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EXEL

Exelixis

$16.32

-0.24 (-1.45%)

15:00
12/22/16
12/22
15:00
12/22/16
15:00

Editorial says Exelixis cabozantinib trial limitations lessen impact of data

In an editorial published in the Journal of Clinical Oncology, authors Brian Rini and Nicholas Vogelzang stated: "Although provocative, there are several issues reflecting inherent limitations of the randomized phase II design that lessen the impact of the CABOSUN data on clinical practice. Namely, the PFS of 5.6 months for the sunitinib arm of CABOSUN was less than expected based on historical clinical trial data. In the registration trial for sunitinib, the PFS for patients in the intermediate-risk group was 10.6 months...Because the oncology literature is littered with examples of positive phase II trials that were followed by negative phase III trials, randomized phase II designs should be used to prioritize experimental agents for further definitive testing, not as standalone indicators of efficacy.19 There would be no need for phase III trials if the results of phase II trials were routinely regarded as definitive and practice changing." Previously, Exelixis announced that, based on the CABOSUN results, the company plans to submit a Supplemental New Drug Application, or sNDA, for cabozantinib as a treatment for previously untreated advanced RCC. Exelixis shares are down 6% to $15.30 in afternoon trading. Reference Link

  • 19

    Jan

EXEL Exelixis
$16.32

-0.24 (-1.45%)

11/03/16
DBAB
11/03/16
INITIATION
Target $17
DBAB
Buy
Exelixis initiated with a Buy at Deutsche Bank
Deutsche Bank analyst Andrew Peters started Exelixis with a Buy rating and $17 price target. He calls the stock his top pick in mid-cap biotech and sees "meaningful upside" from current levels.
11/03/16
11/03/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. BioMarin (BMRN) initiated with a Buy at Deutsche Bank. 2. Ambev (ABEV) reinstated with an Equal Weight at Barclays. 3. ARIAD (ARIA) initiated with a Hold at Deutsche Bank. 4. Thomson Reuters (TRI) reinstated with a Neutral at JPMorgan. 5. Exelixis (EXEL) initiated with a Buy at Deutsche Bank. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage click here.
11/14/16
PIPR
11/14/16
NO CHANGE
PIPR
Piper sees Biotech rally continuing into 2017, lays out five to own
Piper Jaffray analyst Edward Tenthoff expects the rally in Biotechs, following "the trifecta" of a Trump Presidential election, Republican Congress sweep and defeat of Prop 61 in California, to continue into 2017. He recommends focusing on shares of Vertex (VRTX), Regeneron (REGN), Alnylam (ALNY), Exelixis (EXEL) and OncoMed (OMED). Tenthoff has a Neutral rating on Regeneron and Overweight ratings on the other four names.
12/21/16
PIPR
12/21/16
NO CHANGE
PIPR
Piper lays out top BioPharma picks for 2017
Piper Jaffray analysts laid out their top BioPharma picks for 2017. Analyst Richard Purkiss favors Pfizer (PFE) and Eli Lilly (LLY) as his top large pharma picks. Analyst Joshua Schimmer calls Gilead (GILD) and Alexion (ALXN) his top large cap picks. Analyst David Amsellem names Horizon Pharma (HZNP) his top specialty pharma pick. Piper's other top Biopharma picks for 2017 include ACADIA (ACAD), Aimmune (AIMT), Akorn (AKRX), Alnylam (ALNY), Axovant Sciences (AXON), Cara Therapeutics (CARA), CoLucid Pharmaceuticals (CLCD), Eale Pharmaceuticals (EGRX), Exelixis (EXEL), Ionis Pharmaceuticals (IONS), Mallinckrodt (MNK), Neurocrine (NBIX), Nektar (NKTR), Otonomy (OTIC), Reata Pharmaceuticals (RETA), Rigel Pharmaceuticals (RIGL), Ignyta (RXDX), Theravance Biopharma (TBPH), Versartis (VSAR) and Voyager Therapeutics (VYGR). The analysts look for recent momentum in BioPharma to continue in 2017. They believe innovation and potentially repatriation should lead to increased merger activity.

TODAY'S FREE FLY STORIES

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RIC

Richmont Mines

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MGLN

Magellan Health

$83.65

0.35 (0.42%)

15:18
11/24/17
11/24
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Conference/Events
Magellan Health to hold a conference call »

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  • 01

    Dec

SGMS

Scientific Games

$52.00

-0.2 (-0.38%)

15:17
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15:17
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15:17
Conference/Events
Scientific Games to host special shareholder meeting »

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$NSD

NASDAQ Market Internals

15:17
11/24/17
11/24
15:17
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Volume is above average…

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$NYE

NYSE Market Internals

15:16
11/24/17
11/24
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Technical Analysis
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03/08/13
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$NSD

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$NYE

NYSE Market Internals

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Volume is below average…

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M

Macy's

$21.07

0.44 (2.13%)

, WMT

Wal-Mart

$96.62

0.21 (0.22%)

13:29
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11/24
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M

Macy's

$21.07

0.44 (2.13%)

WMT

Wal-Mart

$96.62

0.21 (0.22%)

TGT

Target

$55.88

-1.61 (-2.80%)

BASFY

BASF

$27.39

-0.13 (-0.47%)

TEVA

Teva

$13.70

0.22 (1.63%)

CBS

CBS

$56.54

0.3 (0.53%)

DISH

Dish

$50.43

0.39 (0.78%)

ASX

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$7.07

0.76 (12.04%)

SPIL

Siliconware Precision

$7.94

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QD

Qudian

$12.22

-3.93 (-24.33%)

BABA

Alibaba

$191.19

1.35 (0.71%)

VIPS

Vipshop

$8.14

-0.3 (-3.55%)

03/08/13
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  • 24

    Nov

  • 20

    Feb

  • 18

    Mar

AFL

Aflac

$85.00

-0.05 (-0.06%)

13:26
11/24/17
11/24
13:26
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13:26
Conference/Events
Aflac to hold a conference call »

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03/08/13
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03/08/13
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03/06/13
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  • 01

    Dec

GBL

GAMCO Investors

, WTS

Watts Water

$72.65

0.15 (0.21%)

13:26
11/24/17
11/24
13:26
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13:26
Hot Stocks
Breaking Hot Stocks news story on GAMCO Investors, Watts Water »

Gabelli reports 6.69%…

GBL

GAMCO Investors

WTS

Watts Water

$72.65

0.15 (0.21%)

03/08/13
Wedge Partners
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03/06/13
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03/06/13
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  • 04

    Dec

CC

Chemours

$53.31

0.45 (0.85%)

13:23
11/24/17
11/24
13:23
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13:23
Conference/Events
Chemours to host investor day »

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  • 01

    Dec

$NSD

NASDAQ Market Internals

13:17
11/24/17
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Volume is average for…

03/08/13
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$NYE

NYSE Market Internals

13:16
11/24/17
11/24
13:16
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Technical Analysis
NYSE market internals summary »

Volume is below average…

03/08/13
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AIMT

Aimmune

$35.74

0.16 (0.45%)

13:09
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Aimmune to hold an investor symposium »

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  • 28

    Nov

PN

Patriot National

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CMCM

Cheetah Mobile

$12.02

-0.4 (-3.22%)

12:55
11/24/17
11/24
12:55
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12:55
Options
Cheetah Mobile put volume heavy and directionally bearish »

Bearish flow noted in…

03/08/13
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GM

General Motors

$44.47

0.1828 (0.41%)

12:53
11/24/17
11/24
12:53
11/24/17
12:53
Conference/Events
General Motors holds an investor an analyst webcast »

Management hosts a…

03/08/13
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  • 30

    Nov

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    Jan

  • 16

    Jan

12:45
11/24/17
11/24
12:45
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Week of 11/24…

EBAY

eBay

$35.94

-0.02 (-0.06%)

, OSTK

Overstock.com

$61.05

0.6 (0.99%)

12:43
11/24/17
11/24
12:43
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12:43
Periodicals
Adobe: Black Friday online sales up 18.4% y/y as of 10:00 am ET, CNBC says »

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EBAY

eBay

$35.94

-0.02 (-0.06%)

OSTK

Overstock.com

$61.05

0.6 (0.99%)

AMZN

Amazon.com

$1,156.16

16.67 (1.46%)

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03/06/13
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03/06/13
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  • 27

    Nov

  • 18

    Mar

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