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AMGN

Amgen

$144.07

-1.93 (-1.32%)

, CYTK

Cytokinetics

$12.00

-0.35 (-2.83%)

18:34
11/30/16
11/30
18:34
11/30/16
18:34

Amgen, Cytokinetics say COSMIC-HF trial met primary pharmacokinetic objective

Amgen (AMGN) and Cytokinetics (CYTK) announced The Lancet published results from a Phase 2 clinical trial evaluating omecamtiv mecarbil in patients with chronic heart failure. The COSMIC-HF trial met its primary pharmacokinetic objective and showed statistically significant improvements in all pre-specified secondary measures of cardiac function in the treatment group receiving pharmacokinetic-based dose titration. The results were initially presented as a Late-Breaking Clinical Trial at the American Heart Association Scientific Sessions 2015. The trial, which evaluated 448 patients with chronic heart failure and left ventricular systolic dysfunction, showed that dose titration controlled patient exposure to omecamtiv mecarbil. Patients were randomized 1:1:1 to receive either placebo or treatment with omecamtiv mecarbil dosed as 25 mg twice daily or 25 mg with dose escalation to 50 mg twice daily, depending on plasma concentrations of omecamtiv mecarbil after two weeks of treatment. The pharmacokinetic-based dose titration strategy was designed to maintain patient exposure to omecamtiv mecarbil in the targeted plasma concentration range. Approximately 53% of patients in the dose titration group were escalated to a dose of 50 mg twice daily. Adverse events, including serious AEs, in patients on omecamtiv mecarbil were comparable to placebo. The incidence of adjudicated deaths, myocardial infarction and unstable angina was similar. Other cardiac AEs were generally balanced between placebo and active treatment groups. In patients receiving omecamtiv mecarbil compared to placebo, cardiac troponin increased by 0.001 ng/mL and 0.006 ng/mL in the 25 mg twice daily group and dose titration group, respectively. Events of increased troponin were independently adjudicated and none were adjudicated as an episode of myocardial ischemia or infarction.

AMGN

Amgen

$144.07

-1.93 (-1.32%)

CYTK

Cytokinetics

$12.00

-0.35 (-2.83%)

  • 30

    Nov

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    Dec

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    Jul

AMGN Amgen
$144.07

-1.93 (-1.32%)

11/07/16
MZHO
11/07/16
INITIATION
Target $164
MZHO
Buy
Amgen initiated with a Buy at Mizuho
Mizuho analyst Salim Syed initiated Amgen with a Buy rating and a $164 price target.
11/08/16
ARGS
11/08/16
NO CHANGE
ARGS
Amgen weakness creates buying opportunity, says Argus
After Amgen's stock sunk 10% following its Q3 results, Argus says that the decline was triggered by "news that pricing power for Enbrel would be limited in 2017." However, the firm says that the company's growth outlook is "solid," while it has launched "promising new drugs." The firm keeps a Buy rating on the stock.
11/08/16
11/08/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Adient (ADNT) initiated with a Neutral at JPMorgan. 2. JinkoSolar (JKS) initiated with a Buy at Craig-Hallum. 3. Amgen (AMGN), Gilead (GILD), and Celgene (CELG) initiated with a Buy at Mizuho while the firm initiated Biogen (BIIB) with a Neutral. 4. BioScrip (BIOS) resumed with a Buy at Jefferies. 5. SQM (SQM) initiated with a Market Perform at BMO Capital. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
11/09/16
PIPR
11/09/16
NO CHANGE
PIPR
Piper sees improving environment for Biopharma M&A
The biotech sector is seeing a "massive relief rally" given the "surprise trifecta" of a Republican sweep, the voting down of Prop 61 in California and U.S. dollar weakness, Piper Jaffray analyst Joshua Schimmer tells investors in a research note. The door is now open to discuss potential repatriation of cash outside the U.S., which could be a green light on mergers and acquisitions, the analyst adds. He points out that Amgen (AMGN) and Gilead (GILD) hold the most overseas cash, with Celgene (CELG) and Biogen (BIIB) holding several billion as well. Schimmer believes the broader environment may be improving for M&A. He cautions, though, that the election of Trump does not remove the "major drug pricing overhang question."
CYTK Cytokinetics
$12.00

-0.35 (-2.83%)

12/16/15
PIPR
12/16/15
NO CHANGE
Target $24
PIPR
Overweight
Cytokinetics price target raised to $24 from $17 at Piper Jaffray
Piper Jaffray analyst Charles Duncan raised its price target for Cytokinetics to $24 citing greater conviction in the company's pipeline assets ahead of its "busy" 2016. Piper views Cytokinetics as the leader in muscle-biology and reiterates an Overweight rating on the name.
06/21/16
06/21/16
NO CHANGE
Target $24

Outperform
FBR views Cytokinetics as attractive despite 36% rally
Even with shares up 36% since added to his firm's Alpha Generator list in March, FBR Capital analyst Vernon Bernardino still views shares of Cytokinetics (CYTK) as attractive for an initial investment. The analyst believes partner Amgen (AMGN) will exercise its option and advance omecamtiv mecarbil into Phase III testing in heart failure. Bernardino keeps an Outperform rating on the shares with a $24 price target.

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