Breaking News Instant updates and real-time market news.

ADHD

Alcobra

$2.60

-0.11 (-4.06%)

08:51
10/07/16
10/07
08:51
10/07/16
08:51

Alcobra receives full clinical hold notice from FDA

Alcobra announced that it has received the written full clinical hold notice from the Division of Psychiatry Products of the FDA in follow up to their verbal communication on the matter. As stated in Alcobra's public communications last week, the clinical hold affects Alcobra's Phase III clinical study of Metadoxine Extended Release, or MDX, in adult patients with ADHD, known as the "MEASURE" study. The FDA indicated in the letter that the clinical hold was placed due to electrophysiological neurologic findings in previously submitted long-term animal studies with Metadoxine. The FDA letter did not reference any clinical safety data observed in the MEASURE study or in previous human studies with MDX. The Division recommended that Alcobra schedule a meeting to discuss a plan to collect additional human safety data in its development program. Alcobra will continue to work rapidly and diligently with the FDA to seek the removal of the clinical hold and will provide an update following its meeting with the Agency.

ADHD Alcobra
$2.60

-0.11 (-4.06%)

09/29/16
ROTH
09/29/16
NO CHANGE
Target $7.5
ROTH
Buy
Alcobra price target lowered to $7.50 from $12 at Roth Capital
Roth Capital analyst Michael Higgins lowered his price target for Alcobra to $7.50 from $12 after the company announced that the FDA would be placing a full clinical hold on its primary asset, MDX, which had been expected to report pivotal trial results in Q1 from a trial of 750 patients with ADHD. However, the analyst reiterates a Buy rating on the shares as he continues to believe MDX will reach the primary endpoint in the MEASURE trial.
09/29/16
PIPR
09/29/16
DOWNGRADE
PIPR
Neutral
Alcobra downgraded to Neutral from Overweight at Piper Jaffray
09/30/16
PIPR
09/30/16
DOWNGRADE
Target $3
PIPR
Neutral
Alcobra downgraded to Neutral from Overweight at Piper Jaffray
Piper Jaffray analyst Charles Duncan yesterday after the close downgraded Alcobra to Neutral and cut his price target for the shares to $3 from $10. The analyst cites the near-term increase in clinical risk and timeline uncertainty after the company's Metadoxine program was placed on full clinical hold by the FDA.
09/30/16
09/30/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Alcobra (ADHD) downgraded to Neutral from Overweight at Piper Jaffray analyst Charles Duncan citing the near-term increase in clinical risk and timeline uncertainty after the company's Metadoxine program was placed on full clinical hold by the FDA. 2. CNO Financial (CNO) downgraded to Neutral from Buy at Goldman and to Neutral from Buy at BTIG. 3. CalAmp (CAMP) downgraded to Equal-Weight from Overweight at First Analysis with analyst Howard Smith saying the shares are likely range-bound until the company can build investor confidence in its growth profile. 4. Knoll (KNL) downgraded to Market Perform from Outperform at Raymond James with analyst Budd Bugatch citing the reports from office furniture manufacturers and residential furniture retailers that indicate business activity slowed in July and only modestly recovered in August and September. 5. Core-Mark (CORE) downgraded to Hold from Buy at Jefferies saying he sees earnings risk in 2017 following the loss of Circle K's Southeast. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

NVS

Novartis

$87.21

0.21 (0.24%)

, CMCSA

Comcast

$42.44

-0.45 (-1.05%)

20:25
01/23/18
01/23
20:25
01/23/18
20:25
Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

NVS

Novartis

$87.21

0.21 (0.24%)

CMCSA

Comcast

$42.44

-0.45 (-1.05%)

GE

General Electric

$16.89

0.72 (4.45%)

UTX

United Technologies

$136.03

0.82 (0.61%)

ABT

Abbott

$59.23

-0.34 (-0.57%)

GD

General Dynamics

$207.48

-0.72 (-0.35%)

ITW

Illinois Tool Works

$173.06

-0.33 (-0.19%)

NSC

Norfolk Southern

$151.66

0.19 (0.13%)

BHGE

Baker Hughes

$35.82

0.27 (0.76%)

PGR

Progressive

$57.05

-1.17 (-2.01%)

RCL

Royal Caribbean

$127.22

-1.48 (-1.15%)

SWK

Stanley Black & Decker

$173.89

-1.34 (-0.76%)

ROK

Rockwell Automation

$204.69

0.76 (0.37%)

NTRS

Northern Trust

$106.89

-0.54 (-0.50%)

GWW

Grainger

$229.45

-0.41 (-0.18%)

ROL

Rollins

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 24

    Jan

  • 08

    Feb

  • 16

    Feb

  • 02

    Mar

  • 23

    Apr

  • 17

    May

CERS

Cerus

$4.33

0.14 (3.34%)

19:39
01/23/18
01/23
19:39
01/23/18
19:39
Conference/Events
Cerus to hold a pharmaceutical update conference call »

Management discusses the…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

  • 26

    Feb

XPER

Xperi

$22.85

0.35 (1.56%)

19:26
01/23/18
01/23
19:26
01/23/18
19:26
Conference/Events
Xperi to hold a conference call »

Management holds a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

MDR

McDermott

$7.86

-0.1 (-1.26%)

19:14
01/23/18
01/23
19:14
01/23/18
19:14
Upgrade
McDermott rating change at KeyBanc »

McDermott upgraded to…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

BDRBF

Bombardier

, ERJ

Embraer

$24.13

-0.34 (-1.39%)

19:08
01/23/18
01/23
19:08
01/23/18
19:08
Periodicals
Bombardier invokes Embraer in Boeing trade dispute, Globe and Mail says »

Bombardier (BDRBF) says…

BDRBF

Bombardier

ERJ

Embraer

$24.13

-0.34 (-1.39%)

BA

Boeing

$335.59

-2.41 (-0.71%)

DAL

Delta Air Lines

$59.93

-0.2 (-0.33%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 31

    Jan

  • 21

    Feb

GSBC

Great Southern Bancorp

$52.00

0.45 (0.87%)

19:01
01/23/18
01/23
19:01
01/23/18
19:01
Earnings
Great Southern Bancorp reports preliminary Q4 EPS 86c, consnesus 83c »

Reports preliminary Q4…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 24

    Jan

UUUU

Energy Fuels

$1.72

0.035 (2.08%)

18:48
01/23/18
01/23
18:48
01/23/18
18:48
Hot Stocks
Energy Fuels names Mark S. Chalmers president and CEO »

Energy Fuels announced…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 29

    Jan

18:15
01/23/18
01/23
18:15
01/23/18
18:15
General news
Breaking General news story  »

Chicago Federal Reserve…

RBS

RBS

$8.46

-0.02 (-0.24%)

18:10
01/23/18
01/23
18:10
01/23/18
18:10
Periodicals
RBS plans to leave London headquarters by end of 2019, Reuters reports »

The Royal Bank of…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

TROX

Tronox

$21.88

0.07 (0.32%)

18:09
01/23/18
01/23
18:09
01/23/18
18:09
Hot Stocks
Tronox files lawsuit to prevent FTC from blocking proposed Cristal acquisition »

Tronox filed a lawsuit in…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

UBNK

United Financial

$17.92

-0.03 (-0.17%)

18:00
01/23/18
01/23
18:00
01/23/18
18:00
Hot Stocks
United Financial reports Q4 provision for loan losses $2.3M »

Reports Q4 provision for…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

UBNK

United Financial

$17.92

-0.03 (-0.17%)

17:59
01/23/18
01/23
17:59
01/23/18
17:59
Earnings
United Financial reports Q4 EPS with items 19c, consensus 30c »

Companies must recognize…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

, SPX

S&P 500

17:55
01/23/18
01/23
17:55
01/23/18
17:55
General news
Breaking General news story on SPDR S&P 500 ETF Trust, S&P 500 »

Senate confirms Jerome…

SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

SPX

S&P 500

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

17:55
01/23/18
01/23
17:55
01/23/18
17:55
Conference/Events
Federal Reserve Bank of Chicago President participates in a discussion »

Chicago Federal Reserve…

HESM

Hess Midstream Partners

$21.75

0.45 (2.11%)

17:46
01/23/18
01/23
17:46
01/23/18
17:46
Hot Stocks
Hess Midstream Partners raises quarterly dividend 3.6% to 32.2c per unit »

The distribution will be…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 05

    Feb

  • 26

    Feb

GWB

Great Western

$44.29

0.53 (1.21%)

17:33
01/23/18
01/23
17:33
01/23/18
17:33
Hot Stocks
Great Western announces financial impact resulting from Tax Cuts and Jobs Act »

Great Western Bancorp,…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 25

    Jan

ARAY

Accuray

$5.20

0.05 (0.97%)

, TSS

TSYS

$83.92

0.17 (0.20%)

17:27
01/23/18
01/23
17:27
01/23/18
17:27
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS:…

ARAY

Accuray

$5.20

0.05 (0.97%)

TSS

TSYS

$83.92

0.17 (0.20%)

CERS

Cerus

$4.33

0.14 (3.34%)

NTIP

Network-1 Technologies

$2.60

0.1 (4.00%)

GOOG

Alphabet

$1,169.97

14.16 (1.23%)

GOOGL

Alphabet Class A

$1,176.17

12.01 (1.03%)

QGEN

Qiagen

$33.55

0.5 (1.51%)

SIRI

SiriusXM

$5.68

0.03 (0.53%)

VLO

Valero

$98.69

-0.26 (-0.26%)

UAL

United Continental

$77.97

1.1 (1.43%)

NAVI

Navient

$13.44

-0.08 (-0.59%)

CREE

Cree

$35.02

-1.67 (-4.55%)

COF

Capital One

$105.71

0.22 (0.21%)

TXN

Texas Instruments

$119.89

0.45 (0.38%)

PBYI

Puma Biotechnology

$90.90

-3.05 (-3.25%)

SIGM

Sigma Designs

$7.00

0.025 (0.36%)

FPRX

Five Prime

$22.43

0.14 (0.63%)

RCKT

Rocket Pharmaceuticals

$15.19

1.92 (14.47%)

TK

Teekay Corp.

$10.74

0.05 (0.47%)

SBBP

Strongbridge Biopharma

$8.70

0.25 (2.96%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 23

    Jan

  • 24

    Jan

  • 24

    Jan

  • 31

    Jan

  • 01

    Feb

  • 01

    Feb

  • 01

    Feb

  • 07

    Feb

  • 26

    Feb

  • 28

    Feb

  • 18

    Mar

  • 21

    Mar

  • 24

    Jan

  • 24

    Jan

  • 25

    Jan

  • 26

    Jan

UAL

United Continental

$77.97

1.11 (1.44%)

17:25
01/23/18
01/23
17:25
01/23/18
17:25
Earnings
United Continental sees FY18 EPS $6.50-$8.50, consensus $6.97 »

Sees FY18 CapEx…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 23

    Jan

  • 21

    Mar

17:25
01/23/18
01/23
17:25
01/23/18
17:25
Conference/Events
The Chicago Council on Global Affairs to hold a panel discussion »

The Chicago Council on…

MULE

MuleSoft

$25.08

-0.31 (-1.22%)

17:21
01/23/18
01/23
17:21
01/23/18
17:21
Initiation
MuleSoft initiated at Nomura Instinet »

MuleSoft initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 15

    Feb

MDB

MongoDB

$28.83

0.02 (0.07%)

17:19
01/23/18
01/23
17:19
01/23/18
17:19
Initiation
MongoDB initiated at Nomura Instinet »

MongoDB initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

UAL

United Continental

$77.97

1.1 (1.43%)

17:19
01/23/18
01/23
17:19
01/23/18
17:19
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY19 and FY20…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 23

    Jan

  • 21

    Mar

UAL

United Continental

$77.97

1.1 (1.43%)

17:18
01/23/18
01/23
17:18
01/23/18
17:18
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY18 CASM…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 23

    Jan

  • 23

    Jan

  • 21

    Mar

APTI

Apptio

$24.39

0.02 (0.08%)

17:17
01/23/18
01/23
17:17
01/23/18
17:17
Initiation
Apptio initiated at Nomura Instinet »

Apptio initiated with a…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

  • 05

    Feb

VMW

VMware

$137.96

1.27 (0.93%)

17:16
01/23/18
01/23
17:16
01/23/18
17:16
Initiation
VMware initiated at Nomura Instinet »

Nomura starts VMware with…

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
Barclays

See Street Research during your Free Trial

Get Full Fly Access

Breaking market intelligence sent straight to you
Our team of experts analyze every news story and filter out the noise to deliver real-time market moving news.
Up-to-date information on important industry events
Get real-time updates on events that are moving the market—from conferences and calls to syndicate announcements.
News focused on the companies in your portfolio
Create up to 12 portfolios with 150 stocks each, and see how active they are in market news.