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EXEL

Exelixis

$13.18

0.06 (0.46%)

, RHHBY

Roche

$30.54

-0.29 (-0.94%)

04:51
10/07/16
10/07
04:51
10/07/16
04:51

Exelixis announces Genentech presentation of preliminary phase 1b trial results

Exelixis (EXEL) announced that its collaborator Genentech, a member of the Roche Group (RHHBY), will present preliminary results from a phase 1b clinical trial evaluating the safety and clinical activity of the triple combination of cobimetinib, vemurafenib, and atezolizumab in patients with previously untreated BRAF V600 mutation-positive advanced melanoma. The results will be the subject of a poster discussion presentation at the European Society of Medical Oncology 2016 Congress, which is being held October 7-11 in Copenhagen, Denmark. "Cobimetinib and vemurafenib is FDA-approved to treat specific forms of BRAF V600 mutation-positive unresectable or metastatic melanoma and has been associated with significant improvements in progression-free survival, overall survival and objective response rate as compared to vemurafenib alone," said Michael M. Morrissey, Ph.D., president and chief executive officer of Exelixis. "The preliminary results to be presented at the ESMO Congress suggest that adding atezolizumab to the combination regimen is associated both with a manageable safety profile and promising antitumor activity."

EXEL

Exelixis

$13.18

0.06 (0.46%)

RHHBY

Roche

$30.54

-0.29 (-0.94%)

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EXEL Exelixis
$13.18

0.06 (0.46%)

08/04/16
STFL
08/04/16
NO CHANGE
STFL
Exelixis price target raised to $12 from $10 at Stifel
Stifel analyst Stephen Willey raised his price target on Exelixis after the company reported significantly better than expected Cabometyx and residual/off-label Cometriq sales into the newly launched indication of refractory renal cell carcinom. Willey expects the results to improve investors' confidence towards the company's growth outlook, and he says that anticipation of front-line CABOSUN results places a near-term floor on the stock. The analyst keeps a Buy rating on the shares.
08/22/16
GSCO
08/22/16
NO CHANGE
GSCO
Goldman lists companies to be in focus after Medivation deal
After Pfizer (PFE) announced it has agreed to acquire Medivation (MDVN) for $81.50 per share in cash, Goldman Sachs analyst Salveen Richter said he expects a focus on other commercial small-to-mid-cap cancer companies, including Incyte (INCY), Seattle Genetics (SGEN), ARIAD (ARIA) and Exelixis (EXEL). Also noting that Sanofi (SNY), which was pursuing Medivation, has recently suggested an interest in a rare disease transaction up to potentially as large as $20B, he would expect rare disease companies of that size - such as BioMarin (BMRN), Amicus (FOLD) and Ultragenyx (RARE) - to be in focus as well.
09/28/16
LEER
09/28/16
NO CHANGE
LEER
Exelixis selloff overdone, says Leerink
09/28/16
LEER
09/28/16
NO CHANGE
LEER
Outperform
Exelixis selloff based on ESMO abstracts overdone, says Leerink
Leerink analyst Michael Schmidt believes Exelixis' selloff following the publication of ESMO poster abstracts is overdone. The analyst notes that abstract includes updated data from a Phase Ib trial evaluating the combination of axitinib with pembrolizumab and appears to have sparked competitive concerns for Exelixis. However, he believes it is highly premature to draw conclusions at this point on the company's Cabometyx' market opportunity or potential in Renal Cell Carcinoma. Schmidt reiterates an Outperform rating on the shares. In afternoon trading, Exelixis' stock has dropped over 15% to $13.12 per share.
RHHBY Roche
$30.54

-0.29 (-0.94%)

09/01/16
BMOC
09/01/16
NO CHANGE
BMOC
Bristol-Myers has negative read through from Roche data, says BMO Capital
BMO Capital analyst Alex Arfaei says that the positive data on Roche's (RHHBY) TECENTRIQ for second line NSCLC is negative for Bristol-Myers' (BMY) cancer drug, Opdivo. The analyst does not think that TECENTRIQ's results will be superior to that of Opdivo, but he believes that Roche's drug appears to have "a significant" benefit in PD-L1 positive patients." He predicts that Roche's drug could take "meaningful market share, particularly outside of the U.S." The analyst keeps a Market Perform rating on Bristol-Myers.
09/07/16
09/07/16
NO CHANGE

BioLineRx partnering with Roche company in cancer therapy research
BioLineRx (BLRX) has entered into a collaboration with Genentech, a member of the Roche (RHHBY) Group, to support several Phase 1b studies investigating BioLineRx's BL-8040 in combination with Atezolizumab, Genentech's anti-PDL1 cancer immunotherapy, in multiple cancer indications. The Phase 1b studies will evaluate the clinical response, safety and tolerability of the combination of these therapies, as well as multiple pharmacodynamic parameters, in hematologic malignancies and solid tumors. Under the agreement, Genentech will sponsor and conduct several Phase 1b trials in multiple solid cancer indications. In addition, BioLineRx will sponsor and conduct a Phase 1b study in acute myeloid leukemia patients. The studies are designed to evaluate the safety and efficacy of the combination of BL-8040 and Atezolizumab. Upon completion of the studies, both parties will have the option to expand the collaboration to include a pivotal registration study. Additional details of the collaboration were not disclosed.
09/12/16
JEFF
09/12/16
NO CHANGE
Target $57
JEFF
Hold
Jefferies cuts Bristol-Myers price target, upgrades AstraZeneca
Jefferies analyst Jeffrey Holford lowered his price target for Bristol-Myers Squibb (BMY) to $57 from $69 saying the stock is positioned for a "rough mid term ride." The analyst sees a "difficult catalyst" set for Bristol shares with "numerous" upcoming competitor read-outs in non-small cell lung cancer. The market could see worse than expected data from Bristol's CM-026 and CM-568 studies as well as better than expected data from AstraZeneca's (AZN) MYSTIC study and Roche's (RHHBY) Chemo-IO studies in the first half of 2017, Holford tells investors in a research note. He keeps a Hold rating on Bristol and upgraded this morning AstraZeneca to Buy from Hold. Holford prefers Astra for its immunology exposure.
09/27/16
PIPR
09/27/16
NO CHANGE
Target $62
PIPR
Neutral
Bristol-Myers price target lowered to $62 from $65 at Piper Jaffray
Piper Jaffray analyst Richard Purkiss lowered his price target for Bristol-Myers Squibb (BMY) to $62 saying he sees the company ceding Opdivo's early-mover advantage in lung cancer to competitors. The analyst expects to see details from Roche's (RHHBY) positive OAK trial of Tecentriq vs. docetaxel in non-small cell lung cancer at the upcoming ESMO meeting. Purkiss also expects to see details from Merck's (MRK) positive KEYNOTE-024 trial of Keytruda. The analyst lowered his post-2016 Opdivo forecasts and reiterates a Neutral rating on Bristol shares.

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FX Update: The dollar edged out fresh recovery highs »

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MS

Morgan Stanley

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BNY Mellon

$57.89

0.35 (0.61%)

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BB&T

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PPG

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MTB

M&T Bank

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KEY

KeyCorp

$21.26

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JBHT

J.B. Hunt

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ARNA

Arena Pharmaceuticals

$34.36

0.48 (1.42%)

20:24
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Initiation
Arena Pharmaceuticals initiated at Credit Suisse »

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ROSE

Rosehill Resources

$7.96

0.01 (0.13%)

20:12
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Initiation
Rosehill Resources initiated at Northland »

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HES

Hess Corp.

$54.02

0.48 (0.90%)

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Initiation
Hess Corp. initiated at Macquarie »

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OXY

Occidental Petroleum

$75.86

0.59 (0.78%)

20:10
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Initiation
Occidental Petroleum initiated at Macquarie »

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JUNO

Juno Therapeutics

$69.25

23.65 (51.86%)

19:53
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19:53
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19:53
Downgrade
Juno Therapeutics rating change at Citi »

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WP

Worldpay

$77.89

-0.37 (-0.47%)

19:52
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Upgrade
Worldpay rating change at BMO Capital »

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FRAC

Keane Group

$18.51

0.63 (3.52%)

19:52
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Syndicate
Keane Group 13.3M share Secondary priced at $18.25 »

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INTC

Intel

$44.39

1.25 (2.90%)

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Hot Stocks
Intel says issued firmware updates for 90% of CPUs in past vie years »

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TOSBF

Toshiba, also use TOSYY

, TOSYY

Toshiba, also use TOSBF

$16.95

-0.01 (-0.06%)

19:11
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19:11
Periodicals
Toshiba's Westinghouse to forgo bankruptcy, Reuters reports »

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TOSBF

Toshiba, also use TOSYY

TOSYY

Toshiba, also use TOSBF

$16.95

-0.01 (-0.06%)

BAM

Brookfield

$43.10

0.42 (0.98%)

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RDS.A

Royal Dutch Shell

$70.20

0.22 (0.31%)

, RDS.B

Royal Dutch Shell

$72.34

0.35 (0.49%)

19:02
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Periodicals
Shell, BP each agree to purchase Libyan oil, Bloomberg reports »

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RDS.A

Royal Dutch Shell

$70.20

0.22 (0.31%)

RDS.B

Royal Dutch Shell

$72.34

0.35 (0.49%)

BP

BP

$42.88

0.42 (0.99%)

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AAPL

Apple

$179.10

2.91 (1.65%)

18:31
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Hot Stocks
Trump says Apple investments 'huge win for American workers' »

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MPVD

Mountain Province Diamonds

$2.83

0.075 (2.73%)

18:22
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Mountain Province Diamonds provides update on Gahcho Kue Mine exploration »

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WAC

Walter Investment

$0.76

0.0347 (4.81%)

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Walter Investment prepackaged Chapter 11 plan approved by court »

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TM

Toyota

$140.72

2.75 (1.99%)

, KBSTY

Kobe Steel

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Toyota not affected by Kobe Steel false data scandal, Nikkei reports »

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TM

Toyota

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2.75 (1.99%)

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Kobe Steel

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CBOE

Cboe Global Markets

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, BTC

Bitcoin

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Cboe conducts first settlement of Cboe bitcoin futures »

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Cboe Global Markets

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BTC

Bitcoin

BITCOIN

Bitcoin

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GWRE

Guidewire

$75.64

0.19 (0.25%)

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Guidewire director sells 6,000 common shares »

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AAPL

Apple

$179.10

2.91 (1.65%)

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Apple analyst commentary at Piper Jaffray »

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OBE

Obsidian Energy

$1.21

-0.03 (-2.42%)

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SN

Sanchez Energy

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0.16 (2.83%)

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Breaking Hot Stocks news story on Sanchez Energy »

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NTDOY

Nintendo

$51.53

1.55 (3.10%)

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Nintendo announces Nintendo Labo accessories for Switch consoles »

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PTC

PTC

$66.70

1.41 (2.16%)

, ESIO

Electro Scientific

$22.01

1.91 (9.50%)

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Hot Stocks
On The Fly: After Hours Movers »

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PTC

PTC

$66.70

1.41 (2.16%)

ESIO

Electro Scientific

$22.01

1.91 (9.50%)

NEOT

Neothetics

$1.92

0.0793 (4.31%)

PLXS

Plexus

$64.36

0.59 (0.93%)

AA

Alcoa

$56.99

0.75 (1.33%)

SLM

Sallie Mae

$11.49

0.02 (0.17%)

ARWR

Arrowhead

$5.72

0.12 (2.14%)

PRTK

Paratek Pharmaceuticals

$17.68

-0.075 (-0.42%)

IIPR

Innovative Industrial Properties

$31.30

-2.49 (-7.37%)

ECC

Eagle Point Credit

$19.13

-0.39 (-2.00%)

AGIO

Agios Pharmaceuticals

$70.33

1.53 (2.22%)

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    Jan

BTU

Peabody Energy

$40.00

0.42 (1.06%)

17:17
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Breaking Hot Stocks news story on Peabody Energy »

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  • 07

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MLNX

Mellanox

$64.30

-0.45 (-0.69%)

17:12
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17:12
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Starboard to nominate nine directors for election at Mellanox »

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