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BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

, CELG

Celgene

$118.51

-3.62 (-2.96%)

18:01
11/30/16
11/30
18:01
11/30/16
18:01

bluebird bio jumps after early data on CAR-T myeloma treatment

As part of an announcement of presentations at an upcoming medical symposium, bluebird bio (BLUE) reported interim data from the Phase 1 study of bb2121, its CAR-T treatment candidate for relapsed refractory multiple myeloma. As of the November 18 cut-off, 11 patients had been enrolled and dosed in four cohorts. All 11 dosed patients were evaluable for safety, and the first nine patients have undergone their first multiple myeloma tumor restaging and were evaluable for efficacy. One hundred percent of patients in the second and third cohorts achieved an objective response. Two patients are MRD-negative, and the overall response rate was 78%. Two patients achieved stringent complete responses, with six and four months follow-up. All patients in cohorts two and three with bone marrow involvement at baseline had no detectable multiple myeloma cells in their bone marrow on day 14 or beyond. Among all dosed patients, no dose-limiting toxicities were observed to date, and no Grade 3 or 4 cytokine release syndrome or neurotoxicity was observed. Commenting on the news, Chief Medical Officer David Davidson said the company is "pleased" with the early data, adding that "in light of these positive data, and thanks to the multiple participating clinical sites and centralized manufacturing infrastructure we and our partner Celgene (CELG) have built for this program, we anticipate efficiently completing the dose escalation stage of the trial and initiating the expansion cohort." PRICE ACTION: Shares of bluebird bio are up 14.3% to $69.00 in after-hours trading, while Celgene is up 0.92%.

BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

CELG

Celgene

$118.51

-3.62 (-2.96%)

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BLUE bluebird bio
$60.35

-4.05 (-6.29%)

11/23/16
JANY
11/23/16
NO CHANGE
JANY
Weakness in bluebird bio unwarranted after Juno trial halt, says Janney Capital
11/23/16
11/23/16
NO CHANGE

Buy
bluebird bio weakness unwarranted after Juno trial halt, says Janney Capital
As previously reported, Janney Capital analyst Debjit Chattopadhyay said the weakness in bluebird bio (BLUE) is unwarranted on the heels of Juno's (JUNO) second clinical hold for JCAR015. Chattopadhyay notes several key differences between JCAR015 and bluebird's bb2121, including their targets, diseases, vectors, preconditioning regimens and others. He remains a buyer of bluebird ahead of a "potentially watershed ASH for its lentiglobin platform" and keeps a Buy rating on the stock.
11/23/16
PIPR
11/23/16
NO CHANGE
PIPR
Piper says CAR-T researchers must heed risks highlighted by Juno news
Piper Jaffray analyst Joshua Schimmer said the CAR-T field has "taken another step back" after Juno Therapeutics (JUNO) put a hold on its JCAR015 trial again due to fatal cerebral edema and cautioned companies exploring these therapies to be mindful of "unnecessarily aggressive development and under-appreciation of the potent and possibly highly toxic nature" of the approach. However, Schimmer expressed his confidence that companies he covers in the CAR-T space - namely bluebird bio (BLUE), Cellectis (CLLS), Celgene (CELG), Bellicum Pharmaceuticals (BLCM), Lion Biotechnologies (LBIO) and NantKwest (NK) - will "respect the power of these platforms and remember patients' lives are more important than stock prices."
11/29/16
PIPR
11/29/16
NO CHANGE
PIPR
Piper sees bluebird regaining 'mojo and momentum'
After hosting management for an investor dinner, Piper Jaffray analyst Joshua Schimmer sees bluebird bio regaining its "mojo and momentum." The analyst expects a "steady stream of positive updates and derisking" starting with BCMA CAR-T data update this week and extending into optimizing LentiGlobin's profile for sickle cell and betathal in 2017. Schimmer has an Overweight rating on bluebird shares with a $95 price target. The biotechnology company closed yesterday down 5% to $60.65.
CELG Celgene
$118.51

-3.62 (-2.96%)

11/09/16
STPT
11/09/16
DOWNGRADE
STPT
Hold
Celgene downgraded to Hold from Buy at Standpoint Research
11/09/16
PIPR
11/09/16
NO CHANGE
PIPR
Piper sees improving environment for Biopharma M&A
The biotech sector is seeing a "massive relief rally" given the "surprise trifecta" of a Republican sweep, the voting down of Prop 61 in California and U.S. dollar weakness, Piper Jaffray analyst Joshua Schimmer tells investors in a research note. The door is now open to discuss potential repatriation of cash outside the U.S., which could be a green light on mergers and acquisitions, the analyst adds. He points out that Amgen (AMGN) and Gilead (GILD) hold the most overseas cash, with Celgene (CELG) and Biogen (BIIB) holding several billion as well. Schimmer believes the broader environment may be improving for M&A. He cautions, though, that the election of Trump does not remove the "major drug pricing overhang question."
11/28/16
OPCO
11/28/16
INITIATION
Target $141
OPCO
Outperform
Celgene initiated with an Outperform at Oppenheimer
Oppenheimer analyst Leah Cann initiated Celgene with an Outperform rating and $141 price target, estimating that revenue will grow at a compound annual growth rate of 19% per year for the next five years and that its GAAP EPS can grow by a 31% CAGR over the same span.

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ONCS

OncoSec

$1.39

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Nektar

$13.45

0.25 (1.89%)

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American Society of Clinical Oncology to hold a symposium »

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OncoSec

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NKTR

Nektar

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3M

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BIOLASE

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Chicago Dental Society to hold a meeting »

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COF

Capital One

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Renesas sees Intersil acquisition accretive to non-GAAP EPS, free cash flows »

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HSIC

Henry Schein

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1.61 (0.94%)

18:45
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Henry Schein management to meet with Jefferies »

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TWX

Time Warner

$97.28

0.6225 (0.64%)

18:38
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Turner, Univision to win U.S. Champions League rights, Bloomberg reports »

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TRUE

TrueCar

$14.28

0.18 (1.28%)

18:33
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18:33
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TrueCar's ALG sees February total new vehicle sales 1.325M units, down 1.4% »

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GE

General Electric

$30.19

0.17 (0.57%)

18:24
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18:24
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GE does not see after-tax charges from GE Capital exit plan to exceed $23B »

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CE

Celanese

$88.79

-0.88 (-0.98%)

18:02
02/24/17
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18:02
Hot Stocks
Celanese announces vinyl acetate-based emulsions price increases in Asia »

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ELNK

EarthLink

$5.63

-0.22 (-3.76%)

, WIN

Windstream

$7.27

-0.02 (-0.27%)

17:56
02/24/17
02/24
17:56
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17:56
Hot Stocks
EarthLink, Windstream holders approve merger »

EarthLink (ELNK)…

ELNK

EarthLink

$5.63

-0.22 (-3.76%)

WIN

Windstream

$7.27

-0.02 (-0.27%)

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PFE

Pfizer

$34.26

0.2 (0.59%)

17:43
02/24/17
02/24
17:43
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17:43
Periodicals
Pfizer subpoenaed in investigation of charity connections, Bloomberg says »

Pfizer has received two…

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C

Citi

$59.56

-1.06 (-1.75%)

17:32
02/24/17
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U.S. regulators investigating Citi over foreign hiring practices »

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FDX

FedEx

$193.11

1.93 (1.01%)

17:25
02/24/17
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17:25
Hot Stocks
FedEx, USPS amend transportation agreement »

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URRE

Uranium Resources

$1.94

-0.09 (-4.43%)

17:21
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Breaking Syndicate news story on Uranium Resources »

Uranium Resources files…

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RTN

Raytheon

$153.48

0.19 (0.12%)

17:13
02/24/17
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Raytheon awarded $1B government contract »

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COTV

Cotiviti Holdings

$38.74

-0.06 (-0.15%)

17:06
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Syndicate
Breaking Syndicate news story on Cotiviti Holdings »

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ENH

Endurance Specialty

$92.90

0.02 (0.02%)

17:05
02/24/17
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Earnings
Endurance reports Q4 EPS 30c, may not compare to consensus $1.26 »

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ORPN

Bio Blast Pharma

$1.13

-0.0098 (-0.86%)

17:04
02/24/17
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Syndicate
Breaking Syndicate news story on Bio Blast Pharma »

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MNTA

Momenta

$15.40

0.3 (1.99%)

, PFE

Pfizer

$34.26

0.2 (0.59%)

16:44
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General news
On The Fly: Stocks end week higher as rally continues »

Stocks ended the week…

MNTA

Momenta

$15.40

0.3 (1.99%)

PFE

Pfizer

$34.26

0.2 (0.59%)

STLD

Steel Dynamics

$35.59

0.07 (0.20%)

AKS

AK Steel

$8.02

-0.1 (-1.23%)

X

U.S. Steel

$37.01

-0.3 (-0.80%)

FLR

Fluor

$55.09

-0.26 (-0.47%)

GVA

Granite Construction

$53.91

0.78 (1.47%)

VMC

Vulcan Materials

$117.82

1.47 (1.26%)

PWR

Quanta Services

$37.76

0.62 (1.67%)

ACM

AECOM

$35.77

-0.58 (-1.60%)

JEC

Jacobs Engineering

$56.03

-0.07 (-0.12%)

KBR

KBR

$15.60

-0.55 (-3.41%)

CBI

CB&I

$33.87

-0.02 (-0.06%)

MTZ

MasTec

$40.10

3.05 (8.23%)

KHC

Kraft Heinz

$93.08

0.14 (0.15%)

UN

Unilever; also tag UL

$46.91

0.33 (0.71%)

UL

Unilever; also tag UN

$47.12

0.22 (0.47%)

QSR

Restaurant Brands

$55.47

-0.08 (-0.14%)

PLKI

Popeyes

TROX

Tronox

$17.40

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WMT

Wal-Mart

$72.39

1.08 (1.51%)

HD

Home Depot

$145.95

1.24 (0.86%)

CYH

Community Health

$9.22

0.32 (3.60%)

TOL

Toll Brothers

$33.74

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GRMN

Garmin

$53.03

0.72 (1.38%)

CHS

Chico's

$14.75

0.3 (2.08%)

HPQ

HP Inc.

$17.65

0.05 (0.28%)

CRI

Carter's

$90.04

2.98 (3.42%)

SQ

Square

$17.43

0.28 (1.63%)

JWN

Nordstrom

$46.46

2.52 (5.74%)

FL

Foot Locker

$75.01

6.43 (9.38%)

AAOI

Applied Optoelectronics

$45.98

8.51 (22.71%)

RH

Restoration Hardware

$31.34

6.15 (24.41%)

M

Macy's

$33.17

0.73 (2.25%)

PZZA

Papa John's

$78.70

-0.07 (-0.09%)

FSLR

First Solar

$37.90

0.71 (1.91%)

TXRH

Texas Roadhouse

$42.22

0.13 (0.31%)

TSLA

Tesla

$257.00

1.01 (0.39%)

LB

Labarge

$50.99

2.05 (4.19%)

W

Wayfair

$39.30

0.72 (1.87%)

HPE

HP Enterprise

$22.96

-1.7 (-6.89%)

JCP

J.C. Penney

$6.46

-0.4 (-5.83%)

ACIA

Acacia Communications

$54.04

-9.39 (-14.80%)

BGS

B&G Foods

$43.65

-3.25 (-6.93%)

SPLK

Splunk

$62.80

-2.1 (-3.24%)

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NBEV

New Age Beverages

$3.90

-0.04 (-1.02%)

16:41
02/24/17
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Breaking Hot Stocks news story on New Age Beverages »

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CYTX

Cytori Therapeutics

$1.71

-0.07 (-3.93%)

16:40
02/24/17
02/24
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16:40
Hot Stocks
Breaking Hot Stocks news story on Cytori Therapeutics »

Azaya Therapeutics…

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ADMA

ADMA Biologics

$4.75

-0.03 (-0.63%)

16:40
02/24/17
02/24
16:40
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16:40
Earnings
ADMA Biologics reports FY16 EPS ($1.61), consensus ($1.57) »

Reports FY16 revenue…

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WFC

Wells Fargo

$57.81

-0.68 (-1.16%)

16:38
02/24/17
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16:38
Syndicate
Breaking Syndicate news story on Wells Fargo »

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SHO

Sunstone Hotel

$14.71

-0.05 (-0.34%)

16:36
02/24/17
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Syndicate
Breaking Syndicate news story on Sunstone Hotel »

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TPHS

Trinity Place

$9.97

0.47 (4.95%)

16:36
02/24/17
02/24
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16:36
Hot Stocks
Breaking Hot Stocks news story on Trinity Place »

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SO

Southern Company

$50.50

0.83 (1.67%)

16:35
02/24/17
02/24
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16:35
Syndicate
Breaking Syndicate news story on Southern Company »

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