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ALNY

Alnylam

$70.30

1.73 (2.52%)

, NBIX

Neurocrine

$51.26

0.99 (1.97%)

05:38
10/06/16
10/06
05:38
10/06/16
05:38

Alnylam downgraded to Equal Weight from Overweight at Barclays

Barclays analyst Geoff Meacham downgraded Alnylam Pharmaceuticals (ALNY) to Equal Weight saying he views other SMid cap biotech names as more attractive following the company's recent pipeline setbacks. The analyst removed Revusiran sales from his Alnylam model after the program was discontinued yesterday and he cut his price target for the shares to $50 from $85. Meacham lists Neurocrine (NBIX), Prothena (PTRA) and Incyte (INCY) as names he finds more attractive over the next 12 months. Alnylam is trading down 44% in pre-market trading to $39.25.

ALNY

Alnylam

$70.30

1.73 (2.52%)

NBIX

Neurocrine

$51.26

0.99 (1.97%)

PRTA

Prothena

$62.92

1.11 (1.80%)

INCY

Incyte

$95.69

1.52 (1.61%)

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    Nov

ALNY Alnylam
$70.30

1.73 (2.52%)

09/15/16
09/15/16
INITIATION
Target $82

Underperform
FBR calls Alexion overvalued, starts shares at Underperform
FBR Capital analyst Christopher James initiated coverage of Alexion Pharmaceuticals (ALXN) with an Underperform rating and $82 price target. The biotech focused on patients with ultra-rare disorders closed yesterday up $2.63 to $129.42. Alexion shares are overpriced as the company is facing a competitive near-term landscape, particularly from Alnylam's (ALNY) ALN-CC5, James tells investors in a research note. Further, near-term expansion into additional indications will be challenging given the recent failed study with eculizumab in refractory generalized myasthenia gravis, the analyst contends. He also sees possible pricing pressures from biosimilars, including an Amgen (AMGN) biosimilar product in development. James this morning also initiated Achillion Pharmaceuticals (ACHN) and Arena Pharmaceuticals (ARNA) with Outperform ratings.
09/09/16
LEER
09/09/16
NO CHANGE
LEER
Leerink updates therapeutics best ideas for 2016
In a note to investors this morning, Leerink has updated its best ideas for 2016 from the firm's five therapeutics analysts. The list includes Alexion (ALXN), Dermira (DERM), Intra-Cellular (ITCI), Sanofi (SNY), Allergan (AGN), Alnylam (ALNY), Innate Pharma (IPHYF), The Medicines Co. (MDCO), and Ophthotech (OPHT).
08/22/16
WEDB
08/22/16
NO CHANGE
WEDB
Intellia Therapeutics data positive, says Wedbush
Wedbush analyst David Nierengarten says that additional data on Intella's (NTLA) TTR program in mice was "meaningful" and indicates that the program compares favorably with competing products. The analyst says that competing programs, including those of Alnylam (ALNY) and Ionis (IONS) have shown "only a transient benefit." He reiterates a $38 price target and Outperform rating on Intella.
09/28/16
JANY
09/28/16
INITIATION
Target $74
JANY
Neutral
Alnylam initiated with a Neutral at Janney Capital
Janney Capital analyst Roy Buchanan initiated Alnylam with a Neutral and a $74 fair value estimate. The analyst is not confident about the outcome for the pivotal study for patisiran in transthyretin familial amyloid neuropathy, expected in about 12 months, and give patisiran a 50% chance of success.
NBIX Neurocrine
$51.26

0.99 (1.97%)

06/06/16
BMOC
06/06/16
NO CHANGE
BMOC
Neurocrine price target raised to $66 from $57 at BMO Capital
BMO Capital raised its price target on Neutrocirne (NBIX) as it believes that the company's elagolix drug has a positive read through from data recently presented by AbbVie (ABBV). .
09/23/16
LEER
09/23/16
NO CHANGE
LEER
Outperform
Positive data paves way for Teva SD-809 indication, says Leerink
Leerink analyst Jason Gerberry says the AIM-TD study readout clinically de-risks Teva's (TEVA) SD-809 opportunity for tardive dyskinesia, with the investor focus shifting to market size and competitive differentiation versus Neurocrine's (NBIX) valbenazine. The analyst believes Teva's SD-809 is well positioned to compete against valbenazine with an equally efficacious and well tolerated drug. Further, he expects Teva to exit 2017 with a broader label. Gerberry reiterates an Outperform rating on Teva's shares.
10/04/16
LEER
10/04/16
INITIATION
Target $70
LEER
Outperform
Neurocrine reinstated with an Outperform at Leerink
Leerink analyst Paul Matteis resumed coverage of Neurocrine with an Outperform rating and $70 price target.
06/29/16
HCWC
06/29/16
INITIATION
Target $80
HCWC
Buy
Neurocrine initiated with a Buy at H.C. Wainwright
H.C. Wainwright analyst Andrew Fein started Neurocrine Biosciences with a Buy rating and $80 price target.
PRTA Prothena
$62.92

1.11 (1.80%)

06/10/16
RBCM
06/10/16
NO CHANGE
RBCM
Prothena data positive, says RBC Capital
RBc Capital believes that the Phase I data for Prothena's antibody program, '003, was positive. The firm thinks the treatment "could be a new psoriasis drug or go after other big inflammatory markets." The firm expects '003 to begin to get attention from investors, and it views the product as "somewhat de-risked." RBC keeps an Outperform rating on the shares.
09/27/16
RBCM
09/27/16
NO CHANGE
RBCM
Prothena CEO change 'neutral, natural, and positive' says RBC Capital
Afte Prothena announced its CEO was taking a medical leave and that it was elevating its COO, Gene Kinney, to interim CEO, RBC Capital analyst Michael Yee says "this a a neutral and natural positive development." Yee reports that Kinney " has been generally in charge of and overseen the R&D and clinical development of their 3 lead programs and involved in leading discussions with the FDA." The analyst believes that the company had previously been planning for succession and that investors should not be surprised by this development, as they knew that the CEO had health problems. Yee keeps an Outperform rating on the shares.
08/03/16
LTCO
08/03/16
NO CHANGE
Target $80
LTCO
Buy
Prothena price target raised to $80 from $77 at Ladenburg
Ladenburg Thalmann analyst Robert Hazlett said the recently released clinical data from the Phase 1/2 study of NEOD001 continue to point to promising organ responses that do not appear to be related to prior plasma cell directed therapy. Noting there are catalysts upcoming for NEOD001, PRX002 and PRX003, the analyst raised his price target on the stock to $80, adding that he assigns a 70% probability of Prothena operating independently and a 30% probability to a takeover.
09/27/16
UBSW
09/27/16
NO CHANGE
Target $73
UBSW
Buy
Prothena management has continuity during CEO leave of absence, says UBS
UBS analyst Jeffrey Hung noted that Prothena's COO Gene Kinney will lead the company while its CEO, Dale Schenk, is on a medical leave of absence. Hung notes that the NEOD001 strategy is already largely in place and he believes the Board's confidence in Kinney, combined with his recent promotion, points to the potential for a natural succession. The analyst keeps a Buy rating and $73 price target on Prothena shares.
INCY Incyte
$95.69

1.52 (1.61%)

08/22/16
GSCO
08/22/16
NO CHANGE
GSCO
Goldman lists companies to be in focus after Medivation deal
After Pfizer (PFE) announced it has agreed to acquire Medivation (MDVN) for $81.50 per share in cash, Goldman Sachs analyst Salveen Richter said he expects a focus on other commercial small-to-mid-cap cancer companies, including Incyte (INCY), Seattle Genetics (SGEN), ARIAD (ARIA) and Exelixis (EXEL). Also noting that Sanofi (SNY), which was pursuing Medivation, has recently suggested an interest in a rare disease transaction up to potentially as large as $20B, he would expect rare disease companies of that size - such as BioMarin (BMRN), Amicus (FOLD) and Ultragenyx (RARE) - to be in focus as well.
09/29/16
RAJA
09/29/16
UPGRADE
Target $115
RAJA
Outperform
Incyte upgraded to Outperform from Market Perform at Raymond James
Raymond James analyst Reni Benjamin upgraded Incyte to Outperform with a $115 price target following the release of an abstract showcasing "positive" long-term follow-up results for epacadostat in melanoma. Epacadostat plus pembrolizumab, should ;the results be confirmed in the ongoing Phase III study, could effectively compete with ipilimumab and nivolumab, Benjamin tells investors in a research note.
09/29/16
09/29/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. eBay (EBAY) upgraded to Buy from Hold at Deutsche Bank with analyst Ross Sandler saying eBay is likely to outperform Internet peers over the next two years now that its re-platforming is in the latter stages. 2. BlackBerry (BBRY) upgraded to Neutral from Underperform at Macquarie with analyst Gus Papageorgiou saying he expects operations to stabilize and profitability to return next year. 3. Endo (ENDP) upgraded to Outperform from Market Perform at Northland. 4. Rex Energy (REXX) upgraded to Hold from Sell at Stifel with analyst Michael Scialla saying the production cut may not actually occur, but he believes that other factors, along with positive commentary from OPEC, "appears to be building an oil price floor of $40." 5. Incyte (INCY) upgraded to Outperform from Market Perform at Raymond James with analyst Reni Benjamin saying Epacadostat plus pembrolizumab, should ;the results be confirmed in the ongoing Phase III study, could effectively compete with ipilimumab and nivolumab. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/21/16
09/21/16
NO CHANGE

RBC identifies top biotech takeover candidates
RBC Capital identified the following names as its top potential takeover candidates in the biotech space: ARIAD (ARIA), Spark Therapeutics (ONCE), BioMarin (BMRN), Aerie Pharmaceuticals (AERI), Intra-Cellular (ITCI), TESARO (TSRO), Incyte (INCY), Sarepta (SRPT), and Puma Biotechnology (PBYI). The firm thinks that investors are underestimating the positive impact that M&A will have on biotech stock prices.

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NVS

Novartis

$87.21

0.21 (0.24%)

, CMCSA

Comcast

$42.44

-0.45 (-1.05%)

20:25
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UTX

United Technologies

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ABT

Abbott

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Royal Caribbean

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Stanley Black & Decker

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Rockwell Automation

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Northern Trust

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Grainger

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CERS

Cerus

$4.33

0.14 (3.34%)

19:39
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Cerus to hold a pharmaceutical update conference call »

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XPER

Xperi

$22.85

0.35 (1.56%)

19:26
01/23/18
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19:26
Conference/Events
Xperi to hold a conference call »

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MDR

McDermott

$7.86

-0.1 (-1.26%)

19:14
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Upgrade
McDermott rating change at KeyBanc »

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BDRBF

Bombardier

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Embraer

$24.13

-0.34 (-1.39%)

19:08
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19:08
Periodicals
Bombardier invokes Embraer in Boeing trade dispute, Globe and Mail says »

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BDRBF

Bombardier

ERJ

Embraer

$24.13

-0.34 (-1.39%)

BA

Boeing

$335.59

-2.41 (-0.71%)

DAL

Delta Air Lines

$59.93

-0.2 (-0.33%)

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GSBC

Great Southern Bancorp

$52.00

0.45 (0.87%)

19:01
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Earnings
Great Southern Bancorp reports preliminary Q4 EPS 86c, consnesus 83c »

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UUUU

Energy Fuels

$1.72

0.035 (2.08%)

18:48
01/23/18
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18:48
Hot Stocks
Energy Fuels names Mark S. Chalmers president and CEO »

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General news
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RBS

RBS

$8.46

-0.02 (-0.24%)

18:10
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Periodicals
RBS plans to leave London headquarters by end of 2019, Reuters reports »

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TROX

Tronox

$21.88

0.07 (0.32%)

18:09
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Hot Stocks
Tronox files lawsuit to prevent FTC from blocking proposed Cristal acquisition »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

18:00
01/23/18
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Hot Stocks
United Financial reports Q4 provision for loan losses $2.3M »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

17:59
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Earnings
United Financial reports Q4 EPS with items 19c, consensus 30c »

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SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

, SPX

S&P 500

17:55
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General news
Breaking General news story on SPDR S&P 500 ETF Trust, S&P 500 »

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SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

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S&P 500

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Conference/Events
Federal Reserve Bank of Chicago President participates in a discussion »

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HESM

Hess Midstream Partners

$21.75

0.45 (2.11%)

17:46
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Hess Midstream Partners raises quarterly dividend 3.6% to 32.2c per unit »

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GWB

Great Western

$44.29

0.53 (1.21%)

17:33
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Great Western announces financial impact resulting from Tax Cuts and Jobs Act »

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ARAY

Accuray

$5.20

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TSYS

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On The Fly: After Hours Movers »

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Accuray

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TSYS

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CERS

Cerus

$4.33

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NTIP

Network-1 Technologies

$2.60

0.1 (4.00%)

GOOG

Alphabet

$1,169.97

14.16 (1.23%)

GOOGL

Alphabet Class A

$1,176.17

12.01 (1.03%)

QGEN

Qiagen

$33.55

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SIRI

SiriusXM

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VLO

Valero

$98.69

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UAL

United Continental

$77.97

1.1 (1.43%)

NAVI

Navient

$13.44

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CREE

Cree

$35.02

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COF

Capital One

$105.71

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TXN

Texas Instruments

$119.89

0.45 (0.38%)

PBYI

Puma Biotechnology

$90.90

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SIGM

Sigma Designs

$7.00

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FPRX

Five Prime

$22.43

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RCKT

Rocket Pharmaceuticals

$15.19

1.92 (14.47%)

TK

Teekay Corp.

$10.74

0.05 (0.47%)

SBBP

Strongbridge Biopharma

$8.70

0.25 (2.96%)

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UAL

United Continental

$77.97

1.11 (1.44%)

17:25
01/23/18
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17:25
Earnings
United Continental sees FY18 EPS $6.50-$8.50, consensus $6.97 »

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17:25
01/23/18
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Conference/Events
The Chicago Council on Global Affairs to hold a panel discussion »

The Chicago Council on…

MULE

MuleSoft

$25.08

-0.31 (-1.22%)

17:21
01/23/18
01/23
17:21
01/23/18
17:21
Initiation
MuleSoft initiated at Nomura Instinet »

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MDB

MongoDB

$28.83

0.02 (0.07%)

17:19
01/23/18
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17:19
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17:19
Initiation
MongoDB initiated at Nomura Instinet »

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UAL

United Continental

$77.97

1.1 (1.43%)

17:19
01/23/18
01/23
17:19
01/23/18
17:19
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY19 and FY20…

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UAL

United Continental

$77.97

1.1 (1.43%)

17:18
01/23/18
01/23
17:18
01/23/18
17:18
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY18 CASM…

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