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ALXN

Alexion

$146.46

2.39 (1.66%)

18:01
09/13/17
09/13
18:01
09/13/17
18:01

Alexion: Soliris study results show sustained treatment benefits

Alexion Pharmaceuticals announced results from an interim analysis of an ongoing Phase 3 open-label extension study of the pivotal, placebo-controlled REGAIN study of Soliris for the treatment of patients with refractory generalized myasthenia gravis who are anti-acetylcholine receptor antibody-positive. The new results show sustained treatment benefits across a range of MG-specific assessment scales through an additional 52 weeks for patients who continued to receive Soliris, and also demonstrate rapid, significant and sustained improvements through 52 weeks for patients who had crossed over from placebo in REGAIN to Soliris treatment in the extension study. The safety profile of Soliris was consistent with that observed in the REGAIN study. "There is an urgent need for a treatment for patients with refractory gMG who have attempted multiple therapies and continue to suffer from severe symptoms and complications," said Professor James F. Howard, MD, Department of Neurology at the University of North Carolina, Chapel Hill, USA, and lead investigator in REGAIN and its open-label extension study. "These new results build on the findings of the REGAIN study, and it is encouraging to see the rapid and sustained benefits of Soliris treatment with patients recovering functional ability to carry out activities of daily living, and quality of life."

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ALXN Alexion
$146.46

2.39 (1.66%)

08/16/17
EVER
08/16/17
INITIATION
Target $137
EVER
In Line
Alexion initiated with an In Line at Evercore ISI
Evercore ISI analyst Josh Schimmer initiated Alexion with an In Line and a $137 price target.
09/05/17
JPMS
09/05/17
UPGRADE
Target $175
JPMS
Overweight
Alexion upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Anupam Rama upgraded Alexion Pharmaceuticals to Overweight and raised his price target for the shares to $175 from $163. The stock closed Friday up $1.67 to $144.08. Alexion set low expectations for second half of 2017 earnings and the Street is now shifting its focus to clinical catalysts over the next 6-12 months, Rama tells investors in a research note. The analyst has a positive stance on a supplemental approval of Soliris for myasthenia gravis by the October FDA action date as well as continued confidence in ALXN1210 as a "long-term defense point for Alexion's complement franchise."
09/07/17
LEER
09/07/17
NO CHANGE
LEER
Alexion, Celgene top picks at Leerink
Leerink analyst Geoffrey Porges notes large cap biotech stocks have performed strongly this year and have reversed some of the wide discount they were carrying compared to their history and to other medical products sectors. Further, he points out consensus revenue and earnings estimates for biotech companies have started to trend positively, after negative revisions earlier in the year. Porges still sees significant upside for many of the names in his coverage, and he anticipates that further appreciation can occur on the basis of recovering sentiment and multiples, further estimate revisions toward his current models, and confirmation of option value for unpriced pipeline opportunities. The analyst top picks are now Alexion (ALXN), Celgene (CELG), Regeneron (REGN), and Vertex (VRTX). Among his Market Perform rated stocks, his preference would be for AbbVie (ABBV).
09/13/17
LEER
09/13/17
NO CHANGE
Target $182
LEER
Outperform
Alexion price target raised to $182 from $170 at Leerink
Leerink analyst Geoffrey Porges raised his price target for Alexion to $182 from $170 on valuation. The analyst reiterates an Outperform rating on the shares.

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