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PFE

Pfizer

$31.92

0.38 (1.20%)

08:32
11/30/16
11/30
08:32
11/30/16
08:32

Pfizer says Reflections B3271002 study for PF-05280014 met primary endpoint

Pfizer announced that the pivotal REFLECTIONS B3271002 study, a comparative safety and efficacy study of PF-05280014 versus Herceptin, met its primary endpoint. PF-05280014 is being developed by Pfizer as a potential biosimilar to Herceptin. The trial demonstrated equivalence in the primary endpoint of objective response rate of PF-05280014 versus Herceptin, taken in combination with paclitaxel, in first line patients with HER2-positive metastatic breast cancer. ORR is defined as the proportion of patients with tumor size reduction of a predefined amount and for a minimum period of time2. "As the leading global biosimilars company, we are committed to advancing our robust pipeline of biosimilar therapies in hopes of expanding access to high-quality treatment options for patients living with serious, life-threatening conditions such as cancer," said Sumant Ramachandra, MD, PhD, MBA, Head of Research and Development, Pfizer Essential Health. "Favorable comparative clinical data between proposed biosimilars and their respective reference product contribute to physician and patient understanding of and confidence in the value and importance of biosimilars. We are encouraged by these data and look forward to sharing the complete results with health authorities and the oncology community once available." A separate comparative, randomized, double-blind clinical trial in early breast cancer patients also met its primary endpoint of steady-state Ctrough concentrations in patients treated with PF-05280014 and Herceptin.

  • 04

    Dec

PFE Pfizer
$31.92

0.38 (1.20%)

11/29/16
11/29/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pfizer (PFE) upgraded to Overweight from Equal Weight at Barclays with analyst Geoff Meacham saying he sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders. 2. Comerica (CMA) upgraded to Outperform from Market Perform at Keefe Bruyette. 3. Tractor Supply (TSCO) upgraded to Buy from Neutral at Northcoast with analyst Chuck Cerankosky saying he expects the company to benefit from colder weather and the improving US economy and said product assortments and promotions have also been adjusted to the new economics of the energy patch and its impact on this company's customers. 4. Del Frisco's (DFRG) upgraded to Outperform from Neutral at Credit Suisse with analyst Jason West saying it is a key beneficiary of improved high-end consumer and corporate spending. 5. Veracyte upgraded to Buy from Neutral at Janney Capital with analyst Paul Knight saying the company's "disciplined test development, commercialization, and reimbursement processes" insulate it from a number of problems plaguing the pharma sector. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/29/16
LEHM
11/29/16
UPGRADE
Target $38
LEHM
Overweight
Pfizer upgraded to Overweight from Equal Weight at Barclays
Barclays analyst Geoff Meacham upgraded Pfizer to Overweight and raised its price target to $38 from $37. Meacham sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders.
11/02/16
11/02/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Pfizer (PFE) downgraded to Hold from Buy at Argus and to Market Perform from Outperform at BMO Capital. 2. BP (BP) downgraded to Hold from Buy at Societe Generale. 3. Corning (GLW) downgraded to Buy from Conviction Buy at Goldman with analyst Doug Clark saying the restocking phase of glass/TV cyclical recovery is now "well understood and largely behind us." 4. Adeptus Health (ADPT) downgraded to Underperform from Buy at BofA/Merrill, to Hold from Buy at Jefferies, and to Equal Weight from Overweight at Stephens. 5. Brookdale Senior Living (BKD) downgraded to Underperform from Neutral at BofA/Merrill, to Market Perform from Outperform at Wells Fargo, and to Outperform from Top Pick at RBC Capital. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/02/16
ARGS
11/02/16
DOWNGRADE
ARGS
Hold
Pfizer downgradedon weaker outlook at Argus
As noted earlier, Argus downgraded Pfizer to Hold from Buy. Analyst Jacob Kilstein cited "recent pipeline setbacks, prospects for increased competition, and management's decision to shelve its business separation plan" as reasons for the downgrade.

TODAY'S FREE FLY STORIES

DBOEY

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MESO

Mesoblast

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LIOX

Lionbridge

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CMCSA

Comcast

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DIS

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VIAB

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WAT

Waters

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CR

Crane

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1.18 (1.64%)

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  • 02

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DBOEY

Deutsche Boerse

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BCO

Brink's

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XOM

Exxon Mobil

$81.08

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TXMD

TherapeuticsMD

$5.84

0.2 (3.55%)

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MYL

Mylan

$42.16

-0.17 (-0.40%)

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MCD

McDonald's

$128.65

0.38 (0.30%)

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HSY

Hershey

$108.90

0.25 (0.23%)

16:13
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  • 01

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SSNLF

Samsung

, FB

Facebook

$135.44

0.08 (0.06%)

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SSNLF

Samsung

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SSNLF

Samsung

, HAR

Harman

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HAR

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EFX

Equifax

$129.38

0.16 (0.12%)

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MRK

Merck

$66.16

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EFX

Equifax

$129.38

0.16 (0.12%)

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  • 28

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NOK

Nokia

$5.14

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  • 27

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TGT

Target

$66.51

1.53 (2.35%)

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GPRO

GoPro

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  • 28

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LGND

Ligand

$100.38

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  • 28

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HURN

Huron

$44.30

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  • 28

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ENS

EnerSys

$75.98

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