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ACAD

ACADIA

$26.99

-0.66 (-2.39%)

09:02
12/01/16
12/01
09:02
12/01/16
09:02

ACADIA initiates Phase II Pimavanserin trial for MDD

ACADIA Pharmaceuticals announced the initiation of CLARITY, a Phase II study to evaluate pimavanserin for adjunctive treatment in patients with major depressive disorder who have an inadequate response to first-line therapies for clinical depression. Pimavanserin is a selective serotonin inverse agonist preferentially targeting 5-HT2A receptors that may play a role in depression. CLARITY is a Phase II, 10-week, randomized, double-blind, placebo-controlled, multi-center study designed to examine the efficacy and safety of adjunctive use of pimavanserin in patients with major depressive disorder who have an inadequate response to standard antidepressant therapy with either a selective serotonin reuptake inhibitor or a serotonin norepinephrine reuptake inhibitor. Approximately 188 patients will be randomized to receive either 34 mg of pimavanserin or placebo, orally, once daily, in addition to their ongoing antidepressant for 10 weeks. The primary endpoint of the study is the change from baseline on the Hamilton Depression Rating Scale total score.

  • 01

    Dec

  • 02

    Dec

ACAD ACADIA
$26.99

-0.66 (-2.39%)

11/08/16
11/08/16
UPGRADE
Target $35

Buy
ACADIA upgraded to Buy, Nuplazid sales ahead of estimates, says BofA/Merrill
As previously reported, BofA/Merrill upgraded ACADIA to Buy from Neutral. Analyst Tazeen Ahmad said ACADIA reported Q3 Nuplazid sales of $5.3M, above his $2M estimate and consensus of $2.7M. Ahmad sees meaningful upside supported by management's comments that the upcoming Alzheimer Psychosis trial may not need to be statistically significant to warrant advancement. The analyst lowered his price target to $35 from $39 to reflect raised opex estimates and a smaller EU market.
11/08/16
11/08/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Sysco (SYY) upgraded to Buy from Neutral at BofA/Merrill with analyst Marisa Sullivan citing greater accretion from the Brakes acquisition in fiscal 2017. 2. Windstream (WIN) upgraded to Outperform from Market Perform at Cowen. 3. ACADIA (ACAD) upgraded to Buy from Neutral at BofA/Merrill with analyst Tazeen Ahmad seeing meaningful upside supported by management's comments that the upcoming Alzheimer Psychosis trial may not need to be statistically significant to warrant advancement. 4. Ferrari (RACE) upgraded to Hold from Sell at Evercore ISI with analyst George Galliers citing the LaFerrari Aperta coming to market sooner than expected and incremental contribution and the somewhat defensive nature of the stock. 5. Energy Transfer Equity (ETE) upgraded to Outperform from Market Perform at Bernstein with analyst Jean Ann Salisbury saying Energy Transfer's stock is trading as though the company's Dakota Access and Rover projects will be canceled. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/11/16
GSCO
11/11/16
INITIATION
Target $28
GSCO
Neutral
ACADIA initiated with a Neutral at Goldman
Goldman analyst Salveen Richter initiated ACADIA with a Natural and a $28 price target citing an expected gradual launch of its sole drug Nuplazid for Parkinson's disease psychosis due to limited physician disease awareness.
11/11/16
11/11/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Aegerion (AEGN) resumed with a Neutral at JPMorgan. 2. Lamb Weston (LW) initiated with a Buy at Stifel, initiated with an Overweight at Barclays, and an Equal Weight at Morgan Stanley. 3. bluebird bio (BLUE) initiated with a Market Perform at BMO Capital. 4. Alder Biopharmaceuticals (ALDR) initiated with an Outperform at BMO Capital. 5. ACADIA (ACAD) initiated with a Neutral at Goldman. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.

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