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RGLS

Regulus

$1.40

-0.025 (-1.75%)

, AZN

AstraZeneca

$34.17

-0.65 (-1.87%)

07:05
06/12/17
06/12
07:05
06/12/17
07:05

Regulus announces pipeline updates, expansions

Regulus Therapeutics (RGLS) announced updates to its pre-clinical and clinical development programs. "We are squarely focused on taking the steps necessary to advance our pipeline and continue building shareholder value. To that end, we recognize that we must be disciplined in our investment choices and focus our resources and capital on our most promising discovery and development programs, including the application of important development, regulatory and commercial considerations," said Jay Hagan, President and CEO of Regulus. "MicroRNA therapeutics have the potential to become an important new class of drugs with broad therapeutic application. Regulus' focus will be in diseases with significant unmet medical need in organs to which we have been able to preferentially deliver oligonucleotide therapeutics effectively, such as the liver and kidney." Initiation of the Phase II clinical programs for RG-012 for the treatment of Alport syndrome is on track as planned. The Company announced today that it plans to discontinue clinical development of RG-101 upon completion of the one remaining clinical study, which is expected to occur in July 2017. Comprehensive pre-clinical investigation and thorough evaluation of the clinical data from RG-101 has led to the identification of a bilirubin transport mechanism as the likely cause for the cases of hyperbilirubinemia in the RG-101 program. The IND for RGLS4326 is on track for filing by year end 2017. RGLS5040 (anti-miR-27) for cholestatic disease: RGLS5040, an unconjugated inhibitor of microRNA27, has been discontinued based on a positioning of the compound with respect to the competitive landscape coupled with the results from repeat pharmacology studies as part of IND-enabling work. Separately, AstraZeneca (AZN) informed the Company that it intends to terminate the clinical development program for AZD4076(RG-125) for the treatment of NASH in Type 2 Diabetes/Pre-diabetes. Pursuant to the terms of the licensing agreement, AstraZeneca's rights with respect to AZD4076(RG-125) will revert to Regulus when the termination becomes effective in twelve months. AZD4076(RG-125) was jointly identified and selected as a clinical candidate in April 2015 by AstraZeneca under the companies' strategic alliance to discover, develop and commercialize microRNA therapeutics.

RGLS

Regulus

$1.40

-0.025 (-1.75%)

AZN

AstraZeneca

$34.17

-0.65 (-1.87%)

  • 26

    Jun

RGLS Regulus
$1.40

-0.025 (-1.75%)

12/16/16
CANT
12/16/16
INITIATION
Target $11
CANT
Overweight
Regulus initiated with an Overweight at Cantor
Cantor Fitzgerald analyst William Tanner started Regulus Therapeutics with an Overweight rating and $11 price target.
01/30/17
WELS
01/30/17
DOWNGRADE
WELS
Market Perform
Regulus downgraded to Market Perform from Outperform at Wells Fargo
Wells Fargo analyst Jim Birchenough downgraded Regulus Therapeutics to Market Perform citing the continued clinical hold on RG-101 for the treatment of hepatitis C. The analyst is not optimistic that FDA concerns will be addressed. He lowered his price target range for the shares to $1.00-$2.00 from $6.75-$8.00.
01/30/17
NEED
01/30/17
DOWNGRADE
NEED
Hold
Regulus downgraded to Hold from Buy at Needham
01/30/17
01/30/17
DOWNGRADE

Hold
Regulus downgraded to Hold at Needham
As previously reported, Needham analyst Alan Carr downgraded Regulus to Hold from Buy due to absence of near-term material clinical milestones. The analyst believes opportunity for the company to capture value in HCV is fading given growing number of effective once-daily oral options.
AZN AstraZeneca
$34.17

-0.65 (-1.87%)

05/17/17
JPMS
05/17/17
UPGRADE
Target $72
JPMS
Overweight
Clovis upgraded to Overweight from Neutral at JPMorgan
JPMorgan analyst Cory Kasimov upgraded Clovis Oncology (CLVS) to Overweight and raised his price target for the shares to $72 from $58. The stock closed yesterday up 2%, or $1.05, to $49.56. The shares are down 35% over the last two months for "no clear fundamental reason," Kasimov tells investors in a research note. The analyst is "increasingly comfortable" recommending Clovis ahead of its Phase 3 study evaluating Rubraca in maintenance ovarian cancer now that more PARP class data has emerged. He has not seen "convincing evidence" that there is a clear efficacy difference between Clovis' rucaparib, Tesaro's (TSRO) niraparib and AstraZeneca's (AZN) olaparib.
06/01/17
RHCO
06/01/17
NO CHANGE
RHCO
SunTrust sees $240/share takeout price for Tesaro
After the Wall Street Journal reported yesterday that Tesaro (TSRO) is exploring a sale, albeit with "modest" interest, SunTrust analyst Peter Lawson says his analysis suggests a $240 per share takeout price for the company. Tesaro closed yesterday up $5.88, or 4%, to $149.31. Acquisitions in the PARP inhibitor space are more likely to happen after Clovis Oncology's (CLVS) ARIEL 3 data at the end of June, as the readout will provide a more apples-to-apples comparison to Tesaro and AstraZeneca (AZN), Lawson tells investors in a research note. His "bull case" points to a $286 per share price for Tesaro and $92 per share price for Clovis. Lawson has Buy ratings on both names. JPMorgan's Cory Kasimov this morning said he likes the setup for Clovis shares into the late June data announcement.
06/05/17
PIPR
06/05/17
NO CHANGE
PIPR
Piper views AstraZeneca, J&J as ASCO standouts
The standouts at ASCO over the weekend were the "compelling results" presented on Johnson & Johnson's (JNJ) Zytiga from the Latitude study in prostate cancer and AstraZeneca's (AZN) Lynparza in the OlympiAD trial in BRCA mutant breast cancer, Piper Jaffray analyst Richard Purkiss tells investors in a research note. In lung cancer, Merck's (MRK) updated data in KN021G "appears more promising" than Bristol-Myers' (BMY) updated data in CM012, the analyst adds. Purkiss believes, however, that relative to recent ASCOs, the data "so far in totality is underwhelming."
06/06/17
WELS
06/06/17
NO CHANGE
WELS
Amazon may be the next threat to drug pricing, says Wells Fargo
After CNBC recently reported that Amazon (AMZN) is considering going into the prescription pharmacy business in the U.S., Wells Fargo surveyed nearly 2,900 U.S. adults and found that 54% of those polled said they would use or would probably use "Amazon Pharmacy." While the e-commerce giant has not confirmed its U.S. pharmacy interest, if it did enter the market analyst David Maris believes it could see fast adoption and "usher in a new age of price transparency." Maris also wonders if pharmacy "may be just the beginning" and if Amazon eyes the "even larger prize" of fully integrated digital healthcare. Publicly traded large-cap pharmaceuticals companies include AstraZeneca (AZN), Bristol-Myers (BMY), Eli Lilly (LLY), GlaxoSmithKline (GSK), Johnson & Johnson (JNJ), Merck (MRK), Novartis (NVS), Pfizer (PFE), Roche (RHHBY) and Sanofi (SNY). Publicly traded retail pharmacy operators include CVS Health (CVS), Walgreens (WBA), Fred's (FRED) and Rite Aid (RAD).

TODAY'S FREE FLY STORIES

01:55
11/22/17
11/22
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01:55
Conference/Events
Morgan Stanley analysts hold an analyst/industry conference call »

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DE

Deere

$139.23

2.31 (1.69%)

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Notable companies reporting before tomorrow's open »

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  • 22

    Nov

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    Nov

PCRX

Pacira

$42.65

0.45 (1.07%)

19:24
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  • 28

    Nov

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    Dec

  • 06

    Apr

CEIX

CONSOL Energy

, ICON

Iconix Brand

$2.55

0.28 (12.33%)

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S&P announces changes to S&P SmallCap 600 index »

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CEIX

CONSOL Energy

ICON

Iconix Brand

$2.55

0.28 (12.33%)

CNX

Consol

$16.27

0.23 (1.43%)

PDFS

PDF Solutions

$15.86

0.11 (0.70%)

BBOX

Black Box

$4.15

0.55 (15.28%)

03/08/13
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TIVO

TiVo

$17.65

0.15 (0.86%)

, CMCSA

Comcast

$36.42

0.59 (1.65%)

18:52
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Recommendations
TiVo, Comcast analyst commentary at JPMorgan »

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TIVO

TiVo

$17.65

0.15 (0.86%)

CMCSA

Comcast

$36.42

0.59 (1.65%)

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GKOS

Glaukos

$25.35

-2.86 (-10.14%)

18:48
11/21/17
11/21
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Recommendations
Glaukos analyst commentary at Piper Jaffray »

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DIS

Disney

$103.00

0.25 (0.24%)

, CMCSA

Comcast

$36.42

0.59 (1.65%)

18:31
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11/21
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Periodicals
Hulu sued for failure to offer audio service for blind subscribers, NY Post says »

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DIS

Disney

$103.00

0.25 (0.24%)

CMCSA

Comcast

$36.42

0.59 (1.65%)

CMCSK

Comcast

TWX

Time Warner

$89.56

1.85 (2.11%)

FOX

21st Century Fox

$30.10

0.2 (0.67%)

FOXA

21st Century Fox

$30.88

0.22 (0.72%)

03/08/13
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MGA

Magna

$54.29

0.37 (0.69%)

18:23
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Hot Stocks
Magna announces two share repurchase programs »

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  • 09

    Jan

  • 16

    Jan

PTLA

Portola Pharmaceuticals

$50.80

1.29 (2.61%)

18:23
11/21/17
11/21
18:23
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18:23
Hot Stocks
Portola: FDA extends review period for PAS for Bevyxxa »

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  • 02

    Feb

PBMD

Prima BioMed

$1.65

-0.03 (-1.79%)

18:09
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11/21
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Hot Stocks
Prima BioMed secures European patent grant for lead product IMP321 in cancer »

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CPRT

Copart

$36.70

0.39 (1.07%)

18:06
11/21/17
11/21
18:06
11/21/17
18:06
Earnings
Copart reports Q1 non-GAAP EPS 33c, consensus 27c »

Reports Q1 revenue 419.2M…

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  • 22

    Nov

  • 19

    Dec

PCTY

Paylocity

$47.79

-0.64 (-1.32%)

18:01
11/21/17
11/21
18:01
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18:01
Hot Stocks
Paylocity chairman sells 736,845 common shares »

In a regulatory filing,…

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  • 21

    Nov

MDC

M.D.C. Holdings

$35.10

0.91 (2.66%)

18:01
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11/21
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18:01
Hot Stocks
M.D.C. Holdings declares special 8% stock dividend »

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PDFS

PDF Solutions

$15.86

0.11 (0.70%)

, BBOX

Black Box

$4.15

0.55 (15.28%)

17:59
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11/21
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17:59
Hot Stocks
Breaking Hot Stocks news story on PDF Solutions, Black Box »

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PDFS

PDF Solutions

$15.86

0.11 (0.70%)

BBOX

Black Box

$4.15

0.55 (15.28%)

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HPQ

HP Inc.

$22.46

0.34 (1.54%)

17:58
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11/21
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Hot Stocks
Breaking Hot Stocks news story on HP Inc. »

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  • 21

    Nov

CEIX

CONSOL Energy

, ICON

Iconix Brand

$2.55

0.28 (12.33%)

17:57
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Hot Stocks
Breaking Hot Stocks news story on CONSOL Energy, Iconix Brand »

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ICON

Iconix Brand

$2.55

0.28 (12.33%)

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HPQ

HP Inc.

$22.46

0.34 (1.54%)

17:53
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Breaking Hot Stocks news story on HP Inc. »

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  • 21

    Nov

TMQ

Trilogy Metals

$0.92

-0.0211 (-2.25%)

17:53
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Syndicate
Breaking Syndicate news story on Trilogy Metals »

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TRNO

Terreno Realty

$37.74

0.74 (2.00%)

17:50
11/21/17
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17:50
Initiation
Terreno Realty initiated at National Securities »

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  • 14

    Dec

HPQ

HP Inc.

$22.47

0.355 (1.61%)

17:47
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11/21
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HP Inc.: 'Stay tuned' for news on metal 3D printing »

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  • 21

    Nov

THC

Tenet

$13.34

0.17 (1.29%)

17:47
11/21/17
11/21
17:47
11/21/17
17:47
Initiation
Tenet initiated at William Blair »

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LPNT

LifePoint

$43.85

0.65 (1.50%)

17:47
11/21/17
11/21
17:47
11/21/17
17:47
Initiation
LifePoint initiated at William Blair »

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LHCG

LHC Group

$67.98

1.46 (2.19%)

17:46
11/21/17
11/21
17:46
11/21/17
17:46
Initiation
LHC Group initiated at William Blair »

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  • 12

    Dec

  • 13

    Dec

HLS

HealthSouth

$48.46

0.85 (1.79%)

17:46
11/21/17
11/21
17:46
11/21/17
17:46
Initiation
HealthSouth initiated at William Blair »

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HCA

HCA Healthcare

$75.89

1.28 (1.72%)

17:46
11/21/17
11/21
17:46
11/21/17
17:46
Initiation
HCA Healthcare initiated at William Blair »

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  • 06

    Dec

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