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CTIC

CTI BioPharma

$0.44

0.023 (5.48%)

16:05
12/01/16
12/01
16:05
12/01/16
16:05

CTI BioPharma's pacritinib shows distinct profile as biomarker

CTI BioPharma announced the results of a translational pharmacology study comparing biomarker activity profiles for three JAK inhibitors: pacritinib, ruxolitinib and momelotinib, using the BioMAP Diversity PLUS panel of in vitro human primary cell-based systems. Pacritinib is an investigational oral kinase inhibitor with specificity for JAK2, FLT3, IRAK1 and CSF1R. The JAK family of enzymes is a central component in signal transduction pathways, which are critical to normal blood cell growth and development. The results demonstrated distinct profiles amongst these JAK inhibitors and suggest that clinical responses are likely to be distinct with each agent. Only pacritinib was anti-proliferative to endothelial cells and fibroblasts, effects commonly seen in agents with anti-cancer properties. The resulting distinct phenotypic profiles of pacritinib, ruxolitinib and momelotinib, illustrate that although all were developed as JAK2-ATP binding site inhibitors, they have divergent biological effects and likely will have distinct clinical activities.

  • 03

    Dec

CTIC CTI BioPharma
$0.44

0.023 (5.48%)

02/10/16
WBTH
02/10/16
DOWNGRADE
WBTH
Sell
CTI BioPharma downgraded to Sell from Hold at WallachBeth
WallachBeth analyst Bob Ai downgraded CTI BioPharma to Sell with a 0c price target after the FDA put a full clinical hold on pacritinib. The analyst sees no reason to hold the stock. Piper Jaffray this morning also downgraded CTI Biopharma.
02/10/16
LEER
02/10/16
NO CHANGE
Target $118
LEER
Outperform
Pacritinib hold an incremental positive for Incyte, says Leerink
Leerink analyst Michael Schmidt views the FDA's full clinical hold on CTI BioPharma's (CTIC) pacritinib as an incremental positive for Incyte (INCY). The analyst points out, however, that he didn't view pacritinib as a significant threat to Incyte's Jakafi franchise in myelofibrosis. Nonetheless, the clinical hold on a potential competitor should remove a small overhang on Incyte shares, Schmidt tells investors in a research note. He reiterates an Outperform rating on the name.
02/10/16
LTCO
02/10/16
DOWNGRADE
LTCO
Neutral
CTI BioPharma downgraded to Neutral from Buy at Ladenburg
Ladenburg analyst Robert Hazlett downgraded CTI BioPharma to Neutral saying a full clinical hold challenges pacritinib's future. Piper Jaffay and WallachBeth also downgraded CTI this morning.
02/10/16
02/10/16
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: Antero Resources (AR) downgraded to Neutral from Buy at Goldman... Apollo Investment (AINV) downgraded to Sell from Neutral at Citi... BBA Aviation (BBAVY) downgraded to Neutral from Buy at Goldman... CM Finance (CMFN) downgraded to Outperform from Strong Buy at Raymond James... CTI BioPharma (CTIC) downgraded to Sell from Hold at WallachBeth... Calix (CALX) downgraded to Market Perform from Outperform at Cowen... ConocoPhillips (COP) downgraded to Peer Perform from Outperform at Wolfe Research... Fifth Street Finance (FSC) downgraded to Neutral from Overweight at JPMorgan... Fortis (FRTSF) downgraded to Neutral from Outperform at Credit Suisse... ITC Holdings (ITC) downgraded to Market Perform from Outperform at Wells Fargo... KapStone (KS) downgraded to Hold from Buy at Deutsche Bank... Knight Transportation (KNX) downgraded to Hold from Buy at Evercore ISI... Lake Shore Gold (LSG) downgraded to Sector Performer from Outperformer at CIBC... Medley Capital (MCC) downgraded to Hold from Buy at Jefferies... Pandora (P) downgraded to Market Perform from Outperform at Cowen... Parker-Hannifin (PH) downgraded to Hold from Buy at Evercore ISI... Parkway Properties (PKY) downgraded on real estate headwinds, valuation at Stifel... Plains GP Holdings (PAGP) downgraded to Neutral from Outperform at Credit Suisse... Ruckus Wireless (RKUS) downgraded to Neutral from Buy at SunTrust... SolarCity (SCTY) downgraded to Neutral from Buy at Roth Capital... Tahoe Resources (TAHO) downgraded to Sector Perform from Outperform at RBC Capital... USANA (USNA) downgraded to Neutral from Buy at DA Davidson... Valero (VLO) downgraded to Buy from Conviction Buy at Goldman... Western Union (WU) downgraded to Neutral from Outperform at Macquarie... XL Group (XL) downgraded to Sell from Hold at Deutsche Bank.

TODAY'S FREE FLY STORIES

USO

United States Oil Fund

$11.52

0.16 (1.41%)

13:21
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02/23
13:21
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13:21
Options
Large five-way spread in US Oil Fund as a position is adjusted »

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Treasury Action: yields remained at low ebb »

Treasury Action: yields…

SAGE

SAGE Therapeutics

$61.93

-2.13 (-3.33%)

13:19
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02/23
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13:19
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SAGE Therapeutics analyst commentary  »

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  • 23

    Feb

$NSD

NASDAQ Market Internals

13:18
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02/23
13:18
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13:18
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NASDAQ Market Internals summary »

Volume is above average…

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$NYE

NYSE Market Internals

13:18
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02/23
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13:18
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NYSE Market Internals summary »

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ABT

Abbott

$45.35

0.34 (0.76%)

, STJ

Acquired by ABT

13:16
02/23/17
02/23
13:16
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13:16
Hot Stocks
FTC approves order settling charges that Abbott-St. Jude deal is anticompetitive »

Following a public…

ABT

Abbott

$45.35

0.34 (0.76%)

STJ

Acquired by ABT

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CMI

Cummins

$149.46

-2.788 (-1.83%)

13:16
02/23/17
02/23
13:16
02/23/17
13:16
Options
Cummins put volume heavy and directionally bearish »

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  • 23

    Feb

13:15
02/23/17
02/23
13:15
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13:15
General news
Treasury's $28 B 7-year auction results were mixed but generally good »

Treasury's $28 B…

KO

Coca-Cola

$41.91

0.31 (0.75%)

13:09
02/23/17
02/23
13:09
02/23/17
13:09
Hot Stocks
Coca-Cola: End of refranchising 'in sight' »

Says it would be…

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  • 23

    Feb

  • 09

    May

13:04
02/23/17
02/23
13:04
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13:04
General news
7-Yr Note Auction Coupon Rate data reported »

7-Yr Note Auction Coupon…

13:04
02/23/17
02/23
13:04
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13:04
General news
7-Yr Note Auction Total Amount data reported »

7-Yr Note Auction Total…

P

Pandora

$13.13

0.18 (1.39%)

13:01
02/23/17
02/23
13:01
02/23/17
13:01
Options
Repeat interest in Pandora June spreads »

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ICBK

County Bancorp

$27.77

-0.63 (-2.22%)

13:00
02/23/17
02/23
13:00
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13:00
Hot Stocks
County Bancorp boosts quarterly dividend to 6c from 5c »

County Bancorp earlier…

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  • 29

    Mar

KO

Coca-Cola

$41.95

0.345 (0.83%)

12:58
02/23/17
02/23
12:58
02/23/17
12:58
Hot Stocks
Breaking Hot Stocks news story on Coca-Cola »

Coca-Cola says supports…

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  • 23

    Feb

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    May

CNX

CONSOL

$16.70

-0.34 (-2.00%)

12:56
02/23/17
02/23
12:56
02/23/17
12:56
Options
CONSOL put volume heavy and directionally bearish »

Bearish flow noted in…

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RWLK

ReWalk Robotics

$2.35

0.05 (2.17%)

12:55
02/23/17
02/23
12:55
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12:55
Hot Stocks
ReWalk Robotics awarded $1.2M Department of Veterans Affairs contract 

Reference Link

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  • 21

    Mar

THG

Hanover Insurance

$91.75

0.67 (0.74%)

12:53
02/23/17
02/23
12:53
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12:53
Hot Stocks
Hanover Insurance outlines go-forward strategy at investor day »

The Hanover Insurance…

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  • 23

    Feb

  • 05

    Mar

GLT

Glatfelter

$23.02

0.12 (0.52%)

12:52
02/23/17
02/23
12:52
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12:52
Hot Stocks
Glatfelter board raises quarterly dividend 4% to 13c per share »

Glatfelter announced that…

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  • 27

    Feb

KO

Coca-Cola

$41.99

0.385 (0.93%)

12:50
02/23/17
02/23
12:50
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12:50
Hot Stocks
Coca-Cola COO: Company needs to reshape growth equation for sparkling segment »

Says needs to reshape…

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  • 23

    Feb

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LMT

Lockheed Martin

$264.79

-1.13 (-0.42%)

12:49
02/23/17
02/23
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12:49
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Lockheed Martin awards new contract to IBC Advanced Alloys for F-35 parts »

IBC Advanced Alloys…

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  • 23

    Feb

CL

Colgate-Palmolive

$74.80

1.31 (1.78%)

12:46
02/23/17
02/23
12:46
02/23/17
12:46
Options
Colgate Palmolive call volume above normal and directionally bullish »

Bullish option flow…

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  • 23

    Feb

TSLA

Tesla

$273.51

-3.88 (-1.40%)

, HPQ

HP Inc.

$17.64

1.435 (8.86%)

12:45
02/23/17
02/23
12:45
02/23/17
12:45
General news
On The Fly: Top stock stories at midday »

Stocks began the session…

TSLA

Tesla

$273.51

-3.88 (-1.40%)

HPQ

HP Inc.

$17.64

1.435 (8.86%)

NVDA

NVIDIA

$110.76

-0.31 (-0.28%)

LB

Labarge

$49.44

-8.69 (-14.95%)

SQ

Square

$17.13

2.0858 (13.87%)

CRI

Carter's

$87.79

4.21 (5.04%)

ACM

AECOM

$36.51

-1.48 (-3.90%)

JEC

Jacobs Engineering

$56.08

-0.72 (-1.27%)

KBR

KBR

$16.02

-0.32 (-1.96%)

CBI

CB&I

$33.75

-0.97 (-2.79%)

STLD

Steel Dynamics

$37.37

-0.22 (-0.59%)

AKS

AK Steel

$8.23

-0.56 (-6.37%)

X

U.S. Steel

$37.74

-2.75 (-6.79%)

FLR

Fluor

$55.63

-0.97 (-1.71%)

GVA

Granite Construction

$52.20

-2.115 (-3.89%)

VMC

Vulcan Materials

$116.45

-3.69 (-3.07%)

PWR

Quanta Services

$36.88

-0.7782 (-2.07%)

MTZ

MasTec

$36.50

-1 (-2.67%)

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  • 23

    Feb

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    Feb

  • 05

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  • 07

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  • 07

    Mar

  • 16

    Mar

  • 17

    Apr

12:45
02/23/17
02/23
12:45
02/23/17
12:45
General news
Breaking General news story  »

Dallas Federal Reserve…

VRTU

Virtusa

$28.80

-0.06 (-0.21%)

12:42
02/23/17
02/23
12:42
02/23/17
12:42
Conference/Events
Virtusa management to meet with Needham »

Meeting to be held in…

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  • 23

    Feb

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  • 07

    Mar

  • 16

    Mar

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    Mar

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    Mar

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    Mar

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    Mar

GOOG

Alphabet

$830.76

-0.9 (-0.11%)

, GOOGL

Alphabet Class A

$851.36

2.09 (0.25%)

12:42
02/23/17
02/23
12:42
02/23/17
12:42
Hot Stocks
Google Fiber launches 'Webpass' wireless service in Denver »

Google Fiber announced…

GOOG

Alphabet

$830.76

-0.9 (-0.11%)

GOOGL

Alphabet Class A

$851.36

2.09 (0.25%)

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  • 23

    Feb

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