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CTIC

CTI BioPharma

$0.44

0.023 (5.48%)

16:05
12/01/16
12/01
16:05
12/01/16
16:05

CTI BioPharma's pacritinib shows distinct profile as biomarker

CTI BioPharma announced the results of a translational pharmacology study comparing biomarker activity profiles for three JAK inhibitors: pacritinib, ruxolitinib and momelotinib, using the BioMAP Diversity PLUS panel of in vitro human primary cell-based systems. Pacritinib is an investigational oral kinase inhibitor with specificity for JAK2, FLT3, IRAK1 and CSF1R. The JAK family of enzymes is a central component in signal transduction pathways, which are critical to normal blood cell growth and development. The results demonstrated distinct profiles amongst these JAK inhibitors and suggest that clinical responses are likely to be distinct with each agent. Only pacritinib was anti-proliferative to endothelial cells and fibroblasts, effects commonly seen in agents with anti-cancer properties. The resulting distinct phenotypic profiles of pacritinib, ruxolitinib and momelotinib, illustrate that although all were developed as JAK2-ATP binding site inhibitors, they have divergent biological effects and likely will have distinct clinical activities.

  • 03

    Dec

CTIC CTI BioPharma
$0.44

0.023 (5.48%)

02/10/16
WBTH
02/10/16
DOWNGRADE
WBTH
Sell
CTI BioPharma downgraded to Sell from Hold at WallachBeth
WallachBeth analyst Bob Ai downgraded CTI BioPharma to Sell with a 0c price target after the FDA put a full clinical hold on pacritinib. The analyst sees no reason to hold the stock. Piper Jaffray this morning also downgraded CTI Biopharma.
02/10/16
LEER
02/10/16
NO CHANGE
Target $118
LEER
Outperform
Pacritinib hold an incremental positive for Incyte, says Leerink
Leerink analyst Michael Schmidt views the FDA's full clinical hold on CTI BioPharma's (CTIC) pacritinib as an incremental positive for Incyte (INCY). The analyst points out, however, that he didn't view pacritinib as a significant threat to Incyte's Jakafi franchise in myelofibrosis. Nonetheless, the clinical hold on a potential competitor should remove a small overhang on Incyte shares, Schmidt tells investors in a research note. He reiterates an Outperform rating on the name.
02/10/16
LTCO
02/10/16
DOWNGRADE
LTCO
Neutral
CTI BioPharma downgraded to Neutral from Buy at Ladenburg
Ladenburg analyst Robert Hazlett downgraded CTI BioPharma to Neutral saying a full clinical hold challenges pacritinib's future. Piper Jaffay and WallachBeth also downgraded CTI this morning.
02/10/16
02/10/16
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: Antero Resources (AR) downgraded to Neutral from Buy at Goldman... Apollo Investment (AINV) downgraded to Sell from Neutral at Citi... BBA Aviation (BBAVY) downgraded to Neutral from Buy at Goldman... CM Finance (CMFN) downgraded to Outperform from Strong Buy at Raymond James... CTI BioPharma (CTIC) downgraded to Sell from Hold at WallachBeth... Calix (CALX) downgraded to Market Perform from Outperform at Cowen... ConocoPhillips (COP) downgraded to Peer Perform from Outperform at Wolfe Research... Fifth Street Finance (FSC) downgraded to Neutral from Overweight at JPMorgan... Fortis (FRTSF) downgraded to Neutral from Outperform at Credit Suisse... ITC Holdings (ITC) downgraded to Market Perform from Outperform at Wells Fargo... KapStone (KS) downgraded to Hold from Buy at Deutsche Bank... Knight Transportation (KNX) downgraded to Hold from Buy at Evercore ISI... Lake Shore Gold (LSG) downgraded to Sector Performer from Outperformer at CIBC... Medley Capital (MCC) downgraded to Hold from Buy at Jefferies... Pandora (P) downgraded to Market Perform from Outperform at Cowen... Parker-Hannifin (PH) downgraded to Hold from Buy at Evercore ISI... Parkway Properties (PKY) downgraded on real estate headwinds, valuation at Stifel... Plains GP Holdings (PAGP) downgraded to Neutral from Outperform at Credit Suisse... Ruckus Wireless (RKUS) downgraded to Neutral from Buy at SunTrust... SolarCity (SCTY) downgraded to Neutral from Buy at Roth Capital... Tahoe Resources (TAHO) downgraded to Sector Perform from Outperform at RBC Capital... USANA (USNA) downgraded to Neutral from Buy at DA Davidson... Valero (VLO) downgraded to Buy from Conviction Buy at Goldman... Western Union (WU) downgraded to Neutral from Outperform at Macquarie... XL Group (XL) downgraded to Sell from Hold at Deutsche Bank.

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