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BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

, CELG

Celgene

$118.51

-3.62 (-2.96%)

18:01
11/30/16
11/30
18:01
11/30/16
18:01

bluebird bio jumps after early data on CAR-T myeloma treatment

As part of an announcement of presentations at an upcoming medical symposium, bluebird bio (BLUE) reported interim data from the Phase 1 study of bb2121, its CAR-T treatment candidate for relapsed refractory multiple myeloma. As of the November 18 cut-off, 11 patients had been enrolled and dosed in four cohorts. All 11 dosed patients were evaluable for safety, and the first nine patients have undergone their first multiple myeloma tumor restaging and were evaluable for efficacy. One hundred percent of patients in the second and third cohorts achieved an objective response. Two patients are MRD-negative, and the overall response rate was 78%. Two patients achieved stringent complete responses, with six and four months follow-up. All patients in cohorts two and three with bone marrow involvement at baseline had no detectable multiple myeloma cells in their bone marrow on day 14 or beyond. Among all dosed patients, no dose-limiting toxicities were observed to date, and no Grade 3 or 4 cytokine release syndrome or neurotoxicity was observed. Commenting on the news, Chief Medical Officer David Davidson said the company is "pleased" with the early data, adding that "in light of these positive data, and thanks to the multiple participating clinical sites and centralized manufacturing infrastructure we and our partner Celgene (CELG) have built for this program, we anticipate efficiently completing the dose escalation stage of the trial and initiating the expansion cohort." PRICE ACTION: Shares of bluebird bio are up 14.3% to $69.00 in after-hours trading, while Celgene is up 0.92%.

BLUE

bluebird bio

$60.35

-4.05 (-6.29%)

CELG

Celgene

$118.51

-3.62 (-2.96%)

  • 30

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    Nov

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    Dec

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  • 04

    Dec

BLUE bluebird bio
$60.35

-4.05 (-6.29%)

11/23/16
JANY
11/23/16
NO CHANGE
JANY
Weakness in bluebird bio unwarranted after Juno trial halt, says Janney Capital
11/23/16
11/23/16
NO CHANGE

Buy
bluebird bio weakness unwarranted after Juno trial halt, says Janney Capital
As previously reported, Janney Capital analyst Debjit Chattopadhyay said the weakness in bluebird bio (BLUE) is unwarranted on the heels of Juno's (JUNO) second clinical hold for JCAR015. Chattopadhyay notes several key differences between JCAR015 and bluebird's bb2121, including their targets, diseases, vectors, preconditioning regimens and others. He remains a buyer of bluebird ahead of a "potentially watershed ASH for its lentiglobin platform" and keeps a Buy rating on the stock.
11/23/16
PIPR
11/23/16
NO CHANGE
PIPR
Piper says CAR-T researchers must heed risks highlighted by Juno news
Piper Jaffray analyst Joshua Schimmer said the CAR-T field has "taken another step back" after Juno Therapeutics (JUNO) put a hold on its JCAR015 trial again due to fatal cerebral edema and cautioned companies exploring these therapies to be mindful of "unnecessarily aggressive development and under-appreciation of the potent and possibly highly toxic nature" of the approach. However, Schimmer expressed his confidence that companies he covers in the CAR-T space - namely bluebird bio (BLUE), Cellectis (CLLS), Celgene (CELG), Bellicum Pharmaceuticals (BLCM), Lion Biotechnologies (LBIO) and NantKwest (NK) - will "respect the power of these platforms and remember patients' lives are more important than stock prices."
11/29/16
PIPR
11/29/16
NO CHANGE
PIPR
Piper sees bluebird regaining 'mojo and momentum'
After hosting management for an investor dinner, Piper Jaffray analyst Joshua Schimmer sees bluebird bio regaining its "mojo and momentum." The analyst expects a "steady stream of positive updates and derisking" starting with BCMA CAR-T data update this week and extending into optimizing LentiGlobin's profile for sickle cell and betathal in 2017. Schimmer has an Overweight rating on bluebird shares with a $95 price target. The biotechnology company closed yesterday down 5% to $60.65.
CELG Celgene
$118.51

-3.62 (-2.96%)

11/09/16
STPT
11/09/16
DOWNGRADE
STPT
Hold
Celgene downgraded to Hold from Buy at Standpoint Research
11/09/16
PIPR
11/09/16
NO CHANGE
PIPR
Piper sees improving environment for Biopharma M&A
The biotech sector is seeing a "massive relief rally" given the "surprise trifecta" of a Republican sweep, the voting down of Prop 61 in California and U.S. dollar weakness, Piper Jaffray analyst Joshua Schimmer tells investors in a research note. The door is now open to discuss potential repatriation of cash outside the U.S., which could be a green light on mergers and acquisitions, the analyst adds. He points out that Amgen (AMGN) and Gilead (GILD) hold the most overseas cash, with Celgene (CELG) and Biogen (BIIB) holding several billion as well. Schimmer believes the broader environment may be improving for M&A. He cautions, though, that the election of Trump does not remove the "major drug pricing overhang question."
11/28/16
OPCO
11/28/16
INITIATION
Target $141
OPCO
Outperform
Celgene initiated with an Outperform at Oppenheimer
Oppenheimer analyst Leah Cann initiated Celgene with an Outperform rating and $141 price target, estimating that revenue will grow at a compound annual growth rate of 19% per year for the next five years and that its GAAP EPS can grow by a 31% CAGR over the same span.

TODAY'S FREE FLY STORIES

KBR

KBR

$14.05

-1.43 (-9.24%)

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SMMT

Summit Therapeutics

$11.00

-0.4 (-3.51%)

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Summit Therapeutics publishes results from CoDIFy trial online »

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TKPYY

Takeda Pharmaceutical Co. Ltd.

$24.83

0.85 (3.54%)

18:14
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FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

18:07
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FDIC named receiver of First NBC Bank »

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SGBK

Stonegate Bank

$45.90

-0.52 (-1.12%)

17:47
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Earnings
Stonegate Bank reports Q1 non-GAAP EPS 56c, consensus 57c »

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PROV

Provident Financial

$19.23

-0.03 (-0.16%)

17:45
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Provident Financial announces extension of stock repurchase plan »

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YGE

Yingli Green Energy

$2.66

-0.03 (-1.12%)

17:40
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Yingli Green Energy files extension for 2016 Form 20-F filing »

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EPC

Edgewell Personal Care

$71.49

-0.14 (-0.20%)

17:40
04/28/17
04/28
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17:40
Hot Stocks
Breaking Hot Stocks news story on Edgewell Personal Care »

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ORC

Orchid Island Capital

$10.60

-0.33 (-3.02%)

17:35
04/28/17
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17:35
Syndicate
Breaking Syndicate news story on Orchid Island Capital »

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AEP

American Electric

$67.83

-0.27 (-0.40%)

17:35
04/28/17
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AEP Generation Resources seeks bids for supply of coal »

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ORC

Orchid Island Capital

$10.60

-0.33 (-3.02%)

17:34
04/28/17
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17:34
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17:34
Syndicate
Breaking Syndicate news story on Orchid Island Capital »

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HBHC

Hancock Holding

$46.70

-0.5 (-1.06%)

, FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

17:34
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04/28
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17:34
Hot Stocks
Whitney to acquire branches, assets, liabilities of First NBC from FDIC »

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HBHC

Hancock Holding

$46.70

-0.5 (-1.06%)

FNBC

First NBC Bank

$2.65

-0.2 (-7.02%)

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TSLA

Tesla

$314.07

5.44 (1.76%)

17:31
04/28/17
04/28
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17:31
Periodicals
Tesla aims to hire engineers from Mexico to work at CA plant, Reuters says »

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LMT

Lockheed Martin

$269.45

-1.69 (-0.62%)

17:22
04/28/17
04/28
17:22
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17:22
Hot Stocks
Lockheed Martin awarded $332.1M government contract »

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BA

Boeing

$184.83

1.61 (0.88%)

17:21
04/28/17
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Boeing awarded $541M government contract modification »

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WBA

Walgreens Boots Alliance

$86.54

0.65 (0.76%)

, RAD

Rite Aid

$4.00

0.05 (1.27%)

17:20
04/28/17
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17:20
Periodicals
Walgreens to push regulators over decision on Rite Aid deal, NY Post says »

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WBA

Walgreens Boots Alliance

$86.54

0.65 (0.76%)

RAD

Rite Aid

$4.00

0.05 (1.27%)

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GE

General Electric

$28.99

-0.09 (-0.31%)

17:20
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General Electric awarded $670.7M government contract »

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SIX

Six Flags

$62.61

-0.26 (-0.41%)

17:19
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Six Flags in agreement to repurchase 5M shares from HP Partners »

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LMT

Lockheed Martin

$269.45

-1.69 (-0.62%)

17:18
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Lockheed Martin awarded $1.38B government contract »

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SBBP

Strongbridge Biopharma

$4.50

0.05 (1.12%)

17:16
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Syndicate
Breaking Syndicate news story on Strongbridge Biopharma »

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CYH

Community Health

$8.61

0.18 (2.14%)

17:12
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Community Health completes divestiture of Anniston, Alabama hospital »

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MRUS

Merus

$22.20

-0.14 (-0.63%)

17:07
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Earnings
Merus reports Q4 EPS (EUR1.91) vs. (EUR0.77) last year »

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AEZS

Aeterna Zentaris

$3.35

0.3 (9.84%)

17:01
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  • 09

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ANY

Sphere 3D

$0.19

-0.006 (-3.13%)

17:00
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Breaking Syndicate news story on Sphere 3D »

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MRUS

Merus

$22.20

-0.14 (-0.63%)

16:56
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Merus provides anticipated 2017 pipeline milestones »

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