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HTBX

Heat Biologics

$2.87

-0.11 (-3.69%)

17:32
11/30/16
11/30
17:32
11/30/16
17:32

Heat Biologics' HS-410 bladder cancer trial did not meet primary endpoint

Heat Biologics presented topline data from its 94-patient Phase II trial evaluating HS-410 in combination with standard of care, Bacillus Calmette-Guerin, or as a monotherapy, for the treatment of non-muscle invasive bladder cancer, at the Society of Urologic Oncology Annual Meeting in San Antonio, TX. Researchers reported that there were encouraging signs of anti-tumor activity as HS-410 generated a robust antigen-specific immune response to multiple tumor-associated peptides in treated patients, while there were no immune responses of this type in the placebo. However, these responses did not translate into clinical outcomes, and there was no statistically significant difference in the primary endpoint - proportion of recurrence-free survival at one year - between the vaccine and placebo arms of the trial. Heat will continue to monitor all patients enrolled in the study for an additional 12 months. At that time, Heat will make a final determination whether to progress its bladder cancer program into a Phase 3 trial.

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HTBX Heat Biologics
$2.87

-0.11 (-3.69%)

01/08/16
NBLE
01/08/16
INITIATION
Target $16
NBLE
Buy
Heat Biologics initiated with a Buy at Noble Financial
Noble Financial analyst Rahul Jasuja initiated Heat Biologics with a Buy rating and $16 price target on shares.
02/04/16
CANT
02/04/16
DOWNGRADE
CANT
Speculative Buy
Heat Biologics downgraded to Speculative Buy from Buy at Cantor
Cantor Fitzgerald downgraded Heat Biologics to Speculative Buy saying the partial clinical hold for HS-410 adds uncertainty. The analyst has a fair value range for shares of $2-$12.
02/04/16
02/04/16
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: Anglo Platinum (AGPPY) downgraded to Neutral from Overweight at JPMorgan... Buffalo Wild Wings (BWLD) downgraded to Neutral from Buy at Longbow... Changyou.com (CYOU) downgraded to Neutral from Outperform at Credit Suisse... Enbridge (ENB) downgraded to Neutral from Outperform at Credit Suisse... Esterline (ESL) downgraded to Hold at Drexel Hamilton... Franco-Nevada (FNV) downgraded to Neutral from Outperform at Credit Suisse... GoPro (GPRO) downgraded on results, guidance at Sterne Agee CRT... Heat Biologics (HTBX) downgraded to Speculative Buy from Buy at Cantor... Illumina (ILMN) downgraded to Hold from Buy at Canaccord... Intrawest Resorts (SNOW) downgraded to Neutral from Outperform at Macquarie... Match Group (MTCH) downgraded to Equal Weight from Overweight at Barclays... Memorial Resource (MRD) downgraded to Hold from Accumulate at Tudor Pickering... Pacific Biosciences (PACB) downgraded to Neutral from Overweight at Piper Jaffray... Peabody (BTU) downgraded to Underperform from Market Perform at FBR Capital... Peak Resorts (SKIS) downgraded to Underperform from Neutral at Macquarie... PennyMac Mortgage (PMT) downgraded to Market Perform from Outperform at Wells Fargo... Petrobras (PBR) downgraded to Underweight from Neutral at JPMorgan... Sensata (ST) downgraded to Neutral from Overweight at Atlantic Equities... Shutterfly (SFLY) downgraded to Neutral from Buy at BofA/Merrill... Star Bulk Carriers (SBLK) downgraded to Neutral from Speculative Buy at Seaport Global... Synchronoss (SNCR) downgraded at Stifel... Wabtec (WAB) downgraded to Neutral from Buy at Goldman.
06/20/16
ROTH
06/20/16
INITIATION
Target $2.75
ROTH
Buy
Heat Biologics initiated with a Buy at Roth Capital
Roth Capital analyst Joseph Pantginis started Heat Biologics with a Buy rating and $2.75 price target. Heat owns a "portfolio of unique, differentiated vaccines," Pantginis tells investors in a research note.

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