11/30/16
11/30
08:32
11/30/16
08:32

Pfizer says Reflections B3271002 study for PF-05280014 met primary endpoint

Pfizer announced that the pivotal REFLECTIONS B3271002 study, a comparative safety and efficacy study of PF-05280014 versus Herceptin, met its primary endpoint. PF-05280014 is being developed by Pfizer as a potential biosimilar to Herceptin. The trial demonstrated equivalence in the primary endpoint of objective response rate of PF-05280014 versus Herceptin, taken in combination with paclitaxel, in first line patients with HER2-positive metastatic breast cancer. ORR is defined as the proportion of patients with tumor size reduction of a predefined amount and for a minimum period of time2. "As the leading global biosimilars company, we are committed to advancing our robust pipeline of biosimilar therapies in hopes of expanding access to high-quality treatment options for patients living with serious, life-threatening conditions such as cancer," said Sumant Ramachandra, MD, PhD, MBA, Head of Research and Development, Pfizer Essential Health. "Favorable comparative clinical data between proposed biosimilars and their respective reference product contribute to physician and patient understanding of and confidence in the value and importance of biosimilars. We are encouraged by these data and look forward to sharing the complete results with health authorities and the oncology community once available." A separate comparative, randomized, double-blind clinical trial in early breast cancer patients also met its primary endpoint of steady-state Ctrough concentrations in patients treated with PF-05280014 and Herceptin.

  • 04

    Dec

PFE Pfizer
$31.92

0.38 (1.20%)

11/02/16
ARGS
11/02/16
DOWNGRADE
ARGS
Hold
Pfizer downgradedon weaker outlook at Argus
As noted earlier, Argus downgraded Pfizer to Hold from Buy. Analyst Jacob Kilstein cited "recent pipeline setbacks, prospects for increased competition, and management's decision to shelve its business separation plan" as reasons for the downgrade.
11/02/16
11/02/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Pfizer (PFE) downgraded to Hold from Buy at Argus and to Market Perform from Outperform at BMO Capital. 2. BP (BP) downgraded to Hold from Buy at Societe Generale. 3. Corning (GLW) downgraded to Buy from Conviction Buy at Goldman with analyst Doug Clark saying the restocking phase of glass/TV cyclical recovery is now "well understood and largely behind us." 4. Adeptus Health (ADPT) downgraded to Underperform from Buy at BofA/Merrill, to Hold from Buy at Jefferies, and to Equal Weight from Overweight at Stephens. 5. Brookdale Senior Living (BKD) downgraded to Underperform from Neutral at BofA/Merrill, to Market Perform from Outperform at Wells Fargo, and to Outperform from Top Pick at RBC Capital. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/29/16
LEHM
11/29/16
UPGRADE
Target $38
LEHM
Overweight
Pfizer upgraded to Overweight from Equal Weight at Barclays
Barclays analyst Geoff Meacham upgraded Pfizer to Overweight and raised its price target to $38 from $37. Meacham sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders.
11/29/16
11/29/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pfizer (PFE) upgraded to Overweight from Equal Weight at Barclays with analyst Geoff Meacham saying he sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders. 2. Comerica (CMA) upgraded to Outperform from Market Perform at Keefe Bruyette. 3. Tractor Supply (TSCO) upgraded to Buy from Neutral at Northcoast with analyst Chuck Cerankosky saying he expects the company to benefit from colder weather and the improving US economy and said product assortments and promotions have also been adjusted to the new economics of the energy patch and its impact on this company's customers. 4. Del Frisco's (DFRG) upgraded to Outperform from Neutral at Credit Suisse with analyst Jason West saying it is a key beneficiary of improved high-end consumer and corporate spending. 5. Veracyte upgraded to Buy from Neutral at Janney Capital with analyst Paul Knight saying the company's "disciplined test development, commercialization, and reimbursement processes" insulate it from a number of problems plaguing the pharma sector. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

APLP

Archrock Partners LP

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0.61 (4.67%)

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ADHD

Alcobra

, AVEO

AVEO Oncology

$0.73

0.0281 (4.02%)

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0.08 (0.24%)

BLCM

Bellicum Pharmaceuticals

$13.98

1.33 (10.51%)

BLUE

bluebird bio

$118.50

-1.8 (-1.50%)

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RIO

Rio Tinto

, GLNCY

Glencore

$7.10

0.05 (0.71%)

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GLNCY

Glencore

$7.10

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03/08/13
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ALGN

Align Technology

$149.69

0.27 (0.18%)

09:28
06/23/17
06/23
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Conference/Events
Stifel medical technology analysts hold an analyst/industry conference call »

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  • 23

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PAAS

Pan American Silver

$16.95

0.51 (3.10%)

09:28
06/23/17
06/23
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Conference/Events
Pan American Silver management to meet with JPMorgan »

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  • 29

    Jun

BAESY

BAE Systems

$34.19

-0.635 (-1.82%)

09:25
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BAE Systems rating change  »

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09:25
06/23/17
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Fed funds futures are unchanged to modestly lower »

Fed funds futures are…

CRNCY

Cairn Energy

$4.44

0.15 (3.50%)

09:24
06/23/17
06/23
09:24
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Conference/Events
Cairn Energy management to meet with JPMorgan »

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  • 29

    Jun

RHHBY

Roche

$32.30

-0.3 (-0.92%)

09:22
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06/23
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  • 26

    Jun

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P

Pandora

, SIRI

SiriusXM

09:22
06/23/17
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09:22
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Pandora, SiriusXM analyst commentary  »

Pandora selloff since…

P

Pandora

SIRI

SiriusXM

03/08/13
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  • 28

    Jun

ASML

ASML

$130.02

-0.41 (-0.31%)

09:20
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  • 29

    Aug

RGA

Reinsurance Group

09:20
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Conference/Events
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  • 28

    Jun

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HUM

Humana

, COF

Capital One

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Humana

COF

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  • 20

    Jul

SPX

S&P 500

, VIX

Volatility Index S&P 500 Options

09:18
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Options
Overnight activity included 91 trades in SPX and 17 trades in VIX »

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SPX

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VIX

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09:15
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General news
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BBBY

Bed Bath & Beyond

$33.73

0.07 (0.21%)

09:14
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  • 29

    Jun

BLCM

Bellicum Pharmaceuticals

$13.98

1.33 (10.51%)

09:13
06/23/17
06/23
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09:13
Technical Analysis
Technical View: Bellicum Pharmaceuticals drops in pre-market »

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  • 23

    Jun

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DHI

D.R. Horton

, FOR

Forestar Group

09:13
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FOR

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WGO

Winnebago

09:11
06/23/17
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Conference/Events
Winnebago management to meet with JPMorgan »

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  • 27

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