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CTIC

CTI BioPharma

$0.44

0.023 (5.48%)

16:05
12/01/16
12/01
16:05
12/01/16
16:05

CTI BioPharma's pacritinib shows distinct profile as biomarker

CTI BioPharma announced the results of a translational pharmacology study comparing biomarker activity profiles for three JAK inhibitors: pacritinib, ruxolitinib and momelotinib, using the BioMAP Diversity PLUS panel of in vitro human primary cell-based systems. Pacritinib is an investigational oral kinase inhibitor with specificity for JAK2, FLT3, IRAK1 and CSF1R. The JAK family of enzymes is a central component in signal transduction pathways, which are critical to normal blood cell growth and development. The results demonstrated distinct profiles amongst these JAK inhibitors and suggest that clinical responses are likely to be distinct with each agent. Only pacritinib was anti-proliferative to endothelial cells and fibroblasts, effects commonly seen in agents with anti-cancer properties. The resulting distinct phenotypic profiles of pacritinib, ruxolitinib and momelotinib, illustrate that although all were developed as JAK2-ATP binding site inhibitors, they have divergent biological effects and likely will have distinct clinical activities.

  • 03

    Dec

CTIC CTI BioPharma
$0.44

0.023 (5.48%)

02/10/16
WBTH
02/10/16
DOWNGRADE
WBTH
Sell
CTI BioPharma downgraded to Sell from Hold at WallachBeth
WallachBeth analyst Bob Ai downgraded CTI BioPharma to Sell with a 0c price target after the FDA put a full clinical hold on pacritinib. The analyst sees no reason to hold the stock. Piper Jaffray this morning also downgraded CTI Biopharma.
02/10/16
LEER
02/10/16
NO CHANGE
Target $118
LEER
Outperform
Pacritinib hold an incremental positive for Incyte, says Leerink
Leerink analyst Michael Schmidt views the FDA's full clinical hold on CTI BioPharma's (CTIC) pacritinib as an incremental positive for Incyte (INCY). The analyst points out, however, that he didn't view pacritinib as a significant threat to Incyte's Jakafi franchise in myelofibrosis. Nonetheless, the clinical hold on a potential competitor should remove a small overhang on Incyte shares, Schmidt tells investors in a research note. He reiterates an Outperform rating on the name.
02/10/16
LTCO
02/10/16
DOWNGRADE
LTCO
Neutral
CTI BioPharma downgraded to Neutral from Buy at Ladenburg
Ladenburg analyst Robert Hazlett downgraded CTI BioPharma to Neutral saying a full clinical hold challenges pacritinib's future. Piper Jaffay and WallachBeth also downgraded CTI this morning.
02/10/16
02/10/16
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: Antero Resources (AR) downgraded to Neutral from Buy at Goldman... Apollo Investment (AINV) downgraded to Sell from Neutral at Citi... BBA Aviation (BBAVY) downgraded to Neutral from Buy at Goldman... CM Finance (CMFN) downgraded to Outperform from Strong Buy at Raymond James... CTI BioPharma (CTIC) downgraded to Sell from Hold at WallachBeth... Calix (CALX) downgraded to Market Perform from Outperform at Cowen... ConocoPhillips (COP) downgraded to Peer Perform from Outperform at Wolfe Research... Fifth Street Finance (FSC) downgraded to Neutral from Overweight at JPMorgan... Fortis (FRTSF) downgraded to Neutral from Outperform at Credit Suisse... ITC Holdings (ITC) downgraded to Market Perform from Outperform at Wells Fargo... KapStone (KS) downgraded to Hold from Buy at Deutsche Bank... Knight Transportation (KNX) downgraded to Hold from Buy at Evercore ISI... Lake Shore Gold (LSG) downgraded to Sector Performer from Outperformer at CIBC... Medley Capital (MCC) downgraded to Hold from Buy at Jefferies... Pandora (P) downgraded to Market Perform from Outperform at Cowen... Parker-Hannifin (PH) downgraded to Hold from Buy at Evercore ISI... Parkway Properties (PKY) downgraded on real estate headwinds, valuation at Stifel... Plains GP Holdings (PAGP) downgraded to Neutral from Outperform at Credit Suisse... Ruckus Wireless (RKUS) downgraded to Neutral from Buy at SunTrust... SolarCity (SCTY) downgraded to Neutral from Buy at Roth Capital... Tahoe Resources (TAHO) downgraded to Sector Perform from Outperform at RBC Capital... USANA (USNA) downgraded to Neutral from Buy at DA Davidson... Valero (VLO) downgraded to Buy from Conviction Buy at Goldman... Western Union (WU) downgraded to Neutral from Outperform at Macquarie... XL Group (XL) downgraded to Sell from Hold at Deutsche Bank.

TODAY'S FREE FLY STORIES

MTRX

Matrix Service

$16.88

-0.575 (-3.30%)

18:33
04/27/17
04/27
18:33
04/27/17
18:33
Earnings
Breaking Earnings news story on Matrix Service »

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GIMO

Gigamon

$36.00

-0.6 (-1.64%)

18:33
04/27/17
04/27
18:33
04/27/17
18:33
Earnings
Gigamon sees Q2 adjusted EPS 2c-7c, consensus 19c »

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MTRX

Matrix Service

$16.88

-0.575 (-3.30%)

18:32
04/27/17
04/27
18:32
04/27/17
18:32
Earnings
Matrix Service sees Q3 EPS (56c)-(49c), consensus 13c »

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WDC

Western Digital

$85.71

1.1 (1.30%)

, TOSBF

Toshiba, also use TOSYY

$1.97

-0.01 (-0.51%)

18:31
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WDC

Western Digital

$85.71

1.1 (1.30%)

TOSBF

Toshiba, also use TOSYY

$1.97

-0.01 (-0.51%)

TOSYY

Toshiba, also use TOSBF

$11.89

0.07 (0.59%)

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    Apr

MBFI

MB Financial

$43.09

-0.37 (-0.85%)

18:24
04/27/17
04/27
18:24
04/27/17
18:24
Recommendations
MB Financial analyst commentary  »

MB Financial reports Q1…

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VRSN

VeriSign

$88.53

-0.31 (-0.35%)

18:21
04/27/17
04/27
18:21
04/27/17
18:21
Earnings
VeriSign raises FY17 revenue view to $1.145B-$1.16B from $1.138B-$1.158B »

Consenssus $1.15B. Raises…

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    Apr

RRC

Range Resources

$27.35

-0.26 (-0.94%)

18:21
04/27/17
04/27
18:21
04/27/17
18:21
Upgrade
Range Resources rating change  »

Range Resources upgraded…

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  • 31

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ISBC

Investors Bancorp

$14.53

-0.16 (-1.09%)

18:19
04/27/17
04/27
18:19
04/27/17
18:19
Earnings
Investors Bancorp reports Q1 EPS 16c, consensus 16c »

Reports Q1 loan loss…

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ALGN

Align Technology

$120.09

0.35 (0.29%)

, EHTH

eHealth

$11.74

0.23 (2.00%)

18:16
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04/27
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UP AFTER EARNINGS: Align…

ALGN

Align Technology

$120.09

0.35 (0.29%)

EHTH

eHealth

$11.74

0.23 (2.00%)

TRMB

Trimble

$32.62

0.28 (0.87%)

LPLA

LPL Financial

$38.52

-0.84 (-2.13%)

GOOG

Alphabet

$874.25

2.52 (0.29%)

GOOGL

Alphabet Class A

$891.44

2.3 (0.26%)

AMZN

Amazon.com

$918.38

9.09 (1.00%)

CERN

Cerner

$60.06

0.53 (0.89%)

CY

Cypress Semiconductor

$14.40

0.42 (3.00%)

VRTX

Vertex

$117.42

1.08 (0.93%)

RXDX

Ignyta

$8.75

-0.45 (-4.89%)

HON

Honeywell

$129.88

-0.22 (-0.17%)

ATHN

athenahealth

$121.45

1.6 (1.34%)

CLD

Cloud Peak

$3.53

-0.13 (-3.55%)

PCMI

PCM, Inc.

$30.15

0.1 (0.33%)

ELLI

Ellie Mae

$110.72

1.55 (1.42%)

ARAY

Accuray

$4.60

-0.2 (-4.17%)

FTNT

Fortinet

$40.42

0.52 (1.30%)

SBUX

Starbucks

$61.30

-0.26 (-0.42%)

BIDU

Baidu

$187.86

1.19 (0.64%)

TNDM

TNDM

FLEX

Flex

$16.02

-0.05 (-0.31%)

EXPE

Expedia

$136.20

0.45 (0.33%)

AFL

Aflac

$75.05

0.25 (0.33%)

MSFT

Microsoft

$68.27

0.44 (0.65%)

SRPT

Sarepta

$34.72

-0.14 (-0.40%)

TRXC

TransEnterix

$1.09

-0.01 (-0.91%)

03/08/13
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IBKC

Iberiabank

$79.35

-0.4 (-0.50%)

18:16
04/27/17
04/27
18:16
04/27/17
18:16
Earnings
Iberiabank reports Q1 non-GAAP EPS $1.02, consensus 98c »

Reports Q1 revenue…

03/08/13
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KRNY

Kearny Financial

$15.30

-0.05 (-0.33%)

18:15
04/27/17
04/27
18:15
04/27/17
18:15
Earnings
Kearny Financial reports Q3 EPS 5c, consensus 6c »

Reports Q3 NII $26.21M,…

03/08/13
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CE

Celanese

$87.91

-0.22 (-0.25%)

18:11
04/27/17
04/27
18:11
04/27/17
18:11
Hot Stocks
Celanese increases prive of vinyl acetate-based emulsion in China »

Celanese will increase…

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STX

Seagate

$42.30

0.29 (0.69%)

, WDC

Western Digital

$85.71

1.1 (1.30%)

18:09
04/27/17
04/27
18:09
04/27/17
18:09
Hot Stocks
Breaking Hot Stocks news story on Seagate, Western Digital »

Seagate shares up 1.1%…

STX

Seagate

$42.30

0.29 (0.69%)

WDC

Western Digital

$85.71

1.1 (1.30%)

03/08/13
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  • 27

    Apr

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    Jun

FTNT

Fortinet

$40.42

0.52 (1.30%)

18:09
04/27/17
04/27
18:09
04/27/17
18:09
Earnings
Fortinet raises FY17 EPS view to 89c-91c from 87c-89c, consensus 89c »

Sees FY17 revenue…

03/08/13
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    Apr

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    Jun

FTNT

Fortinet

$40.42

0.52 (1.30%)

18:07
04/27/17
04/27
18:07
04/27/17
18:07
Earnings
Fortinet sees Q2 EPS 19c-20c, consensus 19c »

Sees Q2 revenue…

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  • 27

    Apr

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    Jun

SIMO

Silicon Motion

$44.28

-0.26 (-0.58%)

18:06
04/27/17
04/27
18:06
04/27/17
18:06
Earnings
Silicon Motion sees FY17 revenue $556M-$612M, consensus $580.14M »

Sees FY17 adjusted…

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SIMO

Silicon Motion

$44.28

-0.26 (-0.58%)

18:06
04/27/17
04/27
18:06
04/27/17
18:06
Earnings
Silicon Motion sees Q2 revenue $134M-$140M, consensus $139.02M »

Sees Q2 adjusted…

03/08/13
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    May

  • 01

    Jun

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    Jun

SIMO

Silicon Motion

$44.28

-0.26 (-0.58%)

18:04
04/27/17
04/27
18:04
04/27/17
18:04
Earnings
Silicon Motion reports Q1 adjusted EPS 70c, consensus 69c »

Reports Q1 revenue…

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    Jun

MSFT

Microsoft

$68.27

0.44 (0.65%)

18:01
04/27/17
04/27
18:01
04/27/17
18:01
Hot Stocks
Microsoft sees CapEx growing in Q4 »

Says spent less CapEx in…

03/08/13
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  • 27

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CMCSA

Comcast

$39.59

0.8 (2.06%)

, CMCSK

Comcast

18:01
04/27/17
04/27
18:01
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18:01
Hot Stocks
Comcast 'very pleased' with auction, says no current plans for acquired spectrum »

Comcast issued the…

CMCSA

Comcast

$39.59

0.8 (2.06%)

CMCSK

Comcast

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  • 27

    Apr

CYTR

CytRx

$0.68

-0.121 (-15.02%)

18:00
04/27/17
04/27
18:00
04/27/17
18:00
Syndicate
CytRx announces common stock offering, no amount given »

CytRx Corporation…

03/08/13
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03/06/13
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03/06/13
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  • 02

    Jun

PCMI

PCM, Inc.

$30.15

0.1 (0.33%)

18:00
04/27/17
04/27
18:00
04/27/17
18:00
Earnings
PCM, Inc. backs FY17 adjusted EPS view $2.00-$2.15, consensus $1.73 »

Backs FY17 revenue view…

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  • 27

    Apr

PCMI

PCM, Inc.

$30.15

0.1 (0.33%)

17:59
04/27/17
04/27
17:59
04/27/17
17:59
Earnings
PCM, Inc. sees Q2 EPS 44c-49c, consensus 45c »

Sees Q2 revenue…

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  • 27

    Apr

JNJ

Johnson & Johnson

$123.74

0.23 (0.19%)

17:58
04/27/17
04/27
17:58
04/27/17
17:58
Hot Stocks
Johnson & Johnson awarded $260.5M government contract »

Johnson & Johnson…

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PCMI

PCM, Inc.

$30.15

0.1 (0.33%)

17:58
04/27/17
04/27
17:58
04/27/17
17:58
Earnings
PCM, Inc. reports Q1 adjusted EPS 26c, consensus 14c »

Reports Q1 revenue…

03/08/13
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