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ENTA

Enanta

$30.82

-0.025 (-0.08%)

, ABBV

AbbVie

$63.78

0.33 (0.52%)

06:42
04/21/17
04/21
06:42
04/21/17
06:42

Enanta: Glecaprevir/pibrentasvir shows virologic response in AbbVie's HCV study

Enanta Pharmaceuticals (ENTA) reported that AbbVie (ABBV) announced high SVR rates were achieved with 8 weeks of treatment with its investigational, once daily, ribavirin-free, pan-genotypic regimen of glecaprevir/pibrentasvir in patients with challenging-to-treat genotype 3 chronic hepatitis C virus infection. In results from AbbVie's Phase 3 ENDURANCE-3 study, 95% of GT3 chronic HCV-infected patients without cirrhosis and who were new to treatment achieved sustained virologic response at 12 weeks post-treatment following 8 weeks of treatment with G/P. These results will be featured as an oral presentation at The International Liver Congress in Amsterdam. In addition to evaluating 8 weeks of treatment with G/P, the ENDURANCE-3 study was designed to evaluate whether 12 weeks of G/P treatment is non-inferior to 12 weeks of sofosbuvir plus daclatasvir, a current standard of care for GT3 chronic HCV-infected patients. SVR12 rates of 95% were seen in both 8 weeks and 12 weeks of treatment with G/P. Additionally, 12 weeks of treatment with G/P was demonstrated to be non-inferior to 12 weeks of treatment with SOF+DCV. In the ENDURANCE-3 study, no patients who received 8 weeks of G/P discontinued treatment due to adverse events. Authorization applications for G/P are currently under review by regulatory authorities around the world. G/P has been granted accelerated assessment by the European Medicines Agency, and priority review designations by the FDA and Japanese Ministry of Health, Labour and Welfare. G/P is an investigational regimen and its safety and efficacy have not been established.

ENTA

Enanta

$30.82

-0.025 (-0.08%)

ABBV

AbbVie

$63.78

0.33 (0.52%)

  • 27

    Apr

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    May

  • 08

    May

  • 06

    Jun

ENTA Enanta
$30.82

-0.025 (-0.08%)

04/28/16
JMPS
04/28/16
DOWNGRADE
JMPS
Market Perform
Enanta downgraded to Market Perform from Outperform at JMP Securities
ABBV AbbVie
$63.78

0.33 (0.52%)

04/20/17
RHCO
04/20/17
NO CHANGE
RHCO
Tesaro has no negative read through from AbbVie failure, says SunTrust
SunTrust analyst Peter Lawson says that there is "no impact" on Tesaro's (TSRO) niraparib from the failure of AbbVie's (ABBV) PARP inhibitor, veliparib, in triple negative breast cancer and lung cancer. The analyst believes that niraparib could be more effective than veliparib. Additionally, he notes that during its trial veliparib was used in combination with chemotherapy, while niraparib will be combined with Merck's (MRK) Keytruda for its trial. He thinks that the pairing with Keytruda will result in more effective treatment. The analyst keeps a $235 price target and a Buy rating on Tesaro.
04/20/17
JEFF
04/20/17
NO CHANGE
Target $90
JEFF
Buy
AbbVie cancer drug failure should have little impact, says Jefferies
Jefferies analyst Jeffrey Holford expects the Phase III failure of veliparib to have little impact on AbbVie shares. The analyst says expectations were low and that the drug accounted for less than 1% of his mid-term revenues estimates. He keeps a Buy rating on AbbVie with a $90 price target.
04/20/17
LEER
04/20/17
NO CHANGE
Target $71
LEER
Market Perform
AbbVie veliparib not competitive with other products, says Leerink
Leerink analyst Geoffrey Porges notes that AbbVie announced failed top-line results for its PARP inhibitor veliparib in combination with chemotherapy for metastatic squamous NSCLC and early TNBC. While two disappointing trials would not normally completely doom a program, the analyst says that the lack of effect confirms his view that veliparib has limited activity and is not competitive with other products in this class. For this reason, Porges is taking the probability of success of the program to zero. The analyst reiterated a Market Perform rating on the stock and lowered his price target on the shares to $71 from $72.
04/17/17
JEFF
04/17/17
NO CHANGE
Target $97
JEFF
Buy
Jefferies sees Lilly trading down 5% on baricitinib CRL
Jefferies analyst Jeffrey Holford expects Eli Lilly (LLY) to trade down around 5% after the company and Incyte (INCY) received a complete response letter from the FDA for baricitinib. A significant delay to the U.S. approval of baricitinib could hit Lilly's mid-term earnings and valuation by up to 8%-10%, Holford tells investors in a research note. He notes, however, that the cause or extent of the delay is unclear at this point. Holford keeps a Buy rating on Lilly with a $97 price target. The analyst views the baricitinib CRL as a positive for AbbVie's (ABBV) "best in class" JAK inhibitor, ABT-4494. A delay to baricitinib could result in ABT-494 reaching the U.S. market before baricitinib, the analyst contends.

TODAY'S FREE FLY STORIES

NOV

National Oilwell

$31.84

0.2 (0.63%)

15:10
06/26/17
06/26
15:10
06/26/17
15:10
Options
Notable call writing in National Oilwell »

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    Jul

VTR

Ventas

$71.94

0.215 (0.30%)

15:07
06/26/17
06/26
15:07
06/26/17
15:07
Conference/Events
Ventas management to meet with RBC Capital »

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  • 26

    Jun

MU

Micron

$32.50

0.765 (2.41%)

15:05
06/26/17
06/26
15:05
06/26/17
15:05
Options
Micron call volume above normal and directionally bullish »

Bullish option flow…

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MAR

Marriott

$104.06

0.17 (0.16%)

15:00
06/26/17
06/26
15:00
06/26/17
15:00
Conference/Events
Marriott management to meet with RBC Capital »

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  • 26

    Jun

AAPL

Apple

$146.28

0.65 (0.45%)

, HTZ

Hertz

$10.92

1.38 (14.47%)

14:54
06/26/17
06/26
14:54
06/26/17
14:54
Periodicals
Apple only leasing six cars from Hertz, CNBC says »

After Bloomberg reported…

AAPL

Apple

$146.28

0.65 (0.45%)

HTZ

Hertz

$10.92

1.38 (14.47%)

03/08/13
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03/06/13
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03/06/13
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  • 26

    Jun

NG

NovaGold

$4.50

-0.075 (-1.64%)

14:49
06/26/17
06/26
14:49
06/26/17
14:49
Options
NovaGold options imply 6.4% move in share price post-earnings, above median historical move »

Pre-earnings options…

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  • 27

    Jun

AAPL

Apple

$146.28

0.65 (0.45%)

, HTZ

Hertz

$10.84

1.3002 (13.63%)

14:47
06/26/17
06/26
14:47
06/26/17
14:47
Periodicals
Hertz to manage small self-driving car fleet for Apple, Bloomberg says »

Apple (AAPL) is leasing a…

AAPL

Apple

$146.28

0.65 (0.45%)

HTZ

Hertz

$10.84

1.3002 (13.63%)

GOOG

Alphabet

$965.59

8.5 (0.89%)

GOOGL

Alphabet Class A

$986.09

9.47 (0.97%)

CAR

Avis Budget

$24.24

1.23 (5.35%)

03/08/13
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03/06/13
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03/06/13
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  • 26

    Jun

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OTIC

Otonomy

$18.75

1 (5.63%)

14:46
06/26/17
06/26
14:46
06/26/17
14:46
Conference/Events
Otonomy to hold a breakfast meeting »

Chief Scientific Officer…

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DGX

Quest Diagnostics

$110.05

0.345 (0.31%)

, WMT

Wal-Mart

$75.61

0.77 (1.03%)

14:44
06/26/17
06/26
14:44
06/26/17
14:44
Hot Stocks
Quest Diagnostics, Wal-Mart team up to offer healthcare services »

Quest Diagnostics (DGX)…

DGX

Quest Diagnostics

$110.05

0.345 (0.31%)

WMT

Wal-Mart

$75.61

0.77 (1.03%)

03/08/13
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03/06/13
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03/06/13
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  • 30

    Jul

EBSB

Meridian Bancorp

14:43
06/26/17
06/26
14:43
06/26/17
14:43
Upgrade
Meridian Bancorp rating change  »

Meridian Bancorp upgraded…

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AMD

AMD

$14.17

-0.21 (-1.46%)

, INTC

Intel

$34.19

-0.17 (-0.49%)

14:43
06/26/17
06/26
14:43
06/26/17
14:43
Recommendations
AMD, Intel analyst commentary  »

Goldman reiterates Sell…

AMD

AMD

$14.17

-0.21 (-1.46%)

INTC

Intel

$34.19

-0.17 (-0.49%)

03/08/13
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  • 26

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KTOV

Kitov Pharmaceuticals

$1.71

-0.01 (-0.58%)

, PRXL

Parexel

$86.80

-0.31 (-0.36%)

14:41
06/26/17
06/26
14:41
06/26/17
14:41
Hot Stocks
Kitov sees formal filing of NDA for KIT-302 by end of Q3 »

Kitov Pharmaceuticals…

KTOV

Kitov Pharmaceuticals

$1.71

-0.01 (-0.58%)

PRXL

Parexel

$86.80

-0.31 (-0.36%)

03/08/13
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  • 26

    Jun

RAD

Rite Aid

$3.93

0.8199 (26.36%)

14:40
06/26/17
06/26
14:40
06/26/17
14:40
Options
Heavy trading in RiteAid as shares surge »

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14:40
06/26/17
06/26
14:40
06/26/17
14:40
General news
Treasury Action: yields remain slightly lower »

Treasury Action: yields…

EVLV

EVINE Live

$1.04

-0.03 (-2.80%)

14:39
06/26/17
06/26
14:39
06/26/17
14:39
Conference/Events
EVINE Live management to meet with Craig-Hallum »

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EVLV

EVINE Live

$1.04

-0.03 (-2.80%)

14:38
06/26/17
06/26
14:38
06/26/17
14:38
Conference/Events
EVINE Live management to meet with B. Riley »

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  • 28

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HTZ

Hertz

$10.19

0.65 (6.81%)

14:36
06/26/17
06/26
14:36
06/26/17
14:36
Technical Analysis
Technical View: Hertz spikes higher, levels to watch »

The shares were last at…

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AMAG

AMAG Pharmaceuticals

$18.35

0.15 (0.82%)

14:36
06/26/17
06/26
14:36
06/26/17
14:36
Recommendations
AMAG Pharmaceuticals analyst commentary  »

AMAG delay for Makena…

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FN

Fabrinet

$45.60

5.58 (13.94%)

14:30
06/26/17
06/26
14:30
06/26/17
14:30
Options
Timely call activity in Fabrinet »

Timely call activity in…

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  • 26

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AAPL

Apple

$146.28

0.65 (0.45%)

, HTZ

Hertz

$10.24

0.7 (7.34%)

14:26
06/26/17
06/26
14:26
06/26/17
14:26
Periodicals
Breaking Periodicals news story on Apple, Hertz »

Hertz to manage small…

AAPL

Apple

$146.28

0.65 (0.45%)

HTZ

Hertz

$10.24

0.7 (7.34%)

03/08/13
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03/08/13
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03/06/13
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03/06/13
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  • 26

    Jun

GM

General Motors

$34.49

0.29 (0.85%)

14:25
06/26/17
06/26
14:25
06/26/17
14:25
Conference/Events
General Motors to host a conference call »

EVP & CFO Chuck…

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  • 26

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T

AT&T

$38.15

0.2001 (0.53%)

14:20
06/26/17
06/26
14:20
06/26/17
14:20
Options
Calendar call spread in AT&T rolls short position from July to September »

Calendar call spread in…

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14:19
06/26/17
06/26
14:19
06/26/17
14:19
General news
Averages mixed but internals strong »

The averages remain mixed…

$NSD

NASDAQ Market Internals

14:17
06/26/17
06/26
14:17
06/26/17
14:17
Technical Analysis
NASDAQ market internals summary »

Volume is above average…

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$NYE

NYSE Market Internals

14:16
06/26/17
06/26
14:16
06/26/17
14:16
Technical Analysis
NYSE market internals summary »

Volume is average for…

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