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BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

, CELG

Celgene

$118.51

-3.62 (-2.96%)

18:01
11/30/16
11/30
18:01
11/30/16
18:01

bluebird bio jumps after early data on CAR-T myeloma treatment

As part of an announcement of presentations at an upcoming medical symposium, bluebird bio (BLUE) reported interim data from the Phase 1 study of bb2121, its CAR-T treatment candidate for relapsed refractory multiple myeloma. As of the November 18 cut-off, 11 patients had been enrolled and dosed in four cohorts. All 11 dosed patients were evaluable for safety, and the first nine patients have undergone their first multiple myeloma tumor restaging and were evaluable for efficacy. One hundred percent of patients in the second and third cohorts achieved an objective response. Two patients are MRD-negative, and the overall response rate was 78%. Two patients achieved stringent complete responses, with six and four months follow-up. All patients in cohorts two and three with bone marrow involvement at baseline had no detectable multiple myeloma cells in their bone marrow on day 14 or beyond. Among all dosed patients, no dose-limiting toxicities were observed to date, and no Grade 3 or 4 cytokine release syndrome or neurotoxicity was observed. Commenting on the news, Chief Medical Officer David Davidson said the company is "pleased" with the early data, adding that "in light of these positive data, and thanks to the multiple participating clinical sites and centralized manufacturing infrastructure we and our partner Celgene (CELG) have built for this program, we anticipate efficiently completing the dose escalation stage of the trial and initiating the expansion cohort." PRICE ACTION: Shares of bluebird bio are up 14.3% to $69.00 in after-hours trading, while Celgene is up 0.92%.

BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

CELG

Celgene

$118.51

-3.62 (-2.96%)

  • 30

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    Nov

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  • 04

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BLUE bluebird bio
$60.35

-4.05 (-6.29%)

11/23/16
JANY
11/23/16
NO CHANGE
JANY
Weakness in bluebird bio unwarranted after Juno trial halt, says Janney Capital
11/23/16
11/23/16
NO CHANGE

Buy
bluebird bio weakness unwarranted after Juno trial halt, says Janney Capital
As previously reported, Janney Capital analyst Debjit Chattopadhyay said the weakness in bluebird bio (BLUE) is unwarranted on the heels of Juno's (JUNO) second clinical hold for JCAR015. Chattopadhyay notes several key differences between JCAR015 and bluebird's bb2121, including their targets, diseases, vectors, preconditioning regimens and others. He remains a buyer of bluebird ahead of a "potentially watershed ASH for its lentiglobin platform" and keeps a Buy rating on the stock.
11/23/16
PIPR
11/23/16
NO CHANGE
PIPR
Piper says CAR-T researchers must heed risks highlighted by Juno news
Piper Jaffray analyst Joshua Schimmer said the CAR-T field has "taken another step back" after Juno Therapeutics (JUNO) put a hold on its JCAR015 trial again due to fatal cerebral edema and cautioned companies exploring these therapies to be mindful of "unnecessarily aggressive development and under-appreciation of the potent and possibly highly toxic nature" of the approach. However, Schimmer expressed his confidence that companies he covers in the CAR-T space - namely bluebird bio (BLUE), Cellectis (CLLS), Celgene (CELG), Bellicum Pharmaceuticals (BLCM), Lion Biotechnologies (LBIO) and NantKwest (NK) - will "respect the power of these platforms and remember patients' lives are more important than stock prices."
11/29/16
PIPR
11/29/16
NO CHANGE
PIPR
Piper sees bluebird regaining 'mojo and momentum'
After hosting management for an investor dinner, Piper Jaffray analyst Joshua Schimmer sees bluebird bio regaining its "mojo and momentum." The analyst expects a "steady stream of positive updates and derisking" starting with BCMA CAR-T data update this week and extending into optimizing LentiGlobin's profile for sickle cell and betathal in 2017. Schimmer has an Overweight rating on bluebird shares with a $95 price target. The biotechnology company closed yesterday down 5% to $60.65.
CELG Celgene
$118.51

-3.62 (-2.96%)

11/09/16
STPT
11/09/16
DOWNGRADE
STPT
Hold
Celgene downgraded to Hold from Buy at Standpoint Research
11/09/16
PIPR
11/09/16
NO CHANGE
PIPR
Piper sees improving environment for Biopharma M&A
The biotech sector is seeing a "massive relief rally" given the "surprise trifecta" of a Republican sweep, the voting down of Prop 61 in California and U.S. dollar weakness, Piper Jaffray analyst Joshua Schimmer tells investors in a research note. The door is now open to discuss potential repatriation of cash outside the U.S., which could be a green light on mergers and acquisitions, the analyst adds. He points out that Amgen (AMGN) and Gilead (GILD) hold the most overseas cash, with Celgene (CELG) and Biogen (BIIB) holding several billion as well. Schimmer believes the broader environment may be improving for M&A. He cautions, though, that the election of Trump does not remove the "major drug pricing overhang question."
11/28/16
OPCO
11/28/16
INITIATION
Target $141
OPCO
Outperform
Celgene initiated with an Outperform at Oppenheimer
Oppenheimer analyst Leah Cann initiated Celgene with an Outperform rating and $141 price target, estimating that revenue will grow at a compound annual growth rate of 19% per year for the next five years and that its GAAP EPS can grow by a 31% CAGR over the same span.

TODAY'S FREE FLY STORIES

ADNT

Adient

$63.20

-1.63 (-2.51%)

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Conference/Events
Adient to hold a meeting »

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GIS

General Mills

$55.52

-0.65 (-1.16%)

, MON

Monsanto

$117.25

-0.55 (-0.47%)

20:25
06/27/17
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Earnings
Notable companies reporting before tomorrow's open »

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General Mills

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MON

Monsanto

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PAYX

Paychex

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AAPL

Apple

$143.73

-2.09 (-1.43%)

19:32
06/27/17
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Periodicals
Apple looks to hire 'Siri Event Maven,' 9to5Mac reports »

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TOSBF

Toshiba, also use TOSYY

$2.60

-0.09 (-3.35%)

, TOSYY

Toshiba, also use TOSBF

$15.67

-0.24 (-1.51%)

19:22
06/27/17
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Periodicals
Toshiba to face holder wrath after failing to sell chip unit, Reuters says »

Toshiba is anticipated to…

TOSBF

Toshiba, also use TOSYY

$2.60

-0.09 (-3.35%)

TOSYY

Toshiba, also use TOSBF

$15.67

-0.24 (-1.51%)

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FB

Facebook

$150.58

-3.01 (-1.96%)

19:21
06/27/17
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Periodicals
Facebook previously explored effort to promote flu shots, CNBC reports »

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AAPL

Apple

$143.73

-2.09 (-1.43%)

19:15
06/27/17
06/27
19:15
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19:15
Hot Stocks
Munster lays out five-year Apple model, sees 'Apple Glasses' wearable in 2020 »

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GOOG

Alphabet

$927.33

-24.94 (-2.62%)

, GOOGL

Alphabet Class A

$948.09

-24 (-2.47%)

19:02
06/27/17
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19:02
Hot Stocks
Senator urges FTC oversight of Google in wake of Europe fine »

Senator Richard…

GOOG

Alphabet

$927.33

-24.94 (-2.62%)

GOOGL

Alphabet Class A

$948.09

-24 (-2.47%)

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APO

Apollo Global

$25.90

-0.33 (-1.26%)

18:58
06/27/17
06/27
18:58
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18:58
Periodicals
Apollo Global hits record-breaking $23.5B target for buyout fund, WSJ says »

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QCOM

Qualcomm

$55.43

-1.13 (-2.00%)

18:54
06/27/17
06/27
18:54
06/27/17
18:54
Periodicals
Judge says FTC suit against Qualcomm can proceed, Reuters reports »

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LNEGY

Linde

$19.25

0.08 (0.42%)

18:53
06/27/17
06/27
18:53
06/27/17
18:53
Periodicals
Linde unit agrees to $20M settlement deal in whistleblower case, Reuters says »

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HCHC

HC2 Holdings

$5.82

0.03 (0.52%)

18:50
06/27/17
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Hot Stocks
HC2 Holdings subsidiary to acquire major interest in DTVA »

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MRK

Merck

$65.54

-0.38 (-0.58%)

18:38
06/27/17
06/27
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18:38
Periodicals
Merck's cholesterol drug anacetrapib could serve as catalyst, Barron's reports »

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TROX

Tronox

$13.52

-0.25 (-1.82%)

18:37
06/27/17
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18:37
Hot Stocks
Tronox elects Kaufthal as non-executive chairman »

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ANCUF

Alimentation Couche-Tard

$49.16

1.0803 (2.25%)

, CST

CST Brands

$48.53

-0.01 (-0.02%)

18:19
06/27/17
06/27
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18:19
Hot Stocks
Alimentation Couche-Tard cleared in Canada for acquisition of CST Brands »

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ANCUF

Alimentation Couche-Tard

$49.16

1.0803 (2.25%)

CST

CST Brands

$48.53

-0.01 (-0.02%)

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MSLI

Merus Labs

$1.23

-0.0015 (-0.12%)

18:01
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Merus Labs reminds shareholders to vote for arrangement with Norgine »

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EIGI

Endurance

$8.20

-0.15 (-1.80%)

18:01
06/27/17
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Endurance chief administration officer Andreasen to leave company »

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HII

Huntington Ingalls

$186.97

0.68 (0.37%)

17:41
06/27/17
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Huntington Ingalls receives contract modifications to incorporate upgrades »

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IP

International Paper

$56.18

-0.55 (-0.97%)

17:34
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International Paper agrees to settle Kleen Products class action litigation »

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HUSA

Houston American Energy

$0.67

0.0385 (6.10%)

17:33
06/27/17
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17:33
Syndicate
Houston American Energy requests withdrawal of registration statement »

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KBH

KB Home

$22.82

0.04 (0.18%)

, RYI

Ryerson

$9.00

-0.1 (-1.10%)

17:24
06/27/17
06/27
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17:24
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS: KB…

KBH

KB Home

$22.82

0.04 (0.18%)

RYI

Ryerson

$9.00

-0.1 (-1.10%)

AVAV

AeroVironment

$32.49

1.52 (4.91%)

CAMP

CalAmp

$19.25

-0.37 (-1.89%)

GMRE

Global Medical REIT

$9.83

0.07 (0.72%)

WLL

Whiting Petroleum

$5.48

0.04 (0.74%)

OAS

Oasis Petroleum

$7.93

0.21 (2.72%)

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CHKE

Cherokee

17:22
06/27/17
06/27
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17:22
Hot Stocks
Breaking Hot Stocks news story on Cherokee »

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KBH

KB Home

$22.82

0.04 (0.18%)

17:16
06/27/17
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Hot Stocks
KB Home sees Q3 housing revenue $1.08B-$1.15B »

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KBH

KB Home

$22.82

0.04 (0.18%)

17:16
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Hot Stocks
KB Home raises FY17 housing revenue view to $4.2B-$4.4B from $4B-$4.3B »

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  • 27

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General news
Breaking General news story  »

Minneapolis Federal…

CHKE

Cherokee

17:13
06/27/17
06/27
17:13
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17:13
Hot Stocks
Cherokee receives listing notice over late 10-Q »

Cherokee announced that…

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