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AVEO

AVEO Oncology

$0.68

0.06 (9.68%)

07:03
05/19/17
05/19
07:03
05/19/17
07:03

AVEO Oncology announces completion of CHMP oral explanation for Tivozanib

AVEO Oncology announced its European licensee for tivozanib, EUSA Pharma, has completed an oral explanation to the Committee for Medicinal Products for Human Use, the scientific committee of the European Medicines Agency, as part of the Marketing Authorization Application, review process for tivozanib as a treatment for patients with first-line renal cell carcinoma. It is expected that with the oral explanation complete, the CHMP will proceed to an opinion which they will submit to the European Commission, which has the authority to approve medicines for use in the 28 countries in the European Union. The opinion is expected to be announced at a future CHMP meeting. Tivozanib is an oral, once-daily, vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor. It is a potent, selective and long half-life inhibitor of all three VEGF receptors and is designed to optimize VEGF blockade while minimizing off-target toxicities, potentially resulting in improved efficacy and minimal dose modifications. Tivozanib has been investigated in several tumors types, including renal cell, colorectal and breast cancers.

AVEO AVEO Oncology
$0.68

0.06 (9.68%)

05/19/16
05/19/16
INITIATION

On The Fly: Top analyst initiations
Catch up on today's top five analyst initiations with this list compiled by The Fly: 1. CLSA analyst David Lipschitz initiated Norfolk Southern (NSC) with an Outperform, Kansas City Southern (KSU) with an Underperform, CSX (CSX) with an Underperform, Canadian Pacific (CP) with an Underperform, Canadian National (CNI) with a Sell and Union Pacific (UNP) with a Sell rating. 2. Square (SQ) initiated with a Neutral at Piper Jaffray by analyst Jason Deleeuw, who said he has questions around Square's long-term profitability and believes its business model will need to evolve. 3. UBS analyst Spiro Dounis started Tesoro (TSO) with a Buy rating and $100 price target after initiating the U.S. refiners space with a cautious outlook. Dounis also started Marathon Petroleum (MPC) with a Sell rating and $34 price target. 4. Goldman Sachs analyst Andrew Quail started Kaiser Aluminum (KALU) with a Sell rating and six month price target of $76, saying the company is exposed to end-markets in the late stages of upcycles as production decelerates. Quail also initiated Freeport McMoRan (FCX) with a Neutral rating and six month price target of $12. 5. AVEO Oncology (AVEO) initiated with an Overweight at Piper Jaffray. This list is just a portion of The Fly's analyst coverage. To see The Fly's full Street Research coverage, click here.
06/16/16
PIPR
06/16/16
NO CHANGE
Target $1.7
PIPR
Overweight
AVEO terminated agreement does not impact valuation, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff says Pharmstandard's decision to terminate its development and commercialization agreement for tivozanib in Russia does not impact the valuation of AVEO Oncology. Importantly, milestones under the deal were not included in AVEO's cash guidance, Tenthoff tells investors in a research note. The analyst notes he did not include any value for sales in the terminated territories into his model. Tenthoff reiterates an Overweight rating on AVEO with a $1.70 price target.
01/05/17
PIPR
01/05/17
NO CHANGE
Target $1.75
PIPR
Overweight
Ophthotech termination of AMD pact with AVEO not a surprise, says Piper Jaffray
Piper Jaffray analyst Edward Tenthoff said that following the Phase 3 Fovista miss last month it is "not a surprise" that Ophthotech (OPHT) has terminated the tivozanib development agreement in Age-Related Macular Degeneration with AVEO Pharmaceuticals (AVEO). A CHMP approval decision for tivozanib is expected in the first half of this year, which could trigger a $4M milestone to AVEO, and The confirmatory Phase III TIVO-3 trial in 3rd-line RCC should report top-line data in 2018, noted Tenthoff, who keeps an Overweight rating and $1.75 price target on AVEO shares.

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