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XLRN

Acceleron

$31.66

-0.18 (-0.57%)

, CELG

Celgene

$122.41

-2.05 (-1.65%)

14:00
05/07/17
05/07
14:00
05/07/17
14:00

Acceleron, Celgene report preliminary Phase 2 luspatercept data

Acceleron (XLRN) and Celgene (CELG) announced Saturday preliminary Phase 2 results from the ongoing three-month base and long-term extension studies with investigational drug luspatercept in patients with lower-risk myelodysplastic syndromes at the International Symposium on MDS. Luspatercept is being developed as part of the global collaboration between Acceleron and Celgene. In lower-risk, erythropoiesis-stimulating agent-naive MDS patients, 48% of patients treated with luspatercept achieved red blood cell transfusion independence and 51% of patients achieved a clinically meaningful erythroid hematological improvement response per the International Working Group's criteria. The response rates were positive in patients treated with luspatercept in both ESA-naive and prior ESA-treated patients. In patients with baseline erythropoietin levels less than or equal to 500 international units per liter, RBC-TI and IWG HI-E response rates were positive in both ring sideroblast-positive and -negative patients. Grade 3 non-serious AEs possibly or probably related to study drug were ascites, blast cell count increase, blood bilirubin increase, hypertension, platelet count increase, and pleural effusion. Grade 3 serious AEs possibly or probably related to study drug were general physical health deterioration and myalgia. "We are now planning a Phase 3 clinical trial to expand the development of luspatercept into this lower-risk MDS patient population," commented Celgene. "We continue to be motivated to find additional opportunities for luspatercept to treat anemia due to rare blood disorders and remain on track to initiate Phase 2 trials in myelofibrosis and non-transfusion dependent beta-thalassemia by year-end," said Acceleron.

XLRN

Acceleron

$31.66

-0.18 (-0.57%)

CELG

Celgene

$122.41

-2.05 (-1.65%)

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XLRN Acceleron
$31.66

-0.18 (-0.57%)

03/08/17
UBSW
03/08/17
INITIATION
Target $36
UBSW
Buy
Acceleron initiated with a Buy at UBS
UBS analyst Carter Gould initiated Acceleron with a Buy and a $36 price target.
03/14/17
JPMS
03/14/17
INITIATION
Target $33
JPMS
Neutral
Acceleron initiated with a Neutral at JPMorgan
JPMorgan analyst Whitney Ijem started Acceleron Pharma with a Neutral rating and $33 price target. The analyst sees a lack of near-term catalysts with data for lead candidate luspatercept, being developed for the treatment of anemia, not expected until the second half of 2018.
03/23/17
03/23/17
NO CHANGE

Outperform
Acceleron added to Alpha Generator List at FBR Capital
04/18/17
FBCO
04/18/17
INITIATION
Target $46
FBCO
Outperform
Acceleron assumed with an Outperform at Credit Suisse
Target $46.
CELG Celgene
$122.41

-2.05 (-1.65%)

05/03/17
RHCO
05/03/17
NO CHANGE
RHCO
Celgene should report 'strong' 2017 results, says SunTrust
After meeting with Celgene's COO and CFO, SunTrust analyst Yatin Suneja expects the company to have a ""strong 2017 based on good momentum from core products." The analyst thinks that data and approvals over the next 12-18 months could eaeve it poised "for longer term growth." Suneja keeps a $150 price target and a Buy rating on the shares.
05/05/17
ARGS
05/05/17
DOWNGRADE
ARGS
Hold
Celgene downgraded to Hold from Buy at Argus
05/05/17
ARGS
05/05/17
DOWNGRADE
ARGS
Hold
Celgene downgraded on valuation, drug headwinds at Argus
As noted earlier, Argus downgraded Celgene to Hold from Buy. As reasons for the downgrade, analyst David Toung cited valuation, Revlimid revenue concentration risk, and large discounts for Otezla.
05/05/17
05/05/17
DOWNGRADE

On The Fly: Top five analyst downgrades
Catch up on today's top five analyst downgrades with this list compiled by The Fly: 1. Akamai (AKAM) downgraded to Neutral from Outperform at Baird with analyst William citing the lack of improving media trends, the lack of a near-term catalyst, and Street estimates that appear to him to be too high. Power lowered his price target to $55 from $60 on Akamai shares. 2. Celgene (CELG) downgraded to Hold from Buy at Argus with analyst David Toung citing valuation, Revlimid revenue concentration risk, and large discounts for Otezla. 3. Estee Lauder (EL) downgraded to Hold from Buy at Societe Generale. 4. Ball Corp. (BLL) downgraded to Hold on limited upside at Vertical Research with analyst Chip Dillon citing limited upside to his new $83 price target, which he raised from $81. 5. TreeHouse (THS) was downgraded to Market Perform from Outperform at Wells Fargo and to Neutral from Outperform at Wedbush. This list is just a portion of The Fly's full analyst coverage. To see The Fly's full Street Research coverage, click here.

TODAY'S FREE FLY STORIES

NVS

Novartis

$87.21

0.21 (0.24%)

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Comcast

$42.44

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CERS

Cerus

$4.33

0.14 (3.34%)

19:39
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Conference/Events
Cerus to hold a pharmaceutical update conference call »

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XPER

Xperi

$22.85

0.35 (1.56%)

19:26
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Conference/Events
Xperi to hold a conference call »

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MDR

McDermott

$7.86

-0.1 (-1.26%)

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Upgrade
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BDRBF

Bombardier

, ERJ

Embraer

$24.13

-0.34 (-1.39%)

19:08
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Periodicals
Bombardier invokes Embraer in Boeing trade dispute, Globe and Mail says »

Bombardier (BDRBF) says…

BDRBF

Bombardier

ERJ

Embraer

$24.13

-0.34 (-1.39%)

BA

Boeing

$335.59

-2.41 (-0.71%)

DAL

Delta Air Lines

$59.93

-0.2 (-0.33%)

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GSBC

Great Southern Bancorp

$52.00

0.45 (0.87%)

19:01
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Earnings
Great Southern Bancorp reports preliminary Q4 EPS 86c, consnesus 83c »

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UUUU

Energy Fuels

$1.72

0.035 (2.08%)

18:48
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Hot Stocks
Energy Fuels names Mark S. Chalmers president and CEO »

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18:15
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General news
Breaking General news story  »

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RBS

RBS

$8.46

-0.02 (-0.24%)

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Periodicals
RBS plans to leave London headquarters by end of 2019, Reuters reports »

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TROX

Tronox

$21.88

0.07 (0.32%)

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Tronox files lawsuit to prevent FTC from blocking proposed Cristal acquisition »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

18:00
01/23/18
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Hot Stocks
United Financial reports Q4 provision for loan losses $2.3M »

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UBNK

United Financial

$17.92

-0.03 (-0.17%)

17:59
01/23/18
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17:59
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17:59
Earnings
United Financial reports Q4 EPS with items 19c, consensus 30c »

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SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

, SPX

S&P 500

17:55
01/23/18
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17:55
General news
Breaking General news story on SPDR S&P 500 ETF Trust, S&P 500 »

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SPY

SPDR S&P 500 ETF Trust

$283.29

0.6 (0.21%)

SPX

S&P 500

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17:55
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Conference/Events
Federal Reserve Bank of Chicago President participates in a discussion »

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HESM

Hess Midstream Partners

$21.75

0.45 (2.11%)

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Hot Stocks
Hess Midstream Partners raises quarterly dividend 3.6% to 32.2c per unit »

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GWB

Great Western

$44.29

0.53 (1.21%)

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Great Western announces financial impact resulting from Tax Cuts and Jobs Act »

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ARAY

Accuray

$5.20

0.05 (0.97%)

, TSS

TSYS

$83.92

0.17 (0.20%)

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On The Fly: After Hours Movers »

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$5.20

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TSS

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$83.92

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CERS

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$4.33

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NTIP

Network-1 Technologies

$2.60

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GOOG

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$1,169.97

14.16 (1.23%)

GOOGL

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$1,176.17

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QGEN

Qiagen

$33.55

0.5 (1.51%)

SIRI

SiriusXM

$5.68

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VLO

Valero

$98.69

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UAL

United Continental

$77.97

1.1 (1.43%)

NAVI

Navient

$13.44

-0.08 (-0.59%)

CREE

Cree

$35.02

-1.67 (-4.55%)

COF

Capital One

$105.71

0.22 (0.21%)

TXN

Texas Instruments

$119.89

0.45 (0.38%)

PBYI

Puma Biotechnology

$90.90

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SIGM

Sigma Designs

$7.00

0.025 (0.36%)

FPRX

Five Prime

$22.43

0.14 (0.63%)

RCKT

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TK

Teekay Corp.

$10.74

0.05 (0.47%)

SBBP

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$8.70

0.25 (2.96%)

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UAL

United Continental

$77.97

1.11 (1.44%)

17:25
01/23/18
01/23
17:25
01/23/18
17:25
Earnings
United Continental sees FY18 EPS $6.50-$8.50, consensus $6.97 »

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17:25
01/23/18
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Conference/Events
The Chicago Council on Global Affairs to hold a panel discussion »

The Chicago Council on…

MULE

MuleSoft

$25.08

-0.31 (-1.22%)

17:21
01/23/18
01/23
17:21
01/23/18
17:21
Initiation
MuleSoft initiated at Nomura Instinet »

MuleSoft initiated with a…

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MDB

MongoDB

$28.83

0.02 (0.07%)

17:19
01/23/18
01/23
17:19
01/23/18
17:19
Initiation
MongoDB initiated at Nomura Instinet »

MongoDB initiated with a…

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UAL

United Continental

$77.97

1.1 (1.43%)

17:19
01/23/18
01/23
17:19
01/23/18
17:19
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY19 and FY20…

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UAL

United Continental

$77.97

1.1 (1.43%)

17:18
01/23/18
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17:18
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17:18
Hot Stocks
Breaking Hot Stocks news story on United Continental »

United sees FY18 CASM…

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APTI

Apptio

$24.39

0.02 (0.08%)

17:17
01/23/18
01/23
17:17
01/23/18
17:17
Initiation
Apptio initiated at Nomura Instinet »

Apptio initiated with a…

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  • 05

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VMW

VMware

$137.96

1.27 (0.93%)

17:16
01/23/18
01/23
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17:16
Initiation
VMware initiated at Nomura Instinet »

Nomura starts VMware with…

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