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PFE

Pfizer

$31.92

0.38 (1.20%)

08:32
11/30/16
11/30
08:32
11/30/16
08:32

Pfizer says Reflections B3271002 study for PF-05280014 met primary endpoint

Pfizer announced that the pivotal REFLECTIONS B3271002 study, a comparative safety and efficacy study of PF-05280014 versus Herceptin, met its primary endpoint. PF-05280014 is being developed by Pfizer as a potential biosimilar to Herceptin. The trial demonstrated equivalence in the primary endpoint of objective response rate of PF-05280014 versus Herceptin, taken in combination with paclitaxel, in first line patients with HER2-positive metastatic breast cancer. ORR is defined as the proportion of patients with tumor size reduction of a predefined amount and for a minimum period of time2. "As the leading global biosimilars company, we are committed to advancing our robust pipeline of biosimilar therapies in hopes of expanding access to high-quality treatment options for patients living with serious, life-threatening conditions such as cancer," said Sumant Ramachandra, MD, PhD, MBA, Head of Research and Development, Pfizer Essential Health. "Favorable comparative clinical data between proposed biosimilars and their respective reference product contribute to physician and patient understanding of and confidence in the value and importance of biosimilars. We are encouraged by these data and look forward to sharing the complete results with health authorities and the oncology community once available." A separate comparative, randomized, double-blind clinical trial in early breast cancer patients also met its primary endpoint of steady-state Ctrough concentrations in patients treated with PF-05280014 and Herceptin.

  • 04

    Dec

PFE Pfizer
$31.92

0.38 (1.20%)

11/02/16
ARGS
11/02/16
DOWNGRADE
ARGS
Hold
Pfizer downgradedon weaker outlook at Argus
As noted earlier, Argus downgraded Pfizer to Hold from Buy. Analyst Jacob Kilstein cited "recent pipeline setbacks, prospects for increased competition, and management's decision to shelve its business separation plan" as reasons for the downgrade.
11/02/16
11/02/16
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Pfizer (PFE) downgraded to Hold from Buy at Argus and to Market Perform from Outperform at BMO Capital. 2. BP (BP) downgraded to Hold from Buy at Societe Generale. 3. Corning (GLW) downgraded to Buy from Conviction Buy at Goldman with analyst Doug Clark saying the restocking phase of glass/TV cyclical recovery is now "well understood and largely behind us." 4. Adeptus Health (ADPT) downgraded to Underperform from Buy at BofA/Merrill, to Hold from Buy at Jefferies, and to Equal Weight from Overweight at Stephens. 5. Brookdale Senior Living (BKD) downgraded to Underperform from Neutral at BofA/Merrill, to Market Perform from Outperform at Wells Fargo, and to Outperform from Top Pick at RBC Capital. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
11/29/16
LEHM
11/29/16
UPGRADE
Target $38
LEHM
Overweight
Pfizer upgraded to Overweight from Equal Weight at Barclays
Barclays analyst Geoff Meacham upgraded Pfizer to Overweight and raised its price target to $38 from $37. Meacham sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders.
11/29/16
11/29/16
UPGRADE

On The Fly: Top five analyst upgrades
Catch up on today's top five analyst upgrades with this list compiled by The Fly: 1. Pfizer (PFE) upgraded to Overweight from Equal Weight at Barclays with analyst Geoff Meacham saying he sees a greater likelihood that Pfizer will be able to access its cash overseas under the new administration, which could be used to acquire growth assets and return capital to shareholders. 2. Comerica (CMA) upgraded to Outperform from Market Perform at Keefe Bruyette. 3. Tractor Supply (TSCO) upgraded to Buy from Neutral at Northcoast with analyst Chuck Cerankosky saying he expects the company to benefit from colder weather and the improving US economy and said product assortments and promotions have also been adjusted to the new economics of the energy patch and its impact on this company's customers. 4. Del Frisco's (DFRG) upgraded to Outperform from Neutral at Credit Suisse with analyst Jason West saying it is a key beneficiary of improved high-end consumer and corporate spending. 5. Veracyte upgraded to Buy from Neutral at Janney Capital with analyst Paul Knight saying the company's "disciplined test development, commercialization, and reimbursement processes" insulate it from a number of problems plaguing the pharma sector. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

BK

BNY Mellon

$55.35

-2.54 (-4.39%)

18:39
01/18/18
01/18
18:39
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18:39
Periodicals
BNY Mellon to boost wages for 1,000 workers after tax reform, WSJ says »

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TRNC

tronc

$19.23

0.22 (1.16%)

18:28
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18:28
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18:28
Periodicals
tronc to investigate LA Times' CEO Ross Levinsohn, Financial Times reports »

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  • 18

    Jan

IBM

IBM

$169.12

0.47 (0.28%)

18:19
01/18/18
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18:19
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IBM's Schroeter says mainframe isn't going away »

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  • 18

    Jan

ATR

AptarGroup

$87.24

0.4 (0.46%)

18:16
01/18/18
01/18
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18:16
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AptarGroup chairman King Harris to retire in May »

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FULT

Fulton Financial

$18.30

-0.25 (-1.35%)

18:12
01/18/18
01/18
18:12
01/18/18
18:12
Hot Stocks
Fulton Financial to raise its minimum wage to $12 per hour »

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    Jan

SNAP

Snap

$14.01

0.49 (3.62%)

18:03
01/18/18
01/18
18:03
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18:03
Periodicals
Snap fires roughly two dozen employees, Cheddar reports »

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  • 18

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    Feb

PAVM

PAVmed

$2.54

-0.02 (-0.78%)

17:57
01/18/18
01/18
17:57
01/18/18
17:57
Syndicate
PAVmed files to sell common stock, no amount given »

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PODD

Insulet

$72.89

-0.02 (-0.03%)

, DXCM

Dexcom

$56.28

-0.04 (-0.07%)

17:51
01/18/18
01/18
17:51
01/18/18
17:51
Recommendations
Insulet, Dexcom, TNDM, Medtronic analyst commentary  »

Insulet is a favored…

PODD

Insulet

$72.89

-0.02 (-0.03%)

DXCM

Dexcom

$56.28

-0.04 (-0.07%)

TNDM

TNDM

MDT

Medtronic

$87.26

1.15 (1.34%)

03/08/13
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  • 26

    Feb

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  • 01

    Mar

17:50
01/18/18
01/18
17:50
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17:50
General news
Breaking General news story  »

Cleveland Federal Reserve…

IBM

IBM

$169.12

0.47 (0.28%)

17:39
01/18/18
01/18
17:39
01/18/18
17:39
Earnings
Breaking Earnings news story on IBM »

IBM sees FY18 adjusted…

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  • 18

    Jan

TTD

Trade Desk

$48.36

-1.12 (-2.26%)

17:38
01/18/18
01/18
17:38
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17:38
Initiation
Trade Desk initiated  »

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TWTR

Twitter

$24.04

-0.52 (-2.12%)

, FB

Facebook

$179.80

2.2 (1.24%)

17:37
01/18/18
01/18
17:37
01/18/18
17:37
Hot Stocks
Snap user metrics being put into question by Mashable, Muddy Waters »

After the close, Mashable…

TWTR

Twitter

$24.04

-0.52 (-2.12%)

FB

Facebook

$179.80

2.2 (1.24%)

SNAP

Snap

$14.01

0.49 (3.62%)

03/08/13
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  • 18

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    Feb

TWTR

Twitter

$24.04

-0.52 (-2.12%)

17:37
01/18/18
01/18
17:37
01/18/18
17:37
Recommendations
Twitter analyst commentary  »

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  • 07

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    Feb

IBM

IBM

$169.12

0.47 (0.28%)

17:36
01/18/18
01/18
17:36
01/18/18
17:36
Hot Stocks
Breaking Hot Stocks news story on IBM »

IBM sees FY18 free cash…

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  • 18

    Jan

IBM

IBM

$169.12

0.47 (0.28%)

17:36
01/18/18
01/18
17:36
01/18/18
17:36
Earnings
IBM sees Q1 EPS 17%-18% of $13.80 FY expectation, consensus $2.28 »

Says has momentum in…

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  • 18

    Jan

ZG

Zillow

$43.86

-0.49 (-1.10%)

, Z

Zillow

$43.97

-0.57 (-1.28%)

17:33
01/18/18
01/18
17:33
01/18/18
17:33
Downgrade
Zillow, Zillow rating change  »

Zillow resumed with a…

ZG

Zillow

$43.86

-0.49 (-1.10%)

Z

Zillow

$43.97

-0.57 (-1.28%)

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  • 26

    Feb

AXP

American Express

$99.86

-0.9 (-0.89%)

, HLT

Hilton

$83.95

-0.08 (-0.10%)

17:30
01/18/18
01/18
17:30
01/18/18
17:30
Hot Stocks
American Express 'excited' about co-brand partnership with Hilton and Marriott »

Says delinquencies will…

AXP

American Express

$99.86

-0.9 (-0.89%)

HLT

Hilton

$83.95

-0.08 (-0.10%)

MAR

Marriott

$141.13

-0.87 (-0.61%)

03/08/13
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  • 18

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    Mar

APRN

Blue Apron

$3.20

0.04 (1.27%)

17:30
01/18/18
01/18
17:30
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17:30
Hot Stocks
Breaking Hot Stocks news story on Blue Apron »

Armistice Capital reports…

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  • 13

    Feb

IBM

IBM

$169.16

0.68 (0.40%)

17:29
01/18/18
01/18
17:29
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17:29
Hot Stocks
IBM says SaaS margins continue to expand, but not at scale »

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  • 18

    Jan

MLNX

Mellanox

$65.10

0.8 (1.24%)

, PBCT

People's United

$19.43

-0.02 (-0.10%)

17:24
01/18/18
01/18
17:24
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17:24
Hot Stocks
On The Fly: After Hours Movers »

UP AFTER EARNINGS:…

MLNX

Mellanox

$65.10

0.8 (1.24%)

PBCT

People's United

$19.43

-0.02 (-0.10%)

GWGH

GWG Holdings

$8.10

-0.2 (-2.41%)

CRBP

Corbus Pharmaceuticals

$7.95

-0.25 (-3.05%)

IBM

IBM

$169.12

0.47 (0.28%)

AXP

American Express

$99.86

-0.9 (-0.89%)

03/08/13
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  • 18

    Jan

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  • 18

    Jan

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    Jan

AXP

American Express

$99.86

-0.9 (-0.89%)

17:24
01/18/18
01/18
17:24
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17:24
Hot Stocks
American Express says capital ratios are now below levels forecast in 2017 CCAR »

Plans to "more than…

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  • 18

    Jan

SFNC

Simmons First National

$58.25

-0.55 (-0.94%)

17:20
01/18/18
01/18
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17:20
Hot Stocks
Simmons First National announces two-for-one stock split »

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  • 23

    Jan

FNB

F.N.B.

$14.15

-0.15 (-1.05%)

17:19
01/18/18
01/18
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Hot Stocks
F.N.B. raising minimum hourly wage to $15 by end of 2019 »

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  • 23

    Jan

FORD

Forward Industries

$1.24

-0.01 (-0.80%)

17:18
01/18/18
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17:18
Hot Stocks
Forward Industries to acquire Intelligent Product Solutions »

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ASFI

Asta Funding

$7.35

0.05 (0.68%)

17:16
01/18/18
01/18
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17:16
Hot Stocks
Asta Funding to restate 2014, 2015 and 2016 financial statements »

Asta Funding announced…

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