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OGXI

OncoGenex

$0.45

0.015 (3.46%)

07:31
10/13/16
10/13
07:31
10/13/16
07:31

OncoGenex says Phase 3 ENSPIRIT trial did not meet primary endpoint

OncoGenex Pharmaceuticals announced results from the final analysis of the Phase 3 ENSPIRIT trial of custirsen in patients whose non-small cell lung cancer has progressed following initial treatments. The trial did not meet the primary endpoint of demonstrating a statistically significant improvement in overall survival for patients treated with custirsen in combination with docetaxel compared to docetaxel alone. The median overall survival for the custirsen arm was 9.0 months versus 7.9 months for the control arm with a hazard ratio of 0.915 (one-sided p=0.178). Safety results were consistent with those observed in previous trials of custirsen in combination with chemotherapy. "Following the negative results of previous custirsen trials, an early final analysis of the ENSPIRIT trial was conducted in an effort to conserve capital and extend our cash runway," said Scott Cormack, President and CEO of OncoGenex. "We will continue to take appropriate steps to realize the most value for our shareholders once we receive the results of our apatorsen Phase 2 Borealis-2 bladder cancer trial which are expected by the end of October."

OGXI OncoGenex
$0.45

0.015 (3.46%)

12/02/15
STFL
12/02/15
DOWNGRADE
STFL
Hold
OncoGenex downgraded to Hold from Buy at Stifel
12/02/15
STFL
12/02/15
DOWNGRADE
STFL
Hold
OncoGenex downgraded on data miss at Stifel
As noted earlier, Stifel downgraded OncoGenex to Hold from Buy. The firm downgraded the stock after the company's AFFINITY drug combination failed to achieve a statistical threshold for overall survival in a subpopulation of metastatic castrate-resistant prostate cancer patients with poor-prognostic risk factors. The firm thinks that the drug combination's visibility is currently minimal.
12/02/15
12/02/15
DOWNGRADE

On The Fly: Analyst Downgrade Summary
Today's noteworthy downgrades include: ARM Holdings (ARMH) downgraded on royalty outlook at JMP Securities... ArcBest (ARCB) downgraded to Underperform from Neutral at BofA/Merrill... ArcelorMittal (MT) downgraded to Neutral from Buy at Citi... Banco Bilbao (BBVA) downgraded to Underperform from Neutral at BofA/Merrill... Bayer (BAYRY) downgraded to Neutral from Buy at Citi... Belgacom (BGAOY) downgraded to Sell from Neutral at Citi... C.H. Robinson (CHRW) downgraded to Underperform from Neutral at BofA/Merrill... Cepheid (CPHD) downgraded to Market Perform from Outperform at Wells Fargo... Eagle Bancorp (EGBN) downgraded to Market Perform from Outperform at Keefe Bruyette... Franklin Street (FSP) downgraded to Underweight from Equalweight at Capital One... Golar LNG (GLNG) downgraded to Neutral from Buy at BofA/Merrill... Grifols (GRFS) downgraded to Hold from Buy at HSBC... ITC Holdings (ITC) downgraded to Hold from Buy at Argus... Johnson Controls (JCI) downgraded to Market Perform from Outperform at William Blair... Knight Transportation (KNX) downgraded to Neutral from Buy at BofA/Merrill... Liberty Property (LPT) downgraded to Equalweight from Overweight at Capital One... Mattson (MTSN) downgraded to Hold from Buy at Needham... Nike (NKE) downgraded to Buy from Conviction Buy at Goldman... Old Dominion (ODFL) downgraded to Neutral from Buy at BofA/Merrill... OncoGenex (OGXI) downgraded on data miss at Stifel... STAG Industrial (STAG) downgraded to Equalweight from Overweight at Capital One... SunCoke Energy (SXC) downgraded to Neutral from Buy at Clarksons Platou... Swift Energy (SFY) downgraded to Underperform from Market Perform at Wells Fargo... Swift Transport (SWFT) downgraded to Neutral from Buy at BofA/Merrill... TerraForm Global (GLBL) downgraded to Sell from Neutral at Goldman... Thor Industries (THO) downgraded to Hold from Buy at Gabelli... Werner (WERN) downgraded to Underperform from Neutral at BofA/Merrill.

TODAY'S FREE FLY STORIES

02:40
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01/18
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General news
FX Update: The dollar edged out fresh recovery highs »

FX Update: The dollar…

MS

Morgan Stanley

$55.35

0.75 (1.37%)

, BK

BNY Mellon

$57.89

0.35 (0.61%)

20:25
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Earnings
Notable companies reporting before tomorrow's open »

Notable companies…

MS

Morgan Stanley

$55.35

0.75 (1.37%)

BK

BNY Mellon

$57.89

0.35 (0.61%)

BBT

BB&T

$53.28

0.2 (0.38%)

PPG

PPG

$114.50

-2.14 (-1.83%)

MTB

M&T Bank

$179.21

1.43 (0.80%)

KEY

KeyCorp

$21.26

-0.06 (-0.28%)

JBHT

J.B. Hunt

$120.65

0.01 (0.01%)

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    Mar

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    May

ARNA

Arena Pharmaceuticals

$34.36

0.48 (1.42%)

20:24
01/17/18
01/17
20:24
01/17/18
20:24
Initiation
Arena Pharmaceuticals initiated at Credit Suisse »

Arena Pharmaceuticals…

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ROSE

Rosehill Resources

$7.96

0.01 (0.13%)

20:12
01/17/18
01/17
20:12
01/17/18
20:12
Initiation
Rosehill Resources initiated at Northland »

Rosehill Resources…

03/08/13
Wedge Partners
03/08/13
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03/06/13
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HES

Hess Corp.

$54.02

0.48 (0.90%)

20:10
01/17/18
01/17
20:10
01/17/18
20:10
Initiation
Hess Corp. initiated at Macquarie »

Hess Corp. initiated with…

03/08/13
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03/06/13
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  • 05

    Feb

OXY

Occidental Petroleum

$75.86

0.59 (0.78%)

20:10
01/17/18
01/17
20:10
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20:10
Initiation
Occidental Petroleum initiated at Macquarie »

Occidental Petroleum…

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  • 14

    Feb

JUNO

Juno Therapeutics

$69.25

23.65 (51.86%)

19:53
01/17/18
01/17
19:53
01/17/18
19:53
Downgrade
Juno Therapeutics rating change at Citi »

Juno Therapeutics…

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Wedge Partners
03/08/13
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03/06/13
Citigroup
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WP

Worldpay

$77.89

-0.37 (-0.47%)

19:52
01/17/18
01/17
19:52
01/17/18
19:52
Upgrade
Worldpay rating change at BMO Capital »

Worldpay upgraded to…

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FRAC

Keane Group

$18.51

0.63 (3.52%)

19:52
01/17/18
01/17
19:52
01/17/18
19:52
Syndicate
Keane Group 13.3M share Secondary priced at $18.25 »

The deal size was…

03/08/13
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  • 18

    Jan

INTC

Intel

$44.39

1.25 (2.90%)

19:24
01/17/18
01/17
19:24
01/17/18
19:24
Hot Stocks
Intel says issued firmware updates for 90% of CPUs in past vie years »

Intel said it has made…

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  • 17

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    Jan

TOSBF

Toshiba, also use TOSYY

, TOSYY

Toshiba, also use TOSBF

$16.95

-0.01 (-0.06%)

19:11
01/17/18
01/17
19:11
01/17/18
19:11
Periodicals
Toshiba's Westinghouse to forgo bankruptcy, Reuters reports »

Westinghouse Electric…

TOSBF

Toshiba, also use TOSYY

TOSYY

Toshiba, also use TOSBF

$16.95

-0.01 (-0.06%)

BAM

Brookfield

$43.10

0.42 (0.98%)

03/08/13
Wedge Partners
03/08/13
Credit Suisse
03/06/13
Citigroup
03/06/13
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RDS.A

Royal Dutch Shell

$70.20

0.22 (0.31%)

, RDS.B

Royal Dutch Shell

$72.34

0.35 (0.49%)

19:02
01/17/18
01/17
19:02
01/17/18
19:02
Periodicals
Shell, BP each agree to purchase Libyan oil, Bloomberg reports »

Royal Dutch Shell (RDS.A)…

RDS.A

Royal Dutch Shell

$70.20

0.22 (0.31%)

RDS.B

Royal Dutch Shell

$72.34

0.35 (0.49%)

BP

BP

$42.88

0.42 (0.99%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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  • 18

    Jan

AAPL

Apple

$179.10

2.91 (1.65%)

18:31
01/17/18
01/17
18:31
01/17/18
18:31
Hot Stocks
Trump says Apple investments 'huge win for American workers' »

President Donald Trump…

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03/06/13
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  • 01

    Feb

MPVD

Mountain Province Diamonds

$2.83

0.075 (2.73%)

18:22
01/17/18
01/17
18:22
01/17/18
18:22
Hot Stocks
Mountain Province Diamonds provides update on Gahcho Kue Mine exploration »

Mountain Province…

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WAC

Walter Investment

$0.76

0.0347 (4.81%)

18:17
01/17/18
01/17
18:17
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18:17
Hot Stocks
Walter Investment prepackaged Chapter 11 plan approved by court »

Walter Investment…

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TM

Toyota

$140.72

2.75 (1.99%)

, KBSTY

Kobe Steel

18:10
01/17/18
01/17
18:10
01/17/18
18:10
Periodicals
Toyota not affected by Kobe Steel false data scandal, Nikkei reports »

Toyota (TM) said there…

TM

Toyota

$140.72

2.75 (1.99%)

KBSTY

Kobe Steel

03/08/13
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03/06/13
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CBOE

Cboe Global Markets

$131.52

0.73 (0.56%)

, BTC

Bitcoin

17:47
01/17/18
01/17
17:47
01/17/18
17:47
Hot Stocks
Cboe conducts first settlement of Cboe bitcoin futures »

Cboe Global Markets…

CBOE

Cboe Global Markets

$131.52

0.73 (0.56%)

BTC

Bitcoin

BITCOIN

Bitcoin

03/08/13
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  • 09

    Feb

GWRE

Guidewire

$75.64

0.19 (0.25%)

17:46
01/17/18
01/17
17:46
01/17/18
17:46
Hot Stocks
Guidewire director sells 6,000 common shares »

In a regulatory filing,…

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AAPL

Apple

$179.10

2.91 (1.65%)

17:40
01/17/18
01/17
17:40
01/17/18
17:40
Recommendations
Apple analyst commentary at Piper Jaffray »

Apple cash repatriation…

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  • 01

    Feb

OBE

Obsidian Energy

$1.21

-0.03 (-2.42%)

17:36
01/17/18
01/17
17:36
01/17/18
17:36
Hot Stocks
Breaking Hot Stocks news story on Obsidian Energy »

FrontFour reports 5.7%…

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SN

Sanchez Energy

$5.81

0.16 (2.83%)

17:33
01/17/18
01/17
17:33
01/17/18
17:33
Hot Stocks
Breaking Hot Stocks news story on Sanchez Energy »

Sanchez Energy sees Q1…

03/08/13
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  • 15

    May

NTDOY

Nintendo

$51.53

1.55 (3.10%)

17:32
01/17/18
01/17
17:32
01/17/18
17:32
Hot Stocks
Nintendo announces Nintendo Labo accessories for Switch consoles »

Nintendo introduced…

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  • 17

    Jan

PTC

PTC

$66.70

1.41 (2.16%)

, ESIO

Electro Scientific

$22.01

1.91 (9.50%)

17:28
01/17/18
01/17
17:28
01/17/18
17:28
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS: PTC…

PTC

PTC

$66.70

1.41 (2.16%)

ESIO

Electro Scientific

$22.01

1.91 (9.50%)

NEOT

Neothetics

$1.92

0.0793 (4.31%)

PLXS

Plexus

$64.36

0.59 (0.93%)

AA

Alcoa

$56.99

0.75 (1.33%)

SLM

Sallie Mae

$11.49

0.02 (0.17%)

ARWR

Arrowhead

$5.72

0.12 (2.14%)

PRTK

Paratek Pharmaceuticals

$17.68

-0.075 (-0.42%)

IIPR

Innovative Industrial Properties

$31.30

-2.49 (-7.37%)

ECC

Eagle Point Credit

$19.13

-0.39 (-2.00%)

AGIO

Agios Pharmaceuticals

$70.33

1.53 (2.22%)

03/08/13
Wedge Partners
03/08/13
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03/06/13
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03/06/13
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  • 17

    Jan

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    Jan

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    Jan

  • 07

    Feb

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    Feb

  • 18

    Jan

  • 18

    Jan

  • 18

    Jan

  • 18

    Jan

  • 19

    Jan

BTU

Peabody Energy

$40.00

0.42 (1.06%)

17:17
01/17/18
01/17
17:17
01/17/18
17:17
Hot Stocks
Breaking Hot Stocks news story on Peabody Energy »

Discovery Capital reduces…

03/08/13
Wedge Partners
03/08/13
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03/06/13
Citigroup
03/06/13
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  • 07

    Feb

MLNX

Mellanox

$64.30

-0.45 (-0.69%)

17:12
01/17/18
01/17
17:12
01/17/18
17:12
Hot Stocks
Starboard to nominate nine directors for election at Mellanox »

Starboard Value, the…

03/08/13
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03/08/13
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03/06/13
Citigroup
03/06/13
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  • 18

    Jan

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