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IONS

Ionis Pharmaceuticals

$42.91

1.04 (2.48%)

12:36
04/21/17
04/21
12:36
04/21/17
12:36

Ionis Pharmaceuticals put volume heavy and directionally bearish

Bearish flow noted in Ionis Pharmaceuticals with 3,897 puts trading, or 11x expected. Most active are May-17 43 puts and May-17 40 puts, with total volume in those strikes near 3,300 contracts. The Put/Call Ratio is 3.93, while ATM IV is up nearly 7 points on the day. Earnings are expected on May 3rd.

  • 22

    Apr

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    May

IONS Ionis Pharmaceuticals
$42.91

1.04 (2.48%)

03/10/17
GSCO
03/10/17
DOWNGRADE
Target $25
GSCO
Sell
Ionis Pharmaceuticals downgraded to Sell from Neutral at Goldman
Goldman analyst Salveen Richter downgraded Ionis Pharmaceuticals to Sell and lowered its price target to $25 from $28. The analyst commented Ionis has a "lackluster" track record of developing successful drugs and ongoing toxicity across multiple drugs. If volanesorsen is approved for FCS, Richter expects safety/compliance issues and the launch focus on specialists will result in limited returns, similar to drug Kynamro for high cholesterol.
03/10/17
03/10/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Dollar General (DG) downgraded to Neutral from Buy at Buckingham with the firm's analyst saying the environment has become more difficult since the bullish analyst day last spring. The firm's analyst said shares do not appear to fully factor in sales and margin challenges and sees risk to Street expectations. 2. MEDNAX (MD) downgraded to Neutral from Overweight at JPMorgan with analyst Gary Taylor citing valuation following the recent rally in the shares. The analyst says he can't with confidence bump up his $69 price target given the multi-year slowdown of organic growth and its high Medicaid payor exposure. 3. Loxo Oncology (LOXO) downgraded to Neutral from Buy at Citi with analyst Yigal Nochomovitz saying the stock is now fairly valued. The reflect the equity financing in January which expanded the share count and rising R&D spend, the analyst cut his price target for the shares to $45 from $49. He believes, however, that Loxo management is executing the business plan well. 4. Kimberly-Clark (KMB) downgraded to Hold on competition, valuation at Societe Generale with analyst Iain Simpson saying price competition in the U.S. has picked up as P&G is becoming more aggressive with its mid-tier Luvs and competition in Brazil and China remains "tough." The analyst expects cost cutting to drive margins and views cash returns as "robust," but said valuation has caught up with fundamentals. 5. Ionis Pharmaceuticals (IONS) downgraded to Sell from Neutral at Goldman with analyst Salveen Richter saying Ionis has a "lackluster" track record of developing successful drugs and ongoing toxicity across multiple drugs. If volanesorsen is approved for FCS, Richter expects safety/compliance issues and the launch focus on specialists will result in limited returns, similar to drug Kynamro for high cholesterol. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.
03/13/17
WELS
03/13/17
NO CHANGE
WELS
Ionis Pharma should be bought after negative note, says Wells Fargo
Wells Fargo recommends that investors buy Ionis "ahead of multiple upcoming value drivers" Although another firm on Friday called Ionis' antisense platform a "mirage," that has not realized value, four products that use the platform have been approved, and analysts expect the company to generate $440M in revenue this year, Wells stated. The firm thinks that the company's results can beat expectations.
03/17/17
GSCO
03/17/17
NO CHANGE
Target $108
GSCO
Buy
AveXis price target raised to $108 on higher confidence in AVXS-101 at Goldman
After AveXis (AVXS) reported results for its Phase 1 study of AVXS-101 in spinal muscular atrophy, Goldman Sachs analyst Salveen Richter said data for the treatment continues to impress and increased his probability of success for the drug to 85% from 65% previously. The analyst, who views AVXS-101 as a key competitive threat to Biogen (BIIB) and Ionis' (IONS) Spinraza as the potential first-line treatment for SMA, raised his price target on AveXis to $108 from $91 and keeps a Buy rating on the shares.

TODAY'S FREE FLY STORIES

ATVI

Activision Blizzard

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0.11 (0.17%)

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SND

Smart Sand

$6.42

0.04 (0.63%)

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BBBY

Bed Bath & Beyond

$27.03

-0.27 (-0.99%)

10:53
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NOV

National Oilwell

$35.37

0.19 (0.54%)

10:52
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Options
National Oilwell calls outpace puts 18:1 as shares jump »

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ZLAB

Zai Lab

10:51
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Syndicate
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STX

Seagate

$32.18

-1.34 (-4.00%)

10:50
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Options
Short-term calls on Seagate see interest for a second time this week »

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TFX

Teleflex

$237.42

-2.3252 (-0.97%)

10:47
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Conference/Events
Teleflex management to meet with JMP Securities »

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OFIX

Orthofix

$48.51

-0.49 (-1.00%)

10:45
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10:45
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10:45
Conference/Events
Orthofix management to meet with JMP Securities »

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PFE

Pfizer

$35.93

0.475 (1.34%)

10:45
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Options
Pfizer call volume above normal and directionally bullish »

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10:45
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General news
Euro$ interest rate futures are relatively buoyant »

Euro$ interest rate…

ZLAB

Zai Lab

10:44
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09/20
10:44
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Syndicate
Breaking Syndicate news story on Zai Lab »

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  • 20

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NKTR

Nektar

$21.75

-0.85 (-3.76%)

10:44
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09/20
10:44
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Conference/Events
Nektar management to meet with Jefferies »

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  • 22

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MAT

Mattel

$15.05

0.18 (1.21%)

, HAS

Hasbro

$94.99

1.75 (1.88%)

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MAT

Mattel

$15.05

0.18 (1.21%)

HAS

Hasbro

$94.99

1.75 (1.88%)

JAKK

JAKKS Pacific

$2.83

-0.025 (-0.88%)

KKR

KKR

$19.24

0.15 (0.79%)

VNO

Vornado

$73.34

-0.03 (-0.04%)

AMZN

Amazon.com

$969.86

-4.33 (-0.44%)

WMT

Wal-Mart

$80.29

0.24 (0.30%)

JPM

JPMorgan

$94.12

0.18 (0.19%)

03/08/13
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MODN

Model N

$13.35

-0.15 (-1.11%)

10:43
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10:43
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Conference/Events
Model N management to meet with Craig Hallum »

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  • 22

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MMM

3M

$210.50

-3.06 (-1.43%)

10:43
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  • 24

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ODP

Office Depot

$4.35

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, ADP

ADP

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ODP

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ZLAB

Zai Lab

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  • 20

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10:40
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General news
Energy Action: NYMEX crude »

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APC

Anadarko

$44.64

0.88 (2.01%)

10:35
09/20/17
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Options
Anadarko put volume heavy and directionally bearish »

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  • 27

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JCOM

j2 Global

$73.37

-1.52 (-2.03%)

10:35
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10:35
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Conference/Events
j2 Global management to meet with JMP Securities »

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PFE

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, JNJ

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PFE

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  • 05

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10:31
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General news
Crude inventories for week of September 15 »

Crude oil inventories…

PYPL

PayPal

$63.83

0.91 (1.45%)

10:30
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PayPal analyst commentary  »

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General news
The 1.7% U.S. August existing home sales drop »

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AAXN

Axon

$22.07

-0.33 (-1.47%)

10:29
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Periodicals
Studies about Taser's safety were overstated, Reuters reports »

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