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XLRN

Acceleron

$26.26

-1.23 (-4.47%)

17:01
12/22/16
12/22
17:01
12/22/16
17:01

Acceleron: First patient treated in Phase 2 ACE-083 trial

Acceleron Pharma announced that the first patient has been treated in a Phase 2 clinical trial of ACE-083, the company's locally acting muscle agent, for the treatment of patients with facioscapulohumeral muscular dystrophy. "We are excited to start our first Phase 2 trial for ACE-083," said Matthew Sherman, M.D., Chief Medical Officer of Acceleron. "ACE-083 has generated a strong data set in both preclinical and clinical trials to date. Our understanding of its novel mechanism of action suggests that ACE-083 may become an important new treatment for FSHD patients with muscle weakness that negatively affects their strength and functional abilities." The two-part Phase 2 clinical trial is designed to evaluate ACE-083 in FSHD patients with muscle weakness in either the tibialis anterior, a muscle in the lower leg involved in foot flexion, or the biceps. Part 1 is an open-label, dose-escalation study of ACE-083 administered by intramuscular injection once every three weeks in up to 36 patients to evaluate safety and increases in muscle volume over a three-month treatment period. Part 2 is a randomized, double-blind, placebo-controlled study using the optimal dose level selected in Part 1. Up to 40 patients will be randomized to receive either placebo or ACE-083 administered by intramuscular injection once every three weeks and evaluated for increases in muscle volume, strength, function and safety over a three-month treatment period.

XLRN Acceleron
$26.26

-1.23 (-4.47%)

08/19/16
08/19/16
INITIATION

On The Fly: Top five analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. Aratana Therapeutics (PETX) assumed with a Buy at Jefferies. 2. Arbutus Biopharma (ABUS) initiated with an Outperform at William Blair. 3. Acceleron (XLRN) initiated with a Buy at BTIG. 4. Agios Pharmaceuticals (AGIO) initiated with a Neutral at BTIG. 5. Suncor (SU) reinstated with a Buy at BofA/Merrill. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
09/29/16
SBSH
09/29/16
INITIATION
Target $40
SBSH
Neutral
Acceleron initiated with a Neutral at Citi
Citi analyst Robyn Karnauskas started Acceleron Pharma with a Neutral rating and $40 price target. The company's pivotal programs are already reflected in the shares while Phase 2 catalysts could provide upside, Karnauskas tells investors in a research note.
09/29/16
SBSH
09/29/16
NO CHANGE
Target $127
SBSH
Buy
Citi ups Celgene target to $127 on luspatercept opportunity
Citi analyst Robyn Karnauskas raised her price target for Celgene (CELG) to $127 from $124 citing greater confidence in the company's myelodysplastic syndrome and beta thalassemia opportunities. After initiating coverage of Celgene partner Acceleron (XLRN) with a Neutral rating, Karnauskas now sees adjusted peak sales for these indications of $1.7B versus $825M previously. Investors are missing the "not-so-distant catalyst" as Phase 3 luspatercept data in these indications could come in late 2017/early 2018, the analyst tells investors in a research note. She keeps a Buy rating on shares of Celgene.
12/12/16
OPCO
12/12/16
INITIATION
Target $44
OPCO
Acceleron initiated with an Overweight at Oppenheimer
Oppenheimer analyst Leah Cann initiated Acceleron with an Outperform and a $44 price target saying the successful launch of two experimental products, Luspatercept and Dalantercept, could result in Acceleron having revenues grow to $367.3 million in 2021 from $18.1 million in 2015.

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