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KPTI

Karyopharm

$9.92

0.06 (0.61%)

06:24
10/05/16
10/05
06:24
10/05/16
06:24

Karyopharm to present SIGN Phase 2 data on gynecologic cancers

Karyopharm Therapeutics announced an oral presentation highlighting updated clinical data from the company's ongoing Phase 2 study of selinexor, its Selective Inhibitor of Nuclear Export / SINE compound that inhibits exportin 1, for the treatment of gynecological cancers. Two posters featuring predictive biomarker data supporting selinexor's activity in gynecological and colorectal cancers will also be presented. The oral presentation will describe clinical data from the study, which includes durable anti-cancer activity in gynecological malignancies with disease control rates up to 49% and good tolerability. Selinexor-associated adverse events were found to be manageable. Ovarian cancer patients receiving 50 mg/m2 of selinexor once weekly achieved similar benefit with considerably fewer adverse events compared to those receiving twice weekly dosing. Of the 59 evaluable patients with ovarian cancer, 29 met the primary endpoint for a disease control rate of 49%. Median progression free survival for the ovarian cancer arm was 3 months and median overall survival was 7 months. Of the 20 evaluable patients with endometrial cancer, 9 met the primary endpoint for a DCR of 45%. Median PFS for the endometrial cancer arm was 3 months and median OS was 8 months.

  • 07

    Oct

KPTI Karyopharm
$9.92

0.06 (0.61%)

05/27/16
RAJA
05/27/16
INITIATION
Target $13
RAJA
Outperform
Karyopharm initiated with an Outperform at Raymond James
Raymond James analyst Christopher Raymond initiated Karyopharm with an Outperform and $13 price target. Raymond said Karyopharm is close to a value creation period with key trial read outs that can help advance lead compound selinexor and transition Karyopharm to a commercial entity. Further, its wholly-owned, novel technology platform with an experienced management team and an attractive valuation make shares a compelling investment, the analyst added.
06/27/16
BARD
06/27/16
INITIATION
Target $16
BARD
Outperform
Karyopharm initiated with an Outperform at Baird
Target $16.
08/18/16
HCWC
08/18/16
INITIATION
Target $15
HCWC
Buy
Karyopharm initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Shaunak Deepak started Karyopharm Therapeutics with a Buy rating and $15 price target.
08/30/16
JEFF
08/30/16
UPGRADE
Target $12
JEFF
Buy
Karyopharm upgraded to Buy from Hold at Jefferies
Jefferies analyst Brian Abrahams upgraded Karyopharm Therapeutics to Buy citing increasing confidence that near-term data will support a path forward and potential role for selinexor in the future multiple myeloma landscape. The analyst believes selinexor presents a significant revenue opportunity and he upped his price target for the shares to $12 from $9.

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FQVLF

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VZ

Verizon

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Sanmina

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WWD

Woodward

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TWTR

Twitter

$23.32

-0.34 (-1.44%)

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GE

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$16.17

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, NFLX

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JMBA

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ANET

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