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ONCE

Spark Therapeutics

$56.91

0.07 (0.12%)

13:17
10/14/16
10/14
13:17
10/14/16
13:17

Spark Therapeutics presents data reinforcing efficacy of voretigene neparvovec

Spark Therapeutics announced that Principal Investigator Albert M. Maguire, M.D., professor of ophthalmology at the Perelman School of Medicine of the University of Pennsylvania, presented one-year efficacy data from the crossover group and two-year durability data from the original intervention group for the Phase 3 trial of voretigene neparvovec -- formerly SPK-RPE65 -- during Retina Subspecialty Day at the American Academy of Ophthalmology 2016 Annual Meeting in Chicago. Voretigene neparvovec, an investigational gene therapy for Inherited Retinal Disease caused by mutations in the RPE65 gene, has received both breakthrough therapy and orphan product designations from the U.S. FDA, as well as orphan product designations from the EMA. The crossover group consists of nine subjects who, after one year of undergoing the same retinal and visual function testing as the original intervention group, elected to cross over and receive voretigene neparvovec in both eyes. One year after administration, the mean improvement among all nine subjects, as measured by the primary endpoint, a multi-luminance mobility test, was 2.1 lux levels. Dr. Maguire also presented data that showed that the original intervention group subjects who received voretigene neparvovec maintained improvement demonstrated at year one, as measured in MLMT and full-field light sensitivity threshold testing, for at least two years. The mean MLMT improvement of 1.9 lux levels was sustained after two years. The more than 100-fold average improvement in FST testing observed in the original intervention group at one year similarly was maintained through at least two years.

  • 06

    Nov

ONCE Spark Therapeutics
$56.91

0.07 (0.12%)

09/02/16
STFL
09/02/16
INITIATION
STFL
Buy
Spark Therapeutics initiated with a Buy at Stifel
Target $73.
09/02/16
09/02/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. AbbVie (ABBV) initiated with an Outperform at Raymond James. 2. Spark Therapeutics (ONCE) initiated with a Buy at Stifel. 3. Cornerstone OnDemand (CSOD) initiated with an Overweight at Piper Jaffray. 4. UR-Energy (URG) initiated with an Outperform at FBR Capital. 5. Energy Transfer Equity (ETE) reinstated with an Overweight at JPMorgan. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
09/21/16
09/21/16
NO CHANGE

RBC identifies top biotech takeover candidates
RBC Capital identified the following names as its top potential takeover candidates in the biotech space: ARIAD (ARIA), Spark Therapeutics (ONCE), BioMarin (BMRN), Aerie Pharmaceuticals (AERI), Intra-Cellular (ITCI), TESARO (TSRO), Incyte (INCY), Sarepta (SRPT), and Puma Biotechnology (PBYI). The firm thinks that investors are underestimating the positive impact that M&A will have on biotech stock prices.
10/07/16
GSCO
10/07/16
NO CHANGE
GSCO
Smid-cap Biotech sector upgraded to Attractive from Neutral at Goldman
Goldman analyst Salveen Richter upgraded the Smid-cap biotechnology to Attractive and said he favors and companies with near-term pipeline data or regulatory events where he has conviction.Names he recommends are Buy rated BioMarin (BMRN), bluebird bio (BLUE), GW Pharma (GWPH), Incyte (INCY), Kite (KITE), and Sage (SAGE).

TODAY'S FREE FLY STORIES

GNC

GNC Holdings

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Adobe

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SMTS

Sierra Metals

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0.02 (0.77%)

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GNC

GNC Holdings

$3.47

0.02 (0.58%)

07:06
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Earnings
GNC Holdings sees Q4 adjusted EPS 24c-25c, consensus 23c »

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CBSH

Commerce Bancshares

$58.16

0.365 (0.63%)

07:05
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Earnings
Commerce Bancshares reports Q4 EPS 86c, consensus 72c »

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MS

Morgan Stanley

$55.35

0.75 (1.37%)

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Morgan Stanley reports Q4 annualized return on average common equity of 2.9% »

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IPHI

Inphi

$37.87

0.01 (0.03%)

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SMTS

Sierra Metals

$2.62

0.02 (0.77%)

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MS

Morgan Stanley

$55.35

0.75 (1.37%)

07:04
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Earnings
Morgan Stanley reports Q4 adjusted EPS 84c, consensus 77c »

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CSII

Cardiovascular Systems

$26.24

0.91 (3.59%)

07:02
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SPX

S&P 500

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S&P 500: Pivot points »

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CGEN

Compugen

$2.75

0.25 (10.00%)

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ORCL

Oracle

$50.27

0.68 (1.37%)

, PANW

Palo Alto Networks

$154.23

2.63 (1.73%)

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VMware

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AES

AES Corp.

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ACN

Accenture

$160.21

2.25 (1.42%)

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Accenture awarded $62M contract with Veterans Benefits Administration »

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MS

Morgan Stanley

$55.35

0.75 (1.37%)

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Morgan Stanley reports Common Equity Tier 1 ratio approximately 16.5% »

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GDX

Market Vector Gold Miners

$23.94

-0.43 (-1.76%)

06:58
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Market Vector Gold Miners: Pivot points »

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MS

Morgan Stanley

$55.34

0.75 (1.37%)

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Morgan Stanley reports total client assets were $2.4T at Q4-end »

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GLD

SPDR Gold Trust

$126.14

-1.03 (-0.81%)

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R

Ryder

$88.98

0.46 (0.52%)

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  • 16

    Feb

NUGT

Direxion Gold Miners Bull

$34.40

-1.75 (-4.84%)

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Direxion Gold Miners Bull: Pivot points »

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MS

Morgan Stanley

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0.75 (1.37%)

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Morgan Stanley CEO: We enter 2018 with strong momentum »

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JNUG

Direxion Daily Jr Gld Mnrs Bull 3X Shrs

$18.83

-0.99 (-5.00%)

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DUST

Direxion Daily Gold Miners Bear 3X ETF

$21.38

1.07 (5.27%)

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Direxion Daily Gold Miners Bear 3X ETF: Pivot points »

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BA

Boeing

$351.01

15.85 (4.73%)

06:55
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Periodicals
Lawmakers question safety of SpaceX, Boeing internal helium tanks, WSJ reports »

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